In this issue of Urologic Clinics, guest editors Leonard G. Gomella and Veda Giri bring their considerable expertise to the topic of Prostate Cancer Genetics: Changing the Paradigm of Care. Provides in-depth, clinical reviews on Prostate Cancer Genetics, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

This practical guide is a compendium of contemporary views on the development, treatment, and prevention of urinary stone disease. Emphasis is placed on utilizing current research to highlight areas of potential discovery and inspire novel approaches to easing the burden of urinary stone disease.

The subspecialty of genitourinary or pelvic pain suffers from the lack of objective data and level-1 evidence. Genitourinary Pain and Inflammation: Diagnosis and Management of GU-ITIS is a compilation of skilled creativity based upon critical review of the literature, consensus reports, and professional experiences. It includes detailed chapters that address iatrogenic causes of GU inflammation, caused by catheters, prosthetics, radiation, or chemotherapy. Chapters in Genitourinary Pain and Inflammation: Diagnosis and Management of GU-ITIS also discuss pain syndromes specific to the pelvic floor and the genitourinary system from several perspectives. Experts in the urological and gastrointestinal fields provide the specifics for gaining the basic understanding of inflammation and pains caused by infectious etiologies.

In the 5 years since the publication of Urologic Laparoscopy by the Japanese Society of Endourology and ESWL, the field has moved on apace, particularly technologically. It is with an eye on the need to disseminate the latest information on this progress that this collection has been assembled, highlighting the most recent advances in laparoscopic urologic oncology surgery. With treatment options becoming ever more complicated, it is essential to keep the prime objectives in mind - improved quality of life for the patient, minimal complications, early convalescence, and a better end result. In our effort to cover a broad range of techniques from renal cyst decortication to robotic laparoscopic camera control, we are in debt to surgeons at the forefront of treatment, not only in Japan but worldwide, and to manufacturers who are constantly innovating in their equipment. The contributors are enthusiastic in their expertise, as shown in the quality of the material they have produced.

Peyronie's Disease: A Guide to Clinical Management is the first comprehensive book on this prevalent disorder in adult men (estimated range from 5-9 per cent) designed to clarify misconceptions and myths, provide an update on the etiology, pathophysiology and current research, provide useful information for clinical practice and hopefully stimulate further research into understanding the pathophysiology of this devastating problem. There will also be extensive attention to the current medical and surgical treatments with detail on surgical technique.

This book provides a comprehensive analysis of the value of contrast-enhanced ultrasound (CEUS) in the diagnosis of a wide variety of pathologies. Sonography reliably identifies a wide range of diseases, and the efficacy of modern ultrasound has dramatically improved with contrast enhancement. This book covers almost all aspects of CEUS starting from basic principles and ending with features of its application in individual organs. In particular, it explores the diseases of abdominal, retroperitoneal, and pelvic organs as well as superficial structures, highlighting the characteristic features of typical findings. Focal lesions are discussed in depth, with attention to their early detection and differential diagnosis. Besides, a practical approach to the stratification of the risk of malignancies is provided. The authors summarized their own experience with CEUS in oncology, hepatology, gynecology, urology, endocrinology, and other fields of medicine. The role of CEUS in differential diagnosis of various disorders of the female reproductive system is comprehensively discussed as well. The presentation is clear and concise, and richly illustrated. The book will be a helpful tool for both residents and practitioners approaching ultrasound diagnostics, as well for more experienced radiologists and other professionals.

Michael J. Droller, MD and a panel of experienced clinicians bring their strong background in clinical research to bear on the assessment and management of bladder cancer. Their comprehensive discussion summarizes the state-of-the-art in diagnosis and treatment, based on the latest understanding of bladder cancer's epidemiology, carcinogenesis, and tumor markers. Topics of particular interest include the role of genetics and molecular biology in evaluating bladder cancer clinically, the evaluation of the results of systemic treatment in advanced disease, the current status of tumor markers in bladder cancer, and the means for further study in their applicability. Insightful and evidenced-based, Bladder Cancer: Current Diagnosis and Treatment provides active clinicians and clinical investigators with not only a critical survey of the rapidly expanding research in the area, but also a state-of-the-art tutorial on today's optimal assessment and treatment of bladder cancer.

Pediatric Urology: Evidence for Optimal Patient Management provides pediatric urologists the information needed for state-of-the-art patient care. Chapters are organized around pertinent clinical questions within major areas of pediatric urology, answered using the best available data while also reporting areas for which there is poor evidence. The text includes randomized controlled trials and prospective observational studies, tables that summarize important studies, and figures that illustrate algorithms with best options for management and their expected results. With an easy to use format not found in other volumes, Pediatric Urology: Evidence for Optimal Patient Management is an indispensible and unique resource for experienced pediatric urologists, pediatric surgeons, general urologists with an interest in pediatric urology, as well as fellows and residents in training.

Minimally Invasive Therapy for Urinary Incontinence and Pelvic Organ Prolapse provides a detailed insight into "when, why, what and how" of various minimally invasive surgical procedures for surgical management of SUI, OAB & POP. The volume provides detailed diagrammatic and pictorial step-by-step descriptions of the techniques and management of complications related to these procedures. This book also presents an up to date, one-stop reference for anything pertaining to MIT of these pelvic disorders. Written by experts in the field, Minimally Invasive Therapy for Urinary Incontinence and Pelvic Organ Prolapse is a comprehensive resource designed for both the urologist and urogynecologist treating patients with urinary disorders and pelvic organ prolapsed, as well as for residents in training.

In all varieties of organ transplants, early results have dramatically improved over the past two decades and failures due to acute rejection are becoming rarer. Efficient immunosuppressive regimens have been developed with the objective of very good results at 1, 3 and 5 years. Successful transplants, however, are significantly less frequent at 10 and 20 years, and many patients require retransplantation. Many factors are involved in late graft loss and it is now well recognized that, in addition to chronic rejection, a number of non-immunologic factors play a prominent role. In the case of renal transplantation, a reduced mass loss (transplantation of a single kidney, sometimes from an aged donor, ischemic injury and alteration of some nephrons in the case of early acute rejection) will result in slowly progressing chronic renal failure, even in the absence of any supplementary attack of an immunological nature. The new treatments must be analyzed in the light of their capacity to reduce these late failures. Several preventive measures can also limit both immunologic and non-immunologic factors of late transplant deterioration.

Our understanding of the scientific basis for urothelial malignancy has advanced significantly. Studies in prostate cancer, few and far between 20 years ago, have increased and the degree of Government intervention, both in Europe and America, to support work in this field has risen considerably. Interest too has grown from the pharmaceutical industry, and this has led to the development of new treatment options for all of the urological malignancies and real improvements in remission rates and durations.This book outlines developments in all areas of urological cancer, bringing together summaries of clinical and molecular advances in one volume, which will be invaluable to urologists and oncologists.

Urolithiasis is not only one of the most frequently encountered diseases at uro logical clinics; it is also the disorder whose treatment has shown the most rapid progress in the past decade. In that period, medicine has experienced a real revolution, characterized by minimally invasive treatments, improvement of the quality of life, and cost-effectiveness in treatment outcomes. In urology, the revolution started with the development of endoscopic retrograde treatment of urolithiasis in the upper urinary tract, which led to development of the percuta neous antegrade maneuver in the latter half of the 1970s. The most remarkable event occurred in 1982, when clinical use of extracorporeal shock wave lithotripsy was introduced by the Munich group, represented by Dr. Christian Chaussy, at the 18th Congress of the International Society of Urology in San Francisco. With the advent of these new strategies, open surgery for urolithiasis has all but dis appeared. Today, with the availability of new technology and equipment, guide lines for the treatment of urolithiasis have changed in all developed countries. It is quite timely that the Meeting of International Consultation on Urolithiasis will be held in Paris in June 2001 to establish international guidelines for urolithiasis. Looking through this textbook for urolithiasis, I was greatly impressed to learn that we have already drawn up some guidelines. The book includes all the updated advances of urolithiasis presented by the most prominent and experi enced urologists from all around the world.

The diagnosis and treatment of benign prostatic hyperplasia (BPH) is considered to be one of the most important topics in urology and afflicts millions of older men world-wide. Although it is not life threatening, its clinical manifestation as lower urinary tract symptoms (LUTS) reduces the patient's quality of life over many years. Patients often suffer from LUTS due to BPH for a long time. If left untreated, the patients are at significant risk of potentially severe complications. Over the last decade, new diagnostic approaches and treatment options such as prostate lasers have become more accepted in the urological community. This pocketbook provides an update of several aspects related with BPH / LUTS and covers the entire background, diagnostic process and treatment options available to patients suffering from LUTS due to BPH. It will give trainees in urology and general physicians a quick, concise but complete overview of diagnostic processes and recommended treatment options.

The aim of Bladder Research Congress, San Francisco, California, April 23-25, 1998, was to provide a forum for authoritative investigators who are actively involved in the various disciplines which define the leading edges of bladder research. It is important for such investigators to continue to meet regularly for the purpose of discussing the latest developments in their individual fields, to analyze the significance of current research, to discuss new tactics for unresolved problems, to critically evaluate current theories, and to develop new theories and approaches as needed. The two and a half day meeting was organized into five half day sessions, with each session encompassing one of five topics: (1) Epithelial-Mesenchymal Interactions; (2) Ex tracellular Matrix and Muscle; (3) Nerves and Pharmacology; (4) Infection and Immunol ogy; and (5) Oncology. Each session was introduced by a moderator followed by five to six invited expert speakers with time for extensive interaction from the participants. Two late-afternoon poster sessions allowed further interactions between investigators. This book documents the proceedings of the Bladder Research Congress. It is organ ized into the five half-day sessions of the meeting with moderators overview and an edited transcription of discussions that followed each presentation. I would like to thank Sarah Burke and the Office of Continuing Medical Education, USCF; Joanne Hayward, Editorial Assistant; and Miriam Escamilla, Administrative Assis tant. I hope you find this resource useful. Laurence S. Baskin, M.D."

Kidney stone is a significant disease with a 12-15% prevalence in the United States. Patients with a history of stones have a 50% risk of making another stone in 5 years or 80% risk in their lifetime. The goal of this book is to educate the reader on the nuts and bolts of stone disease and to provide new and updated information to help them tackle this painful disease.

A working knowledge of the basic sciences that underpin mechanisms of disease and the body's response is widely recognised to be a critical part of urological training. This book is aimed at trainees to ensure they are up to date with this breadth of knowledge and it provides succinct summaries which are ideal for revising the basic sciences component of final assessments and examinations. The chapters cover anatomy and physiology, the basic principles of immunology and oncology and particular diseases. It is a compendium of "need to know" facts and is aimed at both FRCS (Urol) candidates and a wider gloabl surgical audience looking for an up to date summary.

"Ureteroscopy: Indications, Instrumentation& Technique" provides a comprehensive and state-of-the-art review of ureteroscopy and will serve as a valuable resource for urologists throughout the world. The volume provides evidence based outcomes to support the expanding indications for ureteroscopy as well as a strong emphasis on appropriate patient selection. The book also provides detailed recommendations for the step-by-step approach to ureteroscopy from both an instrumentation and techniques perspective. The work is extensively illustrated with endoscopic images and accompanied by a web site of video clips which further highlight the clinical application of available endoscopic techniques. The text also includes highly practical presentations of complex endourologic case presentations with expert analysis and editorial commentary. Example cases would include common but challenging cases of ureteroscopy for transitional cell cancer, horseshoe kidneys, hutch diverticulum, and pregnancy.

"Ureteroscopy: Indications, Instrumentation& Technique" provides a unique and valuable resource in the field of ureteroscopy and will include basic instructions for those currently in training or those who have yet to adapt intrarenal ureteroscopy into their surgical armamentarium. Advanced ureteroscopic approaches are also covered for those wishing to enrich their current clinical expertise. "

This book offers a comprehensive and inclusive insight into the history of prostate cancer and its sufferers. Until recently, little practical help could be offered for men afflicted with the devastating diseases of the genitourinary organs. This is despite complaints of painful urination from aging men being found in ancient medical manuscripts, despite the anatomical discoveries of the European Renaissance and despite the experimental surgical researches of the eighteen and nineteenth centuries. As diseases of the prostate, including prostate cancer, came to be better understood in the early twentieth century, therapeutic nihilism continued as curative radical surgeries and radiotherapy failed. The therapeutic 'turn' came with hormonal therapies, itself a product of the explosive growth of U.S. biomedicine from the 1940s onwards. By the 1990s, prostate cancer screening had become a somewhat ubiquitous but controversial feature of the medical encounter for American men as they aged, which greatly influenced the treatment pathways and identity of the male patient: as victim, as hero, and ultimately, as consumer.

Essentials of Pediatric Urology provides surgical trainees with an up to date and comprehensive account of the urological disorders of childhood . In addition, this popular textbook makes a valuable practical contribution to clinical decision making by Adult Urologists and General Pediatric Surgeons who treat conditions of the genitourinary systems in children. This established resource fulfils a unique role as the only international textbook of Pediatric Urology written primarily for trainees and those practising adult Urology, Pediatric Surgery, and Pediatric Urology. The third edition continues to meet this need as well as providing a ready source of reference for non-specialists including Pediatricians and Nurses.

Brief, well-illustrated chapters, an easy-to-read format, and a convenient, portable size make Penn Clinical Manual of Urology, 3rd Edition, your go-to resource for fast reference on the effective diagnosis and treatment of urologic disorders. Concise and practical, this manual is indispensable for both residents and practitioners as a daily clinical guide as well as an outstanding review tool for board exam preparation. Covers key topics such as recent advances in urologic oncology, including prostate cancer diagnosis and treatment; pelvic surgery; urinary tract function, dysfunction, and reconstruction; and male sexual health. Contains self-assessment questions online for every chapter and suggested readings for further study, making it an excellent resource for clinical questions and answers, as well as for exam study. Includes new algorithms and suggested core readings, clinical pearls, and updated content on physical examination. Highlights new imaging techniques that aid in the identification and treatment of a wide range of urologic issues-from simple to complex. Includes an abundance of clinical photos, algorithms, tables, charts, and MRI/CT scans that highlight and clarify the text. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

Clinical Urologic Endocrinology: Principles for Men's Health provides an organized, accessible reference on men's endocrinological health. Over 30 million men in the US alone suffer from erectile dysfunction and over 13 million men in the US suffer from hypogonadism (low testosterone). One out of seven couples also suffer from subfertility of which 50-60% have male factor involvement. More and more men are coming forward to seek treatment for such issues, which in the past were considered taboo and there is a strong need for a book which provides guidance for practitioners who support men in their reproductive and sexual concerns. This book covers in depth the key issues in male reproductive health in one easy-to-use resource. Clinical Urologic Endocrinology: Principles for Men's Health is a valuable reference for urologists, endocrinologists, internal medicine physicians, family medicine physicians, sex therapists, and allied health professionals providing care for men in the areas of sexual health, fertility, and men's endocrinological health.

The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis. Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.