The causative organisms of Urinary Tract Infection are dynamic in terms of their virulence and resistance patterns, leading to challenges in the prevention and treatment of urinary infection. This is of relevance in both primary and secondary care, and many of the challenges are similar in both developed and developing countries alike. UTI is also associated with considerable cost in terms of morbidity, economic and research expenditure. Written by an exceptional and well-known team of clinical experts, the purpose of Urinary Tract Infections addresses key questions facing physicians about this condition. This book is written primarily for general physicians who wish to have a broad understanding of a number of important issues concerning infection in parts of the urinary tract. Specialists may also find the book useful as a quick reference guide.

Urological disease affects huge numbers of patients at some point in their lives. Diagnostic techniques are critical to ensure the correct diagnosis is made in a timely manner. A huge number of new technologies have been introduced in recent years to aid in this diagnostic pathway in the form of urine tests, blood tests and imaging modalities. Both urologists and other clinicians interested in urology have struggled to keep up with the rapid evolution of these techniques. This book contains up to date and state of the art contributions from major names in the field. It describes the diagnostic pathways for the key aspects of urological disease. Readers will be able to equate symptoms and signs with the relevant investigations. The book focuses on the diagnostic pathways involved, bringing together international leaders in the field who describe the current status of urological investigation.

Infertility is defned as the inability to conceive after having unprotected intercourse for a year. Infertility is increasing worldwide and has various causes both in the male and the female partner. Immune reactions to sperm can contribute up to 2-30% of infertility. The sperm has both autoantigenic as well as isoantigenic potential, and is thus capable of p- ducing antisperm antibodies (ASAs) and sperm-reactive T cells in both infertile men and women. Also, over 75% vasectomized men produce autoantibodies to sperm that can cause a problem in regaining fertility even after successful re-anastomosis in vasovasostomy. Early claims regarding the incidence and involvement of ASAs in involuntary human infertility were probably overemphasized because of unreliable techniques and naivety concerning the complexity of the immune response and antigenic nature of the sperm cell. These factors, the lack of well-designed and controlled experimental studies, and the dearth of effective therapeutic modalities resulted in the confusion of the occurrence and importance of ASAs in human infertility. Consequently, evaluation of infertile couples for ASAs and their possible role in infertility was not considered a signifcant proposition. The development of more accurate assays and the discovery of mucosal immunity capable of responses independent of systemic immunity have caused inclusion of sperm cells and genital tract secretions in the analysis of ASAs.

Originally published in 1936, this book was written to provide students and practitioners with a concise guide to urinary diseases, with their methods of investigation and treatment. Illustrative figures are incorporated throughout and an appendix section is also included. This book will be of value to anyone with an interest in urology and the history of medicine.

More than one in six men will develop prostate cancer in their lifetime. In recent years there has been an explosion of information regarding PSA screening and biomarkers for the disease. In Prostate Cancer Screening, Second Edition, the world's leading experts on prostate cancer detection update the first edition with the latest findings. The book incorporates a series of thoughtful and cutting-edge works from the world's experts in prostate cancer screening, ranging from the current status quo of prostate cancer screening across the globe to consensus on optimal utilization of the traditional PSA and DRE tests, to cutting-edge research in new biomarkers, biomeasures, and extended risk algorithms for prostate cancer. An additional chapter covers family-based linkage analysis as well as possible pitfalls in prostate cancer biomarker evaluation studies. Timely and authoritative, Prostate Cancer Screening, Second Edition, is an essential text for urologists, oncologists and family physicians, as well as researchers in the biomarker industry who seek methods to better develop and support markers and measures of prostate cancer.

"Imaging and Technology: Principles and Clinical Applications"is a practical and user-friendly consolidated source book for urologists, and urologists in training, regarding the basic science of imaging modalities used on a day-to-day basis in urological practice. Similarly, the intention is to provide an introduction to the technology that is used in the practice of urological surgery and the management of urological patients in the clinical setting. This knowledge level is appropriate for certification for independent consultant practice in urology in the UK. The book is also valuable to urologists and urological trainees outside of the UK and in other surgical specialities."

In keeping with the aims of other books in this Series the Editors have concentrated on the practical aspects of management -in this case of the urinary tract in patients with spinal cord injury. It is well accepted that the management of such patients is best done by those with special experience in this field. Nevertheless, it is essential that urologists should be well informed on matters relating to the neuropathic urinary tract since not all patients will be managed in special centres and, whether their problems are acute or chronic, the wrong clinical decision can lead them into a lifetime of problems. The plan of this book is directed towards examining particular problems and providing definitive answers. Even in this enlightened age of medical progress there are many clinical situations where there is often a choice of treatment. Readers of this Series will be aware that, despite an apparent abundance of information on a topic, it is sometimes not possible to reach a firm conclusion on a management problem. Keith Parsons and John Fitzpatrick are to be congratulated on ensuring that for this subject there are good clear guidelines. The data in the book are up to date and the excellent approach to the subject makes it a valuable addition to Clinical Practice in Urology.

Investigations into the mechanisms of spennatogenesis, sperm matura tion and fertilization provide the basis of our understanding of male re productive physiology. Since in recent years molecular and cellular en docrinology has provided particularly important contributions to our knowledge, the European Workshops on Molecular and Celluar Endo crinology of the Testis, held regularly during even years since 1980, have become a prominent forum for researchers in the field to discuss recent findings and exchange new ideas. The most recent of these Testis Workshops, the 7th, was held on May 5 - 10, 1992 at Castle Elmau in the Bavarian Alps. The main lectures of this Workshops form the core of this book. In order to provide a broader view of the current status of male re production research, this volume also contains the proceedings of the Schering Foundation Workshop on "Basic Mechanisms of Reproduc tion and Male Fertility Control" which was held in Berlin on October 31 to November 2, 1991. The topics of the two meetings were planned to complement each other. By combining the proceedings of both workshops, it became possible to produce a book that covers a wide spectrum of current highlights in male reproduction research and pro vides the reader with an up-to-date review of the field. The timeliness of the book is emphasized by the fact that it was al ready available when the 7th European Testis Workshop took place.

This concise, truncated version of Parekattil and Agarwal's "Male Infertility: Contemporary Clinical Approaches, Andrology, ART & Antioxidants" is the first resource dedicated solely to antioxidants and male infertility. With select chapters that will prove invaluable to the practitioner of reproductive medicine, "Antioxidants in Male Infertility" addresses issues such as:

- Molecular mechanisms of antioxidants in male infertility

- Oxidative stress

- The impact of infection, aging, obesity, and injury on male infertility

- Natural and synthetic antioxidants and antioxidant therapy

- Antioxidants in ICSI and IMSI

Also included is a new chapter reviewing the physiological role of reactive oxygen species in sperm function.

Practical for clinicians and researchers alike, "Antioxidants in Male Infertility" contains all of the need-to-know information about these cutting-edge topics in reproductive medicine.

The thoroughly updated and revised third edition of Management of Prostate Cancer provides concise and authoritative guidance to today's best therapeutic regimens for the diagnosis and treatment of prostate cancer. Highlighting the latest major advances in the field, the book includes chapters on the most controversial areas of prostate cancer - screening, chemoprevention, and active surveillance; updated chapters on genetic risk and progression, biopsy schemes, treatment of complications, and comparative treatment outcomes for surgery; and new chapters on risk factors, new markers, nomograms, and focal therapy. This volume also features overviews of new and emerging drugs and treatment paradigms for castrate resistant disease, advances that promise to extend life and perhaps even cure a subset of men with metastatic disease. With its comprehensive illustrations and contributions from renowned experts in the field, Management of Prostate Cancer, 3rd Edition is an invaluable resource for practitioners in the treatment of prostate cancer.

Benign prostatic enlargement (BPE) is one of the most common diseases in older men and it is caused by an histopathological condition called benign prostatic hyperplasia (BPH). Clinical manifestations of BPH include symptoms, signs and sequelae of bladder outlet obstruction caused by the enlarged prostate. Although no longer life-threatening, the prevalence of moderate-to-severe urinary symptoms in the community is high, increasing from 22% among men aging 50-59 years to 45% among those in the seventh decade of life. Male LUTS/BPH Made Easy is a full-color comprehensive reference on the management of lower urinary tract symptoms (LUTS) due to Benign Prostatic Enlargement (BPE). Aimed at urologists in residence and training, Male LUTS/BPH Made Easy, updates the reader on the most current treatments and assists in clinical decision making based on the latest evidence."

Prostate cancer is the most common neoplasm in men and its management is very complex, in terms of both diagnosis and treatment. In recent years the value of multidisciplinary management within a prostate cancer unit has been increasingly recognized. Such a multidisciplinary approach within a specialized unit involves a variety of specialists, including urologists, oncologists, radiotherapists, radiologists and pathologists. This book describes in detail the advantages of multidisciplinary management of prostate cancer. It opens by explaining the nature of the required multidisciplinary team and the potential benefits of the prostate cancer unit as a structure for the delivery of specialist multidisciplinary care. Epidemiological aspects favoring multidisciplinary management are described and each element of care within the context of the prostate cancer unit is then discussed; also has been described the role of advanced imaging (Multiparametric MRI) in the management of PCa. Early diagnosis, risk classification, treatment decision making, surgery, radiotherapy, medical therapies and health care support are all fully considered. This book will be informative and enlightening for all who are involved in the management of patients with prostate cancer. "

Prostate cancer is the second leading cancer in men in Western society. A major concern, and an area of intensive research, involves understanding why certain prostate cancers remain localized or indolent, whereas others become aggressive and metastasize. The differences between these cancer types have profound implications for patients and physicians. Indolent d- ease, which grows very slowly, generally does not cause any problems to the patient, whereas aggressive disease requires immediate treatment, the earlier the better. At present, there are no markers that discriminate between these two entities, thus causing a dilemma for the management of patients who have recently been diagnosed. The aim of Prostate Cancer Methods and Protocols is to explore cutting-edge molecular methods that may have the potential to reveal markers of disease for use in more accurate diagnoses of prostate c- cer and, consequently, to lead to new treatment strategies. This book provides a comprehensive collection of both in vitro and in vivo step-by-step protocols currently used by leaders in prostate cancer research, advice on approaches that can be used in the study of prostate cancer, as well as reviews covering areas less amenable to laboratory research, such as environmental factors in prostate cancer, to provide the reader with an overview of the prostate cancer research field as it currently stands.

This heavily revised third edition gives an essential textbook which provides a comprehensive guide to robotic surgical techniques in urology. Extensively updated chapters cover general aspects of surgery such as aspects of operating room preparation and anesthesia. Instructions on how to use a variety of the latest techniques for procedures associated with the kidney, prostate, bladder and testicle are covered. Detailed information on how to improve outcomes, avoid potential complications and pitfalls is also provided. Instructive video clips assist the reader in being able to visualize how to enhance their methodologies further. Robotic Urologic Surgery is a detailed up-to-date resource that includes contributions from leading robotic urologic surgeons from around the world. It assists readers in refining their surgical technique and improving their patient care. Therefore, it is a critical resource for all practicing and trainee physicians involved in the care of these patients.

This book is a point-of-care resource for effective sexual and reproductive healthcare for patients of all ages, sexual orientations, gender identities and medical backgrounds in the primary care setting. This useful guide is divided into three parts, and other than part three, which deals exclusively with transgender and gender diverse patients, all content will relate to patients of all gender identities. Part one presents sexual and reproductive health (SRH) using a lifespan approach, including chapters on pediatrics, adolescents and young adults, adults, and older adult patients. Part two presents an approach to common SRH issues that span multiple age groups, including contraception and family planning, sexually transmitted infections and cancer screenings as well as sexual and reproductive health in the setting of common medical conditions. Part three is dedicated to sexual and reproductive health for transgender and gender non-binary patients, including psychosocial, medical, surgical and legal aspects of health. This book provides primary care clinicians with a framework for providing effective sexual and reproductive healthcare to patients of all ages, sexual orientations and gender identities in a way that is inclusive, focuses on health, and addresses the needs unique to specific populations.

This new edition updates the previous one and adds additional content related to postoperative management, pain management, LGBTQ care, and uroradiology. This book is designed to meet the needs of nurse practitioners, advanced practice nurses globally and physician assistants working in urology. Content assumes some background knowledge regarding the normal anatomy and physiology of the genitourinary system and the pathophysiology underlying specific urologic health-related problems. This ensures that the provider can pursue exemplary management of patients with acute and chronic urologic conditions in a wide variety of settings, including independent practices, and academic urologic practices. This manual fills the gaps that traditional curricula may have left, permitting the reader to proceed with confident management of adult patients with urologic care needs, promoting the role of a skilled clinician in urology, especially for chronic, non-operative urologic conditions while recognizing those conditions which may benefit from surgical management.As the burden of urologic disease increases with an aging U.S. population, it is increasingly clear that nurse practitioners and physician assistants will be called on to move into roles caring for patients with urologic disease. Use of NPs and PAs to their highest education will become an increasingly important strategy for maintaining access and reducing costs, in the context of urologist workforce that is shrinking. However, urology topics receive sporadic attention in NP and PA curricula, leaving practicing NPs and PAs with gaps in their knowledge concerning trends and recommendations for management of urologic health conditions. As this demand for provider visits for urologic concerns increases, the demand for provider services to care for patients with urologic health concerns will also increase, and presents the opportunity for both NPs and PAs to move into specialty practice environments within urology.

The evolution of the classification of neoplasms of the urinary passages has changed greatly since Friedman and Ash published the first series AFIP fascicle on the urinary bladder in 1959. In their classification, there were four variants of urothelial neoplasia, some adenomas, adenocarcinoma, and smooth muscle and lymphoid tumors. Today the classification continues to accrue entities based upon morphology, immunophenotype, and compelling clinical associations. The classification of renal cell carcinomas has undergone a profound transformation, with the emergence of many new entities, often with characteristic genetic alterations, with significant implications for prognosis and treatment. This comprehensive, detailed, and highly illustrated fascicle is a remarkable resource to surgical pathologists and other specialists who treat patients with tumors of these sites.

Male urogenital glands (also named male accessory sex glands) have received relatively little attention from electron microscopists, with the possible exception of the prostate gland. Moreover, even though comparative studies have clearly shown that these glands exhibit species-dependent features, very few studies, scattered over various publications, are available on the urogenital glands of man. This volume, the 11th of the series on Electron Microscopy in Biology and Medicine, presents an unprecedented collection of information on the functional microanatomy and cytoarchitecture of these organs in humans. Through the integration of transmission and scanning electron microscopy with a variety of modern techniques, it documents the most important aspects of the histophysiology of these glands from their development to some pathological alterations. In order to cover some key mechanisms of their cell biology, such as the action of sex hormones, the epithelio-mesenchymal interactions, and the dynamic of the secretory process, reports on human organs have been supplemented by some studies on experimental animals. The outstanding level of the contributions and the quality of the illustrations make this book, which has been compiled by some of the world authorities on the topic, a work of reference for students, scientists, and professionals interested in biomedical foundations of andrology, as well as a stimulus for future research in this exciting and relatively neglected chapter of human reproduction.

Minimally invasive urologic surgery is revolutionizing how physicians treat many urologic diseases. Laparoscopy in particular has reduced the pain, morbidity, and recovery time for many procedures traditionally per formed through an open incision. Since laparoscopy is now the preferred modality for many benign conditions, the indications have expanded with the technique, so that it is now applied to the management of most urologic cancers. The aim of Laparoscopic U rolo g ic Oncology is to provide the first com prehensive textbook dedicated to the minimally invasive management of urologic cancers. The book is not intended to review the biology of urologic tumors, which is well covered in other texts, but rather their management. In particular, it focuses on surgical technique and the role of laparoscopic surgery in the management of these tumors. It also addresses patient con ditions for which a minimally invasive alternative does not exist. The book is not a surgical atlas, but it does provide a balanced insight into its indica tions, contraindications, and results. Furthermore, the authors compare results to conventional open surgery, discuss controversies, and identify the shortcomings of minimally invasive procedures. In particular, such issues as the adequacy of oncologic results and their morbidity are com pared to those experienced with conventional open techniques. Laparoscopic Urologic Oncology focuses on educating both general urologists and urologic oncologists on the current and future role of laparoscopy and other minimally invasive techniques in urologic oncology.

This short, pithy book - addressed to primary care physicians, will also be invaluable to those studying urology, prior to taking any professional exam. Urological problems are so common as to represent a significant burden for many care physicians and GPs in their everyday practice worldwide. A major concern is how far to go themselves in the diagnosis and treatment of a urological diseases and when to refer the patient for specialist care. Problem Based Urology will provide an easy and user friendly tool to help in decision making on the main urological problems and the most appropriate timing for referral to specialist care. Within each chapter, one or more flow charts will help the reader, step-by-step, to formulate the most likely diagnosis on the basis of findings from medical history, examination and investigations and to start an appropriate first line treatment or to refer the patient to the specialist where appropriate. Each step of the flow chart will be explained in legends consecutively numbered at the bottom of the flow chart diagram. Besides, each chapter will be enriched with tables reporting the most common diseases to be accounted in the differential diagnosis, treatment choices manageable by the primary care physician or GP.

The twenty-first century will be the era of the market economy, a century char acterized by the penetration of market forces into every social field, even into government activities, education, and medical care. Guidelines for the provision of clinical care have been developed in recent years chiefly in American health-care services, which are the most thoroughly exposed to the market economy. The problem of escalating medical costs in the United States led the government and consumer groups to introduce clinical practice guidelines. Guidelines were introduced to control medical costs and quality. Initially, guidelines were developed mainly on the consumer side, but professionals, too, soon recognized the importance of clinical practice guidelines. The involvement of diverse groups in the development of guidelines has inten sified the need to create and improve scientific methods for drawing up those guidelines. Owing to the development of systematic and structured abstraction methods, evidence-based guidelines have been proposed. Principally, guidelines are a sum mary of published treatments created by statistical analysis of clinical outcomes."

The title of this book is a challenge. Anyone with the least knowledge of present day urology will know that there are many very controversial aspects of this subject. Urology is not alone in this unsettled environment for there are similar debates in almost all other aspects of surgery. In addition to the rapid changes in technology, an important part of the explanation for these controversies is simply that more surgeons are prepared to admit that no area of their work is so established that it does not bear further scrutiny and assessment. Argument can be tedious but debate is healthy. This book aims to present material that is debatable: experienced practitioners of each topic explain why an opinion or preference can be sustained. The purist might wish to have these opinions resolved by a well-planned clinical trial, but experience of clinical trials shows that they do not always produce results that are easily translated into a positive change in clinical practice. Would the reader be persuaded more by a statistically significant difference or by an experienced clinician who has reached certain conclusions? Both are risky, but since surgical techniques are often not easily converted into appropriate studies or trials the Editors have obtained the best opinion on each controversy and innovation. The media adore controversy for its own sake. The medical profession accepts controversy but knows that few events in medicine are absolute and few procedures can be done only by one method.

This treatise commemorates the 32nd anniversary of the first successful allogenic kidney transplant in a human being and the beginning of a con tinuing challenge for well over a generation of anesthesiologists. If compari sons can be permitted, this epoch-making event can be ranked with the first pulmonary lobectomy and subsequently the initial ligation of a patent ductus arteriosus in the late 1930s when thoracic and cardiac surgery began. Was it merely a coincidence that brought these events to the fore so close upon one another after many years of ideation and frustration? Not so, according to Lewis Thomas, for this was the time of medicine's second revolution-its transformation from an empirical art into a powerfully effective science. The remote Galenic conception of disease with its emphasis on disturbed body humors was about to be supplanted by effective therapeutics, as signified by the introduction of the sulfonamides and antibiotics for the specific treatment of infection. Anesthesiology had been dormant up to that era, still relying upon a few agents, more or less utilized from the beginning, and purveyed by a handful of specialists who had not yet begun to ask the scientific questions necessary for their maturation into a bona fide discipline. However, anesthesiology was in evitably caught in the ferment, for as Peter Caws observed, "It serves to re mind us that the development of science is a step-wise process: nobody starts from scratch and nobody gets very far ahead of the rest."