The fastest evolving field in urology is certainly male reproductive medicine and surgery. Getting sperm and egg together is beyond what science fiction could have imagined only a few decades ago. Such remarkable progress created a whole host of issues including epidemiologic, surgical, medical, and societal. The authors contributing to this issue were asked to consider their topics today and a couple of decades into the future. As the foundations of reproductive genetics and the male endocrine system undergird all, they are explored in depth. Common conditions such as infection and inflammation, the ever problematic varicocele, and ejaculatory dysfunction are thoughtfully reviewed. The key to the modern management of male infertility, the evaluation and treatment of azoospermia whether it is due to obstruction or spermatogenic dysfunction, is discussed in detail. For the practicing urologist, the nuts and bolts of the infertility office visit, semen analysis and processing, and contraception are reviewed. With increasing public interest, nutraceuticals, lifestyle, and the environment's impact on male reproductive health are examined. And to put male reproductive dysfunction and its treatment in the broadest context, male reproductive epidemiology and reproductive health care delivery are explored. All of these topics are covered by leaders in male reproductive medical thought and practice.

There is a clear need for a more comprehensive and inclusive body of information for supplementary and alternate treatment of urological conditions. To meet this need, our book will compile evidence-based information for clinicians, healthcare providers, and patients. As the first comprehensive educational guidebook focusing on alternative therapies for urological ailments, this book will be useful for healthcare providers as well as patients suffering from these conditions (including urinary tract infections, benign prostatic hyperplasia, kidney stones, incontinence, and pelvic pain) who are looking for alternative and supplementary remedies. Many physicians and patients are reluctant to use these remedies and this book will demystify this area in urology.

Millions of people suffer in quiet agony, but the right foods and supplements, along with setting the right mood, can help foster sexual intimacy and satisfaction. This User's Guide to Complete Sexual Satisfaction explains the many ways you and your partner can enhance your sexuality and lead more fulfilling lives.

The second edition of Top Tips in Urology provides highly clinical tips and rapid-reference "tricks of the trade" to the most common questions and problems that arise for both the practicing urologist and the urologic surgeon. Covering each of the major areas of urology and with contributions for experience practicing urologists and surgeons, this book is a unique book containing valuable information for all urologists dealing with patients on a day to day basis.

The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on "Sex and gender factors affecting metabolic homeostasis, diabetes and obesity" to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.

The author presents valuable research material on every conceivable aspect of the prostate in a cogent and easily accessible narrative. This book defines exactly what the prostate is and how it is vulnerable to disease. Contains an excellent glossary of terms, a list of helpful resources, and an index.

This volume covers classic and modern cell and molecular biology of prostate cancer, as well as novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation and genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis and progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Cell & Molecular Biology of Prostate Cancer is one of two companion books comprehensively addressing the biology and clinical aspects of prostate cancer. Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, the companion volume, discusses both classic and the most recent imaging approaches including analysis of needle biopsies, applications of nanoparticle probes and peptide-based radiopharmaceuticals for detection, early diagnosis and treatment of prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature.

Mind Over Bladder is a trusted and informative guidebook for bladder control, written with respect and humor by a nationally known urogynecologist, revised and expanded for the 21st century woman. Urinary Incontinence plagues millions of women worldwide, vastly more women than men. The reasons for this are many, including we have children, go through menopause and our anatomy is pretty different. Since these issues affect approximately 30-40% or greater of all women, can include issues with prolapsing organs (bladder, uterus, rectum) and can limit a woman's freedom and ability to live a full and active life, an actual guidebook seemed not only necessary but overdue. Mind Over Bladder answers this need. Informative, respectful and written with humor by a leading urogynecologist, Mind Over Bladder asks and answers the question of "What is incontinence and what can I do about it?". This unique approach begins at the beginning takes women through basic bladder and pelvic plumbing to getting a diagnosis and formulating a treatment plan. Mind Over Bladder arms women with information and practical solutions to help lead better, drier and happier lives.

The second of two companion books which address the biology and clinical aspects of prostate cancer. This volume, Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, discusses both classic and the most recent imaging approaches for detection, early diagnosis and treatment of prostate cancer. The companion title, Cell & Molecular Biology of Prostate Cancer, covers classic and modern cell and molecular biology as well as genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis, progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature.

This book represents the first interdisciplinary text on the emerging field of rehabilitative surgery, in which state of the art procedures from multiple surgical specialties are combined. It proposes a completely new framework for understanding, coordinating, and providing treatment for paralyzed or severely neurologically impaired patients and explains the potentially critical impact of surgery in creating a new baseline of functional status, thereby improving the patient's daily life. Every major aspect of reconstructive surgical treatment is considered, including anesthesia, orthopedic surgery, plastic surgery, neurosurgery, general surgery, vascular surgery, and otolaryngology. The most up-to-date and evidence-based surgeries are clearly described and evaluated, with coverage of treatment of pressure sores, placement of feeding tubes, and upper extremity interventions to improve function and hygiene. Cutting-edge protocols are presented for the surgical treatment of severe nerve injuries, spinal cord injuries, and stroke or cerebrovascular accidents, and a first description and evaluation of phrenic nerve repair to assist weaning of paralyzed patients from ventilators is provided. Both surgical and nonsurgical readers will find this book to be an ideal guide and reference.

Clinical management of bladder cancer is challenging of the heterogeneity among bladder tumors with respect to invasion and metastasis, and frequent occurrence of new tumors in the bladder among patients treated with bladder preservation treatments. Treatment of bladder cancer spans from tumor resection and intravesical treatment, to neoadjuvant chemotherapy, radical surgery and adjuvant chemotherapy. At the same time, bladder cancer is also at the forefront of biomarker development because of the ease of developing noninvasive urine tests. The features of environment-driven carcinogenesis and divergent molecular pathways in the development of low- and high-grade tumors provide a unique opportunity for advance molecular research in cancer biology. Bladder Tumors: Molecular Aspects and Clinical Management is a collection of comprehensive reviews on the state-of-the art basic science research and clinical management of bladder cancer. The book progresses from epidemiology of bladder cancer, molecular basis of bladder carcinogenesis, to standard and molecular aspects of bladder cancer diagnosis and prognosis, and also includes various treatment aspects of both non muscle invasive and muscle invasive bladder cancer. The book features: * Epidemiology, bladder carcinogenesis and divergent molecular pathways of bladder cancer development. * Pathology of bladder tumors, cystoscopy, cytology and newer techniques of bladder cancer diagnosis. * Molecular basis, efficacy and economics of diagnostic and prognostic markers for bladder cancer, with an added feature of recent inventions of molecular nomongrams. * Clinical management of low-grade and non muscle invasive bladder tumors. * Intravesical chemotherapy versus immune (BCG) therapy. * Clinical management of patients with muscle invasive bladder cancer, including neoadjuvant therapy, various aspects of cystectomy including urinary diversion and recent advances such as laproscopic cystectomy * Ad

This book provides current, comprehensive, and clear explanations of the physics behind medical and biomedical applications of shock waves. Extracorporeal shock wave lithotripsy is one of the greatest medical advances of our time, and its techniques and clinical devices are continuously evolving. Further research continues to improve the understanding of calculi fragmentation and tissue-damaging mechanisms. Shock waves are also used in orthopedics and traumatology. Possible applications in oncology, cardiology, dentistry, gene therapy, cell transfection, transformation of fungi and bacteria, as well as the inactivation of microorganisms are promising approaches for clinical treatment, industrial applications and research. Medical and Biomedical Applications of Shock Waves is useful as a guide for students, technicians and researchers working in universities and laboratories. Chemists, biologists, physicians and veterinarians, involved in research or clinical practice will find useful advice, but also engineers and physicists may benefit from the overview of current research endeavors and future directions. Furthermore, it may also serve to direct manufacturers towards the design of more efficient and safer clinical, industrial and laboratory equipment.

In this volume, undisputed leading experts from Europe and beyond come together to cover the field of andrology in its entirety, providing a guide that will be of value to urologists and other physicians in their daily clinical practice. It is designed for a wide audience, including both those coming into contact with andrological issues for the first time and more experienced readers requiring updated guidelines and advice on the most controversial and thorny issues. A wide range of topics is covered, including male genital abnormalities, disorders of pubertal development, gender identity disorders, Peyronie's disease, sexual dysfunction, hypogonadism and infertility, urogenital infections, urogenital cancers, and andrological emergencies. Clinical Andrology will prove an invaluable quick consulting tool, rigorous in its scientific content but at the same time easy to read and rich in images and tables.

In Essential Urologic Laparoscopy: The Complete Clinical Guide, Second Edition, editors Sean P. Hedican and Stephen Y. Nakada provide a complete update of their critically acclaimed first edition while adding new material related to Hand Assisted Laparoscopic Radical Cystectomy, Laparoscopic Retroperitoneal Lymph Node Dissection and Laparoscopic Assisted Renal Ablation. The authors offer clear, concise chapters focusing on getting started, laparoscopic instrumentation, and step-by-step procedural adult laparoscopy. Each chapter is organized so that the reader can easily identify key points and pitfalls, providing user-friendly text that describes the essential equipment necessary for performing urologic laparoscopy. Authorative and highly practical, Essential Urologic Laparoscopy: The Complete Clinical Guide, Second Edition provides a comprehensive guide to performing effective and cutting-edge urologic laparoscopy and is a must have for any urologist looking to create, maintain, or expand a successful practice in minimally invasive urologic surgery.

This book systematically reviews and discusses recent studies and articles on the immunology of female genital tract tissue. The scope is broad, encompassing innate immune responses, adaptive (humoral and cell-mediated) immunity, the immunology of menstruation, the immunology of viral and bacterial infections, the immunology of normal and abnormal pregnancy, and immunological infertility. Throughout, tables and illustrations are judiciously used to facilitate understanding. Immunology of the Female Genital Tract will serve as an invaluable source of up-to-date information for all with an interest in this subject.

This book provides a state-of-the-art review of the role of radiation therapy in various pelvic malignancies as well as the consequences of the radiation in the pelvic tissues. With sections covering the role of radiation therapy in the various pelvic malignancies, the pathophysiology of radiation related injury and the risk factors that increase the possibility of such an injury, and the latest in medical, endoscopic and surgical therapies for these radiation related complications the text offers a concise yet comprehensive overview of radiation therapy in the human pelvis, its role and the adverse effects on the pelvic organs. Written by experts in the field with readers in mind, Radiation Therapy for Pelvic Malignancy and its Consequences is the first of its kind standalone reference on the subject. Radiation Therapy for Pelvic Malignancy and its Consequences is of great value to urologists, medical radiation and gynecological oncologists, and gastroenterologists.

The principal role of the diagnostic surgical pathologist is to serve a patient by assisting the clinician in charge of the patient's care. In that capacity,the pathologist provides the vital informationthat should be directly and indirectly useful in guiding the clinician toward the most appropriate therapy. The material pathologists receive most commonly is a biopsy or a part of an organ removed after a definitive pro- dure. To extract useful information, pathological evaluation proceeds according to a set of guidelines. Simply reporting a diagnosis of cancer is inadequate. Detailed additional information is needed so that the clinician can go on to establish a the- peutic plan as needed. To best serve the patient, close interaction between the cli- cian and the pathologist is vital. In the field of urological pathology, there are problems specific to this system. Typically, in the prostate, because of its location, there is little room for a surgeon to work to obtain adequate resection margins, unlike with many other organs. As a result, questions arise such as "What constitutes an adequate surgical margin?" "What is the significance of extraprostatic extension of neoplasm that is still inside the resection margin?" and "What is the significance of neoplastic glands found on the resection margin marked with the ink?" It has been shown that a prostate needle core biopsy can generate much information that is immediately useful in predicting the extent of cancer in the prostate and, consequently, the outcome for the patient.

This volume provides a comprehensive, state-of-the art review in the field of experimental and human nephrogenesis. The book reviews new data on the effects on kidney development by neonatal asphyxia, obstructive uropathies, nephrotoxic drugs, malnutrition, underfeeding, overfeeding and provides all possible preventive measures to ensure the well-being of the kidney at birth. The book also discusses the possible implications between renal development and the insurgence of kidney disease in adult life and the correlation with renal carcinogenesis. Written by well recognized experts in their fields, Kidney Development in Renal Pathology is a valuable tool for pathologists, neonatologists, nephrologists, gynecologists and researchers with an interest in kidney diseases.

With the rising incidence of urolithiasis, the management of ureteral stones continues to become a larger component of urologic practice. Though almost all urologists deal with ureteral stones, there have been many recent improvements in instrumentation and adjunctive equipment as well as improvements in imaging and the data we can obtain from radiologic imaging in order to guide stone management. Newer topics such as how to limit radiation exposure to both the patient and the urologist, the accuracy and limitations of low-dose computed tomography as well as a review of the most recent studies will be covered in this book. The purpose of this book is to provide a complete updated roadmap to treating ureteral stones, from early management decisions from information found on radiologic studies to adjusting to intra-operative challenges.