Scientists have reached a critical point in the development of new therapies for prostate cancer. The information gleaned from the Human Genome Project, alongside the emergence of new technologies for the use of genetic data has expanded the physician's understanding of disease progression and widened his armamentarium for prostate cancer prevention and control. This expertly-written reference thoroughly analyzes the scientific principles and methodologies behind the most recent translational therapies and provides the necessary context, data, and studies for practitioners to select appropriate candidates for treatment and effectively apply new therapies in clinical practice.

This book provides a comprehensive, state-of-the art review of the genitourinary tumor pathology field and the most contemporary insights regarding specimen submission, histologic morphology, immunohistochemistry, and molecular studies useful in the diagnosis of genitourinary neoplasms. Discussion of the clinical implications of pathological findings is contributed by renowned clinicians in the field. This handsome volume guides the reader through the intricacies of genitourinary tumor pathology, diagnosis, reporting, and prognosis. Written by experts in the field, Genitourinary Pathology: Practical Advances is of great value to anatomic pathologists, urologists, fellows in genitourinary pathology, as well as upper level residents training in pathology.

Geriatric urology represents one of the largest overall sectors of care provided within the specialty of urology. As the incidence and prevalence of many clinical urologic conditions increase significantly in older adults, the practice of urology involves a need for advanced knowledge of the basic principles of geriatrics. Geriatric Urology outlines important topics in the care of elderly urology patients. The first section covers the biology of aging, changes in the genitourinary system, and common diseases including urologic conditions that may serve as warning signs of other disorders. Section two covers geriatric syndromes and implications for urologic care including frailty, polypharmacy, dementia, and wound healing. Urologic conditions in older adults are explored in detail including urinary incontinence, pelvic organ prolapse, urinary tract infection, nocturia, and benign prostate diseases. Other topics covered include obtaining informed consent, development of advance directives, palliative medicine and care of the dying patient. Geriatric Urology is of great value to urologists, geriatricians, internists, residents and family practitioners.

Transitional Urology is designed to fill a critical gap that exists in the published literature by comprehensively addressing the urological challenges facing adolescents and adults with complex congenital anomalies of the genitourinary system. It provides a valuable resource to pediatricians and pediatric urologists facing urological management issues beyond their expertise in their aging patients as well as technical guidance to adult urologists who may have had little or no experience caring for patients with a congenital condition. This work will service as a field guide to congenitalism, providing a "how to" approach to guide the urologist using real clinical examples for the most common and challenging urological problems encountered. It also provides a framework for the transition process from pediatric to adult-centered care, with a special emphasis on the multidisciplinary nature needed to provide patient-centered care. Specific conditions that require special consideration, including myelomeningocele, exstrophy, posterior urethral valves, and hypospadias are highlighted. Topics considered common in the general urology practice- like infertility and sexual dysfunction are addressed within the context of patients with neurological or anatomical complexity. In addition, this text reviews urological complaints for which basic clinical algorithms are well-established within the context of a congenitally-abnormal bladder. Chapters discuss how and when special testing like video urodynamnics and positional fluoroscopy may be warranted to provide critical diagnostic guidance. The text also review how typical age-related urological phenomena, like elevated PSA, hypogonadism, and BPH, may present in this subset of patients and how treatment of these conditions may be different than the general population.

While there are Pediatric Urology texts for Pediatric Urologists and for General Urologists, there are none for Primary Care Physicians. This book is written specifically for the primary care physician, the initial contact for the many children with urologic conditions. This text will assist the primary care physician in the recognition of and participation in the care of children with these common problems. These include both congenital and acquired conditions. Management may involve medical and/or surgical intervention. The contributing authors were selected for their internationally recognized expertise and straight forward educational styles. Pediatric Urology for the Primary Care Physician will significantly help our primary care colleagues in the evaluation and management of children with genito-urinary problems.

Many patients leave the doctor's office feeling frustrated and rushed, with unanswered questions. It's a common concern-that by expediting a patient's visit, doctors may miss important information for the sake of brevity. And for patients seeking to discuss alternative therapies outside of conventional medicine, they especially need time to discuss and confirm the truth of their personal research. In The Unfettered Urologist, readers will learn and benefit from the opinions, intuition, and common sense of Martha B. Boone, M.D. -a urologist with over thirty years of working experience and fifteen years of collegiate study. Those seeking detailed insight into the world of urology will learn what Dr. Boone always wanted to tell her patients, but could never pack into a fifteen minute office visit. The Unfettered Urologist explains: Common urology problems and options for readers to start treatment at home, with the confidence of an experienced specialist Inside information not available in medical texts or medical websites Important questions to facilitate office visits when needed When to save healthcare dollars for prevention and treatment (prior to seeing a doctor) The inner workings of the medical profession and thus be able to better utilize the system True stories of medical scenarios and real-life cases Healing techniques outside of conventional medicine that have worked in conjunction with traditional medicine In some cases, how to avoid invasive procedures Entertaining, informative, and packed with unexpected insight, The Unfettered Urologist leads readers through the health care system with humor and candor.

Benign prostatic hyperplasia (BPH) is an age-related, nonmalignant condition that may lead to bothersome lower urinary tract symptoms. The standard treatment of BPH has been ordinary loop transurethral prostatectomy, but new therapies have been developed as a combined result of research, technological advances, and the cumulative experience of urological surgeons. Among the most promising therapeutic alternatives to ordinary loop resection are those that deliver topical or interstitial heat to prostatic tissue. Transurethral microwave thermotherapy, visual laser ablation with the Nd:YAG laser, high-intensity focused ultrasound, and transurethral electrovaporization are some of the techniques described in this book. These innovative procedures, employed by skilled urologists using state-of-the-art instruments, hold forth the promise of improved quality of life for BPH patients and represent significant advances in the field of urology.

Every year, in the United States and the third world combined, 13.3 million boys and 2 million girls are circumcised. Whether because of perceived medical, cultural, or religious necessity, most of these parents feel they have no alternative but to allow their children to undergo this surgery. Sparking intense debate, the circumcision of children is a highly controversial and complex phenomenon that touches a variety of sociological areas, such as religious beliefs, identity issues, medical conceptualizations, fear, and superstition. The contributors to this volume comprise an international panel of experts in the fields of medicine, psychology, law, ethics, sociology, anthropology, history, theology, and politics. In 18 chapters they discuss the history of circumcision; document the physical and psychological consequences of circumcision; present the latest anatomical discoveries about the male prepuce; analyze the role of circumcision in various traditions; reveal the medical industry's investment in the practice; describe current legislative efforts to protect children from circumcision; and outline effective, culturally sensitive methods that are being implemented today to safeguard the human rights of at-risk children. For its insights into this troubling aspect of culture, Understanding Circumcision: A Multi-Disciplinary Approach to a Multi-Dimensional Problem is a critically important contribution to the growing body of literature on this subject.

In 1996, the National Bladder Foundation (NBF) was founded by a dedicated group of physicians and researchers propeIled by the urgent need to find better treatments for bladder disease. Committed to increasing bladder disease research and to supporting its research community, the NBF coordinates and sponsors the International Bladder Symposium (IBS) in Washington, DC. Now considered to be a premier scientific assembly, the IBS brings together international leaders in bladder disease research to present and discuss their findings. It is the only international conference where all areas of bladder disease research are exclusively covered and where bladder disease researchers are provided with a unique opportunity to share their results and theories. IBS participants contributed the research papers included in this publication in 2000 and 2001. AIl substantial areas of bladder disease research are addressed, including oncology and ceIlular biology, neurophysiology, neurogenic bladder and incontinence, immunology, inflammation and infection, muscle, matrix and obstruction, and new frontiers and therapies of the bladder. Assembled in one publication, these papers and their findings demonstrate the high scientific caliber of the dedicated researchers in this field and the potential for significant discoveries in treatment options in the next decade.

This book provides a systematic review of the management and treatment of this disease. The concise and highly structured chapters feature essential background knowledge and commentary on recent advances within each step of a range of patient pathways. Management of Muscle Invasive Bladder Cancer provides a framework for patients' care based on the research, as well as practically and clinically oriented guidelines. This book is relevant to trainees and practicing urologists and oncologists, in addition to medical professionals involved in the treatment of bladder cancer.

Unique case-based format facilitates understanding of difficult clinical scenarios Focuses on tips and tricks to help prevent common mistakes Key pictures show a range of colorectal pediatric situations

This is a reference manual for daily use in the Reproductive Medicine or Andrology laboratory, which goes beyond the literature available in the scientific journals by compiling insights into a detailed and applied clinical approach. All established practitioners in Reproductive Medicine will find much of practical relevance about the latest insights into sperm selection and analysis.

There is a clear need for a more comprehensive and inclusive body of information for supplementary and alternate treatment of urological conditions. To meet this need, our book will compile evidence-based information for clinicians, healthcare providers, and patients. As the first comprehensive educational guidebook focusing on alternative therapies for urological ailments, this book will be useful for healthcare providers as well as patients suffering from these conditions (including urinary tract infections, benign prostatic hyperplasia, kidney stones, incontinence, and pelvic pain) who are looking for alternative and supplementary remedies. Many physicians and patients are reluctant to use these remedies and this book will demystify this area in urology.

Premature Ejaculation presents a unique and innovative therapeutic program for the successful treatment of premature ejaculation. This descriptive and well-structured program is fundamentally different from traditional sex therapy and contemporary sexual medicine. Centred on the management of sexual excitement, it enables couples to prolong the length of intercourse without having to interrupt their lovemaking or resort to medication. The program's sexological approach also empowers couples with the skills and knowledge to strengthen their sex life leading to a healthier and happier relationship. Combining theory and practical instruction, Francois de Carufel's book promotes a better understanding of premature ejaculation. It offers a new perspective on the causes of this dysfunction and provides practitioners and therapists with concrete ways to assist men and women in improving their sex life. Premature Ejaculation will be of interest and value to health professionals and graduate students in all fields dealing with sexual difficulties, including psychology, social work, medicine, physical therapy, nursing and counselling.

Premature Ejaculation presents a unique and innovative therapeutic program for the successful treatment of premature ejaculation. This descriptive and well-structured program is fundamentally different from traditional sex therapy and contemporary sexual medicine. Centred on the management of sexual excitement, it enables couples to prolong the length of intercourse without having to interrupt their lovemaking or resort to medication. The program's sexological approach also empowers couples with the skills and knowledge to strengthen their sex life leading to a healthier and happier relationship. Combining theory and practical instruction, Francois de Carufel's book promotes a better understanding of premature ejaculation. It offers a new perspective on the causes of this dysfunction and provides practitioners and therapists with concrete ways to assist men and women in improving their sex life. Premature Ejaculation will be of interest and value to health professionals and graduate students in all fields dealing with sexual difficulties, including psychology, social work, medicine, physical therapy, nursing and counselling.

A working knowledge of the basic sciences that underpin mechanisms of disease and the body's response is widely recognised to be a critical part of urological training. This book is aimed at trainees to ensure they are up to date with this breadth of knowledge and it provides succinct summaries which are ideal for revising the basic sciences component of final assessments and examinations. The chapters cover anatomy and physiology, the basic principles of immunology and oncology and particular diseases. It is a compendium of "need to know" facts and is aimed at both FRCS (Urol) candidates and a wider gloabl surgical audience looking for an up to date summary.

1. Einleitung 2. 2.1. Der Stand der anatomischen Wissenschaft an der Schwelle zum 16. Jahrhundert 2.2.1 Biographie 2.2.2. Leonardos urologisch-anatomische Zeichnungen 3. Das 16. Jahrhundert 3.1 Andreas Vesal 3.1.1. Biographie 3.1.2. Vesals Abb. zum Urogenitalsystem 3.1.3. Vesals Konsil uber die Behandlung einer Nierensteinerkrankung 3.2 Charles Estienne 3.2.1. Charles Estienne - Biographie 3.2.2. Die Darstellung des Urogenitaltraktes bei Charles Estienne und Estienne la Riviere 3.3 Bartholomaeus Eustachi 3.3.1 Biographie 3.3.2 Eustachis urologisch-anatomische Graphik 4. Das 17. Jahrhundert 4.1 Regnier de Graaf 4.1.1 Biographie 4.1.2 De Graafs urologisch-anatomische Abbildungen 4.2 Godefridus Bidloo 4.2.1 Biographie 4.2.2 Bidloos urologisch-anatomische Abbildungen von 1685 5. Das 18. Jahrhundert 5.1. Giovanni Domenico Santorini 5.1.1. Biographie 5.1.2. Santorinis Darstellungen zum Plexus venosus vesicoprostaticus 5.2. William Cheselden 5.2.1. Biographie 5.2.2. Cheseldens Darstellungen zum Urogenitaltrakt 5.3. Weitere urologisch-anatomische Abbildungen aus dem 18. Jahrhundert 5.3.1. Urologisch-anatomische Buntkupferdrucke 6. Das 19. Jahrhundert 6.1. Justus Christian Loder 6.1.1. Biographie 6.1.2. Loders Darstellungen zum Urogenitaltrakt 6.2. Antonio Scarpa 6.2.1. Biographie 6.2.2. Scarpas Darstellungen zum mannlichen Urogenitaltrakt 6.3. Martin Munz 6.3.1 Biographie 6.3.2. Die Lithographischen Darstellungen von Martin Munz zumUrogenitaltrakt 6.4. Marc Jean Bourgery 6.4.1. Biographie 6.4.2. Farblithographische Darstellungen des Urogenitaltraktes im Atlas von Marc Jean Bourgery 7. Die Urologie an der Schwelle zum 20. Jahrhundert 7.1. Gustav Simon 7.1.1. Biographie 7.1.2. Die erste wissenschaftlich geplante Exstirpation einer Niere durch Gustav Simon 7.2. Henry Morris 7.2.1. Biographie 7.2.2. Die erste operative Entfernung einer Nebenniere aufgrund eines Tumorleidens durch Henry Morris 1885 7.3. Bernhard Bardenheuer 7.3.1. Biographie 7.3.2. Die erste totale Blasenexstirpation aufgrund eines Tumorleidens ohne Harnleiterneuimplantation durch Bernhard Bardenheuer 1887 7.4. Karl Pawlik 7.4.1 Biographie 7.4.2. Die erste totale Blasenexstirpation mit Harnleiterneueinpflanzung bei einer Frau durch Karl Pawlik 1889 7.5. Hugh Hampton Young 7.5.1 Biographie 7.5.2. Die erste perineale radikale Prostatavesikulektomie aufgrund eines Proststakarzinoms durch H. H.Young 1904 7.6. Friedrich Voelcker 7.6.1 Biographie 7.6.2. Die Erstbeschreibung der totalen Samenblasenexstirpation auf ischiorektalem Weg durch Friedrich Voelcker 1912 8. Schlussbetrachtung

Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling. Key Features Discusses the signaling pathways that contribute to successful spermatogenesis Covers comprehensive information about Spermatogenesis at one place Explores the vital aspects of male fertility and infertility Explains the epigenetic regulation of germ cell development and fertility Highlights the translational opportunities in molecular signaling in testis

* Focuses on the technical aspects of surgery to ensure improved surgical technique * Easy to read, understand and apply the information * Fully illustrated with over 300 colour illustrations *Clear step-by-step techniques, to provide further insights into clinical practice*

Translational Urinomics provides an overview of urine analysis using proteomics, metabolomics, transcriptomics or any combination thereof for the diagnosis and prognosis of diseases related to the urinary system and the kidneys. The text approaches urine biomarkers from a new perspective, incorporating up-to-date studies of mass-spectrometry-based biomarker discovery as well as the latest advances in personalized medicine. The integration of technology-driven techniques, such as OMICS also provides a unique opportunity for improved diagnostics accuracy of urinary-related diseases. For nephrologists and urologists looking for new approaches to well-known problems, this edited volume serves as a valuable guide.

Covering the entire spectrum of this fast-changing field, Diagnostic Imaging: Genitourinary, fourth edition, is an invaluable resource for general radiologists and trainees-anyone who requires an easily accessible, highly visual reference on today's genitourinary (GU) imaging. Drs. Ghaneh Fananapazir, Bryan R. Foster, and their team of highly regarded experts provide up-to-date information on recent advances in technology and the understanding of GU diseases and disorders to help you make informed decisions at the point of care. The text is lavishly illustrated, delineated, and referenced, making it a useful learning tool as well as a handy reference for daily practice. Serves as a one-stop resource for key concepts and information on GU imaging, including a wealth of new material and content updates throughout Features more than 2,500 images (state-of-the-art cross-sectional imaging, full-color medical illustrations, radiologic images, clinical photographs, H&E stains, and gross pathology photographs), plus 500 additional images and video clips online Features updates from cover to cover including updated Bosniak 2019 criteria, PI-RADS v2.1 terminology, updated cancer staging chapters, new interventional techniques, new contrast agent guidelines, and new chapters on transgender imaging Contains a new 10-chapter section on kidney transplant, including post-transplant procedures Covers key procedures such as renal biopsy; percutaneous genitourinary interventions; kidney ablation/embolization; and venous sampling and venography Covers all aspects of GU imaging, including typical and variant findings; GU anatomy, physiology, imaging protocols, and work-ups; and new developments in diagnostic criteria and terminology Uses bulleted, succinct text and highly templated chapters for quick comprehension of essential information at the point of care Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices

This book effectively summarizes our knowledge of recent advances in prostate cancer. It focuses on our state-of-the-art understanding of risk factors, prevention, detection, prognosis and treatment of prostate cancer and identifies basic science findings that are being translated into clinical practice. In addition, the book singles out key areas of research that have potential for clinical translation. Both basic scientists and clinicians will be invited to provide up-to-date reviews in each area of prostate cancer. During the last decade the pace of clinical discovery and the scientific advances in prostate cancer have been very rapid. For instance, currently there are more than 100 drugs in the pharmaceutical pipeline that have the potential for clinical management of prostate cancer. Therefore, it has been very difficult for clinicians and basic scientists to keep pace with the field as a whole. Recently, some of these discoveries are already having an impact on clinical practice. For example, the discovery of the androgen receptor gene amplification in prostate cancer has led to the development of a "super-antiandrogen," which is being tested in clinical trials. Also, recent knowledge of androgen synthesis in prostate cancer cells has led to clinical trials with steroid-metabolism inhibitors. Finally, robotic surgery has also dramatically changed clinical practice. Thus, this important book serves to provide readers with a one-stop overview of the field of prostate cancer research and its translation into the clinical arena.

Urological Emergencies: A Practical Approach, Second Edition provides a concise, evidence based review of common urgent and emergent urological conditions in children and adults. Descriptions of the appropriate diagnostic and therapeutic considerations on topics of traumatic, infectious, obstructive, hemorrhagic, iatrogenic, vascular and congenital urological emergencies in adults and children are provided. The text is organized by pathophysiology rather than organ system, allowing the reader to develop approaches to the care of patients with acute urological conditions based on mechanism of disease. Relevant pathophysiological background and epidemiology are reviewed, necessary diagnostic testing recommended, and detailed medical, surgical and endourological management approaches have been provided. All chapters incorporate published guidelines and best practice recommendations from appropriate organizations including the American Urological Association, the Centers for Disease Control and Prevention, and various International Consultations on Urological Diseases. New or significantly revised chapters in each of the subsections address innovations in trauma care and prevention, new strategies in management of kidney stones, and special care needs of children with acute urological problems. Urological Emergencies: A Practical Approach, Second Edition is of great value to practicing urologists, urology residents, emergency medicine trainees and practitioners, and primary care providers including MD's, PA's, and NP's without immediate access to urological consultation.

Modern science has shown that the widely held beliefs of clinicians about urinary tract infection (UTI) are wrong. A large body of meticulous, rigorous data, from different centres around the world makes this point. How can it be that doctors continue to practise in contradiction of what we now know? A few clinicians are now changing their approach with gratifying results so it is timely to encourage others to do likewise. Clinical guidelines have achieved such influence that most doctors feel compelled to follow them and may face censure if they do not. Regrettably the guidelines are mistaken and contradict the known science. The inertia of bureaucracy and the fear of antimicrobial resistance (AMR) do not help to encourage reflection. However, things are changing and the future should see new and better informed advice. It is a tragedy that these circumstances are leading to widespread suffering amongst many women, some men and children who experience untreated or inadequately treated infection that may plague them for years. This situation has to change. This book sets out the truth about this neglected field and explains the many errors that haunt the topic. The style makes the message accessible to all clinicians. The story is convincing, because the clinical stories that illustrate the text will be so familiar to practising clinicians, who have been baffled by their experiences. Above all, this book will help you and your patients by detailing an accessible, practical approach to resolving this difficult clinical problem in common practice. The scope of the book will cover: the history of the medicine of urinary tract infection (UTI); the urinary microbiome and what the microbes are really up to; the battles between the pathogens and the innate immune system; the truth about the tests and the criteria used to define UTI; antimicrobial resistance and the importance of Darwinian evolution; the science and ground-breaking research on UTIs; the use of antibiotics; successful treatment; supportive and other related treatments; ethics; the future; and, above all, the experiences of the patients.