Pathology of the Human Placenta remains the most comprehensive and authoritative text in the field. It provides extensive information on the normal placenta, encompassing physiology, metabolism, and endocrinology, and covers the full range of placental diseases in great detail. Further chapters are devoted to abortions, molar pregnancies, multiple pregnancies, and legal considerations. This sixth edition of the book has been extensively revised and expanded to reflect the most recent progress in the field, and a brand new chapter has been added on artificial reproductive technology. Some 800 illustrations are included, many of them in color. The detailed index has been further improved and tables updated. Pathology of the Human Placenta will be of enormous value to pathologists and obstetrician-gynecologists alike.

With its focus on narrow band imaging, this book is an excellent reference for new as well as experienced practitioners in the field of endoscopy. Narrow band imaging has brought about a revolutionary improvement in diagnostic endoscopy, enabling objective diagnosis and precise detection of lesions. It has enhanced the capability of endoscopy to facilitate qualitative diagnoses for the great benefit of patients who undergo endoscopic examinations. However, a standardized system of classification has not yet been established and many clinicians and researchers are not yet highly skilled in utilizing the technique or interpreting the images that are produced. This atlas addresses those issues, providing clear, simple and easy-to-understand descriptions illustrated with generous use of endoscopic images.

2-D and 3-D anal ultrasound are among the most recent and advanced tools available for both the diagnosis and the management of anorectal diseases. They are neither expensive nor harmful for the patients and progressively replaced anal mapping with EMG electrodes for the diagnosis of sphincter's defects and anismus, which represents nearly 50% of the cases of chronic constipation. Anal US may provide the clinician with useful information for both classification, diagnosis and management of anorectal sepsis, anal incontinence and anorectal-perineal chronic pain. Almost any case presented in this Atlas shows both imaging and clinical pictures, thus allowing both the radiologist and the clinician to assess the reliability of the exam and the outcome of the selected treatment.

Of all the techniques used to treat non melanoma skin cancer, the highest cure rates belong to the Mohs surgical procedure. Critical to this technique is optimal preparation and interpretation of frozen sections. With more than 400 high resolution figures, the Atlas of Mohs and Frozen Section Cutaneous Pathology is the premier textbook on the topic, serving as a highly practical guide to microscopic analysis, diagnosis, and discrimination of common and problematic cutaneous neoplasms. Highlights of the Atlas include diagnosis of basic and routine dermatologic entities, diagnosis and distinction of rare and/or deadly neoplasms such as dermatofibrosarcoma protuberans and merkel cell carcinoma, a troubleshooting guide dealing with quality control of the frozen section technique, and discussion of new techniques including immunohistochemistry. Comprehensive and presented in full color, the Atlas of Mohs and Frozen Section Cutaneous Pathology is an indispensable reference for anyone involved with the Mohs procedure, including dermatologic surgeons, Mohs cutaneous surgeons, as well as pathologists and dermatopathologists who perform frozen section analysis of cutaneous specimens.

Molecular Surgical Pathology provides a concise review of recent advancement of molecular pathology in each organ system. The text is intended as a "first knowledge base" in the rapidly evolving field of molecular pathology and is organized in a user friendly outline format. Each chapter is organ-based and covers important aspects of molecular pathology and its impact on our daily practice of surgical pathology. The topics presented herein constitute the fundamentals and core base of knowledge required for the daily practice of surgical pathology. This book focuses on the practical utilities of molecular techniques and molecular biomarkers in daily practice of surgical pathology. The emphasis is on the impact of molecular pathology for tumor classification, diagnosis and differential diagnosis as well as its implications for patient management and personalized care. Numerous tables, diagrams and color illustrations are included throughout. Molecular Surgical Pathology will prove a very useful resource for pathologists in training who are preparing for the Board and in-service examination. It will also be a unique and invaluable resource for medical oncologists, physicians, other medical professionals and basic research scientists with interest in molecular pathology of human cancers.

As a result to the recent significant developments, both in the field of cutaneous pathology and clinical dermatology, many cutaneous neural tumors are now being diagnosed by specialists like dermatopathologists, and treated by dermatologists or dermatologic surgeons. Cutaneous Neural Neoplasms: A Practical Guide provides an essential aid in diagnosis by discussing the cardinal clinico-pathologic features of cutaneous tumors relevant to these specialists. It covers detailed pathologic features, and their differential diagnosis. Applicable special diagnostic techniques are extensively illustrated. Whenever relevant, key therapeutic recommendations are provided. The authors approach each entity by presenting clinical and/or gross photographs when relevant with discussion of the clinical features, followed by the tabulated list of key pathologic features with corresponding histopathologic illustrations. Therapeutic recommendations are summarized. Cutaneous Neural Neoplasms: A Practical Guide is an important new volume that fills a major gap in the currently available resources for practicing physicians, and provides them with an appropriate knowledge base to handle these challenging tumors in the most up-to-date fashion.

This new edition differs from the preceding ones in that there has been extensive revision of most chapters. Recent advances in research gained by immunohistochemical, molecular biological, and cytogenetic methods are included, as far as they are applicable for daily diagnostic work. The chapter on neoplasms, in particular, has been greatly expanded in accordance with the new WHO International Histological Classification of genital tract tumors, covering all pertinent differential diagnostic aspects. The chapter on malignant lymphomas and hematopoetic neoplasms involving the endometrium is a new contribution to this edition (F. D. , Ulm). We have revised the chapter on gestational diseases, incorpor- ing recent advances in the differential diagnosis of gestational trophoblastic tumors. New discoveries and experiences in correlating structure and function in infertility and in h- mone replacement therapy of peri- and postmenopausal patients are also included. Many new microphotographs have been added to illustrate the advances in tumor research and in immunohistochemical detection methods. We have updated the list of references including recent relevant publications. To the correspondents and consultants who have contributed valuable observations and suggestions, bringing thereby to our attention omissions in the second edition, we acknowledge our cordial thanks. We thank Dr. Wolfram Klapper, Director of the L- phom Register of the University of Kiel, for case material for making the micropho- graphic illustrations of lymphomas. The staff of Springer-Verlag has earned our gratitude for their skill in preparing this new edition.

This succinct book guides the trainee through the hurdles of fledgling cytology practice and can also be used throughout the career as an aide memoire by the more experienced. Whilst there are several well established and excellent textbooks on general cytology, these are by and large reference books rather than bench books that can lie beside each individual trainee's microscope and be resourced continually before and during each case. With numerous illustrations to enthuse the reader and make cytological practice a more enjoyable and educational experience, the book also highlights points of diagnostic difficulty, particularly with regard to the differentiation of neoplastic from non-neoplastic disease. This bench book will be an invaluable reference guide to histo- and cyto-pathology trainees as well as consultants who want a quick refresher/reference point.

This timely book covers the need to know clinical practices for all those involved in molecular laboratory science. The field of molecular medicine is evolving at an astounding speed. Propelled by the new insights and technologies, advances are being made at an unprecedented rate. With dual measure given to today's breakthroughs, this book is a collection of the most current practices relevant to the clinical molecular laboratorian. It begins with an introductory section on techniques and procedure. It then presents four separate sections on infectious disease, oncology, pre/post-natal, and identity testing, with specific chapters clearly outlining clinical protocols used in daily practice. Modern Clinical Molecular Techniques cuts to the heart of what is essential for the practicing molecular laboratory scientist. It is an outstanding resource for those operating within or looking to set up a clinical molecular laboratory.

Atlas of Conducted Electrical Weapon Wounds and Forensic Analysis provides a comprehensive publication on the subject of Conducted Electrical Weapon (CEW) wounds and signature markings created by this class of weapon. This volume will serve as a very useful resource for all professions tasked with assisting persons that have allegedly been subjected to a CEW exposure. The volume provides an introduction to basic CEW technology and the types of CEWs currently available. It also serves as a comprehensive pictorial atlas of signature markings that CEW exposures make in the immediate and more remote post-exposure periods. Also, it discusses the ability of forensic specialty examinations of the CEW itself to aid in the determination of whether the alleged CEW exposure is consistent with the objective evidence and the subjective statements. Finally, this text addresses the important and growing area of factitious CEW markings that will be useful for consideration by investigators and litigators. Atlas of Conducted Electrical Weapon Wounds and Forensic Analysis provides an objective atlas of evidence for reference that will benefit those professionals who often must make diagnostic, treatment or legal judgments on these cases including Emergency and Primary-Care Physicians, Medical Examiners, Forensic Pathologists, Coroners, Law Enforcement Investigators, and Attorneys.

Inflammatory Dermatopathology: A Pathologist's Survival Guide provides expert guidance for the reader to develop a systematic approach to the diagnosis of inflammatory disorders of the skin. It covers the most common and clinically important inflammatory disorders of the skin through an image-rich easy to read format. Each section includes practical tips to help navigate the differential diagnosis. Microscopic features are listed as bullet points to enhance readability. Examples of diagnostic comments that practicing pathologists can utilize in their own reports are also provided. Demonstrating a global understanding of inflammatory dermatoses in a quick and efficient manner, Inflammatory Dermatopathology: A Pathologist's Survival Guide will both guide the reader in how to approach inflammatory dermatoses, as well as provide a tool that will help with the writing of surgical pathology reports.

This book presents an up-to-date and thorough overview of cancer of unknown primary, encompassing topics ranging from epidemiology, tumor biology, and prognostic factors through to the most recent diagnostic and therapeutic advances. All aspects of management are covered, including radiological, nuclear medicine, and pathological diagnosis, site-specific therapies, platinum-based combination chemotherapy, radiotherapy, and novel targeted treatments. Clear guidance is offered on diagnosis of the tissue of origin by means of gene expression and micro-RNA analyses and its therapeutic implications. Detailed directions are also provided on the identification of subsets of patients with a more favorable prognosis, in whom specific treatment offers the chance of long-term survival or even cure. Readers will find Cancer of Unknown Primary to be an ideal source of practically oriented information that will assist in delivery of the best possible care for patients with this challenging diagnosis.

In this volume Dr Hui has brought together a comprehensive overview of gestational trophoblastic disease that includes all the currently recognized entities: complete and partial hydatidiform moles, placental site trophoblastic tumor, epithelioid trophoblastic tumor, gestational choriocarcinoma, persistent gestational trophoblastic neoplasia, placental site nodule and exaggerated placental site reaction. Each entity is reviewed in detail, with emphasis on genetic background, clinical presentation, pathologic findings and ancillary studies, differential diagnosis and clinicopathological correlations. Descriptions of the pathology are supported by numerous excellent photomicrographs. Recent advances in our understanding of the genetics of gestational trophoblastic diseases are stressed. Introductory chapters cover the developmental biology of the placenta and the genetic basis of gestational trophoblastic disease, and one chapter is devoted to the molecular diagnosis of gestational trophoblastic disease. This chapter includes a review of the use of short tandem repeat (STR) genotyping which is of particular value in the diagnosis of hydatidiform moles. The final chapter covers clinical aspects of gestational trophoblastic disease, including treatment. The text throughout is current and thoroughly referenced. This book will be of great value to pathologists, community gynecologists, gynecological pathologists and medical students.

This book covers new and exciting topics which have emerged in the area of autopsy recently, including the three different post-mortem CT-angiography systems currently available to practitioners in this field; a highly topical chapter on the role of genetic abnormalities in the handling of drugs within the body and how this can affect the interpretation of toxicological results in relation to how the drug may have caused or contributed to death; an update on the current classification and considerations related to deaths due to hanging; a review of injuries and fatalities caused by animals including post-mortem scavenging; an authoritative review of poisons and toxins from water and the life that inhabits it; and recent advances in knowledge in the use of entomology as an investigative tool as well as knowledge related to colonisation of cadavers by insects, animals and birds. Essentials of Autopsy Practice: Advances, Updates and Emerging Technologies is a multi-subject book, aimed at different grades of practitioners, from different practice areas, covering topics that are currently discussed and anticipated to be discussed in the field of autopsy practice over the next few years.

Readable and highly illustrated, Robbins and Cotran Pathologic Basis of Disease, 10th Edition presents an in-depth, state-of-the-art overview of human diseases and their cellular and molecular basis. This best-selling text delivers the latest, most essential pathology knowledge in a readable, interesting manner, ensuring optimal understanding of the latest basic science and clinical content. More than 1,000 high-quality photographs and full-color illustrations highlight new information in molecular biology, disease classifications, new drugs and drug therapies, and much more. This superb learning package also includes an enhanced eBook with a full complement of ancillary content on Student Consult. Access to this product, which may be at the discretion of your institution, is up to 3 years of online and perpetual offline access. Elsevier reserves the right to restrict or remove access due to changes in product portfolio or other market conditions. Provides uniquely authoritative and readable coverage, ideal for USMLE or specialty board preparation, as well as for coursework. Covers the hot topics you need to know about, including novel therapies for hepatitis C, classification of lymphomas, unfolded protein response, non-apoptotic pathways of cell death, coronavirus infections, liquid biopsy for cancer detection, regulation of iron absorption, clonal hematopoiesis and atherosclerosis, thrombotic microangiopathies, heparin-induced thrombocytopenias, inflammatory myopathies, genetic tools for treatment of cystic fibrosis, and many more. Uses an outstanding full-color, user-friendly design to simplify your study and quickly direct you to the information you need to know, with learning features such as boldface overviews at the beginning of each section, key concepts boxes, suggested readings, schematic diagrams that illustrate complex concepts, and new gross and microscopic figures for clarity of morphology. Brings you up to date with the latest information in molecular and genetic testing, mechanisms of disease, personalized medicine and its impact on treatment of human diseases, the role of microbiome and metabolome in non-communicable diseases, and much more. Provides access to a wealth of interactive ancillaries online: pathology case studies, videos, self-assessment questions, Targeted Therapy boxes that discuss drug therapy for specific diseases, interactive cases, and more. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices

Diagnose oral diseases quickly and accurately! Oral Pathology: Clinical Pathologic Correlations, 7th Edition presents diseases and conditions by appearance and presentation, so that you can easily identify and plan treatment for common oral and paraoral problems. An atlas-style overview of pathologic conditions opens the book, and then each chapter describes pathologies in detail - depicting each with full-color clinical photos and photomicrographs. In addition to covering the latest advances in oral pathology, this edition includes new radiographic images demonstrating advanced imaging techniques. Expert educators Joseph Regezi, James Sciubba, and Richard Jordan provide a quick reference that's ideal for the lab, NBDE review, or chairside use! Organization of oral and maxillofacial diseases by clinical appearance - such as red-blue lesions or pigmented lesions - matches what you would expect to see upon a patient's presentation, and provides a practical tool for developing differential diagnoses and planning treatment. Nearly 1,000 full-color clinical photographs, photomicrographs, radiographs, and drawings help you learn to identify lesions and disease states. An atlas-style Clinical Overview section makes it easy to find key information, with one page showing clinical photos of common conditions and the facing page listing symptoms, causes, and significance. Nearly 200 summary boxes and tables offer clear, at-a-glance information on the clinical features, diagnosis, and treatment for many conditions. Correlation of histopathology with clinical features of oral diseases assists the clinician in recognizing specific conditions and developing differential diagnoses and rational treatment approaches. Student resources on an Evolve companion website include 30 case studies, interactive lecture modules, and a 150-question practice exam to prepare you for the NBDE and for clinical practice. UPDATED content reflects current information and the latest advances in oral and maxillofacial pathology.

Sickle Cell Disease is the most common genetic disease world wide and in the UK. It has marked geographical variation in its distribution in the UK, with a concentration in London and other major conurbations (Birmingham and Manchester). In these areas, specialist centres have become established offering expert, up to date care for both inpatients and out patients with Sickle Cell Disease. Although patient numbers are increasing outside these areas, the expertise of health professionals can be patchy. This book aims to provide a user friendly, accessible resource for areas with smaller numbers of patients, to allow them to provide equitable care with the larger well established centres. Sickle Cell Disease can be associated with acute life threatening complications, when clear, easily available advice is needed, and with chronic long term complications which may need liaison with other health professionals. Clear treatment protocols for all the common complications of sickle cell disease, are outlined here, with summaries of key evidence and references.

This text provides a comprehensive review of the cytology of disease processes of the mediastinum and mediastinal lymph nodes with emphasis in lung and gut nodal cancer staging in specimens obtained by EUS-FNA. This book also reviews the cytology of intramural masses of the gastrointestinal tract using a pattern-based diagnostic approach. The cytomorphology of lesions obtained by EUS-FNA is peculiar by the common presence in the obtained sample of normal luminal gastrointestinal contents, and the cytopathologist should be familiar with this pattern not often seen when the sampling is done by percutaneous approach. Technical considerations pertaining to the operator performing the procedure as well as to the cytopathologist, with emphasis on rapid on-site interpretation are also covered. Most lesions described in the book also have endoscopic US image correlation. Cytology of the Mediastinum and Gut is a useful and practical guide for cytological interpretation and differential diagnosis of lesions obtained by EUS-FNA of mediastinum and gut. All chapters are written by experts with many years of experience in the field and contain the cytology, immuno-profile, molecular profile, and ultrasound features of the masses described.

Our goal is to develop automated methods for the segmentation of thr- dimensional biomedical images. Here, we describe the segmentation of c- focal microscopy images of bee brains (20 individuals) by registration to one or several atlas images. Registration is performed by a highly parallel imp- mentation of an entropy-based nonrigid registration algorithm using B-spline transformations. We present and evaluate different methods to solve the cor- spondence problem in atlas based registration. An image can be segmented by registering it to an individual atlas, an average atlas, or multiple atlases. When registering to multiple atlases, combining the individual segmentations into a ?nalsegmentationcanbeachievedbyatlasselection,ormulticlassi?erdecision fusion. Wedescribeallthesemethodsandevaluatethesegmentationaccuracies that they achieve by performing experiments with electronic phantoms as well as by comparing their outputs to a manual gold standard. The present work is focused on the mathematical and computational t- ory behind a technique for deformable image registration termed Hyperelastic Warping, and demonstration of the technique via applications in image regist- tion and strain measurement. The approach combines well-established prin- ples of nonlinear continuum mechanics with forces derived directly from thr- dimensional image data to achieve registration. The general approach does not require the de?nition of landmarks, ?ducials, or surfaces, although it can - commodate these if available. Representative problems demonstrate the robust and ?exible nature of the approach. Three-dimensional registration methods are introduced for registering MRI volumes of the pelvis and prostate. The chapter ?rst reviews the applications, xi xii Preface challenges, and previous methods of image registration in the prostate.

The second edition of this volume reflects the recent advances in the FCM analysis of hematopoietic disorders. The chapters have been revised to incorporate new text and figures. The volume is aimed at hematopathologists, hematologists, pathologists, and laboratory technicians.

Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts in their field with subspecialty training and extensive clinical experience. Each chapter describes a variable number of tumors and includes an overview of the classification system and clinicopathological characteristics of each tumor. This is followed by a discussion of the molecular pathology relevant to a specific tumor, including specific molecular markers of the tumors, methods used for diagnosis or clinical management, clinical significance of the markers, and if appropriate, a description or discussion of current activities in translational research or issues that need to be addressed in the future. Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine will be of great value to pathologists, oncologists, hematologists, internal medicine and pediatric specialists, as well as pharmaceutical professionals and translational and clinical researchers.

First published in 1936, as the second edition of 1933 original, this book was written to provide a radiological study of the digestive tract's anatomy, physiology and pathology. Illustrative figures, detailed appendices and a bibliography are also included. This book will be of value to anyone with an interest in anatomy, physiology and the history of medicine.

In pathology education within North America, there exists a wide gap in the pedagogy between medical school and residency. As a result, the pathology intern often comes into residency unprepared. Completely illustrated in color, this book lays the foundation of practical pathology and provides a scaffold on which to build a knowledge base. It includes basic introductory material and progresses through each organ system. Within each chapter, there is a brief review of salient normal histology, a discussion of typical specimen types, a strategic approach to the specimen, and a discussion of how the multitude of different diagnoses relate to each other.

Bei diesem Buch handelt es sich um eine Zusammenstellung zahlreicher Artikelund Beitr{ge, die 1989 in diversen neurologischen Fachzeitschriften und B}chern zum Thema "Hydrozephalus" erschienen sind.

Designed for quick, easy reference in the office or clinic, Atlas of Vulvar Disease is a robust pictorial and textual guide to the diagnosis, treatment, and management of vulvar diseases. Written by Edward J. Wilkinson, MD, a professor of pathology and expert in gynecologic pathology, and I. Keith Stone, MD, a professor of obstetrics and gynecology, this atlas is a must-have resource for both clinicians and pathologists focused on women's health. Organized by dermatologic findings, Atlas of Vulvar Disease presents a complete overview of diseases within each broader topic area. Each disorder includes a definition, general features, clinical presentation, microscopic features, differential diagnosis, clinical behavior and treatment, and progressive therapeutic options, to guide the diagnosis and treatment of various vulvar diseases. Hundreds of full-color clinical photographs and relevant histopathologic photographs illustrate the clinical appearance and histopathologic characteristics of the full spectrum of vulvar diseases. Tables on sexually transmitted diseases, vesicobullous disease, and the classification of vulvar diseases are included to assist in differential diagnosis. Clinical pathological correlations aid in the diagnosis and interpretation of laboratory findings. Two indexes facilitate quick look up a disease entity or a clinical presentation. A free companion web site features the full-text as well as an extensive image bank of clinical and histopathologic photographs from the book.