My lifetime encompasses the postwar subsidence in the early 1920s
of the greatest influenza pandemic in history, direct encounters
with FM1 virus at Fort Mon mouth in 1947, the care of influenza
patients in the 1950s, the pursuit of the in fluenza virus through
the modern pandemics of 1957 and 1968, and a present in which the
genes of the virus have dissembled in the DNA of vaccinia virus and
Escherichia coli through the wand of "high tech. " If my corpus
could be fossilized for archival and archaeological purposes, it
would be found to contain immune cells branded with the imprint of
the "swine" influenza virus of post-1918 and brain cells no less
imprinted with memories of the abortive return of its descendant
during America's bicentennial. But before that unlikely event, I
wanted to try to make some sense out of this baffling dis ease and
its viruses-expecting no definitive revelations but hoping for a
sharper definition of problems. Hence this book. It is an audacious
act in these days of specialization to essay a book such as this
singlehandedly, but I have done so for selfish reasons. I wanted to
reexam ine old questions about the nature of influenza and its
epidemics in the light of the dazzling advances in molecular
biology of the past few years. No virus has been better studied,
but few diseases are less well understood."
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