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Books > Medicine > Clinical & internal medicine > Urology & urogenital medicine
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Proteinuria (Paperback, 1985 ed.)
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Proteinuria (Paperback, 1985 ed.)
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Decoding the significance of proteinuria as an indicator of
severity or prognosis in kidney disease is a stimulating challenge
to students and practitioners of nephrology. Sir Richard Bright in
1827 associated pro with the disease that bears his name. In the
subsequent more teinuria than a century and a half, however, the
meaning of the linkage between proteinuria and renal disease
remains elusive. Proteinuria is discovered on routine urinalysis in
about 10 million Americans, most of whom express no symptoms of
kidney disease, each year. From the studies of Robinson (updated in
these pages), we know that proteinuria, per se, can be present for
20 years without change in re nal function, as described in
orthostatic proteinuria. By contrast, pro teinuria may be the
harbinger of swift kidney destruction, rarely cul minating in
clinical collapse, a syndrome typifying "malignant proteinuria" as
detailed herein by Avram. Although proteinuria is ubiquitous, an
orderly management strategy for rational handling of proteinuria of
less than nephrotic range is lack ing. Separation of tubular
proteinuria and transient proteinuria of fever is now possible
routinely. This book provides a record of the contribu tions of
investigators and clinicians whose work forms the substrate for
production of understanding and, ultimately, marching orders for
prac titioners seeking optimized management for their proteinuric
patients."
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