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Books > Medicine > Clinical & internal medicine > Urology & urogenital medicine
This book sheds new light on the physiology, molecular biology and
pathophysiology of epithelial ion channels and transporters. It
combines the basic cellular models and functions by means of a
compelling clinical perspective, addressing aspects from the
laboratory bench to the bedside. The individual chapters, written
by leading scientists and clinicians, explore specific ion channels
and transporters located in the epithelial tissues of the kidney,
intestine, pancreas and respiratory tract, all of which play a
crucial part in maintaining homeostasis. Further topics include the
fundamentals of epithelial transport; mathematical modeling of ion
transport; cell volume regulation; membrane protein folding and
trafficking; transepithelial transport functions; and lastly, a
discussion of transport proteins as potential pharmacological
targets with a focus on the pharmacology of potassium channels.
The authors aim to provide essential information on various
clinical cases on urological cancers. The main messages are well
referenced and the texts phrasing is written in a simple and
user-friendly style. The book also contains summarizing tables and
high quality original pictures. Several expert panels (American
Urologists Association, European Association of Urologists,
Association Francaise des Urologues, etc) are proposing guidelines
aiming at providing detailed recommendations to the Urologists
facing difficult urological scenarios and no significant
discordance exist between them since they are all based on the
existing published studies dealing with different aspects of the
urological cancers.
Prostate brachytherapy has been the subject of heated debate among
surgeons and the proponents of the various brachytherapy methods.
This very first interdisciplinary book on the subject provides a
comprehensive overview of innovations in low dose rate (LDR), high
dose rate (HDR), and pulsed dose rate (PDR) interstitial
brachytherapy for the management of local or locally advanced
prostate cancer. In addition to detailed chapters on patient
selection and the use of imaging in diagnostics, treatment
guidance, and implantation control, background chapters are
included on related medical physics issues such as treatment
planning and quality assurance. The results obtained with the
different treatment options and the difficult task of salvage
treatment are fully discussed. All chapters have been written by
internationally recognized experts who for more than a decade have
formed the teaching staff responsible for the successful
GEC-ESTRO/EAU Prostate Brachytherapy Teaching Course.
Clinical Reproductive Medicine and Surgery offers a succinct
overview of both the medical and surgical management of
reproductive disorders, as well as coverage of associated imaging
modalities. The book includes chapters on major reproductive
endocrinology and infertility issues such as polycystic ovary
syndrome and amenorrhea, management of endometriosis and fibroids
(including interventional radiology), imaging modalities such as
ultrasonography and sonohysterography, preservation of fertility,
and recurrent pregnancy loss. Residents, fellows, and practitioners
interested in reproductive endocrinology and infertility will find
this focused and practical text invaluable.
This book aims to offer a comprehensive and up-to-date overview of
male stress urinary incontinence that will serve as a useful tool
and reference for urologists, andrologists, physiotherapists,
general practitioners, and nurses. Detailed information is provided
on diagnostic workup, including clinical assessment and the role of
urodynamic evaluations and other instrumental examinations, and on
the full range of potential treatments, from conservative and
pharmacological interventions to surgical options. In addition to
careful descriptions of the surgical procedures themselves, clear
advice is given on the management of iatrogenic complications of
incontinence surgery. Helpful treatment algorithms and
recommendations offer further practical support. Relevant
background knowledge is provided in expert reviews of topics such
as the functional anatomy of the male pelvis and the
pathophysiology, epidemiology, and classification of male urinary
incontinence.
This thesis focuses on the synthesis and vaccine evaluation of the
prostate tumor- associated carbohydrate antigen RM2. The author
first presents the use of the [1+2+3] one-pot sequential strategy
to successfully synthesise the RM2 antigen and its analogues as
single stereoisomers in every glycosylation step, producing good
yields and stereoselectivity. He then introduces the conjugation of
the synthetic RM2 antigen to the carrier protein CRM197 in an
average number of 1-10 to create the prostate cancer vaccine
candidate, which is combined with -galactosylceramide C1, its
analogue C34, or Alu. The results of the vaccination studies in
mice are also described and indicate that the strongest anti-RM2
antigen titer is exhibited when one molecule of diphtheria toxin
(DT) is conjugated with an average of 4.7 molecules of RM2 antigen
(DT-RM4.7) and adjuvanted with the glycolipid C34. More
importantly, the induced mouse antibodies mediate the effective
complement-dependent cytotoxicity (CDC) against the prostate cancer
cell line LNCap. The study presented in this thesis is the first
ever to successfully synthesize this complex glycan molecule. Owing
to the steric hindrance of the adjacent sialyl moiety, the
introduction of two sialic acid units to the compact and rigid 3,4
di branched galactoside unit is very challenging and the -selective
and efficient glycosylation of the galactosamine moiety at the
4-position of di branched galactose is also problematic.
This book aims to provide specialists and practitioners with a
reliable source of information on all aspects of Peyronie's
disease, which is too often still considered a mysterious
condition. The focus is in particular on those aspects of the
disease that are most hotly debated, including etiology, risk
factors, nosology, natural history and medical therapy. Clear
guidance is also provided on surgical techniques, with explanation
of why and when to apply plication surgery, corporoplasty and
plaque surgery and the best approach to complicated cases.
Throughout, strenuous efforts have been made to ensure clarity and
simplicity of expression and ease of consultation. While clear
international guidelines are lacking, this has allowed the authors
to devote much space to personal ideas, conveying the fascinating
and sometimes conflicting nature of this field of medicine and,
hopefully, stimulating further research.
Men's Health is a concise, didactic compendium that covers three
important aspects of male sexual health:- Testosterone Deficiency
Syndrome; Premature Ejaculation and Sexually Transmitted Infections
(STIs). The chapters that deal with Testosterone Deficiency
Syndrome cover the epidemiology of the condition in the local
context, the science behind the condition, its clinical
presentation and treatment choices. The section on Premature
Ejaculation advises the health practitioner on how to investigate
this condition and describes the various treatment options
available to the patient. The chapters on Sexually Transmitted
Infections cover special aspects of the diagnosis, prevention and
treatment of STIs occurring in Men which are not normally
highlighted in the usual texts on STI management. Written by
experts in the field, Men's Health is a valuable and timely
resource for urologists, andrologists, endocrinologists as well as
other health professionals practicing in these areas.
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Men's Health 4e
Roger S. Kirby, Culley C. Carson, …
Hardcover
R6,295
Discovery Miles 62 950
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