In this issue of Urologic Clinics, guest editors Leonard G. Gomella and Veda Giri bring their considerable expertise to the topic of Prostate Cancer Genetics: Changing the Paradigm of Care. Provides in-depth, clinical reviews on Prostate Cancer Genetics, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

This monograph addresses an innovative autologous muscle-derived stem cell therapy for urinary incontinence in women. It provides a detailed overview of studies and research projects on the use of stem cells for the treatment of urinary incontinence. It provides updated information about this condition for the era of regenerative medicine, making it a valuable resource for both students and physicians.

Since the publication of the first edition of "Urethral Reconstructive Surgery," important refinements have been added to the urologic surgical armamentarium. Extensively revised and updated, "Advanced Male Urethral and Genital Reconstructive Surgery, Second Edition "guides urologists in a practical manner on how to evaluate and manage complex urethral and male genital reconstructive challenges. Chapters have been added on wound healing, synchronous urethral strictures, non-transecting anastomotic urethroplasty (including muscle and vessel sparing), overlapping buccal grafts, male urethral slings, genital skin grafting, Peyronie s surgery, priapism, pediatric strictures and prosthetics. Such chapters greatly strengthen the overall appeal of the book. The volume closes with a new comprehensive appendix of preferred instruments.

With broad contributions by international authorities in reconstructiveurologic surgery, "Advanced Male Urethral and Genital Reconstructive Surgery, Second Edition" is a valuable resource for all urologists, from residents to reconstructive surgeons."

Overactive Bladder Syndrome (OAB) is a clinical entity characterised by urgency, with or without increased urinary frequency and/or urgency incontinence. It is a chronic condition with a high prevalence that increases with age, thus being a growing health problem especially in developed countries due to increased life expectancy. Patients with this disorder are often reluctant to seek advice due to embarassment, fear of social exclusion or the belief that symptoms are an expected consequence of ageing. Costs associated with treatments, use of pads/diapers and general economic burden are expected to increase in the future. OAB has a negative impact on quality of life (QoL) in varying degrees, depending upon the severity of symptoms and the presence of urgency incontinence. It has been linked to increased risk of fractures, institutionalisation and depression in older populations particularly prone to the development of OAB. This books discusses the prevalence, risk factors and management options available for OAB.

Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Each volume is easily accessible through eBook format. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology. All chapters describe the most recent techniques, review the latest results, and analyze the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic minimally invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides quick references and over 4000 images that are appropriate for fellows as well as those teaching in the field.

Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Each volume is easily accessible through eBook format. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology. All chapters describe the most recent techniques, review the latest results, and analyze the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic minimally invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides quick references and over 4000 images that are appropriate for fellows as well as those teaching in the field.

Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology.

Die neu uberarbeitete und erweiterte Rontgenfibel dient dem angehenden Radiologen als Einfuhrung und Hilfestellung in den verschiedenen Disziplinen seines Fachgebiets. Sie informiert schnell und umfassend uber alles, was fur die radiologische Untersuchung wichtig ist: von der Indikation uber Instrumentarium/Apparaturen und deren praktische Anwendung bis hin zur Medikation. Die konventionellen radiologischen Verfahren werden ebenso dargestellt wie Computertomographie, Dopplersonographie, spezifische Techniken in der Neuro-und der Kinderradiologie sowie die Grundprinzipien der minimal-invasiven therapeutischen Verfahren. Dabei halten sich die einzelnen Kapitel eng an den chronologischen Ablauf der jeweiligen Untersuchung; vorangestellt sind ihnen Entscheidungshifen zur Prufung der Indikation (Rontgenverordung ) und die notigen vorbereitenden Massnahmen."

The European Workshop on Molecular and Cellular Endocrinology of the Testis was organized for the first time at Geilo, Norway, 8-11 April 1980. Since then, these meetings have been held in Holland, France, Italy, England, Sweden/Finland (Aland), Germany, and Bel- gium. This year the circle has been closed: The 9th European Testis Workshop is back in the Norwegian mountains where it all started. The Scientific Committee of the First European Testis Workshop included Dr. H.J. van der Molen (Rotterdam), Dr. V. Hansson (Oslo), Dr. B. Cooke (London), Dr. V. Monesi (Rome), Dr. E.M. Ritzen (Stockholm), and Dr. J.M. Saez (Paris). Since then, two of the founders have left the Scientific Committee. Dr. Monesi died suddenly on 29 December 1979, 3 1/2 months before the first workshop took place. Thus, in spite of being one of the founders, he never experienced a Eu- ropean Testis Workshop. Dr. Mario Stefanini, from the same research institute in Rome, replaced Dr. Monesi on the Scientific Committee. Another founder of this workshop series, Dr. H.J. van der Molen (Rot- terdam), is one of the pioneers in research on molecular endocrinology of the testis in Europe. He left the Scientific Committee due to a change in his scientific career and was replaced by Dr. F.F.G. Rom- merts, whose lectures on "Testomania" have been a characteristic fea- ture of these meetings.

This issue provides much needed updates since Dr. Sheinfeld's issue published in 2007. Dr. Lin has assembled expert authors to provide clinicians with the full breadth of clinical updates on testicular cancer. New to this issue are articles on clinical outcomes, survivorship, and several articles on the management of Nonseminomatous Germ Cell Tumors.

This issue of Hematology/Oncology Clinics of North America, guest edited by Dr. Joaquin Bellmunt, is devoted to Bladder Cancer. Articles in this issue include: Diagnosis and Staging of Bladder Cancer; Epidemiology of Bladder Cancer; Molecular Biology of Bladder Cancer; Pharmacogenomics in Bladder Cancer; Management of Non-muscle Invasive Bladder Cancer; Non-urothelial Bladder Cancer and Rare Variant Histologies; Management of UUT; New Trends in Surgical Management of Bladder Cancer; Bladder Preservation Strategies; Perioperative Therapy of Bladder Cancer (Neoadjuvant and Adjuvant); First Line Treatment and Prognostic Factors of Metastatic Disease: Platinum Eligible Patients; First Line Treatment of Metastatic Disease: Platinum Ineligible Patients; Salvage Therapy in Metastatic Disease; and Future Directions and Targeted Therapies in Bladder Cancer.

All unsuccessful revolutions are the same, but each successful one is different in its own distinctive way. The reason why revolutions occur is that new forces attain increasing significance and classic institutions are incapable of accomodating these forces. Such has been the pattern of events in the English, American and French revolutions. These successful revolutions produced a new dynamic and new perspectives. One English revolutionary put this succinctly: "Let us be doing, but let us be united in doing." This book sets out what is a revolution in. the perspectives of diagnostic imaging of the kidney and urinary tract. Forces which have brought about this revolution are the advent of reliable techniques in radioisotope studies, ultrasonics and computerized tomographic (CT) scanning. This last modality carries with it specific problems for routine paediatric work and its role in the study of kidney and urinary tract problems is discrete and circumscribed. However, in conjunction with classic radiology, each of these techniques yields information of a different type and so a synthesis of data accrues.

This issue of Infectious Disease Clinics, edited by Dr. Kalpana Gupta, is devoted to Urinary Tract Infections. Articles in this issue include Epidemiology and Definition of Urinary Tract Infection Syndromes; Approach to a Positive Urine Culture; Diagnosis and Management of UTI in the Emergency Room; Diagnosis and Management of UTI in Older Adults; Diagnosis, Management, and Prevention of Catheter-Associated UTI; Management of Non-Catheter Associated Complicated UTI; Management of UTI due to Multi-Drug Resistant Organisms; Diagnosis and Fungal Management of Fungal UTI; UTI Issues in Special Populations; Prevention of Recurrent UTI; and UTI Pathogenesis.

The clinical management of urolithiasis is now in a new era of ureteroscopic lithotripsy. Ureteroscopic lithotripsy has become an effective and safe treatment for both renal and ureteral stones, and its indications have been expanding. The advantages of ureteroscopy over shock-wave lithotripsy are its ability to directly access stones throughout the entire urinary collecting system either unilaterally or bilaterally, and to actively remove stone fragments. For large renal stones, percutaneous nephrolithotomy is now a standard treatment, but its major complication rates are not negligible. Ureteroscopic lithotripsy is a type of endoscopic surgery that is performed through the natural orifice, which thus avoids the onset of any renal parenchymal damage. New surgical techniques which combine percutaneous and transurethral approaches have been developed. Ureteroscopes and their working devices have rapidly improved, and further improvements will lead to even better outcomes in the next decade. This book presents the latest knowledge and the skills used for ureteroscopic surgery for urolithiasis. It consists of four sections (Indications, Instrumentations, Techniques and Evaluations). This book provides essential information for urologists who want to learn the techniques of this type of endourological surgery.

Acute kidney injury (AKI), defined as an abrupt decrease in renal function over a period of hours to days, is a common complication among hospitalised patients with different acute diseases. Its incidence has been increasing in recent years and is reported to be very high especially in the acute settings. Since clinical signs and symptoms of acute renal damage are not specific, it is difficult to promptly distinguish AKI at the time of patient presentation. Currently the diagnosis of AKI requires serial assessment of laboratory tests over a period of several days, and is based mainly on the evaluation of serum creatinine (sCr) and decrease in urine output as supported by Risk, Injury, Failure, Loss, and End-Stage Kidney Disease (RIFLE) criteria, Acute Kidney Injury Network (AKIN) criteria, and the recent Kidney Disease: Improving Global Outcomes (KDIGO) practice guidelines for AKI. Such a need for repeated sCr evaluations and monitoring of urinary output for too long time after admission could therefore result in a diagnostic delay. With delays in diagnosis, clinicians miss opportunities to start appropriate treatment to minimise damage, and patients incur more severe AKI with subsequent greater risk of developing progression of renal damage leading to chronic kidney disease (CKD), dialysis and increased risk of severe cardiovascular diseases and death.

Urinary tract infections (UTI) are one of the most common bacterial infections seen. Episodes of UTI can effectively be treated with antibiotics, often given on an empirical basis. In this book, the authors present current research in UTI's. Topics discussed in this compilation include the antibiotic and non-antibiotic methods of prophylaxis for recurrent UTI's; UTI's in children; virulence factors of uropathogenic Escherichia coli and their role in development of UTI's; and the treatment for UTI's due to multidrug-resistant bacteria.

"Erectile Dysfunction as a Cardiovascular Impairment" organizes and summarizes the many aspects of biology and metabolism in cardiovascular and sexual function. Coverage includes how blood vessels are discovered to work, their role in hypertension, atherosclerosis, type-2 diabetes, oxidative stress, metabolic syndrome, and erectile dysfunction.
Unifies medical disorders linked to cardiovascular and heart disease as endothelium impairment, to which
vasculogenic erectile dysfunction is now added and given equal rank for the first timePresents hypertension, atherosclerosis, metabolic syndrome, and erectile dysfunction as symptoms of diseaseOffers clinical research on vasculogenic erectile dysfunction predicting onset and severity of heart disease.

This book is the most comprehensive, multidisciplinary textbook on genital surgery. This reference provides readers with the essential information needed to keep up to date with state of the art reconstructive techniques for the male and female genitalia. Drs Chris Salgado and Richard Redett have assembled a text book with chapters from over (20) nationally and internationally recognised innovators and experts in the field of genital reconstruction. The many contributing authors provide authoritative and concise information on male and female genital anatomy, function, aesthetics and reconstruction for problems including congenital anomalies, sexual reassignment surgery and erectile dysfunction. The educational value of this book is greatly enhanced by numerous illustrations which depict anatomy and surgical techniques. This remarkable textbook is an invaluable resource for plastic surgeons, gynaecologists and urologists interested in the field of functional and aesthetic genital reconstruction. No other source provides such comprehensive coverage of this topic.

This book is a cumulative work that covers ureteral anatomy, physiology, and disorders. It aims to highlight the ureters by bringing together national and international experts in their respective fields to discuss ureteral pathology and management of ureteral disease. Chapters discussing ureteral trauma, injury, obstruction, stones, cancers, surgeries, and tissue engineering will enhance patient care and introduce us to the future of ureteral surgery. At the very least, this book will improve overall medical knowledge on these often ignored but vital urinary structures.

The estimated prevalence of erectile dysfunction (ED) ranges from 15 - 50 million men in the United States alone, with all age groups of men affected. Despite still-existing taboos surrounding male impotence, more men are seeking help and treatment with the advent of newer treatment options in recent years, most notably oral PDE-5 inhibitors that shed light on the primary vascular cause and treatment target in most cases. In the majority of men, ED has a physical cause and can be effectively treated. Increased knowledge of cause and treatment options, however, requires clinicians to become acquainted with side effects of drugs, alternative treatments, new research in the field, and potential disease conditions that might co-exist with ED. Part of the Oxford American Urology Library, this practical manual illuminates the pathophysiology of erectile dysfunction and approaches to diagnostic evaluation and therapeutic options, including specifics of ED in men with chronic diseases such as diabetes, hypertension, coronary artery disease, heart failure, and chronic kidney disease. All currently available treatment options from prostaglandins to vacuum devices, PDE-5 inhibitors, and interventional and surgical therapies are described for their efficacy and safety based on the published literature and ongoing research trials.

Neuro-Urology Research: A Comprehensive Overview describes the current status of the neuro-urology field, discusses potential future directions and explains the latest neuroscience tools that can be used in neuro-urology research. The first section provides an overview of the circuit-based interrogation of subcortical and spinal networks involved in bladder filling and voiding. The second section discusses the translational potential of research for patients including specific chapters on the sensation of bladder stretch, bladder pain, the effects of hormones and the potential results of neurodegeneration on bladder function. The third section compares traditional and current studies determining the need for addressing or readdressing principles or adjusting dogma. Section four introduces techniques including optogenetic manipulation and calcium imaging of neural activity, and on how these methods can be applied to neuro-urology research. The fifth and final section proposes studies in directions that have remained underexplored or otherwise controversial. Perfect for all currently researching neuro-urology, this detailed understanding of the cellular and synaptic circuits that control bladder filling and voiding and of the circuitry regulating bladder function, has the potential to inform the development of newer therapeutics for treating LUTS.

In the last few years, there has been a significant volume of research published in the field of urinary dysfunction. Urinary incontinence can affect both men and women of all age-groups with varying degrees of severity. It is becoming an increasingly dominant health care issue with enormous economic burden and places considerable impact on the overall quality of life, impairing several areas with physical, social, emotional and sexual limitations. This up-to-date and exhaustively written textbook addresses a very difficult, underestimated, and probably inadequately considered clinical subject. This book provides comprehensive information on urinary incontinence and is primarily intended for medical practitioners, residents and medical students for daily practice. However the general public will find this book easy to read and provides ample information that is useful in understanding urinary incontinence.

The first guide to identifying and assessing changes following urologic surgery with follow-up protocols What is the normal appearance of a kidney after radio frequency ablation of a tumor and what does a local recurrence look like? How does the urine flow down the ureters after a trans-uretero-ureterostomy? What is the normal appearance of the urinary tract after a cystoplasty? Most clinicians would be hard-pressed to provide answers to such fundamental questions concerning post-surgical anatomy and physiology, and equally challenged to find evidence-based information on the subject. Most of the literature in radiology and urologic surgery is orientated towards diagnosis and disease management. Although this often includes complications and outcomes, the clinician is often in the dark as to the anatomical and physiological changes that follow successful treatment especially in cases involving conservative or reconstructive surgery. To rectify this, the editors invited colleagues to share insights gleaned during their careers. The results are contained in Radiology and Follow-up of Urologic Surgery. Extremely well-illustrated throughout with color photographs and line drawings, Radiology and Follow-up of Urologic Surgery: * Features sections devoted to each of the organs of the genito-urinary tract with chapters covering the major diseases and operations that are used to treat them * Focuses on the new normal following surgery with an emphasis on the identification of normal changes versus complications * Covers the radiologic changes and biochemical and histological findings which are found following reconstructions * Offers guidelines for clinical and radiological follow up after urological surgery in some key areas Radiology and Follow-up of Urologic Surgery is essential reading for surgical residents in urology, as well as radiology residents specializing in urology. It also belongs on the reference shelves of urologists, urological surgeons, obstetric/gynecologic surgeons, and radiologists with an interest in the field, at whatever stage in their career.

This book seeks to provide a general medical audience with a picture of the current state of play with regards to the evaluation and treatment of patients with erectile dysfunction. The authors aim to cover everything from the primary care approach to addressing the issue, through the important psychological causes and consequences of erectile dysfunction, the new diagnostic techniques involved in assessing the problem, the complex interplay between vascular and neurological disorders, as well as problems relating to hormonal disruption and diabetes.