Each year nearly 35,000 men are diagnosed with prostate cancer. Of these, more than 10,000 die from the disease, and figures are rising. But better awareness, earlier diagnosis and more sophisticated treatments can save lives, and have already reduced death rates in some countries. This new edition of Coping Successfully with Prostate Cancer presents the latest research on prostate cancer and describes the many treatments available. Topics include; symptoms and stages of the disease, other prostate problems, the possible influence of diet, geography and viral factors, screening and investigation, including PSA, the decision to treat, or not to treat, treatments, including surgery and radiation therapy, branchytherapy and laser, dealing with advanced prostate cancer, lifestyle measures, coping with sex, research and the future. In this thoroughly updated and positive book, Dr Tom Smith says that it is possible for men with prostate cancer to lead successful, happy and fufilled lives.

These proceedings of the 2018 XIII International Symposium on Spermatology focus on comparative biology, and encourages discussion and the exchange of ideas. The aim of this Symposium was to provide a unique opportunity and bring together scientists from a wide spectrum of research fields - human, domestic animals and other mammals, vertebrates, insects, and plants. The underlying focus is on the function of the spermatozoon - a common feature for sexual reproduction, but extremely varied. By exploring the variability, a better understanding of male reproductive functions can develop. These proceedings address the mechanisms of physiology and pathophysiology, rather than diagnosis and treatment. The symposium featured keynote lectures by invited speakers, followed by presentations on specific aspects of the general topic of the session. Experimental studies are given priority over clinical studies of patient populations. The proceedings comprise both keynote speakers' texts and selected free communications. Posters were considered for publication in the proceedings, and the volume includes exhibited materials on the work of prominent spermatologists, highlighting their important past achievements in the field.

This book provides a definitive account of koro, a topic of long-standing interest in the field of cultural psychiatry in which the patient displays a fear of the genitals shrinking and retracting. Written by Professor A.N. Chowdhury, a leading expert in the field, it provides a comprehensive overview of the cultural, historical and clinical significance of the condition that includes both cutting-edge critique and an analysis of research and accounts from the previous 120 years published literature. The book begins by outlining the definition, etymology of the term, and clinical features of koro as a culture-bound syndrome, and contextualizes the concept with reference to its historical origins and local experience in Southeast Asia, and its subsequent widespread occurrence in South Asia. It also critically examines the concept of culture-bound disorder and the development of the terminology, such as cultural concepts of distress, which is the term that is currently used in the DSM-5. Subsequent chapters elaborate the cultural context of koro in Chinese and South Asian cultures, including cultural symbolic analysis of associations with animals (fox and turtle) and phallic imagery based on troubling self-perceived aspects of body image that is central to the concept. The second section of the book offers a comprehensive, global literature review, before addressing the current status and relevance of koro, clinically relevant questions of risk assessment and forensic issues, and research methodology. This landmark work will provide a unique resource for clinicians and researchers working in cultural psychiatry, cultural psychology, anthropology, medical sociology, social work and psychosexual medicine.

This volume covers classic and modern cell and molecular biology of prostate cancer, as well as novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation and genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis and progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Cell & Molecular Biology of Prostate Cancer is one of two companion books comprehensively addressing the biology and clinical aspects of prostate cancer. Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, the companion volume, discusses both classic and the most recent imaging approaches including analysis of needle biopsies, applications of nanoparticle probes and peptide-based radiopharmaceuticals for detection, early diagnosis and treatment of prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature.

Since the first randomized controlled studies were conducted on medical circumcision to assess their effectiveness on reducing HIV transmission, health systems have made considerable progress in adopting this practice in their HIV/AIDS and sexual reproductive health policies. As such, medical circumcision is being adopted as an additional intervention measure to support previous practices for reducing HIV infections in various countries or settings. James Kityo's pioneering book examines contexts, processes, policy projections, and likely engagements by reviewing sexual reproductive health policies or practices, and literature on medical circumcision, and identifies existing opportunities and challenges. His book also explores the medical, gender, ethical, socio-economic, and human rights dimensions of medical circumcision as an HIV/AIDS prevention method. Following peer-reviewed studies, Kityo found compelling evidence documenting the effectiveness of medical circumcision in reducing HIV transmission, and discusses this evidence in the context of HIV/AIDS in a developing health system in Sub-Saharan Africa. The author concludes that there is a range of opportunities from research and current practice to enable policy makers to adopt medical circumcision and other interventions at their disposal in order to reduce infections from HIV and AIDS-related deaths. The author suggests feasible recommendations for implementing successful HIV/AIDS prevention programs in developing nations' health systems, including medical circumcision's gradual inclusion in health practices; stakeholder support; an elaborate review of this intervention by women, politicians, religious communities, and funding agencies. The author introduces a guided action plan, which can be used as a launch pad to enhance the learning process in the integration of medical circumcision in existing health practices.

The second of two companion books which address the biology and clinical aspects of prostate cancer. This volume, Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, discusses both classic and the most recent imaging approaches for detection, early diagnosis and treatment of prostate cancer. The companion title, Cell & Molecular Biology of Prostate Cancer, covers classic and modern cell and molecular biology as well as genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis, progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature.

The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on "Sex and gender factors affecting metabolic homeostasis, diabetes and obesity" to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.

This text provides a comprehensive, state-of-the art review of pharmacotherapy for the overactive bladder, and serve as a valuable resource forclinicians, surgeons, and researchers with an interest in OAB. The early chapters will describe the pathophysiology of OAB, algorithm, and provide the readers with a practical guide for evaluating the OAB patient. The next section describes the unique challenges involved in the study of OAB and helps the reader navigate the complexities of the literature on the topic. All chapters are written by experts in their fields and include the most up-to-date scientific and clinical information. The text includes a review of the clinical guidelines for OAB, and a detailed description of the individual therapies, including antimuscarinics, Beta-3 agonists, (insert comma) and chemodenervation. Extensive tabulation of contemporary literature makes this a matchless resource that provides a detailed account of the current evidence for the use of each of these therapies. The text concludes with chapters on unique populations with OAB, and future directions in the research field.Contemporary Pharmacotherapy of Overactive Bladder unites a unique set of thought leaders in the field of voiding dysfunction to create a comprehensive resource that will be useful for a variety of clinicians who treat OAB, including urologists, urogynecologists, general gynecologists, family practitioners, and geriatricians.

The manual provides a complete overview of the clinical assessment, diagnosis and rehabilitation of pelvic floor dysfunctions. The book will help physical therapist students, practicing physical therapists or medical professionals to reinvent the world of pelvic floor rehabilitation with needful details about the anatomy, physiology, causes of pelvic floor dysfunctions, associated pathologies, types of pelvic floor muscle dysfunctions and sexual dysfunction in female and male along with different pelvic floor dysfunctions in female, male and pediatric population. This book also mentions different efficient techniques of pelvic floor evaluation, methodologies and treatment options for common pelvic floor muscles condition. A complete overview of functional anatomy, dysfunctions, causes, types of dysfunctions (hypertonus, hypotonus, incoordination, visceral), clinical assessment, diagnosis and rehabilitation of pelvic floor conditions in female, male and children. Evaluation and rehabilitation for conditions like vaginal laxity, urinary incontinence (stress urinary incontinence, urge urinary incontinence and mixed incontinence), pelvic organ prolapse, sexual dysfunction, pelvic pain, endometriosis, interstitial cystitis, vaginismus and dyspareunia in female. Evaluation and rehabilitation for conditions like erectile dysfunction, premature ejaculation, postvoidal dribbling, prostatitis, postprostatectomy rehabilitation and pelvic pain in male have been discussed. Evaluation and rehabilitation for conditions like enuresis and encopresis in children. Het's MMT, Het's SERF Assessment, Het's Ring Clock Assessment, Het's RR Scale and HPP guidelines. Most simplified practical approach to noninvasive, transvaginal and transrectal evaluation and rehab. Functioning of multiple types of biofeedback and rehabilitation devices like ultimate noninvasive, smart and extremely efficient technology PF360 for urogenital/urogynec/ anorectal rehabilitation. Basics of medical and surgical management of conditions related to pelvic floor dysfunctions.