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Atlas of Skin Pathology (Paperback, 1986 ed.)
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Atlas of Skin Pathology (Paperback, 1986 ed.)
Series: Current Histopathology, 11
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Dermatopathology is both exciting and exasperating. tum corneum
cells. This occurs in disorders of keratiniza Skin has an elegant
simplicity in its functions yet a tion because the process of
desquamation is disturbed (Figure 1. 1). ferocious complexity in
its structure. This is one of the paradoxes that underly the
pathology of skin disease Parakeratosis. The presence of nucleated
horn cells in and may go some way in explaining the multitudinous
the stratum corneum. Normally the horn cells (corneocy disorders to
which the skin is subject. The ready visibility tes) are thin
lamellae of less than 1 f. lm thickness. They of the skin may also
help explain why straightforward contain no detectable cytoplasmic
contents as these are histological examination cannot always
provide an lost in the granular cell layer. Parakeratosis occurs
when answer to a clinicians's question. Quite dramatic appear the
process of keratinization is disturbed such as when ances may be
due to alterations of the relative rates of the rate of epidermal
cell production is increased (as in blood flow, with or without
oedema, in the different psoriasis) so that nuclei are not broken
down before the vascular plexuses or around different structures in
the stratum corneum is reached and when damage occurs horizontal
dimension, neither of which may result in to the upper epidermis
(Figure 1. 2). 'much to see' histologically. The inherent sampling
error Porokeratosis.
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