Cancer Metastasis - Related Genes (Paperback, Softcover reprint of the original 1st ed. 2002)

Being diagnosed with cancer is devastating. But when the cancer cells have to spread to form secondary colonies, the prognosis for the patient is worse. If meaningful improvements in survival are to occur, then control of metastasis will be a foundation. Relatively little is known about the control of the metastatic process at the molecular level. This volume begins to explore our current knowledge regarding the underlying molecular and biochemical mechanisms controlling the metastatic phenotype. While all of the authors attempted to put their findings into a context for translation to the clinical situation, the state-of-the-art does not fully allow this. Nonetheless, we write these summaries of our work as an early effort toward that end. I am grateful to all of the authors who have contributed generously of their time and energies to make this volume a reality. To metastasize, neoplastic cells dissociate from the primary tumor, enter a circulatory compartment (typically lymphatics or blood vasculature), survive transport, arrest, exit the circulation and finally proliferate at a discontinuous site in response to local growth factors. Unless cells accomplish every step of the metastatic cascade, metastases cannot develop. The process is highly inefficient, i. e. ,

General

Imprint:	Springer
Country of origin:	Netherlands
Series:	Cancer Metastasis - Biology and Treatment, 3
Release date:	October 2013
First published:	2002
Editors:	D. R Welch
Dimensions:	235 x 155 x 15mm (L x W x T)
Format:	Paperback
Pages:	270
Edition:	Softcover reprint of the original 1st ed. 2002
ISBN-13:	978-9401739221
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Medicine > General issues > Public health & preventive medicine > Epidemiology & medical statistics Books > Medicine > Other branches of medicine > Pathology > Gross pathology Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > General Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	9401739226
Barcode:	9789401739221

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