A. Kompressions- (Quetschungs-)Verletzungen des Kopfes.- B. Disseminierte intravaskulare Koagulation bei Bestehen einer Schadel-Hirn-Verletzung.- C. Zentrale pontine Myelinolyse.- D. Traumatische Gefassverletzungen.- E. Traumatische intrazerebrale und intrazerebellare Blutungen und Hamatome.- F. Kombnierte traumatische intrakranielle Blutungen und Hamatome.- G. Zentrale traumatische Grosshirnschaden einschliesslich der Balkenlasionen.- H. Traumatische Hirnstammschaden.- J. Zur Problematik der sogenannten Bollinger-Spatapoplexie.- K. Traumatische Enzephalopathien mit prolongierten Bewusstseinsstoerungen (das sogenannte apallische Syndrom).- L. Folgen intrakranieller Drucksteigerung - dissoziierter Hirntod oder intravitaler Hirntod (Hirntod, "coma depasse", uberschrittenes Koma, "cerebral death", "respirator brain", "mort du cerveau").- M. Traumatische Hirnnervenschaden.- N. Gewebeschaden der Hypophyse und des Hypothalamus bei Schadel-Hirn-Verletzungen.- O. Gewebs- und Gefassschaden infolge chiropraktischer Eingriffe oder sogenannter "Adjustierungen" an der HWS und deren Auswirkungen auf Gehirn und Ruckenmark.- P. Schadel-Hirn-Verletzung und Parkinsonismus.- Q. Schadel-Hirn-Verletzungen und Hirngeschwulste.- R. Komplikationen nach zerebraler Angiographie.- S. Tottreten mit den beschuhten und unbeschuhten Fussen.- T. Patienten die "sprechen und dann sterben" ("who talk and die").- Literatur.

Enzymes are bio-catalysts which effect transformation of substrates to products with high specificity. The usage of enzymes in domestic and industrial applications is well known and has been well documented since the early history of civilization. With the advances in understanding of enzymology, usage of enzymes in industrial and biotechnological pro cesses and molecular medicine has proliferated. One of the key factors in the widespread application of enzymes in modern technologies is the development of enzyme immobilization tech niques, which overcome certain practical, functional and economic con straints. Many natural enzymes can be stabilized by immobilization on solid matrices, with most of the activity retained, for a variety of applica tions. An important application of immobilized enzymes is in liquid chromatography. In the last decade, post-column enzyme detection has become established as an important discipline in liquid chromatography. The new detection approach offers more sensitive and specific ways for measuring major classes of biomolecules. Reactors are fabricated by packing the immobilized enzymes into small columns, which can be placed immediately after an HPLC column."

Fully updated throughout, the second edition of this bestselling book provides a comprehensive guide to the pathology of soft tissue tumors and tumor-like lesions. Reflecting the latest WHO classification throughout, this new edition incorporates advances in clinicopathologic, biologic and genetic studies. As such, detailed coverage of immunohistochemistry and molecular diagnostics is included for each entity. Soft tissue tumors are broadly defined to include metastatic melanomas, carcinomas, and lymphoid proliferations in soft tissue, enabling the reader to distinguish between easily confused entities. Chapters are richly illustrated throughout with high-quality colour images, depicting both typical histology and variants of each entity. Each printed copy of this new edition is also packaged with a password, providing online access to the book's text and images. Written and edited by renowned international leaders in the field, this is an essential guide to all diagnostic modalities in soft tissue pathology.

Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen eration, injury and repair. As indicated in Dr. N. Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique described has 3 remarkable features: 1) it is highly reproducible, resulting in the removal of 68% of the liver, 2) it has minimal if any mortality, and 3) it consists only of blood vessel ligation and does not involve cutting through or wounding hepatic tissue.

Cardiac Markers is a comprehensive, up-to-date summary of clinical information on serum cardiac markers for coronary artery disease. This book reviews in detail the biochemistry, clinical significance, and analytical measurements for each marker, as well as the advantages and limitations of existing and proposed markers. Comprehensive descriptions of therapeutic approaches to manage patients are presented. Also included are up-to-date listings of primary references and commercial methodologies, the latest data on the pathophysiology of unstable angina, and a discussion of the new emergency-room chest pain centers. Anyone who needs to know how to examine, diagnose, treat, and manage patients with acute chest pain and heart attacks will find this book indispensable.

Hematopathology: Genomic Mechanisms of Neoplastic Diseases will keep physicians abreast of the rapid and complex changes in genomic medicine, as exemplified by the molecular pathology of hematologic malignancies. This timely volume will update physicians on the complexities of genomic lesions, as well as offer an integrated framework encompassing molecular diagnosis, the new WHO classification of hematologic neoplasms with focus on molecular pathology, prognostic value of molecular tests, and molecular monitoring of response to gene-targeted therapy. As such, it will be of great value to hematologists, oncologists, pathologists, internal medicine and pediatric specialists, as well as bioscientific staff and laboratorians in private hospitals and academic institutions.

Cytopreparation: Principles & Practice by Gary W. Gill fills a long-standing need for an easy-to-use and authoritative manual on the fundamentals of cytopreparation up-to-and- including microscopy, screening, and data analysis. The text describes in phenomenological terms the most common materials and methods of specimen collection through mounting for gyn, non-gyn, and FNA specimens, as well as the underlying mechanistic bases. The author provides his expertise and information that will empower and enable readers to review and improve their laboratories' cytopreparatory techniques as they apply to the vast majority of specimens. This unique volume provides facts that are not readily available anywhere. Cytopreparation: Principles & Practice is intended for everyone associated with, and involved in, making cytologic preparations that are useful for their intended purpose. It will serve as a valuable reference tool for educators in cytology and histology, cytotechnology and histotechnology students, cytotechnologists, cytopreparatory technicians, cytopathologists, anatomical/clinical pathologists, pathology residents and cytopathology fellows.

Eminent clinicians and specialists thoroughly review in great detail every aspect of pituitary tumors. The topics covered include prolactinomas, somatotroph adenomas, corticotroph adenomas, thyrotroph adenomas, nonfunctioning tumors, pituitary tumors, invasive adenomas, and pituitary carcinomas, as well as lesions, exclusive of pituitary adenomas, that occur in the sellar region. Also discussed are the new methods in endocrine diagnosis, high resolution imaging, receptor-mediated pharmacotherapy, microsurgical techniques, improved methods of radiation delivery, and the development of a precise and physiologically meaningful classification of pituitary tumors. Much-needed and brilliantly multidisciplinary, Diagnosis and Management of Pituitary Tumors offers all those dealing with pituitary cancer patients today's most comprehensive guide to diagnosis and treatment, one whose coordinated treatment strategies have sharply improved long-term survival rates for many patients.

Frozen sections are performed while a patient is undergoing surgery as a basis for making an immediate diagnosis that will impact treatment decisions. Frozen section diagnosis is often a highly demanding situation for the pathologist who must render a diagnosis quickly for the patient and surgeon. The Frozen Section Library series will provide concise, user-friendly, site specific handbooks that are well illustrated and highlight the pitfalls, artifacts and differential diagnosis issues that arise in the hurried frozen section scenario.

The physiology and pathology of membrane (contact or surface) digestion of the three main components of the food of animals and man is a rapidly developing field, and there is little doubt that newer ob servations will become available as time progresses. As the dis coverer of the phenomenon of membrane digestion, Professor Ugolev is well aware of the relative infancy of this subject, and in presenting the book at this time his primary purpose was to acquaint the reader with the experimental basis for the observed phenomenon and to stimulate interest in the further work required for the elucidation of details and for proper orientation. Translations as means of communication of ideas and experimental facts are of obvious importance and they require no apologies or explanations, particularly to those who are engaged in scientific endeavors. In making this book available to those who find the Russian language an insurmountable barrier, our main efforts were directed toward preserving the author's meaning, spirit, and intent as accurately as possible. It is hoped that this objective has been attained, and that the minor unintentional errors will be forgiven by the reader and by the author. The translator wishes to express to Professor Ugolev, whom he met in Leningrad in 1965, his appreciation for the trust in the ability of the translator to make Professor Ugolev's labor oflove, the present book, available in the English language."

In the literature, there is no comprehensive survey and assessment of the histology of natural and unnatural injuries to humans that has been scien- tifically researched and practically examined from the point of view offo- rensic medicine. Even today, an analysis of the international literature shows that the significance of histology in medicolegal examinations has not hitherto been systematically presented in the English language. Above all, there is a lack of a critical appraisal of the evidence value of histology and its significance within the scope of concrete forensic determinations. In the present volume, I have attempted to rectify this situation and thus bridge the prevailing gap in the literature. It is not, however, intended that a new area of histology be established as an independent discipline within forensic medicine. Rather, those facilities of histology will be emphasized that should be considered by scientists in forensic practice. There are of course older and more recent studies on branches of the subject (Kasianow 1954; Gerin 1965; Raekallio 1965,1970; Pioch 1966; Berg 1972; Benecke 1972; Perper and Wecht 1980). Otherwise, isolated histological examination findings on organ and tissue damage have been dealt with in old and new standard works on forensic medicine (Hofmann and Haberda, von Neureiter, Walcher, Pons old, Mueller, Popielski and Kobiela, Prokop, Poulsen, Tedeschi et aI. , Uotila, Gresham).

Since Harvey Cushing's extensive study on brain meningiomas no similar study has been conducted on spinal cord meningiomas. The high scientific value of this book is based on the careful elaboration of data from patients affected by spinal meningiomas who have been examined and operated on over the last 33 years (1962-1995) at the Neurosurgical School of the University of Florence, Italy. The main focus of this study was on the anatomic and clinical relationship that enabled early diagnosis of spinal meningiomas. More over this book emphasizes the interaction between neurology and neuroradiology in the form of "dynamic neurology." Myeloradiculographic findings are described together with those using more recent techniques such as CT and MRI.

In recent years, remarkable discoveries have been made concerning the underlying mechanisms of aging. In Life-Span Extension: Single-Cell Organisms to Man, the editors bring together a range of illuminating perspectives from researchers investigating the aging process in a variety of species. This novel work addresses the aging process in species ranging from yeast to man and, among other subjects, features detailed discussions of the naked mole-rat, an exceptionally long-lived rodent; the relationship between dietary factors/food restriction and aging; and an evolutionary view of the human aging process.

Single mutations that extend life span have been identified in yeast, worms, flies, and mice, whereas studies in humans have identified potentially important markers for successful aging. At the same time, it has been discovered that the genes and pathways identified in these studies involve a surprisingly small set of conserved functions, most of which have been the focus of aging research for some time. For example, the mTOR pathway, a regulator of translation and protein synthesis, has been identified as a common longevity pathway in yeast and Caenorhabditis elegans. In mammals, this pathway intersects with neuroendocrine pathways and with the insulin/insulin-like growth factor pathways, which have been identified as major modulators of life span and aging in both invertebrates and mice.

Novel, emerging technologies and the increasingly wide variety of systems that are now used to study aging and the mechanisms of aging provide enormous opportunities for the identification of common pathways that modulate longevity. It is these common pathways that are the focus of this important volume.

Violence is a steadily increasing feature of modern When a doctor is called to a scene of death wounds society caused by devices such as motor vehicles, indus may readily be visible on the corpse. His careful exam trial equipment and aircraft, which are fabricated by ination and interpretation of the injuries can provide man, or caused by man himself. There are few practi valuable assistance to the police in the early stages of tioners of medicine who will not encounter wounding any investigation that may follow. He may be able to in some form in the course of a lifetime of practice. say that the wound was self-inflicted, or he may think Most wounds will require his skills in treatment; others that the wound had been inflicted homicidally. The demand interpretation because the appearance of the events that follow such interpretations are clearly very wound itself and the pattern in which wounds may be different so far as the police are concerned. For this, arranged can provide much information about the ways and other reasons, a detailed knowledge of wounds and in which they have been caused. For example, the wounding is an essential part of medical training. grouping and position of wounds can suggest whether Scientific investigation of the whole subject of trauma the injuries were inflicted accidentally, suicidally or in has been advancing very slowly over the years."

Dermatopathology is evolving as a significant subspecialty. In most instances, the increasing workload may be readily dealt with by the experienced pathologist. Many dramatic changes, however, have occured in dermatopathology which necessitate a review in a number of areas. This volume provides such a review of selected topics. The contributions by internationally recognized experts deal with the impact of HIV on the skin, the application of molecular techniques in infection, the understanding of fibrohistiocytic tumours, differentiating Spitz from Spitzoid melanomas and toxic epidermal necrolysis from graft-versus-host disease, as well as the recognition and updated classification of primary lymphomas. This text is undoubtedly valuable to histopathologists and dermatologists who, often together, diagnose, manage and provide therapy in this exciting medical field.

Seventeen cutting-edge chapters review both basic research and clinical applications of chromosomal markers of cancer. The new markers offer great promise, not only for their clinical utility in diagnosis, prognosis, and disease monitoring, but also for their contributions to a better understanding of the mechanisms of tumor development and progression. The chapters-all written by leading authorities-skillfully reveal fresh insights into the translational role of cytogenetics in identifying the cellular and molecular changes that occur in cancer. Coverage is devoted to many tissue systems-colon, breast, prostate, lung, skin, brain, and kidney-where the diagnostic and prognostic utility of chromosome markers is clearly demonstrated. A seminal book certain to become the front-line reference and authoritative resource needed by all scientists and clinicians engaged in cancer research, diagnosis, and management.

A medical book need not be pretty, but it must be necessary and informative. This monograph on the clinical and diagnostic pathology of graft-versus-host disease, provid ing detailed visual information on the histo morphological and immunohistological fea tures of GvHD, is intended to close a gap in the otherwise comprehensive medical literature on GvHD. B. Heymer Acknowledgements No one accumulates knowledge alone. lowe thanks to: Prof. G. R. F. Kruger, Houston, for introducing me to the histomorphological analysis of GvHD Prof. R. Arnold, Berlin, for many fruitful clinico pathological discussions Prof. K. H. Muller-Hermelink, Wurzburg, for expert advice in difficult histological differential diagnoses Prof. W. Mohr, Ulm, for continuous support and encouragement in moments of fatigue Last, but by no means least, Mrs. R. Endres-Klein, Ulm, without whom the preparation of this book would have been impossible In addition, I am grateful to the editorial staff at Springer, Heidelberg. B. Heymer Contents 1 Introduction. . . . . . . . . . . . . 1 1. 1 What Is Graft-Versus-Host Disease? 1 1. 2 Has the Pathology of GvHD Changed in the Past Decades? . . . . 1 1. 3 Why Write a Synopsis of the Clinical and Diagnostic Pathology of GvHO? 2 2 Occurrence of GvHD . . . . . . . . . 5 2. 1 GvHD After Allogeneic Bone Marrow Transplantation . . . . . . . . . . . . . 6 2. 2 GvHD After Allogeneic Peripheral Blood Stem Cell Transplantation 6 2. 3 Alternative Donors . . . . . . . . . . . . 7 2. 4 Umbilical Cord Blood . . . . . . . . . . 7 2. 5 GvHD After Materno-fetal Transfusion 8 2. 6 GvHD After Blood Transfusion . . . . . 9 2."

The Oxford American Handbook of Clinical Examination and Practical Skills is a comprehensive pocket guide for medical, physician assistant, and nurse practitioner students. It is designed to help students transition from classroom to clinical internships, preceptorships, and clerkships. Providing clear and user-friendly guidance on all aspects of history taking, physical examination, common practical procedures, data interpretation and communication skills, it gives realistic advice on coping with and mastering common situations.
Each systems chapter follows a structured format covering applied anatomy, history, examination, and the presentation of common and important disorders. The procedures section includes approximately forty practical procedures that the final year medical student and senior nurse are expected to perform. The section on data interpretation covers the basics of chest x-rays, abdominal x-rays, ECGs, lung function tests and several other areas that the student is expected to carry out in their early years of training.