Prostate cancer is the most common type of cancer in men (other than skin cancer). Of all the men who are diagnosed with cancer each year, more than one-fourth have prostate cancer. This book includes within its scope the prevention, risk factors, symptoms, diagnosis, treatment, and rehabilitation of prostate cancer. Leading-edge scientific research from throughout the world is presented.

Das Harnblasenkarzinom gehoert weltweit zu den haufigsten Krebserkrankungen und wird meist erst im Endstadium erkannt. Gegenwartig verwendete diagnostische Verfahren sind invasiv, zeit- und kostenintensiv und verbunden mit dem Risiko weiterer Komplikationen. Die Entwicklung von nicht-invasiven Tumormarkern fur die Diagnose und Nachsorge von Harnblasenkarzinomen ist von grossem klinischen Interesse und koennte anhand von RNA-Markern im Patientenurin realisiert werden. Im ersten Schritt wurde daher das Transkriptom vom Urin gesunder Patienten mit dem von Harnblasenkarzinom-Patienten im fortgeschrittenen Tumorstadium verglichen und potentielle Tumormarker identifiziert. Anschliessend wurde der Fokus auf die Analyse von linearen und zirkularen RNA-Spezies des TRAM1- und S100A6-Genlokus gelegt und umfassende Studien zur Detektion und Verifizierung der Transkripte durchgefuhrt. Dabei empfahlen sich insbesondere S100A6-RNAs durch eine solide Nachweisbarkeit im Patientenurin und eine erhoehte Expression mit fortschreitendem Krankheitsstadium als Tumormarker fur das Harnblasenkarzinom. Zirkulare RNAs standen aufgrund ihrer vermuteten erhoehten Stabilitat in Koerperflussigkeiten und der bereits bekannten Tumor-biologischen Funktionen ebenfalls im Mittelpunkt der Untersuchungen. Ein besseres Verstandnis der vielfaltigen Funktionen von zirkularen Transkripten koennte zudem die Entwicklung von therapeutischen Strategien zur Behandlung von Blasentumoren vorantreiben.

Qualifizierte Diagnostik des Urinsediments! Dieses Lehrbuch vermittelt umfassend in Theorie und Praxis die qualifizierte Diagnostik des Urinsediments. Es erklart die Grundlagen der Urinsedimentdiagnostik und gibt daruber hinaus auch versierten Untersuchern zahlreiche Tipps. Exzellente Digitalfotografien in der Hellfeld- und Phasenkontrast-Mikroskopie zeigen eindeutig alle morphologischen Merkmale und unterstutzen das sichere Erkennen und Differenzieren der Bestandteile des Urinsediments. Fur Nephrologen, Urologen, Gynakologen, Internisten, Allgemeinmediziner, Studierende der Medizin, MTLAs und medizinisches Fachpersonal. Die 3. Auflage wurde umfassend aktualisiert, einige Kapitel ganzlich erneuert und durch zahlreiche neue hochaufloesenden mikroskopischen Aufnahmen als auch durch Kurzvideos als Zusatzmaterial erweitert.

This book provides an overview of research and practice dealing with the specific needs of gay and bisexual men living with prostate cancer, as well as the special psychosocial needs of their partners. The intention is twofold: to provide insight into the unique experiences and concerns of gay or bisexual men living with prostate cancer in order to inform and assist future research, clinical practice and supportive care, and policy; and to ensure that the needs of gay and bisexual men are recognized and advanced on the mainstream prostate cancer agenda. Featuring both cutting-edge research and powerful portraits of gay and bisexual men living with prostate cancer, this book will be indispensable for health care, oncology, and mental health practitioners who seek to address their specific experiences and challenges.

The Penis Book is the comprehensive guide to everything you need to know about the penis, for men and women alike. Written by Dr. Aaron Spitz - one of America's top urologists and a regular on The Doctors - the book is full of in-depth information, expert medical advice, and even humor to put the reader at ease. In addition to information on everything from sexually transmitted infections to the science of blood flow, Dr. Spitz presents an easy-to-follow five-step plan for holistic penis health, including advice on eating a plant-based diet, meditation, and heart-healthy workouts. This book will be the essential guide to caring for the penis in anyone's life.

"Oxalate Metabolism in Relation to Urinary Stone" is the third monograph to appear in the "Bloomsbury Series". Edited by Alan Rose, the book describes the current clinical and biochemical features of oxalate metabolism. Its content and direction fulfil the goals of the Series emphasising the strong links between basic science and clinical medicine. London Jack Tinker 30 March 1988 Preface The first oxalate workshop was held in London in 1979 and the proceedings published privately by the Wellcome Foundation. At that time the importance of urinary oxalate as a risk factor more important for calcium oxalate stone formation than urinary calcium had been recognized. Nevertheless measurements of urinary oxalate still left a lot to be desired and in particular the non-enzymatic conversion of ascorbate to oxalate had not been rediscovered so that many measurements must have been wrong. Plasma oxalate was still difficult or impossible to measure by any reasonable, accessible methods and consequently there was still much argument and speculation about the handling of oxalate by the kidneys. A lot of work has been performed in the last eight years on oxalate metabolism and it therefore seemed to the organisers to be a good time to hold a second oxalate workshop.

Die systematische Integration der Patientenperspektive in medizinische Entscheidungsprozesse durch Patient-Reported Outcome Measures (PROMs) gewinnt weiter an Bedeutung. Dies gilt insbesondere fur Erkrankungen, die mit einem hohen Leidensdruck verbunden sind. Hierzu zahlt auch die Harninkontinenz - eine Erkrankung, die uberwiegend Frauen betrifft und mit vielfaltigen Einschrankungen assoziiert ist. Wichtige PROMs in der Harninkontinenzversorgung sind der Questionnaire for Urinary Incontinence Diagnosis (QUID), der bei der Abgrenzung zwischen Belastungs- und Dranginkontinenz - den beiden haufigsten Inkontinenzformen - unterstutzt, sowie der Incontinence Severity Index (ISI), der auf eine Beurteilung des Schweregrads fokussiert. Gegenstand dieses Buchs ist eine Studie unter 161 inkontinenten Frauen, in der QUID und ISI erstmals ins Deutsche ubersetzt und evaluiert wurden. Im Zentrum stand die Untersuchung klassischer psychometrischer Gutekriterien wie Sensitivitat, Spezifitat, Reliabilitat und Validitat. Im Ergebnis kann der Einsatz beider Frageboegen empfohlen werden. Die massige Spezifitat des QUID bei der Unterscheidung zwischen Belastungs- und Dranginkontinenz ist jedoch zu berucksichtigen.

The editors have drawn together contributions from twelve practising GU nurses to provide a detailed description of GU conditions and the role of the GU nurse. Among the topics covered are: cytology and colposcopy, contact tracing, syphilis, gonorrhoea, chlamydia, pelvic inflammatory disease, bacterial vaginosis, genital warts and HIV/AIDS. By sharing information and the first--hand experiences of GU nurses from clinics around England and Wales it is hoped that this book will help to improve the quality of care given to patients attending GU departments.

Robotics is one of the hottest topics in medicine today, with an international interest that is exponentially growing. The introduction of robotic technology into modern operating theatres has provoked a revolutionary change in the basic surgical approach, with many advantages over traditional open surgical treatment, including faster recovery and a significantly lower risk of surgical trauma.

While the benefits of minimally invasive surgery are apparent, the expansion of laparoscopic surgery throughout the field has been relatively slow due to the steep learning curve and the level of practice and specialism required to perform such procedures. Although revolutionary upon conception, standard laparoscopy involves the surgeon working from monitors with no depth perception and also with a surgical motion that is counter-intuitive. The introduction of robotic technology however, has surpassed the traditional laparoscopic approach by providing full three dimensional vision, intuitive motion and wristed instrumentation with motion scaling.

These dramatic innovations have broadened the scope of surgeons that can now perform complex laparoscopy, and while still in its infancy, robotic assisted surgery has begun to infiltrate all fields of surgery. However, while the practical adoption of the techniques and procedures has increased over the last 5 years, the educational resources have not, leaving the only available learning tools as videos, case observation and proctorships.

There is therefore a severe market void for such a publication as this, with steadily growing sales around the world of robotic surgical systems. A compact book, overseen by such a respected figure and featuring contributions from the field leaders, is sure to be very successful within the next few years.

The Guest Editors of this issue of Urologic Clinics of North America have put together a comprehensive collection of articles that provides the current knowledge on urologic cancer immunotherapy. Expert authors have contributed clinical review articles on the following topics: Era of personalized vaccines for GU cancers; TCR and dendritic vaccine platforms for GU cancers; Neo-adjuvant platforms for GU cancer immunotherapy; Immune-editing in Cancer: Role of tumor microenvironment and immune-suppressive pathways in localized and aggressive disease; Clinical integration of neo-adjuvant platforms for prostate cancer immunotherapy; Immunotherapy for muscle and non-muscle invasive bladder cancer: BCG and beyond; Immunotherapy for metastatic bladder cancer; Immunotherapy options for metastatic castrate-resistant prostate cancer; Role of tissue infiltrating lymphocytes: Understanding TCR; Therapeutic platforms for IPSC-derived CAR-T; Immune-suppression in prostate cancer: Underlying causes and influence on response to immunotherapy; and Racial disparity in response to immunotherapy. Urologists will come away with the most current information they need to improve outcomes in the urologic cancer patient.

Managing urologic cancer by preserving, as opposed to removing, affected tissue, is rapidly becoming the favoured choice for urologists and oncologists. Discover all available options and how to achieve the best possible patient management with this expert guide to the area. The editor, Mark Schoenberg, is an internationally-renown expert in this exciting new area and has recruited an outstanding team featuring some of the leading urologists/oncologists in North America and Europe to assist him.

Senior investigators internationally have here collaborated to produce an international reference work. Each contributor provides critical and thought provoking concepts and ideas based on the latest developments in their field. The result is a must read and timely reference work for investigators who are interested in how spermatogenesis is currently understood and which are the most promising avenues for future research; an Introduction sets the context for the chapter and points out the relevance of the research for basic research scientists and clinicians.

The guest editors, Dr. William Huang and Dr. Ezequiel Becher, have assembled a state-of-the art issue devoted to Advanced and Metastatic Renal Cell Carcinoma (RCC). They have secured expert authors to contribute clinical reviews on the important topics involving treating and managing patients with RCC. Specific articles are devoted to the following topics: Imaging for Metastatic RCC; Adjuvant Therapy for Localized High Risk RCC; Current Standards for Therapeutic Sequencing for Advanced RCC; Role of Lymphadenectomy in patients with advanced RCC; Cytoreductive Nephrectomy in the Era of TKI/IO - Who, When and Why; Minimally Invasive Surgery for Patients with Locally Advanced and Metastatic Disease RCC; Evolving Role of Urologists in the Management of Advanced RCC; Neoadjuvant Therapy for Locally Advanced RCC; Epidemiology and Risk Assessment/Biomarkers for Patients with Advanced RCC; Radiation Therapy for Patients with Metastatic RCC; Evolving Role of Metastatectomy for Patients with Metastatic RCC; and Management of Non-Clear Cell Metastatic RCC. Readers will come away with the information they need to treat and manage patients and to improve outcomes.

Together with Consulting Editor Dr. Samir Taneja, Dr. Badrinath Konety has put together a comprehensive issue that addresses Salvage therapies for Non-Muscle Invasive Bladder Cancer. Expert authors have contributed clinical review articles on the following topics: BCG salvage therapy: Definition and context; Who will respond to BCG? Predictors and nomograms; Identification of candidates for salvage therapy: Definition of BCG "Failure"; Predictors of response to Intravesical therapy; Precision medicine for NMIBC; Salvage therapy using BCG derivatives or single agent chemotherapy; Intravesical heated Mitomycin: Biology and clinical utility; Mitomycin derivatives in the salvage setting; Combination intravesical therapy; Intravesical gene therapy; Immunoncology as salvage therapy; Role of IDO inhibitors in salvage therapy; and Novel agents for intravesical therapy. Readers will come away with the clinical information they need to improve outcomes in patients with bladder cancer.

Nocturia: Etiology, Pathology, Risk Factors, Treatment and Emerging Therapy includes the background, prevalence, etiology, risk factors, adverse effects and morbidity, as well as current and emerging treatments related to nocturia. Often considered a normal part of aging, nocturia can often be overlooked as a risk factor associated with serious outcomes such as mortality, morbidity, negative economic implications and decreased quality of life. This book provides comprehensive information on all aspects of nocturia as well as how the emerging therapies can provide safe, effective and low-cost treatment. This is an important reference for researchers, urologists and clinicians interested in improving diagnosis and treatment of nocturia.

In consultation with Consulting Editor, Dr. Samir Taneja, Dr. Sia Daneshmand has put together a state-of the-art issue of the Urologic Clinics devoted to Modern Management of Testicular Cancer. The issue focuses on surgical techniques and diagnostic modalities for testicular cancer. Clinical review articles are specifically devoted to the following: Imaging For Testicular Cancer; Management of Stage I Germ Cell Tumors; Management of Stage II Germ Cell Tumors; Current Management Of Disseminated GCT; Post-Chemotherapy Resection of Residual Mass in NSGCT; Indications For Surgery in Disseminated Seminoma; Growing Teratoma Syndrome; Management of The Primary Testicular Tumor; High-Dose Chemotherapy and Autologous Stem Cell Transplantation; mRna As Biomarkers For Germ Cell Tumors; Minimally Invasive RPLND: Is There a Role?; Complications of RPLND; Preservation of Fertility in Testis Cancer Management. Readers will come away with the latest information they need to optimize surgical and management outcomes in the patient with testicular cancer.

This issue of Primary Care: Clinics in Office Practice, guest edited by Drs. Gretchen Irwin and Laura Mayans, is devoted to Urology. Articles in this issue include: Dysuria; UTI and Pyelonephritis; Nephrolithiasis; Interstitial Cystitis; BPH; Urinary Incontinence; Enuresis; Erectile Dysfunction; Prostate Cancer Screening; Hematuria; and Urologic Cancers.

Circumcision remains as one of the most controversial topics in current urological practice. The most important argument against circumcision is the permanent change of anatomy, histology and function of the penis, with potential complications, with rates reported to be low in developed countries, whereas it may be up to 85% when circumcision is carried out by traditional circumcisers, rather than by medically trained professionals in developing countries. In some studies, reporting the complications of circumcision, primary haemorrhage was the most common (52%), whereas infection, meatal stenosis, incomplete circumcision, penile oedema, glandular injury, penile adhesions, iatrogenic hypospadias and urethral injuries were also detected at different rates. At times minor complications after circumcision which cannot be avoided even when the procedure is undertaken by specialized pediatric surgeons or urologist, in a properly equipped centres; specially if the child or his penis is congenitally abnormal, the obvious examples are, circumcising a child with an excessive suprapubic fat or a child with webbed penis or microphallus . This title aims to minimize complications of MC and to compete against its serious impact on men's' health, it will educate and teach physicians about potential complications and how they could manage it early on and avoid further patient problems This title will shed some light over the common as well the uncommon complications, which usually raise a debate about its management. There are different sets to classify MC complications: Either early, or late, minor or major, local or systemic, rare or common. Both rare and common complications will be discussed with comprehensive photos and illustrations for each complication and its operative remedy.

In consultation with Consulting Editor, Dr. Samir Taneja, Guest Editors Dr. Brian Matlaga and Dr. Ojas Shah have put together a timely look at Emerging Technologies in Renal Stone Management. The issue focuses on techniques and newer generation of lasers, fiberoptics, and imaging techniques. Clinical review articles are specifically devoted to the following: Next Generation Reusable Ureteroscopes: Fiberoptic and Digital; Single-Use Ureteroscopes; Disposable Stone Retrieval Devices; New Generation Laser Fibers; Emerging Laser Techniques for Stone Management; Ultrasonic and Pneumatic Lithotripters; Emerging technologies in lithotripsy; New technologies to aid in percutaneous access; Innovations in Ureteral Stent Technology; New imaging techniques in the Management of Stone Disease; Radiation Mitigation Techniques; Ultrasound Technology in the Management of Stone Disease; Emerging Mobile Platforms to Aid in Stone Management; and Assessing Cost-Effectiveness of New Technologies in Stone Management. Readers will come away with the latest information they need to optimize treatment and management outcomes in the patient with stone disease.

Die historische Entwicklung der Fachdisziplin der Urologie ist spannend und interessant. Insbesondere, weil die Wurzeln des Faches u.a. in Deutschland und OEsterreich liegen. In diesem Essential werden wichtige Schlusselmomente aus der Urologie, Andrologie und benachbarter Gebiete zusammengetragen. Kurzweilig erhalt der Leser einen UEberblick zur historischen Entwicklung dieses medizinischen Fachgebietes. Neben den grossen Themenkomplexen wie der Steintherapie, Prostatachirurgie, Uro-Radiologie und Zystoskopie-Endoskopie finden auch spezielle Aspekte der Entwicklung der medizinischen Fachgesellschaft, der Urodynamik und der Transplantationsmedizin Berucksichtigung. Die Zielgruppen Urologen, angehende Facharzte der Urologie, interessierte Mediziner, Allgemeinarzte, Medizinhistoriker

Since the last edition of the Tumors of Prostate Gland, Seminal Vesicles, Penis, and Scrotum, there have been numerous significant developments in the diagnosis and treatment of prostate and penile cancers. The new Fifth Series Fascicle of the AFIP Atlas of Tumor and Non-tumor Pathology includes these developments as well as abundant images and diagrams to depict the morphological spectrum of disease entities. In this richly illustrated atlas, the authors emphasize the gross and light microscopic diagnosis and differential diagnosis, present immunohistochemistry and molecular pathology studies that are of current value in diagnosis, and discuss pathological diagnosis in terms of prognosis and treatment.

In consultation with Consulting Editor, Samir Taneja, the Guest Editors have created an issue that provides a current look at urologic disease in the pediatric patient. Authors represent the top academic institutions and have contributed review articles on the following topics: Antibiotic Prophylaxis; Peritransplant Management by the Pediatric Urologist; Pediatric Stone Disease; Anesthesia in the Pediatric Patient; Neurogenic Bladder/Augmentation; Fertility Issues in Pediatric Urology; Transitional Urology; Minimally Invasive Surgery Update; Exstrophy Epispadias and Global Urology; Bladder/Bowel Dysfunction; Prenatal Hydronephrosis; and Overview of DSD/Genital Surgery in Children. Readers will come away with the clinical updates they need for proper diagnosis and treatment of the pediatric patient.

Expert Opinions in Female Pelvic Medicine and Reconstructive Surgery covers a range of female urologic disorders, using a case-based approach to provide timely guidance on diagnosis and management. Forty cases of varying complexity are introduced by the editors and illustrated where appropriate by clinical findings. One or two expert reviewers then present their protocols for the management of each case, and their projected prognosis. Sometimes these views may diverge, as they do in practice. In all cases therefore, the editors add a final commentary to those of the expert reviewers, to summarise current management protocols and guide the reader towards an optimum treatment plan. Presents 40 urological cases Expert reviewers present their protocols for each case and the editors summarise the current management procedures Clinical findings are presented with images and urological graphs Provides an expert guide to the diagnosis and management of female urologic disorders

Scrotoscopic Surgery presents a systematic approach to the theory, procedures and clinical application of scrotoscopic techniques for the improved treatment of scrotal diseases. Currently, open operations remain the most common choices to treat scrotal content diseases, such as epididymal cyst and hydrocele. However, open surgeries also bring disadvantages, including discomfort, damage and complications. To solve these problems, this book presents best practices for scrotoscopic surgery, providing practitioners with tactics that will help them ensure the best outcomes for patients.

Prostate Cancer: A Case Report discusses the prevention, treatment modalities, and side effects of the medications used to treat prostate cancer. The book presents the most appropriate information, allowing patient empowerment to make informed decisions on their choice of treatments. Through the analysis of a real case report, the book also discusses the main complication associated with prostate cancer-bone metastasis-and provides information on treatment modalities for lung and liver metastasis. Diet, physical activities and the management of stress are also discussed, as is palliative care and the use of palliative sedation when other treatment modalities have failed. Cannabis, the pros and cons of euthanasia, and concerns raised by society are also covered. Esteemed author Dr. Plourde has more than 12 years' experience working on drug safety, especially for biologic products involved in the treatment of various cancers. For more than 4 years he has suffered from prostate cancer with metastasis to the lungs and bones. During this time he has learned a lot on prostate cancer from the medical literature and from discussions with various specialists. The case report presented in this book represents his own medical history. Prostate Cancer: A Case Report provides the most relevant and up to date information on the various aspects involved in the screening, diagnosis and treatment of prostate cancer.