This very popular revision guide, originally published in its first edition as General Pathology Vivas, is packed with useful information in A-Z format covering the essentials of pathology for examination candidates. This accessible and informative text will help to dispel some of the anxiety facing those studying for their viva or oral examinations. It has been written by a pathologist with many years of experience teaching pathology. This edition, first published in 2006, includes many updated entries to provide even broader coverage of the key topics and concepts that are an essential prerequisite to understanding basic pathology. This concise account is aimed at undergraduate medical candidates and for the oral parts of the MRCS, MRCP and FRCOG examinations. It will also serve as a valuable aide memoire for the junior surgeon or doctor at all levels of experience, especially those training junior staff themselves.

Rotator cuff surgery is currently the most common surgical procedure involving the shoulder. Unfortunately despite major technical advances, there is still a significant rate of failure of primary rotator cuff repair, ranging from 10% to 40%. This book describes the diagnosis, classification, assessment, and management of failed rotator cuff repairs. It also explores the etiology of the failed repairs, presents a series of treatment options, and discusses the complications. In a multidisciplinary format it addresses both how to prevent failure and how to diagnose and manage the failed rotator cuff, including imaging, laboratory testing, nutrition, surgery and rehabilitation. This comprehensive book, published in collaboration with ISAKOS, appeals to all stakeholders in orthopedic medicine and surgery.

Session I: Breastfeeding and Maternal-Neonatal Interactions. Epidemiological Aspects of Breastfeeding.- Characteristics of Human Milk Antibodies and Their Effect in Relation to the Epidemiology of Breastfeeding and Infections in a Developing Country.- T Cell Development in the Fetus and Neonate.- Growth Factors and the Development of Neonatal Host Defense.- Session II: Development of the Neonatal Immune System.- Amniotic Fluid: The First Feeding of Mucosal Immune Factors.- Ontogeny of the Secretory IgA System in Humans.- IgA-Secreting Cells in the Blood of Premature and Term Infants: Normal Development and Effect of Intrauterine Infections.- Development of T Cells with Memory Phenotype in Infancy.- The Effect of Human Milk, Protein-Fortified Human Milk and Formula on Immunologic Factors of Newborn Infants.- Ontogeny of the Mucosal Immune Response in Children.- Session III: Function of Cytokines in the Development of the Immune System.- Are Cytokines in Human Milk?.- The Developing Gastrointestinal Tract and Milk-Borne Epidermal Growth Factor.- Growth Factor Signal Transduction in Human Intestinal Cells.- Role of IL-6 in Human Antigen-Specific and Polyclonal IgA Responses.- Immunological Properties and Differentiation Potential of Human Colostral Lymphocytes of B Cell Lineage.- Session IV: Innate Immune Factors.- The Effects of Colostrum on Neutrophil Function: Decreased Deformability with Increased Cytoskeleton-Associated Actin.- Peroxidases in Human Milk.- Lactoferrin Binding to Its Intestinal Receptor.- Free Fatty Acids and Monoglycerides: Anti-Infective Agents Produced During the Digestion of Milk Fat by the Newborn.- The Role of Milk-Derived Antimicrobial Lipids as Antiviral and Antibacterial Agents.- Anti-Adhesive Molecules in Human Milk.- The Effect of Human Milk on the Adherence of Enterohemorrhagic E. Coli to Rabbit Intestinal Cells.- Session V: Specific Immune Factors.- Identification and Use of Protective Monoclonal IgA Antibodies Against Viral and Bacterial Pathogens.- Production and Use of Monoclonal IgA Antibodies Complexed with Recombinant Secretory Component for Passive Mucosal Protection.- Epithelial Transport of IgA Immune Complexes.- Association of Human Milk SIgA Antibodies with Maternal Intestinal Exposure to Microbial Antigens.- Serum and Breast Milk Antibodies to Food Antigens In African Mothers And Relation To Their Diet.- Modulation of the Immune Response by Maternal Antibody.- Maternal Determinants of Neonatal Immune Response: Effect of Anti-Idiotype in the Neonate.- Immunoglobulin G Subclasses in Human Colostrum and Milk.- Secretory Defenses Against Giardia Lamblia.- Session VI: Antiviral Immunity.- Epidemiological Perspective of Breastfeeding and Acute Respiratory Illnesses in Infants.- Serotypes of Rotavirus That Infect Infants Symptomatically and Asymptomatically.- Immune Response to Rotavirus Vaccines Among Breast-FED and Nonbreast-FED Children.- Recent Advances in Development of a Rotavirus Vaccine for Prevention of Severe Diarrheal Illness of Infants and Young Chiuldren.- Rotavirus Specific Breast Milk Antibody in Two Populations and Possible Correlates of Protection.- Human Milk and HIV Infection: Epidermiologic and Laboratory Data.- Characterization of a Human Milk Factor That Inhibits Binding of HIV GP120 to Its CD4 Receptor.- Breast Milk Transmission of Cytomegalovirus (CMV) Infection.- Antibody Responses to Cytomegalovirus in Serum and Milk of Newly Delivered Mothers.- Protection of Neonatal Mice from Fatal Reovirus Infection by Immune Serum and Gut Derived Lymphocytes.- Passive Immune Protection from Diarrhea Caused by Rotavirus or E. Coli: an Animal Model to Demonstrate and Quantitate Efficacy.- Session VII: Antibacterial Immunity.- The Antibody Response in Infants after Colonization of the Intestine with E. Coli O83. Artificial Colonization Used as a Prevention Against Nosocomial Infections.- Antibodies to Streptococci Pneumoniae in Sera and Secretions of Mothers and Their Infants.- T...

Part of the highly regarded Biopsy Interpretation Series, Biopsy Interpretation of the Liver, 4th Edition, provides practical, highly illustrated information on the diagnosis and prognosis of the full range of biopsies of the liver. Practical, well-organized, and highly readable, this fully revised volume by Dr. Michael S. Torbenson addresses both common and unusual issues that arise in the day-to-day interpretation of liver biopsies, teaching the best diagnostic practices as well as how to avoid the most common pitfalls. Frames each diagnosis in its most common clinical context, explaining how the pathology can be used to make key clinical management decisions. Presents key differential features of tumors, organized according to diagnostic category Features high-quality photomicrographs and illustrations throughout, including updated images both in print (over 700) and online-more than 900 images in all. Includes two new chapters on Radiology Report Interpretation and Cytogenetics and Genomics. Provides access to more than 100 questions and answers online for self-assessment and review. , Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. ,

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease.
Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy.
The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.

There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format provides the brevity and clarity that the user is not likely to receive in a textbook, even if adequately indexed. With the inclusion of descriptions for terms used in toxicology, drug metabolism/pharmacokinetics, and regulatory science, the scope of the IDTP is considerably broadened and decidedly unique in its appeal to all safety scientists. With over 800 photos and illustrations to provide visual context,* an important aim of the IDTP is to present pathological changes as reference examples for terminology, nomenclature, and term descriptions for the entry entry-level as well as seasoned toxicologic pathologist. It will also aid students and non-pathology specialists such as study directors, senior toxicology report reviewers, scientific management of contract research organizations, regulatory agencies, and drug development companies to better understand the biological significance of tissue changes. The IDTP provides a single reference volume for these users to further their understanding and appreciation of biologically significant pathology findings. The IDTP consists of four major areas: 1. A-Z Dictionary of Pathology encompassing all organ systems, together with relevant non-pathology terms supported by references in "For Further Reading" sections. 2. Appendix 1: An Overviews of Drug Development, Nonclinical Safety & Toxicologic Pathology, and Important/Special Topics. 3. Appendix 2: Diagnostic Criteria of for Proliferative Proliferative Lesions in Rodents (Rat and Mouse) and Selected Non-Rodent Laboratory Species containing illustrations with detailed references and links to source material. 4) Appendix 3: Mini-Atlas of Organ System Anatomy and Histology to help re-acquaint the non-pathologist safety scientist with many normal anatomical structures. The editors and contributing scientists (board-certified veterinary pathologists, board-certified toxicologists, allied health safety scientists, health regulatory representatives) have experience from bench-level pathology and toxicology to managing global preclinical safety units in leading pharmaceutical companies. They have considerable experience mentoring pharmaceutical industry project team members, interacting with industry clinicians and representatives of decision-making bodies within the industry, as well as with global health authorities, such as the FDA and EMA. These activities convinced them of the necessity for and usefulness of the IDTP. As experts in their field, they have undertaken the hard work of writing and compiling the information, making the IDTP an exceptional, go-to reference. *Illustrations Editor: Gregory Argentieri

It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.

Forensic Pathology is a comprehensive reference that uses a case-oriented format to address, explain and guide the reader through the varied topics encountered by forensic pathologists. Developed in response to a severe void in the literature, the book addresses topics ranging from medicolegal investigation of death to death scene investigation, forensic autopsy, and artifacts of resuscitation as well as complications of medical therapy, forensic osteology, forensic odontology, forensic photography, and death certification. The book includes various types of cases, including sudden natural death, asphyxia, motor vehicle collisions, death in custody, child abuse and elder abuse, acute psychiatric and emotional deaths, and pregnancy. It contains sample descriptions of pathological lesions which serve to aid pathologists in reporting their findings to law enforcement agencies, attorneys, and others involved in investigations of sudden death. The concepts outlined in the text are beautifully illustrated by large, colorful photographs. There are also "Do and Don't" sections at the end of each chapter that provide guidance for handling the types of cases examined. This work will benefit not only experienced forensic pathologists, but also hospital pathologists who occasionally performs medicolegal autopsies; doctors in training; medical examiners; law enforcement personnel; crime scene investigators; attorneys; and fellows and students of the medical sciences.

Designed to provide those engaged in modern medical imaging with a coherent perspective of the entire discipline so that one protocol is no longer an isolated or independent mode of imaging from others, to wit: single photon emission computed tomography (SPECT), positron emission tomography (PET) or magnetic resonance imaging (MRI). Introduces biomagnetic imaging as a third new modality.

This updated and revised third edition of INTRODUCTION TO MOLECULAR MEDICINE explains the fundamental principles vital to an understanding of the human genome, gene regulation and expression, and genetic engineering. Principles are then applied to the diagnosis and treatment of human disease in infectious diseases, inherited genetic diseases, the immune system and blood cells, cancer, and public health. Fully rewritten and with dozens of new illustrations, the Third Edition presents the basics of molecular biology and its impact on medicine in a concise, conversational format. Each chapter begins with an overview and ends with a summary. This edition also contains new discussions on the human genome project and genetic engineering with updated genetic maps. Ross' Introduction to Molecular Medicine remains a must-have information source for all physicians, residents, and medical students, as the book's stellar reviews demonstrate: "Well written and...presented in a style that is eminently readable...as an introduction to the applications of molecular biology and clinical medicine, Dr. Ross' book is recommended...of particular interest to pathology and clinical medicine residents." --ARCHIVES OF PATHOLOGY on the Second Edition. "will appeal to students and clinicians who will appreciate an introduction to this complicated field which unlike others, is easy and good fun to read." -- Annals of Oncology.

Written by biomedical scientists and clinicians, with the purpose of disseminating the fundamental scientific principles that underpin medicine, this new edition of the Oxford Handbook of Medical Sciences provides a clear, easily digestible account of basic cell physiology and biochemistry. It also includes an investigation of the traditional pillars of medicine (anatomy, physiology, biochemistry, pathology and pharmacology) integrated in the context of each of the major systems relevant to the human body. It is cross-referenced to the Oxford Handbook of Clinical Medicine, Oxford Handbook of Clinical Specialities, and Oxford Handbook of Practical Drug Therapy. Thoroughly illustrated, it is the ideal introduction to the medical sciences for medical students and biomedical scientists, as well as a valuable refresher for junior doctors.

5 Function of Splenic Compartments . . . . . . . . . . . . . . . 45 5. 1 Splenic White Pulp Compartments during Primary T Cell-Dependent Antibody Responses against Protein Antigens . . . . . . . . . . . . . . . . . . . . . . . . . 46 5. 1. 1 Priming of CD4+ Helper T Cells by Dendritic Cells in the PALS . . . . . . . . . . . . . . . . . . . . 46 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 5. 1. 1. 1 5. 1. 2 Interaction of Primed CD4+ T Cells with Antigen-Specific B Cells in the PALS and Formation of Extrafollicular Foci . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 5. 1. 2. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50 5. 1. 3 Formation of Germinal Centres . . . . . . . . . . . . . . . . . . . 50 5. 1. 3. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 5. 1. 4 Localisation of Memory B Cells in the Marginal Zone . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 5. 1. 4. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 57 5. 2 Function of the Marginal Zone during Primary Antibody Responses against T Cell-Independent Type 2 Antigens . . . . . . . . 57 5. 2. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59 Function of the Red Pulp . . . . . . . . . . . . . . . . . . . . . . . . . 59 5. 3 5. 3. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 5. 4 Role of the Spleen in CD8+ Cytotoxic T Cell Responses . . . . . . . . . . . . . . . 61 5. 4. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 The Spleen, Natural Killer Cells 5. 5 and Gamma/Delta T Cells . . . . . . . . . . . . . . . . . . . . . . . . 62 5. 5. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 6 Recirculation of Lymphocytes Through the Spleen . . 65 6. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 7 The Role of Cytokines and Chemokines in the Development of Splenic Compartments . . . . . . 69 7. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 8 Unsolved Problems of Human Splenic Structure and Function . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 VI 8. 1 Arterial Blood Supply to the Splenic Follicles and to the Perifollicular Zone. . . . . . . . . . . . . . . . . 73 . . . . 8. 1. 1 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 74 8.

An internationally known scientist joins the bestselling coauthor of ""The Melatonin Miracle"" to introduce the healing power of the antioxidant network--the different antioxidants that work together with much more strength than they do individually.

This volume will be of great value to all those researchers in the area of the inflam matory response, notably academics, clinicians and members of the pharmaceutical industry. The book has in the main been restricted to three inducible enzymes, namely nitric oxide synthase (iNOS), cyclooxygenase (COX-2) and hemeoxygenase (HO-l), although matrix metalloproteinases, xanthine oxidoreductase and tissue transgluta minases are reviewed. The modulation of these enzymes is viewed as possible novel therapeutic advances in the area of inflammation and also cancer. The latter topic may well be the subject of a further book. It will be interesting to observe the progress of such new therapies in the next decade. Already some of these enzyme modulators have been approved for the treat ment of inflammatory disease, as evidenced by the new families of COX-2 inhibitors. We believe such advances will herald a series of new and exciting agents to be included in the clinician's armamentarium in the constant struggle against inflammatory disease. The editors wish to thank all contributors to this volume on inducible enzymes. It should however be stressed that the views expressed by the authors are personal and do not necessarily reflect those of the editors. Indeed, the reader may find con flicting statements in a number of the chapters. We believe that this is entirely appro priate as this volume reflects the latest work in a rapidly developing area."

This second edition updates the "WHO Classification of Endocrine Tumours" proposed in 1980 and incorporates many new tumour entities and pertinent concepts that have developed since that time. It is the result of a collaborative effort between 9 pathologists from different countries, in addition to informal contributions and discussions by many other colleagues. In particular, efforts have been made to integrate into the fundamental backbone of the histologic classification a number of prognostic and functional parameters now essential for appropriate diagnosis and clinicopathologic evaluation of endocrine tumours.

Ageing and dementia are closely related conditions. Increasing age of the general population causes increasing incidence of dementing disorders in later life, although cognitive impairment is not necessarily a consequence of advancing age. The book presents the papers of the International Symposium on Ageing and Dementia, October 17-19, 1997 in Graz, where internationally renowned experts in the field of ageing and dementia gave an overview of the current knowledge about the epidemiology, pathomorphology, clinical diagnosis and course of brain ageing processes and related dementing disorders, biochemical markers and imaging procedures for the diagnosis of Alzheimer's disease and current approaches to a successful treatment of dementia. "... this book will be of interest to clinicians with previous experience of clinical dementia assessements, and to researchers who want a comprehensive update on research areas of dementia with which they are less familiar. It will also be of interest to those following the development of neurotrophe factors for treatment of dementia who need an extensive introduction to the preclinical studies of Cerebrolysin (R). The book will be fairly useful as a textbook for clinicians who are learning about clinical dementia assessments for the first time." Acta Psychiatrica Scandinavica

In the past several years much progress has been made in understanding the basic mechanisms of pancreatic physiology and the pathogenesis, diagnosis, and treatment of pancreatic disease. A symposium took place in Munich on 18-19 September 1998 that aimed at summarizing current knowledge of the exocrine pancreas and giving di rection to future research. It targeted all practitioners and scientists working in the field of exocrine pancreatic disease. The symposium was also designed to stimulate young persons embarking on a career in this area. It was an exciting meeting for all of us. We wish to extend our thanks to all participants for their prompt submission of manuscripts and to Springer Verlag for speedy publication, providing us with an up-to-date volume on pancreatic research. We would also like to thank G. Beyendorff-Hajda and W. Glockner, as well as D. Kriiger, representatives of Knoll Deutschland GmbH, for their organiza tional assistance and Knoll itself for its generous sponsorship, which enabled colleagues from other countries to participate and made publication of the symposium possible."

This second edition is the result of a collaborative effort of ophthalmic pathologists from 11 countries and is more extensive and detailed than its predecessor published in 1980. Several new tumour entities have been added, while the list of histological variants has been expanded and examples of immunoreactivity included. The publication of the revised eye and adnexal tumour classification is accompanied by 112 photomicrographs.

Neurodegeneration is one of the most important subjects of the investigation now and in the coming 21st century. Alzheimer's disease is the leading cause of dementia in the elderly people and Parkinson's disease is one of the major neurologic disorders with the prevalence between 1 and 2/1 000 population in advanced countries. Many others are suffering from intractable neurodegener ative disorders such as amyotrophic lateral sclerosis, Huntington's disease, or spinocerebellar degeneration. No truly effective treatment is available for any of these neurodegenerative disorders except for Parkinson's disease; even in Parkinson's disease, still it is impossible to slow down the disease process with the currently available treatment. It is urgently needed to develop new effective technique to halt or slow down the disease process in each of those disorders. Recent advance in the molecular biological and molecular genetic technique has brought us great progress in the understanding of etiology and pathogenesis of these disorders, but still it is not known how neurons are going to die in these disorders. To explore the question, mutual cooperation and exchange of ideas between basic scientists and clinical peoples are of utmost importance."

Expert clinicians and basic scientists with a special interest in Parkinson's disease review the current state of science and clinical therapeutics of the disease. Therefore these articles represent an authorative review of the current state of knowledge regarding preclinical course and symptomatology, subtypes with their impact on the pathology, genetic alterations, novel mechanisms of neuronal cell death, diagnostic tools and old and novel therapeutic approaches with respect to neuroprotection and neuroregeneration in Parkinson's disease. Particular emphasis has been placed on a novel antiparkinsonian drug called budipine with various modes of action also influencing altered non dopaminergic systems in Parkinson's disease. It is evident, that many questions on the cause, course and treatment of Parkinson's disease are still unanswered and therefore the ideal way to treat a parkinsonian patient remains to be defined.

This book is the fourth edition of a highly regarded text which was first published in 1988. It introduces the reader to the interpretation of routine laboratory biochemical test results and covers all aspects of interpretative chemical pathology (including reproductive endocrinology, which was not covered previously).

The approach is based on case material from the authors' laboratory and employs algorithms and similar aids for interpretation. The material is structured so that it is comprehensible to beginners as well as being useful for the more experienced practitioners. The envisaged audience is medical undergraduates, general practitioners, clinical biochemists and laboratory technicians.

This classification is based primarily on the microscopic charac- teristics of tumours and, therefore, is concerned with morpho- logically identifiable cell types and histological patterns, as seen with conventional light microscopy. The term tumours is used synonymously with neoplasm. The phrase tumour-like is applied to lesions which resemble neo- plasms, clinically or morphologically, but do not behave biologi- cally in a neoplastic manner. They are included in this classifica- tion because they give rise to problems in differential diagnosis and because of the unclear borderline between neoplasms and certain non-neoplastic lesions. Synonyms are listed only if they have been used widely, or if they are considered to be helpful to the understanding of the lesion. In such cases, the preferred term is given first, followed by the synonym. Although the emphasis of this classification is on histological typing, in the examination of kidney tumours, consideration should be given to the degree of cellular anaplasia, the extent of local spread, vascular and lymphatic invasion, and the occur- rence of metastasis. The scheme of histological grading suggested here is as fol- lows: Grade I applies to the tumours that have the least degree of cellular anaplasia compatible with a diagnosis of malignancy; . grade II! applies to tumours with the most severe degrees of cel- lular anaplasia; and grade I! applies to those tumours in be- tween. This scheme is applicable to the carcinomas of the renal parenchyma and pelvis.

In his original essay on the shaking palsy (1817) James Parkinson remarked that the "senses and intellect were uninjured." Thus, it was only in later years that the complexity ofparkinsonism and in particular Parkinson's disease with dementia was recognised. Cognitive impairment in Parkinson's disease is common and is estimated to affect more than forty per cent of patients with disease onset after age 65. Recent studies suggest that pathology of Parkin son's disease now ranks second to Alzheimer's disease as the commonest sub strate of dementia in elderly patients. The condition is heterogeneous and there remain many complicated and unresolved questions concerning cause, diagnosis and classification. In an attempt to clarify these issues, scientists and members of the European Brain Bank Network (EBBN) gathered in London for a meeting entitled "Dementia in Parkinsonism." The resultant monograph is testimony to the wide-ranging clinical, morphological and biochemical aspects of this condition. We are grateful to all contributors for expressing their expert opinions and for being so generous with their time taken in prepa ration of the manuscripts. The meeting was funded by the Commission of the European Communities as part of a Biomed-l Programme. We wish to thank Amgen Limited, Lilly Industries Limited and Roche Products Limited for additional sponsorship. The expert secretarial assistance of R. Nani in the pre paration of this book has been very much appreciated. London, November 1997 S. E. Daniel F. F. Cruz-Sanchez A. J. Lees Contents Stern, G.: The language of the basal ganglia . . . . . . . . . . . . . . . . . . . . . ."

Since 1975, when the University of Oklahoma faculty created their review course for second-year medical students, the Oklahoma Notes have been among the most trusted and widely used reviews for the National Boards.
Each Oklahoma Notes book presents the core information of one segment of the medical school curriculum. Written by some of the most effective medical educators in the country, and now thoroughly updated and revised, the Oklahoma Notes feature: Concise text presented in outline format for rapid review; contents oriented to promote Boards success; self-assessment questions geared to the current format of the USMLE exam; more tables and figures designed to facilitate self-assessment and review; and low-cost, complete coverage of all subjects taught in the first two years of medical school.

This fully updated edition incorporates the newest classification systems, such as the Bethesda System for reporting thyroid cytopathology; the Paris System for reporting urinary cytology, and the Milan System for reporting salivary gland cytopathology. Over 1,000 high-quality color photos illustrate the key diagnostic cytological features described. Succinct bullet points condense vital information, making the text more accessible for busy clinicians. The full spectrum of infection, inflammatory, benign and malignant processes throughout the body are presented in detail, including chapters on cervical, breast, and central nervous system diagnostic criteria. Key information pearls and differential diagnosis indicators give insight from experts in the field. Not limited to light microscopic findings, many other genetic, molecular, and immunologic diagnostic modalities are covered in this essential and comprehensive resource. An online version of the book with expandable figures can be accessed on Cambridge Core, via the code printed on the inside of the cover.