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Overactive bladder (OAB) syndrome and urinary incontinence are prevalent conditions that affect millions of people worldwide. As such, it is important that these conditions are understood, diagnosed and treated appropriately. Part of the Oxford Urology Library, this pocketbook provides a practical and easy-to-read reference, covering all clinically relevant aspects of OAB and incontinence. With chapters covering the epidemiology, diagnosis and treatment of OAB and urinary incontinence, this book will serve as a useful guide for urologists, gynaecologists, geriatricians, trainees, nurses, continence advisors, physiotherapists, medical students and general practitioners all over the world.
This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.
The Fourth Edition of Urodynamics Made Easy provides a concise and user-friendly guide to the principles and clinical practice of urodynamics as applied to the routine diagnosis and management of patients. The emphasis of this book is on the ethos behind the practice of urodynamics and how this needs to be integrated into the evaluation of all patients with lower urinary tract symptoms. It offers clear information presented in a visually appealing and easily accessible format. A great and simple teaching tool that will assist the novice as well as the more experienced practitioner Superbly illustrated in full colour. An invaluable and practical, yet comprehensive, resource for all those interested in growing their understanding of and expertise in pelvic floor diseases. This edition has been completely updated, especially in relation to the electronic urodynamic measuring devices now available. The clinical relevance has also been enhanced. Urodynamics made Easy provides an invaluable source of information to urologists, gynaecologists and urodynamic nurses, and will also be of interest to general surgeons, radiologists and general practitioners.
This book will explore and explain the best diagnostic and treatment strategies for men with a big prostate. Men are living longer and the opportunity to develop significant benign prostatic hyperplasia is increasing. Men with very large prostates can often be extremely challenging to manage and all urologists and healthcare professionals carrying out general urology and managing men with prostate problems will have come across this issue. There are a number of diagnostic, interventional, and surgical management options available, with some of these being more suited to a large prostate than others. The various treatment strategies and their evidence base are discussed. Valuable tips from expert authors who are experienced in the management of the particularly large prostate are included to allow readers to be confident when managing this increasingly important and prevalent group of patients. This book is of particular use to healthcare practitioners who manage men with BPH in the outpatient or emergency setting, as well as those in the operating theatre who want further tips on how to deal with the particularly big prostate.
Now in its fourth volume, the Biennial Review of Infertility brings together the most up-to-date research and clinical information on male and female infertility, emerging assisted reproductive techniques and evolving controversies in reproductive medicine. An impressive panel of contributors presents cutting-edge information in a clear and well-balanced manner. Volume 4 discusses hot topics in contemporary reproductive medicine, including stem cell technologies for male infertility, the current state of ovarian tissue cryopreservation and time-lapse video microscopy of embryos. The expanded section on controversies allows for point/counterpoint discussion between experts with differing opinions on topics like eSET and the use and role of dietary supplements in IVF cycles. Created to provide an ongoing appraisal of current knowledge, the Biennial Review of Infertility stimulates communication amongst all clinicians and researchers working to help couples resolve their infertility.
This book aims to provide specialists and practitioners with a reliable source of information on all aspects of Peyronie's disease, which is too often still considered a mysterious condition. The focus is in particular on those aspects of the disease that are most hotly debated, including etiology, risk factors, nosology, natural history and medical therapy. Clear guidance is also provided on surgical techniques, with explanation of why and when to apply plication surgery, corporoplasty and plaque surgery and the best approach to complicated cases. Throughout, strenuous efforts have been made to ensure clarity and simplicity of expression and ease of consultation. While clear international guidelines are lacking, this has allowed the authors to devote much space to personal ideas, conveying the fascinating and sometimes conflicting nature of this field of medicine and, hopefully, stimulating further research.
This thesis focuses on the synthesis and vaccine evaluation of the prostate tumor- associated carbohydrate antigen RM2. The author first presents the use of the [1+2+3] one-pot sequential strategy to successfully synthesise the RM2 antigen and its analogues as single stereoisomers in every glycosylation step, producing good yields and stereoselectivity. He then introduces the conjugation of the synthetic RM2 antigen to the carrier protein CRM197 in an average number of 1-10 to create the prostate cancer vaccine candidate, which is combined with -galactosylceramide C1, its analogue C34, or Alu. The results of the vaccination studies in mice are also described and indicate that the strongest anti-RM2 antigen titer is exhibited when one molecule of diphtheria toxin (DT) is conjugated with an average of 4.7 molecules of RM2 antigen (DT-RM4.7) and adjuvanted with the glycolipid C34. More importantly, the induced mouse antibodies mediate the effective complement-dependent cytotoxicity (CDC) against the prostate cancer cell line LNCap. The study presented in this thesis is the first ever to successfully synthesize this complex glycan molecule. Owing to the steric hindrance of the adjacent sialyl moiety, the introduction of two sialic acid units to the compact and rigid 3,4 di branched galactoside unit is very challenging and the -selective and efficient glycosylation of the galactosamine moiety at the 4-position of di branched galactose is also problematic.
This text provides a central resource for physicians, entrepreneurs, and the MBA students about how innovation occurs in medical device industry. The book uses the rise and fall of vaginal mesh kits to highlight the evolution of responses by the physicians, patients and the regulatory bodies. There are specific chapters reviewing the US regulatory issues and business practices that were consequential to withdrawal of most vaginal mesh kits from the US market. The book is meant to be concise, evidence-based, and practical for the first time readers to understand the innovation forces. Concise textual information from acknowledged experts is complemented by high-quality diagrams and images to provide a thorough update of this rapidly evolving medical device industry. The case study chapters fully elucidate the anatomical basis that led to conceptualization of vaginal mesh kits, their introduction into the market, medicolegal and business implications followed with innovation that occurred by the surgeons to utilize ultrasound for and innovative surgeries to overcome device complications. With a luxurious number of well-marked pictures, readers will gain a clear understanding of the medical device innovation and evolution. Innovation and Evolution of Medical Devices: The vaginal Mesh Kits provides a rich practical resource written in a simple a step-by- step approach for all readers in their approach to new medical devices and technologies.
This encompassing volume gathers contributions by renowned experts in the field of pediatric urology to offer a systematic and complete review of the field. The book opens with a general section covering the basis of renal function from the fetus to adulthood, diagnostic imaging, anesthesia and infections. In subsequent sections on the kidneys, upper urinary tract, bladder, urethra and genitalia, specific anomalies are described in depth, from embryological, clinical and diagnostic aspects through to surgical treatment options. Detailed attention is devoted to the role of new technologies such as endoscopic and robotic surgery, but without disregarding the classical principles of pediatric urologic surgery. Urogenital tumors are fully covered and the book closes with a large chapter on renal transplantation. Numerous black and white and color illustrations will assist the reader in better understanding the various anomalies and the surgical procedures.
With the rising incidence of urolithiasis, the management of ureteral stones continues to become a larger component of urologic practice. Though almost all urologists deal with ureteral stones, there have been many recent improvements in instrumentation and adjunctive equipment as well as improvements in imaging and the data we can obtain from radiologic imaging in order to guide stone management. Newer topics such as how to limit radiation exposure to both the patient and the urologist, the accuracy and limitations of low-dose computed tomography as well as a review of the most recent studies will be covered in this book. The purpose of this book is to provide a complete updated roadmap to treating ureteral stones, from early management decisions from information found on radiologic studies to adjusting to intra-operative challenges.
This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in depth review of proven therapeutic options, including bone targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigations are also reviewed. The text provides up to date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence based medicine.
As a concise yet comprehensive summary of the current status of the field, "Management of Castration Resistant Prostate Cancer "serves as a very useful resource for physicians and researchers dealing with this challenging malignancy.
Upper Tract Urothelial Carcinoma represents the first book of its kind to be dedicated solely to UTUC. It's aim is to improve understanding and eventually care of a disease that is greatly understudied and underappreciated, yet commonly dealt with by many medical and urologic oncologists. The volume features new data regarding genetic susceptibility, gene expression studies and causative factors; contemporary concepts and controversies regarding diagnosis and staging of UTUC; prediction tools and their value in treatment decisions within each disease stage and patient selection and treatment options such as endoscopic management, distal ureterectomy, radical nephroureterectomy and chemotherapy. Up-to-date information regarding boundaries of surgical resection, indication and extent of lymphadenectomy is covered as well as the role of perioperative/neoadjuvant chemotherapy in patients with high-risk UTUC. Upper Tract Urothelial Carcinoma will be of great value to all Urologists, Medical Oncologists and fellows in Urologic Oncology as well as upper level residents in training in Urology and Medical Oncology.
Pediatric Urology: Surgical Complications and Management, 2nd edition focuses 100% on the most common problems that can occur during pediatric urologic surgery, and how best to resolve them, ensuring the best possible outcome for the patient. As well as being thoroughly revised with the latest in management guidelines, brand new to this edition are a host of clinical case studies highlighting real-life problems during urologic surgery and the tips and tricks used by the surgeon to resolve issues faced. These will be invaluable for urology trainees learning their trade as well as for those preparing for Board or other specialty exams. Chapters will include problem solving sections as well as key take-home points. In addition, high-quality teaching videos showing urologic surgery in action will be included via the companion website - again proving an invaluable tool for all those seeking to improve their surgical skills. Edited by an experienced and international trio of urologists, they will recruit the world s leading experts, resulting in a uniform, high-quality and evidence-based approach to the topic. Pediatric Urology: Surgical Complications and Management, 2nd edition is essential reading for all urologists, especially those specialising in pediatric urology and urologic surgery, as well as general surgeons.
Primer on Prostate Cancer will provide readers with a thorough introductory review on prostate cancer, treatment guidelines, and emerging therapies available for the disease. The book was originally commissioned due to recent developments in therapies for prostate cancer. This concise pocket book will review prostate cancer's epidemiology, clinical features, diagnosis, and medical management (discussing surgery, radiotherapy, hormone therapy, chemotherapy, bone-targeting therapy, and more). Busy healthcare professionals will benefit from this text, which will not only cover the basics of prostate cancer, but discuss up-to-date national and international treatment guidelines and upcoming therapies.
Depend on Hinman's for up-to-date, authoritative guidance covering the entire scope of urologic surgery. Regarded as the most authoritative surgical atlas in the field, Hinman's Atlas of Urologic Surgery, 4th Edition, by Drs. Joseph A. Smith, Jr., Stuart S. Howards, Glenn M. Preminger, and Roger R. Dmochowski, provides highly illustrated, step-by-step guidance on minimally invasive and open surgical procedures, new surgical systems and equipment, and laparoscopic and robotic techniques. New chapters keep you up to date, and all-new commentaries provide additional insight from expert surgeons. Provides access to procedural videos online, including Percutaneous Renal Cryotherapy, Greenlight Photovaporization of the Prostate, Holmium Laser Enucleation of the Prostate, Cryoablation of a Renal Tumor, and Sling Procedures in Women. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, videos, and references from the book on a variety of devices. Features 10 new chapters, including Radical Cystectomy in the Male, Robotic Urinary Diversion, Laparoscopic and Robotic Simple Prostatectomy, Transrectal Ultrasound-Directed Prostate Biopsy, Transperineal Prostate Biopsy, Prostate Biopsy with MRI Fusion, Focal Therapies in the Treatment of Prostate Cancer, Brachy Therapy, Male Urethral Sling, and Botox Injection for Urologic Conditions. Includes new commentaries in every chapter from today's leading urologists. Offers a step-by-step incremental approach, highlighted by new illustrations, photos, and images. Keeps you current with significant revisions to all female sling chapters, urethroplasty chapters, and more. Helps you find what you need quickly with a clear, easy-to-use format - now reorganized to make navigation even easier.
Following the undergraduate curriculum set by the British Association of Urological Surgeons, Urology at a Glance offers practical advice on diagnosis and management of one of the most rapidly developing medical specialties. Building on basic science, the book provides an overview of clinical approaches to assist the medical student or junior doctor on rotation, as well as looking at practical procedures and specific details of the most commonly encountered urological disorders. Vibrantly illustrated and containing common clinical scenarios, Urology at a Glance provides all the information and latest guidelines needed for a medical student or junior doctor to excel in this field.
The Penis Book is the comprehensive guide to everything you need to know about the penis, for men and women alike. Written by Dr. Aaron Spitz - one of America's top urologists and a regular on The Doctors - the book is full of in-depth information, expert medical advice, and even humor to put the reader at ease. In addition to information on everything from sexually transmitted infections to the science of blood flow, Dr. Spitz presents an easy-to-follow five-step plan for holistic penis health, including advice on eating a plant-based diet, meditation, and heart-healthy workouts. This book will be the essential guide to caring for the penis in anyone's life.
Written entirely by surgical urologists, Surgical Management of Urolithiasis: Percutaneous, Shockwave and Ureteroscopy presents a comprehensive overview of the past, present, and future of surgical techniques, with a focus on educating urologists on the full spectrum of stone procedures. In addition to the technical issues, detailed complications are described. Basic as well as advanced techniques are presented in both a didactic and visual mode with representative endoscopic images and radiographs. Recent advancements which are not routinely a core component of surgical training programs are also covered in detail. Compact and extensively illustrated, Surgical Management of Urolithiasis: Percutaneous, Shockwave and Ureteroscopy is a unique and valuable resource in the field of surgical urolithiasis, essential both for those currently in training and for those already in clinical practice.
Over the last decades, acrosomal exocytosis (also called the "acrosome reaction") has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reported in neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process.
Within this single volume, surgeons and medical students are able to find up-to-date clinical information and advice needed to manage this unique condition of small renal masses. The book aims to present information on the topic in a clear and logical way, with the help of figures, tables, and images that will assist in the practical application of the skills that are obtained from the book. The growth of new technologies and the continued development of existing techniques have led to a considerable number of new options that can be offered to patients by urologists. Despite these advances, challenges still remain and this book offers individual solutions to each aspect of the management of small renal masses, so that every diagnosis can be tailored to each patient. Written by leading experts, this book gives expert insight and advice into the diagnosing and managing of this condition. From making an accurate diagnosis to selecting the appropriate treatment for the patient, this book will provide a comprehensive guide on all aspects of the management of small renal masses.
This text provides a comprehensive, state - of - the art review of this new and emerging field, as the number of men who suffer from post-prostatectomy incontinence increases by greater than 10,000 per year. How to evaluate and manage this devastating disorder has become a necessary part of nearly every urologic practice. This book serves a valuable resource for physicians with an interest in managing patients with post-prostatectomy incontinence. In addition, treatment includes algorithms and suggested office evaluation that will help guide conservative management that is appropriate for most patients. The text provides insight into the history of male incontinence surgery, as well as the current surgical techniques for the operative management of post-prostatectomy incontinence in those who fail conservative management. This text reviews current data regarding surgical outcomes for the most common and newly developed incontinence procedures, as well as step-by-step descriptions of the key surgical steps necessary for success. All chapters are written by world renowned experts in this field and include the most up to date clinical information.
This book effectively summarizes our knowledge of recent advances in prostate cancer. It focuses on our state-of-the-art understanding of risk factors, prevention, detection, prognosis and treatment of prostate cancer and identifies basic science findings that are being translated into clinical practice. In addition, the book singles out key areas of research that have potential for clinical translation. Both basic scientists and clinicians will be invited to provide up-to-date reviews in each area of prostate cancer. During the last decade the pace of clinical discovery and the scientific advances in prostate cancer have been very rapid. For instance, currently there are more than 100 drugs in the pharmaceutical pipeline that have the potential for clinical management of prostate cancer. Therefore, it has been very difficult for clinicians and basic scientists to keep pace with the field as a whole. Recently, some of these discoveries are already having an impact on clinical practice. For example, the discovery of the androgen receptor gene amplification in prostate cancer has led to the development of a "super-antiandrogen," which is being tested in clinical trials. Also, recent knowledge of androgen synthesis in prostate cancer cells has led to clinical trials with steroid-metabolism inhibitors. Finally, robotic surgery has also dramatically changed clinical practice. Thus, this important book serves to provide readers with a one-stop overview of the field of prostate cancer research and its translation into the clinical arena.
This definitive manual provides a quick reference on pediatric urologic problems for medical students and physicians in training. Presented in two clearly outlined sections, part one introduces, in 12 chapters, the common forms of presentation of urological conditions in children, with emphasis on anamnesis, differential diagnosis and the appropriate use of diagnostic tools. Treatment modalities are also briefly discussed.
Part two consists of 11 chapters that discuss the common pediatric urological conditions. The emphasis for part two is the provision of practical and up-to-date information in a standardized, easy-to-read format. There is extensive cross-referencing between parts one and two. Finally, an appendix presents practical information such as renal length, grading of reflux, etc.
Are you a urologist, trainee, or medical student managing patients with conditions like BPH, urinary stones or priapism? Do you require a rapid-reference guide to clinical management? If so, this full colour, practical handbook is the ideal resource, providing rapid-access information on the clinical management of all major urologic disorders and problems likely to be encountered daily. With a strong emphasis on user-friendliness and point-of-care accessibility, sections are divided according to the major areas of urology, with each chapter containing the following features: case histories multiple choice questions key points box key weblinks box common errors in diagnosis/treatment boxes An experienced contributor team outlines the skills required to provide appropriate assessment and management of patients; in particular identifying the correct diagnostic and management options for each disorder, and how to perform basic urological procedures safely and effectively. Information corresponds to relevant American Urological Association (AUA) and European Association of Urology (EAU) guidelines for clinical management. Perfect for quick browsing prior to performing a consultation, preparing for ward rounds, or when brushing up for the Boards, Handbook of Urology is the ideal quick-stop manual for urologists of all levels involved in day to day management of patients.
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