General pathology is a broad and complex scientific field which seeks to understand the mechanisms of injury to cells and tissues, as well as the body's means of responding to and repairing injury. Areas of study include cellular adaptation to injury, necrosis, inflammation, wound healing, and neoplasia. The foundation of pathology is the application of this knowledge to diagnose diseases in humans and animals. In this book, the authors present topical research in the study of pathology, including challenging the authority of the autopsy in coronial investigations; pathological examination of influenza virus-associated and auto-immune encephalitis/encephalopathy in children; histopathological investigation in forensic autopsies; psychopathology of suicide in Bali and the pathology of fatty acid oxidation disorders on sudden unexpected death in infancy.

The discovery of C-reactive protein in the laboratory of O. T. Avery at Rockefeller University in 1929-30 was the first specific obser- vation of the acute phase plasma protein response (Tillett and Francis 1930). This was one of three contributions of fundamental importance which emerged from that laboratory, the other two being the recognition that polysaccharides could act as antigens and that DNA transmits genetic information. In the course of charac- terization of pneumococcal carbohydrate antigens, a somatic poly- saccharide common to all Rand S forms of pneumococci was identified and designated Fraction "C" (Tillet et al. 1930). Testing of sera from patients with pneumococcal infection revealed the presence of material which precipitated with the C-polysaccharide but which differed from antibody in that calcium was required for the reaction. Furthermore, the amount of reactive material was greatest when patients were acutely ill and decreased in the convalescent phase, the precise opposite of specific anti-pneumo- coccal antibodies. Subsequently, the C-reactive material was shown to be a protein and to be present in the sera of individuals who were acutely ill with other, non-pneumococcal infections and tissue damaging conditions, hence Avery coined the term "acute phase" and called the protein "acute phase protein" (Abernethy and Avery 1941; MacLeod and Avery 1941). At that time methods were too insensitive to detect C-reative protein (CRP) in sera of healthy subjects and it was considered to be a pathological product.

Surgical pathologists play a central role in patient surveillance and treatment by surgeons, radiation oncologists, and medical oncologists. Although salivary gland tumors are uncommon overall, their histopathologic diversity and challenge command the attention of practicing surgical pathologists. Atlas of Salivary Gland Pathology focuses on the diagnostic approach to salivary gland neoplasia-one of the more challenging fields within surgical pathology-emphasizing the need to understand downstream implications with respect to patient surveillance and treatment. The presence of formidable histologic mimicry in salivary gland neoplasia is well-documented in the pathology literature and has also been observed in the consultation practice of the volume editor. This textbook is designed with the needs of practicing surgical pathologists and pathologists-in-training in mind, providing a comprehensive overview of both common and rare salivary gland neoplasms. The primary educational objectives for readers include the following: 1) distinguish benign from low-grade malignant salivary gland neoplasms, 2) effectively use histochemical, immunohistochemical, and cytogenetic studies in challenging cases, 3) understand which diagnoses merit additional surgery and/or adjuvant therapy (radiation, chemotherapy), and 4) enhance pathologist-to-clinician communication in the setting of salivary gland disease.

Examination of the bone marrow has always been, and to-date techniques whose application will undoubtedly to a large extent still is, within the domain of the haema increase in the future. tologist. This is because smears of bone marrow aspirates After lengthy discussions and enquiries, the conclusion together with peripheral blood films and results of other was reached that the magnifications of most of the tests and investigations provided the information on which illustrations could be omitted without detracting from the usefulness of the Atlas. The magnifications used are the clinical diagnosis was based. Recently, the widespread availability of both improved indicated in Fig. 1.25. In addition, not every detail specif biopsy needles and techniques for processing has greatly ically indicated in a figure or its legend is necessarily increased the number of routinely taken bone biopsies mentioned in the text; and often a range of observations and placed the examination of bone marrow biopsy is illustrated and in these cases the legends are self sectiors also in the field of histopathology - so that explanatory. this Atlas is one of the Current Histopathology series. This Atlas is directed to haematologists and to histo Therefore, the haematologist and the histopathologist pathologists and to anyone interested in the investigation now complement each other in the interpretation of bone and understanding of the human bone marrow. marrow smears, imprints and sections, thus utilizing all available information and expertise to arrive at a diagnosis.

The Practitioner's Path in Speech-Language Pathology: The Art of School-Based Practice bridges the gap between theory and practice, evidence-based practice and practice-based evidence, and the science and artistry of speech-language pathology. This book takes a critical look at areas related to wellness, professional development, and growth that can impact the personal self along with the professional self. It examines each area through an overview of inter-disciplinary research in addition to personal narratives illustrating key principles and strategies and offers the reader a professionally balanced perspective.The first section of the book helps us understand the importance of building a foundation for our clinical path through a discussion about scientific and evidence-based principles, different types of knowledge systems, and development of wisdom. The second section of the book helps us understand the importance of supporting our foundation through an introduction to reflection, counsel and care, balance and harmony, growth and detachment. The third section of the book includes chapters that serve as pillars of practice: organizational frameworks, materials and activities, measuring progress, best practices, and the importance of community. The fourth and final section of the book highlights shared vision, clinical expertise, emotional intelligence, leadership trends, the scholarship of teaching and learning, and research dissemination.This book challenges us to consider our own perceptions about the explicit nature of professional practice, and facilitates the development of four attitudes that can have a profound impact on both clinical success and professional satisfaction: "a scientific attitude", "a therapeutic attitude", "a professional attitude", and "a leadership attitude". It contains a blend of clinical evidence and research, practitioner views, common sense, philosophical stances, and historical overviews. "The Practitioner's Path in Speech-Language Pathology" is designed for students and practitioners who are actively involved with the process of knowledge acquisition, and targets issues we encounter along our path to becoming reflective practitioners, as they relate to the excellence behind and scholarship within teaching and learning.

Forensic neuropathology is an important specialty within forensic pathology. In addition to traumatic brain injury in the adult and child, forensic neuropathologists must also consider the role of natural disease within the forensic setting such as cerebrovascular disease, as well as neurotoxicology. Focusing on difficulties that arise in the medico-legal context, the chapters include techniques for the post-mortem examination of the brain and related structures. Forensic pathologists, neuropathologists, general pathologists, clinical forensic specialists as well as neuroscientists, neurologists and neurosurgeons will all find useful information. In addition, members of the legal profession have found this an important reference work. Chapters have been extensively revised and new content includes - Chronic traumatic encephalopathy-related pathology - Sudden unexplained death in epilepsy - Biomechanics of head injury - Updates on pathological aspects of head injury including infant head injury with ocular pathology - Clinical aspects of head injury and spinal injury including a new chapter on neuroradiology Reviews of the First Edition This outstanding book is unique. Well-illustrated with high-quality colour photographs and line drawings, it reads well. Strongly recommended for trainees in histopathology, neuropathology, paediatric pathology, and forensic pathology, as well as for consultants practising in these fields.

Die Fortschritte der Neurowissenschaften in den vergangenen Jahrzehnten haben wesentlich dazu beigetragen, dass auch die Neuropathologie einen neuen Stellenwert in der Medizin erhalten hat. In diesem Band werden bei der Klassifikation der vielfaltigen krankhaften Veranderungen vor allem auch molekularbiologische Befunde neben den Methoden der Immunohistochemie und Elektronenmikroskopie berucksichtigt. In einer Synopsis von klinischen Daten, morphologischen Befunden und neuen Erkenntnissen der Molekularbiologie werden in Verbindung mit einer exakten Datenverarbeitung nicht nur die haufigsten Krankheiten analysiert, sondern auch die selteneren Krankheitsbilder abgehandelt. Auf der Basis einer umfangreichen Materialsammlung, einer informativen Bilddokumentation und einer vergleichenden Analyse des Schrifttums stellt der vorliegende Band eine Fundgrube uber die "Pathologie der peripherien Nerven" dar."

Part of the highly regarded Biopsy Interpretation Series, Biopsy Interpretation of the Liver, 4th Edition, provides practical, highly illustrated information on the diagnosis and prognosis of the full range of biopsies of the liver. Practical, well-organized, and highly readable, this fully revised volume by Dr. Michael S. Torbenson addresses both common and unusual issues that arise in the day-to-day interpretation of liver biopsies, teaching the best diagnostic practices as well as how to avoid the most common pitfalls. Frames each diagnosis in its most common clinical context, explaining how the pathology can be used to make key clinical management decisions. Presents key differential features of tumors, organized according to diagnostic category Features high-quality photomicrographs and illustrations throughout, including updated images both in print (over 700) and online-more than 900 images in all. Includes two new chapters on Radiology Report Interpretation and Cytogenetics and Genomics. Provides access to more than 100 questions and answers online for self-assessment and review. , Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. ,

Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into the brain. Abnormalities of the blood-brain barrier are increasingly recognized as a key component in the pathogenesis of a range of primary diseases of the brain and the secondary involvement of the brain from pathological processes in other organs. In The Blood-Brain Barrier in Health and Disease, Volume 2, international experts present comprehensive reviews and research accounts on blood-brain barrier dysfunction in infectious and inflammatory diseases, cerebrovascular diseases, stroke, trauma, vitamin deficiency, exposure to neurotoxicants, primary and metastatic brain tumors, and neurodegenerative diseases. This book is intended to serve as a guide and reference to basic and advanced information for researchers, students, and clinicians interested in this fast-expanding field and stimulate further research well into the future.

Selected as a Doody's Core Title for 2022! Filled with more than 1,000 images, the latest edition of this award-winning comprehensive classic-written by anatomic pathologists for anatomic pathologists-has been updated with new information on surgical principles and techniques. Like previous editions, the book is designed to bridge the gap between normal histology and pathologic alterations. Now featuring the latest developments and advances made since the previous edition five years ago. Unique among pathology textbooks in using human-as opposed to animal-tissues for discussions on histology. Essential reading for all anatomic pathologists, and particularly helpful for pathology residents throughout their training. Chapters and sections organized by biological system as well as body region. Enhance Your eBook Reading Experience: Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This new book is designed to enable researchers to design and undertake all aspects of a phage display project, from designing an experimental strategy and constructing a library to performing selections and analyzing the results.All of the protocols and chapters are extensively cross-referenced, allowing readers to move beyond the specific examples provided in order to customize the procedures for their own protein or selection system of interest. Phage Display is an up-to-date, comprehensive and integrated experimental guide to the technique, which is essential reading for anyone currently using, or wishing to use the technique for basic research and drug discovery.

The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.

Generations of medical and other health science students have been helped to pass their exams by the Illustrated books. The visual presentation of the subject matter, divided in to one-page units, makes for easy learning and recall. Now fully revised in this eighth edition, Pathology Illustrated covers all the essential information in as clear and concise a way as possible, focussing on what is most clinically important. Pathology remains central to the study of medicine and forms the bridge between the basic sciences and clinical medicine, making this book an essential purchase for today's student. Covers both basic and systematic pathology Each topic clearly summarised in one/two pages Visual presentation for easy learning and recall Fully updated throughout - including new and expanded coverage on the essentials of genetic disease, haemodynamics and shock and basic techniques in molecular biology Includes an all new interactive eBook version: downloadable for anytime access to the complete contents enhanced with new, interactive multiple-choice questions for each chapter, to test your understanding and aid exam preparation

This book aims to examine all immunohistochemical and molecular pathological biomarkers that can be useful and effective in patient diagnosis, prognosis and treatment decision, especially when faced with a carcinoma of unknown primary. For this purpose, epithelial malignancies of all systems and related biomarkers are examined one by one, and to look at the subject through the metastatic regions window, biomarkers that can be used to determine the primary focus for carcinomas seen in the areas most frequently metastasized are emphasized. With this bi-directional perspective, the reader is able to find biomarkers of any type of carcinoma on a system basis, as well as access to which biomarkers can be used when faced with a metastatic carcinoma. The importance of biomarkers in patient follow-up and treatment is also conveyed through the clinician's eye, and so biomarkers are handled with a holistic approach in all aspects. This book primarily targets pathologists, as well as clinicians (oncologists and surgeons) who manage cancer patients.

Selected as a Doody's Core Title for 2022! Focusing on the essential information you need to know for the clinical practice of surgical pathology, this award-winning volume in the Lippincott Manual series provides concise, high-yield content that reflects today's fast-changing advances in the field. In one convenient, portable resource, you'll find complete coverage of surgical pathology for every organ and anatomic site -all at your fingertips for quick review and reference. Washington Manual of Surgical Pathology, 3rd Edition, is an ideal reference for surgical pathologists at all levels of training and practice. Includes new WHO classifications and access to more than 2,700 high-quality images online. Offers brief, logical approaches to gross examination and dissection; microscopic diagnosis of medical as well as surgical diseases; and tumor classification. Features separate chapters devoted to ancillary surgical pathology techniques, including immunohistochemistry, immunofluorescence microscopy, electron microscopy, frozen section diagnosis, flow cytometry, DNA and RNA based molecular methods, and imaging technologies. Presents valuable content in a concise, practical format that includes easy-to-follow guidelines, tables, diagrams, and algorithms. Previous edition winner of the BMA Medical Book Award First Prize in Pathology. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook , powering your content with natural language text-to-speech.

This book provides up-to-date and practical knowledge in all aspects of whole slide imaging (WSI) by experts in the field. This includes a historical perspective on the evolution of this technology, technical aspects of making a great whole slide image, the various applications of whole slide imaging and future applications using WSI for computer-aided diagnosis The goal is to provide practical knowledge and address knowledge gaps in this emerging field. This book is unique because it addresses an emerging area in pathology for which currently there is only limited information about the practical aspects of deploying this technology. For example, there are no established selection criteria for choosing new scanners and a knowledge base with the key information. The authors of the various chapters have years of real-world experience in selecting and implementing WSI solutions in various aspects of pathology practice. This text also discusses practical tips and pearls to address the selection of a WSI vendor, technology details, implementing this technology and provide an overview of its everyday uses in all areas of pathology. Chapters include important information on how to integrate digital slides with laboratory information system and how to streamline the "digital workflow" with the intent of saving time, saving money, reducing errors, improving efficiency and accuracy, and ultimately benefiting patient outcomes. Whole Slide Imaging: Current Applications and Future Directions is designed to present a comprehensive and state-of the-art approach to WSI within the broad area of digital pathology. It aims to give the readers a look at WSI with a deeper lens and also envision the future of pathology imaging as it pertains to WSI and associated digital innovations.

This volume explores the latest techniques used to study Mycobacterium ulcerans, and more specifically M. ulcerans disease (Buruli ulcer). The chapters in this book are organized into three parts and cover methods for the detection of M. ulcerans and the analysis of host-pathogen interaction; the quantification and characterization of mycolactone, the macrolide toxin of M. ulcerans; and drug development against M. ulcerans. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mycobacterium ulcerans: Methods and Protocols is a valuable resource that helps scientists advance their research on Buruli ulcer, which is still an under-researched field in infection biology.

Immunometabolism has emerged as an intersectional crossroad between metabolism and immune response. Over the past decade, it has become clear that most - if not all - immune cell functions are not separated from cellular metabolism. Although seminal works have addressed the metabolic fate of immune cells during differentiation and function, the physiological status of a given tissue is also dependent on the cell metabolism. The dialogue between immune cells and their microenvironment can also modulate cellular metabolism, which can trigger the onset and progression of a multitude of inflammation-mediated diseases. Thus, uncovering the specific characteristics of the metabolism in different immune cells types and in different conditions, can shed light into the molecular mechanisms of disease and help develop new drugs and therapeutic strategies to treat immune diseases. The edited volume Essentials aspects of Immunometabolism will give the readers a broad view on how metabolic pathways can influence many types of immune cells during activation, differentiation and function, in health and disease. Of note, the structure of the book was created thinking not only on the experienced immunologist but also on undergraduate and graduate students, physicians, and all members of the scientific community interested in this exciting field of research.

This book provides the description of the granulomatous diseases of otorhinolaryngology, head and neck with their characteristic features, investigations and management. It includes wide variety of infective, idiopathic, neoplastic, hereditary, reactive and various other types of chronic granulomatous reaction in the ear, nose, throat and head neck region. Further, the description is supported with various illustrations including clinical photographs, radiological pictures of CT scan, MRI scan etc. Histopathological and microbiological images which show characteristics and differentiating features are also included to aid in the diagnosis of the diseases. Histopathological colored images with high magnification and immunohistochemistry images are provided for better illustrations. This book also elaborates the important medical and surgical management of the granulomatous diseases. Every chapter ends with the 'Essential features' of that particular granulomatous disease, and this will certainly help the post-grad students and clinicians to differentiate the diseases, early diagnosis and management of the patients with chronic granulomatous diseases.

Blood Science The second edition of the leading introduction to blood science, with updated new illustrations and case studies Blood Science: Principles and Pathology integrates hematology and blood transfusion, -clinical biochemistry, and immunology to provide a thorough introduction to this rapidly expanding discipline. Reflecting recent changes in education and training for healthcare scientists, this comprehensive textbook covers the analytical techniques used in blood -science, the diagnosis and management of various blood disorders, and more. Fully revised, the second edition presents new case studies and high-quality images -throughout, illustrating the practical skills and knowledge required by today's under-graduate students and practitioners. Detailed yet accessible chapters contain learning objectives and summaries, links to further readings and resources, and real-world case studies with easy-to-follow interpretations. Throughout the text, the authors highlight how laboratory data and clinical details are used to investigate patients with actual or suspected diseases in real-world scenarios: Multi-disciplinary view merging biochemical, hematological, immunological, and genetical knowledge into a single discipline: Blood science Discusses advances in molecular genetics identifying mutations resulting in the occurrence of certain pathological conditions such as leukaemia Presents an expanded concluding chapter with detailed case reports that integrate biochemistry, immunology, and haematology, which all contribute to the investigation of respective conditions Explains the potentials for developing tests such as non-coding RNAs Offers further reading suggestions to dive even deeper into discussed subjects and concepts Designed to meet the needs of undergraduate students taking blood science modules in biomedical, biological, and healthcare science programs, Blood Science: Principles and Pathology, Second Edition is also an invaluable guide for new graduates entering the field, as well as those training for professional qualifications or working with blood samples in laboratory-based environments.

This book utilizes a uniform approach to provide a framework for the diagnosis of mesenchymal tumors of the breast while highlighting their mimics. Emphasis is placed on a practical approach to the morphologic interpretation and useful ancillary tests while exploring the differential diagnoses in depth. Given the overall low incidence of mesenchymal lesions of the breast along with their mimics, surgical pathologists are not consistently exposed to these spindle cell lesions. Compounding this problem is the broad differential that these lesions engender, with entities ranging from reactive/reparative lesions to poorly differentiated spindle cell malignancies. Furthering the challenge, the diagnoses may be complicated by fixation issues, sampling method, small sample size, lack of clinical history and prior treatment effects. The goal of this book is to introduce readers to the spectrum of these lesions while providing a systematic approach that helps establish accurate diagnoses that in turn drive appropriate clinical follow up and treatment. Chapters cover the spectrum of benign and malignant mesenchymal tumors and their mimics that are found in the breast in an easy to read format with richly detailed images to aid in diagnoses. The text also discusses practical components to aid in establishing and evaluating the differential diagnosis. Given how morphologically and clinically diverse these lesions are, Mesenchymal Tumors of the Breast and Their Mimics provides a construct for integrating the varied components that go into establishing a diagnosis for this challenging aspect of breast pathology.