Topics that are essential to the surgical pathologist in cytopathology are included in this issue of Surgical Pathology Clinics. Topics include cytopathology of the Thyroid; Pancreas, Salivary glands; Lung; Urine; Gynecologic; Metastasis of unknown origin; and Preparation techniques and Cell transfer. Expert cytopathologist and prolific author and researcher and expert clinician Tarik Elsheikh leads this issue as Guest Editor. "The latest edition of this book is always in use by our trainees and cytology staff. A most helpful up to date reference book" Reviewed by: Dr David Poller, Consultant Pathologist & Reader in Pathology on behalf of PathLab.org, Aug 2014 "The latest edition of this book is always in use by our trainees and cytology staff. A most helpful up to date reference book" Reviewed by: Dr David Poller, Consultant Pathologist & Reader in Pathology on behalf of PathLab.org, Aug 2014

Molecular pathology has significantly matured over the past decade to establish itself as a discipline in its own right. Patient diagnosis, prognosis, management and care have been influenced by molecular pathology testing algorithms on a global scale. Whether it pertains to carrier status of deleterious genes, diagnosis by molecular techniques, assessment of appropriate remission post treatment, parentage or forensics testing - molecular pathology continues to increase its presence and influence in the diagnostic laboratory armamentarium. Furthermore, intellectualization and proprietization of molecular pathology with respect to the discovery of new genes and or new techniques continues to pose new challenges of test ownership, legalities, liabilities, widespread acceptance and utility. This issue of Laboratory Clinics seeks to provide selective state of the art understanding of molecular pathology with respect to its relationship to key pathology disciplines as well as the current challenges and promise for the future

Breast cancer is a disease requiring multidisciplinary management including surgery, medical and radiation oncology, radiology, pathology, nuclear medicine, genetic counseling, and psychological support. Each member of the team needs to be updated continuously on breast cancer treatment because of its rapidly changing nature. From the diagnostic procedures to operations and even in metastatic stages of breast cancer, surgeons play an essential part in multidisciplinary teams. After standard surgical options, oncoplastic breast surgery is rapidly becoming one of the most important surgical topics that should be learned by attending surgeons. The idea of writing this book stemmed from a collaboration between the European Academy of Senology (EAoS), European Institute of Oncology (IEO), Euro-Asian Society of Mastology (ESOMA), and SENATURK (Turkish Academy of Senology), which have been working together to promote better training in breast care for professionals. The book offers invaluable support for breast surgeons by covering critical and essential information in senology. It will also greatly benefit the other members of multidisciplinary teams, surgery residents, gynecologists, and plastic and reconstructive surgeons.

This issue of Neuroimaging Clinics focuses on the endovascular treatment of pathology in adults and children. Topics include cerebral aneurysms, cerebral vasospasms, dural fistulas, carotid stenosis, acute ischemic stroke, vascular malformations, and more.

Obstetricical care and the growing number of pregnancies in older women or medically challenged women creates an expanding need for placental pathology that can provide information on neonatal care, risk assessment, and infant and mother outcomes. In the Surgical Pathology Clinics, Essential Gross Examination of the Placenta is presented with an abundance of images along with clear steps in the examination. Also presented are Placenta Accreta and Percreta; Ascending Infection - Acute Chorioamnionitis; Maternal Floor Infarction and Massive Perivillous Fibrin Deposition. Additionally, Umbilical Cord Pathology, Monozygotic Twinning, and Fetal Thrombotic Vasculopathy, Neonatal Stroke and other sequelae are discussed. Each of the topics presents abundant clinical photos and histology slides supporting diagnosis. Editor Rebecca Baergen, whose specialty areas are fetal pathology, placental pathology, gynecology and perinatal pathology, leads a group of authors who are experts in placental pathology, including her mentor and one of the pioneers in placental and perinatal pathology, Dr. Kurt Benirschke.

This issue focuses on three disease sections: Diabetes, Hematology and Coagulation, and covers diagnostic and management issues during pregnancy of selected topics in each section. The chapters cover new concepts, evolving management and important impacts on the mother and unborn child.

This book is a comprehensive treatise on infective and inflammatory pathologies of the cornea with corresponding clinical images and diagrammatic illustrations. Corneal infections and inflammations are a major cause of ocular morbidity and visual impairment. Early diagnosis and treatment can lead to improved visual outcome and quality of life. Both infectious (bacterial, fungal, viral and protozoan) and non-infectious keratitis that cause corneal vascularisation, scarring and vision loss are covered extensively. The illustrated clinical findings presented in the form of diagrams, photographs, cases and videos aim to serve as a practical teaching tool for fellows, trainees and practising ophthalmologists. KEY FEATURES Focuses on clinically relevant parts of corneal diseases, using illustrations with arrows indicating different pathologies and signs Serves as a ready clinical compendium for trainees, fellows and ophthalmologists Explores various corneal pathologies through a wealth of accompanying illustrations and teaching videos

In October of 2011, CLSI published a new guideline EP23A on "Laboratory Quality Control Based on Risk Management.? In March, 2012, CMS announced its intention to incorporate key concepts from EP23A into its Interpretative Guidelines and QC policy for "Individualized Quality Control Plans.? Thus begins a new era of Quality Control in the Age of Risk Management. This issue is intended to help laboratories with the transition between traditional QC practices and the new risk management approach. Laboratories face a steep learning curve to apply risk analysis for identifying and prioritizing failure-modes, developing and implementing control mechanisms to detect those failure-modes, and assessing the acceptability of the residual risks that exist after implementation of a QC Plan. One of the main benefits of the new risk analysis based QC Plans should be an integration of all the control mechanisms that are needed to monitor the total testing process, including pre-analytic, analytic, and post-analytic controls.? One of the main risks of the new approach is an expectation that Statistical QC is no longer important, even though SQC still remains the most useful and flexible approach for monitoring the quality of the analytic process. The key to the future is the successful integration of all these control mechanisms to provide a cost-effective quality system that monitors all phases of the total testing process. This issue should help laboratories understand the evolution of QC practices to include risk management, but also to recognize the need to maintain traditional techniques such as Statistical QC, especially during the transition to well-designed and carefully-validated QC Plans. Risk analysis may be risky business unless laboratories proceed carefully and cautiously.

Clinically accessible information for pathologists on histology, molecular pathology, differential diagnosis, and clinical overview is presented. Common and rare entities are covered with an abundance of images to highight key features.
Topics for pathologists covering the fast moving field of breast pathology include: Less common variants and mimics of DCIS; Invasive lobular carcinoma and its variants; Important inflammatory and reactive lesions; Small glandular proliferations; Vascular lesions of the breast; Combined epithelial-myoepithelial lesion; Immunhistochemical pitfalls in the diagnosis of breast lesions; Pathology considerations in patients treated with neoadjuvant chemotherapy; Molecular classification of breast cancer: Jorge Reis-Filho; Prognostic factors for patients with breast cancer: Traditional and New

Biotin and Other Interferences in Immunoassays: A Concise Guide is aimed at clinical laboratory scientists, medical technologists and pathologists who are often the first individuals contacted by a clinician when a laboratory test result does not correlate with clinical presentation. Research scientists working in diagnostics companies will also find this information essential. Sources of errors in non-immunoassay based methods used in clinical chemistry and toxicology laboratory are also discussed so readers can get all important information from one concise guide. This succinct, user-friendly reference provides the necessary information to address high levels of biotin in clinical laboratory results.

The Year Book of Pathology and Laboratory Medicine brings you abstracts of the articles that reported the year's breakthrough developments in pathology and laboratory medicine, carefully selected from more than 300 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed! Chapters in this annual cover the most current information on all aspects of pathology and laboratory medicine including: molecular diagnostics, dermatopathology, anatomic pathology techniques, outcomes analysis, cytopathology, clinical immunology, clinical microbiology, neuropathology and hematology.

Written in response to reader requests for a short, "to the point" text that clearly summarizes the most important chemical elements of therapeutically relevant drug classes, Essentials of Foye's Principles of Medicinal Chemistry is a concise, quick-reference source of reliable information in the field. Derived from the highly regarded Foye's Principles of Medicinal Chemistry , this focused text provides an essential understanding of drug action and demonstrates its practical application to today's pharmacy practice. Highlights the "take home" chemical points of every chapter in the parent text, and uses an easy-to-read, bulleted format to convey essential concepts. Covers mechanism of action (MOA), structure-activity relationships (SAR), physicochemical and pharmacokinetic properties, metabolism, and clinical applications in all chapters. Uses numerous figures and tables to illustrate key concepts and make reference quick and easy. Summarizes additional information such as adverse effects, drug-drug or drug-food interactions, chemical points of interest, and unique aspects of clinical use in side boxes or Chemical Note side bars. Concludes each chapter with a section emphasizing the clinical relevance of chapter content, as well as review questions for self-assessment. Written by the same international team of renowned researchers and academicians as Foye's Principles of Medicinal Chemistry Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like: Complete content with enhanced navigation Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web Cross-linked pages, references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use

The Year Book of Pathology and Laboratory Medicine brings you abstracts of the articles that reported the year's breakthrough developments in pathology and laboratory medicine, carefully selected from more than 300 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed Chapters in this annual cover the most current information on all aspects of pathology and laboratory medicine including: molecular diagnostics, dermatopathology, anatomic pathology techniques, outcomes analysis, cytopathology, clinical immunology, clinical microbiology, neuropathology and hematology.

This book provides a quick, pattern-based reference for interpreting histologic changes in non-neoplastic liver. It is designed to guide the reader based on morphologic pattern and basic clinical information. Each chapter covers a broad but identifiable pat tern of pathologic liver findings (e.g., "portal inflammation" or "steatosis") and discusses the major disease entities that manifest as such a pattern. As liver biopsies can be complex and daunting, such an approach should improve the reader's ability to identi fy a likely diagnosis or differential and to distinguish among the possible disease enti ties. Sample reports at the end of each chap ter offer guidance on how to sign out cases. Non-Neoplastic Liver Pathology: A Patholo gist's Survival Guide will be of value to practicing pathologists without specialized training in hepatic pathology, pathology residents and fellows trying to learn the basics of non-neoplastic liver pathology, and hepatologists interested in reviewing liver biopsies with pathologists

This issue of Clinics in Laboratory Medicine titled, "Conceptual Advances in Pathology" addresses the key factors impacting pathology and details the technology surrounding the field. The Guest Editor, Zoltan Oltvai, MD., splits the issue into three sections; Technological Advances, Process Advances, Educational and Practice Needs, and the Business of Pathology.

Clinically accessible information for pathologists on histology, differential diagnosis, and clinical overview is presented. Topics in this subject on Cardiovascular Pathology include: Examination of the Explanted/Autopsy Heart; Native Valves; Prosthetic Valves; Cardiac Transplant Biopsies; Diagnostic (Native Heart) Biopsies; Aorta; Temporal Arteritis/Vasculitis/Vascular Lesions; Cardiac Tumors; and Cardiac Devices. Each article presents Key Considerations; Pitfalls of working with the particular entity; Differential Diagnosis summaries; Gross and histologic features with clinicopathologic correlates; Complications; Technical considerations; Post transplant biopsy findings where relevant; and Communicating results.

Exocrine pancreatic tumors of non-ductal origin: Acinar carcinoma, pancreatoblastoma and solid-pseudopapillary neoplasm;? Pancreatic cystic tumors of mucinous type;? Pancreatic cystic lesions of non-mucinous type;? Pancreatic endocrine tumors;? Inflammatory lesions and pseudotumors of the pancreas;? Ductal adenocarcinoma of the pancreas;? PanINs;? Cytology of the Pancreas.

The Year Book of Pathology and Laboratory Medicine brings you abstracts of the articles that reported the year's breakthrough developments in pathology and laboratory medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed

This issue of Clinics in Laboratory Medicine includes the following topics: Detection of cancer biomarkers by cerium oxide nanoparticles; Quantum dot-based assays for cancer biomarkers; Monoclonal antibody conjugated fluorescent magnetic nanoparticles for in vivo diagnosis of cancer; RNA quantification with gold nanoprobes for cancer diagnostics; Nanostructured silica materials for imaging in cancer; and Nanoparticle-based cancer cell sorting.

Non-neoplastic Lesions of the Oral Cavity; Odontogenic Lesions;? Nasal Cavity, Paranasal Sinuses, and Nasopharynx; Squamous Cell Carcinoma of the Oral Cavity and Oropharynx; Larynx and Hypopharynx; Salivary Glands; Bone Lesions

This issue of Clinics in Laboratory Medicine, Guest Edited by Caroline Astbury, PhD, FACMG, will focus on Cytogenetics, with topics including: Chronic lymphocytic leukemia; Acute lymphocytic leukemia; Acute myelogenous leukemia; Chronic myelogenous leukemia; Plasma cell myeloma; Lymphomas; Solid tumors; Myelodysplastic syndromes; SNP arrays in clinical practice; Prenatal arrays; FISH (including Paraffin-embedded (PET) FISH); New and old microdeletion and microduplication syndromes; Sex chromosome and sex chromosome abnormalities; Autosomal aneuploidy; Microarray-CGH interpretation and Genomic Integrity; Structural chromosome rearrangements and complex chromosome rearrangements; and UPD/imprinting.

Dr. Lefkowitch is one the most well known experts on liver pathology and has updated the topic since it last published over 5 years ago. Important topics updated include benign liver tumor, vascular disorders of the liver, autoimmune hepatitis, and non-alcoholic fatty liver disease. Special emphasis is given to articles devoted to immunochemistry in liver tumors, hepatic granulomas, and diagnostic pitfalls in liver transplantation.

Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.

This issue of Clinics in Laboratory Medicine, Guest Edited by Zoltan Oltvai, MD, will focus on Conceptual Advances in Pathology. The issue will discuss the convergence of anatomic pathology, clinical pathology and genomics and other sciences, with the technological underpinning of digital pathology. Topics will include: CAD in digital pathology and Modeling protein motion.