The Pediatric and Perinatal Autopsy Manual is a clear and practical yet comprehensive guide for pathology trainees and non-pediatric pathologists. With chapters organized by types of autopsy, this manual answers questions such as: what do I do in cases of congenital malformation or suspected metabolic disease? What is important in the diagnosis of intrapartum and neonatal death? What must I consider in a baby with intrauterine growth restriction and stillbirth? How do I perform a post-mortem in a case of sudden death in infancy? Chapters describe the most important conditions to consider when examining the organs, both macroscopically and histologically, as well as descriptions of how to perform the autopsy. The book is richly illustrated throughout with numerous color images. Written and edited by leading experts in the field, this is an essential resource for non-pediatric general and trainee pathologists as well as forensic pathologists.

A growing body of literature indicates that diseases can affect women and men differently. As sex differences extend far beyond biology, it is crucial to adopt a bicultural approach towards understanding human disease patterns and processes. This 1998 book synthesizes modern medical research with paleopathological investigations. Conditions such as osteoporosis and osteopenia, iron deficiency anaemia, infection and immune reactivity and trauma are explored. Recognizing the relationship between these conditions and aspects of sex and gender in past populations assists in the formulation of models from which modern disease processes can be better understood. Exploring the differences will provide provocative ideas for all those in physical anthropology, archaeology, evolutionary biology, history of medicine and women's studies interested in how sex and gender impacts on disease.

Questo volume si prefigge di fornire a tutti coloro che, di fronte ad un sospetto clinico di Pneumopatia Infiltrativa Diffusa, si sentono confusi stante la molteplicita delle patologie in gioco a fronte di una sintomatologia, di un radiogramma del torace e di reperti funzionali sovente aspecifici. Nella pratica clinica, l'iniziale orientamento in questo labirinto e sempre dato sempre piu spesso dalla Tomografia Computerizzata ad Alta Risoluzione (HRTC) i cui reperti consentono di formulare le prime ipotesi e di programmare gli accertamenti successivi ma talvolta sono di per se stessi conclusivi. La proposta degli Autori e di usare proprio l'HRTC come "filo d'Arianna" per districarsi nel dedalo di queste pneumopatie, e precisamente di partire dalla TC del Paziente, identificarne il pattern predominante per mezzo di immagini di riferimento e poi, con l'aiuto di tavole sinottiche, di restringere il ventaglio delle ipotesi diagnostiche ad una o comunque ad un numero limitato di malattie. Ciascuna malattia e poi trattata in uno spazio dedicato dove vengono descritti l'epidemiologia ed i fattori di rischio, le modalita di presentazione e i dati funzionali e successivamente vengono illustrati gli aspetti anatomopatologici, radiologici ed i reperti del lavaggio broncoalveolare. Non mancano paragrafi che ne delineano evoluzione e complicanze ed altri che propongono concretamente l'iter diagnostico piu opportuno per giungere alla diagnosi definitiva."

Das Pathologische Museum gehorte mit seinen uber 20.000 von Rudolf Virchow zusammengetragenen Objekten zu den umfangreichsten und bedeutendsten der Welt. Als Teil der Berliner Universitat diente es dem Unterricht und der Forschung, die Halfte des Hauses war als Schausammlung fur die Offentlichkeit zuganglich. Die Frage, was ein Museum, die Musealisierung einer Wissenschaft, im 19. Jahrhundert fur einen Forscher und sein Fach bedeuten und welche Funktionen dieser Institution zugedacht werden konnten, steht im Zentrum dieses kulturgeschichtlichen Annaherungsversuches an Virchows Pathologisches Museum. Diese Geschichte des Pathologischen Museums handelt vor allem vom ambivalenten Status von Sammlungsobjekten zwischen Aufklarung und Sakralisierung, Wissenschaft und Kunst, Fortschrittsglauben und Vergangenheitssicherung."

This new publication takes a critical, evidence-based look at the efficacy of new diagnostic tests which are increasingly being used to evaluate organ damage and dysfunction. The use of biomarkers is growing, with a steady stream of new products being brought out by the pharmaceutical industry. However, in many cases the evidence which supports the use of these new methods as opposed to traditional biochemical tests has not yet been demonstrated, and it is intended that this volume will help clarify the strengths and weaknesses of using these biomarkers across a wide range of applications and in the various organs of the body. This approach will provide an invaluable overview of the diverse applications of biomarkers in medicine.

Die hAufigste pathologische WandverAnderung des Dickdarms ist die Divertikulose. WAhrend die PrAvalenz der Divertikelerkrankung zu Beginn des 20. Jahrhunderts noch bei 5% lag, betrAgt sie heute mehr als 50%. Dementsprechend stellt die Divertikulitis in praktisch jedem Krankenhaus einen relevanten Anteil der zu behandelnden Patienten dar. Die zum Teil umwAlzenden Neuerungen und Weiterentwicklungen in Diagnose und Therapie der Divertikulitis erfordern, den gegenwArtigen Kenntnisstand umfassend zu definieren und im Sinne der "evidence-based" Medizin klare Empfehlungen zum Arztlichen Vorgehen zu formulieren. Den Rahmen hierfA1/4r bildete ein Symposium in Aachen unter Beteiligung renommierter nationaler und internationaler Referenten aus den Bereichen Pathologie, Gastroenterologie und Chirurgie.

Primarilly designed for medical students and junior doctors in clinical practice, this should also be a useful reference to postgraduate students in chemical pathology (clinical biochemistry), laboratory scientists, pathologists and medical laboratory technologists. Covering the field of chemical pathology, the biochemical basis of disease, it provides a basic understanding of the relationship between abnormal biochemical test results and disease states. A rational approach to proper selection and interpretation of biochemical investigations is adopted for each organ system or analyte. Emphasis is placed upon areas and problems most commonly met in clinical practice. Material is presented in a clear, condensed format to aid the study process, and the text is supplemented with illustrations.

Das vorliegende Werk ist das Ergebnis umfangreicher vergleichender Untersuchungen an Wirbelsaulenpraparaten im Rahmen eines Schwerpunktes der Weichteil- und Knochenpathologie an den Berufsgenossenschaftlichen Kliniken Bergmannsheil Bochum. Schwerpunkte des Buches sind:
- Wertigkeit und Aussage moderner bildgebender Verfahren, besonders der Computertomographie zur Diagnose und Differentialdiagnose degenerativer Veranderungen des Achsenskelettes.
- Darstellung der rontgenographischen Befunde unter Berucksichtigung von Standard-Verfahren bis zur 3D-Rekonstruktion in der Computertomographie.
- Detaillierte Korrelation zu makroskopischen und mikroskopischen morphologischen Befunden der degenerativen Wirbelsaulenveranderungen mit besondererBerucksichtigung der kleinen Wirbelgelenke."

Frozen section of Neuropathology-related cases is performed while the patient is undergoing surgery. Intraoperative consultation is used to help guide intraoperative management of the case and to ensure that adequate and appropriate tissue has been obtained for purposes of making an accurate final diagnosis. Frozen section diagnosis is often a highly demanding situation for the pathologist, who must render a diagnosis quickly and provide sound guidance and advice. In addition to the need for rapid recall of differential diagnoses, there are many pitfalls and artifacts that add to the risk of frozen section diagnosis that are not present with permanent sections of fully processed tissue that can be examined in a more leisurely fashion. Most standard pathology textbooks focus primarily on permanent section material and largely ignore the topic of frozen section. The purpose of this volume is to add to the Frozen Section Library series and provide a convenient, user friendly handbook to assist in the evaluation of central nervous system related frozen sections. It provides a useful reference, organized around differential diagnoses, primarily by location in the central nervous system. The text will be illustrated with color pictures and include tables as appropriate. This text provides a valuable tool for the practicing surgical pathologist both in community and in academic centers as well as pathology residents and fellows in training when confronted with Neuropathology frozen section.

Gerade im Alter kommt es vor, dass man vergesslicher wird und sich Wichtiges oft nicht mehr merken kann. Geistige Fitness kann aber von Jung und Alt gemeinsam geubt und verbessert werden. Das gilt fur gesunde Menschen genauso wie fur Personen, die an Alzheimer oder einer anderen Demenzerkrankung leiden. Das Trainingsbuch "Nimm dir Zeit fur Oma und Opa" enthalt Gedachtnisubungen in allen Schwierigkeitsstufen fur altere Menschen und ihre Angehoerigen. Durch kurze tagliche UEbungseinheiten werden die Gedachtnisleistung, Konzentration und Aufmerksamkeitsfahigkeit gefoerdert. Wortflussigkeit und Allgemeinwissen werden trainiert. Die UEbungen sind auch fur bereits an Alzheimer erkrankte Personen geeignet. Die Autoren Croy und Gatterer sind Psychotherapeuten. Sie haben ihre beruflichen und privaten Erfahrungen mit kognitiven Trainings fur altere Menschen in diesem Buch verarbeitet.

Die Neuroonkologie hat sich in den vergangenen Jahren als eine eigene Disziplin sowohl innerhalb der Neurologie als auch interdisziplinar etabliert: ubergreifend fur Onkologie, Interne Medizin mit onkologischen Patienten, Neurochirurgie, Radiochirurgie und theoretische Facher. Eine rasche Weiterentwicklung erfolgt sowohl in der Diagnostik als auch beim Therapieangebot. Das Buch ist nach pathophysiologischen Gesichtspunkten aufgebaut. Dies ermoeglicht den AErzten eine rasche Identifikation der wahrscheinlichsten Ursache der Stoerung und zugleich eine ausfuhrliche Differentialdiagnose. Damit ist die "Praktische Neuroonkologie" ein unentbehrlicher Ratgeber in der taglichen Arbeit fur Neurologen, Onkologen und alle AErzte, die Patienten mit neuroonkologischen Problemen behandeln. Die Auflistung aller wichtigen in der Neuroonkologie verwendeten Skalen und Instrumente zur Erfassung der Lebensqualitat garantiert den praktischen Nutzen dieses Kompendiums.

Cytologic examination of the cerebrospinal fluid is a technically simple, yet productive, diagnostic procedure. Here is a practical guide to this method, as used in the diagnosis of different pathologies. High-quality slides depict the common cerebrospinal fluid cell types, cell anomalies in inflammatory conditions and neoplastic and non-neoplastic disorders, and cases with contaminants. It 's required reading for pathologists, as well as neurologists and neurosurgeons.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Many people have problems with their legs - from aching/tired legs and swollen ankles to varicose veins, from lumps appearing to skin discolouration and leg ulcers to name a few. Sometimes symptoms and signs are obviously due to veins - and other times people might be unaware of hidden varicose veins. However with 30-40% of the adult population having some venous dysfunction, venous disease is behind a lot of leg problems. Vein Health and Problems in Lockdown and Isolation has been written by Mark S Whiteley, an internationally recognised expert in varicose veins, leg ulcers and venous disease. In this book Mark goes through: Why a lockdown or isolation can worsen leg problems What symptoms and signs you might notice during a lockdown How the leg veins work What can go wrong with leg veins What problems varicose veins and hidden varicose veins can cause How to look after your vein health in a lockdown or during isolation What you should do if you notice certain symptoms or signs during a lockdown or isolation Vein health and problems in lockdown and isolation will help the reader understand venous disease better - and help the reader identify which symptoms and signs might be venous disease, and how urgently they need to be treated. Some sections such as how to look after the vein health in a lockdown are quite specific for these stressful times, whereas most of the book is relevant to anyone with venous problems, even if they don't know their symptoms and signs are due to hidden varicose veins!

Ein einfacher Zugang zur Liquorzelldiagnostik wird anhand eines umfangreichen Farbbildteiles und leicht verstandlicher Erlauterungen sowohl zu den theoretischen und technischen Grundlagen der Liquorzytologie als auch zur Bearbeitung der Proben im Labor ermoeglicht. Normale und pathologische Liquorzellbilder - auch aus atypischen Liquorproben (Drainagen, Liquorrhoe) - werden ausfuhrlich beschrieben und den entsprechenden neurologischen Erkrankungen zugeordnet. Als Erganzung dazu werden die Grundprinzipien der Proteindiagnostik im Liquor cerebrospinalis und deren Beurteilung dargestellt. Die ubersichtliche, pragnante Aufbereitung erleichtert sowohl die Arbeit der im Labor Tatigen als auch die Diagnosestellung durch den Facharzt.

This authoritative textbook offers in-depth coverage of all aspects of molecular pathology practice and embodies the current standard in molecular testing. Since the successful first edition, new sections have been added on pharmacogenetics and genomics, while other sections have been revised and updated to reflect the rapid advances in the field. The result is a superb reference that encompasses molecular biology basics, genetics, inherited cancers, solid tumors, neoplastic hematopathology, infectious diseases, identity testing, HLA typing, laboratory management, genomics and proteomics. Throughout the text, emphasis is placed on the molecular variations being detected, the clinical usefulness of the tests and important clinical and laboratory issues. The second edition of Molecular Pathology in Clinical Practice will be an invaluable source of information for all practicing molecular pathologists and will also be of utility for other pathologists, clinical colleagues and trainees.

Die Arbeit fasst die bisherigen Erkenntnisse uber intrazellulare Transportprozesse und ihre klinische Bedeutung zusammen, beschreibt die Methoden zur Untersuchung intrazellularer Transportprozesse und prasentiert neue Ergebnisse aus eigenen Forschungsarbeiten uber Krankheiten mit Veranderungen des intrazellularen Proteintransportes wie Zoliakie, Ornithin-Transcarbamylase-Mangel und Morbus Gaucher."

Der besonderen Bedeutung der medizinischen Qualitatssicherung durch die Obduktion im Rahmen der internen arztlichen, aber auch oeffentlichen Diskussion wird in diesem Buch Rechnung getragen. Dabei werden die gewoehnlichen Hauptleiden und Todesursachen, wie Erkrankungen des Herz-Kreislauf-Systems, des Gastrointestinal- und Respirationstrakts sowie des Urogenitalsystems dargestellt, mit Schwerpunkt auf der Makroskopie, nicht der Mikroskopie. Kurze, pragnante Texte und eine grosszugige, informative Bebilderung foerdern ein genaueres Verstandnis der Alltagspathologie. Mit diesem Taschenbuch erhalten niedergelassene und Krankenhausarzte einen kurzen, verstandlichen Leitfaden als Diskussionsgrundlage fur die klinisch-pathologische Konferenz.