Treatment of Cancer is a multi-author work and comprehensive guide on modern cancer treatment that aims to give clinician and student alike the framework for an integrated approach to patient care, including radiotherapy, chemotherapy, and surgery. Much information is presented in tables and charts for easy assimilation, and clear algorithms for patient pathways are included to make decisions straightforward while allowing for sound clinical judgement.

The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis. Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.

This book aims to provide specialists and practitioners with a reliable source of information on all aspects of Peyronie's disease, which is too often still considered a mysterious condition. The focus is in particular on those aspects of the disease that are most hotly debated, including etiology, risk factors, nosology, natural history and medical therapy. Clear guidance is also provided on surgical techniques, with explanation of why and when to apply plication surgery, corporoplasty and plaque surgery and the best approach to complicated cases. Throughout, strenuous efforts have been made to ensure clarity and simplicity of expression and ease of consultation. While clear international guidelines are lacking, this has allowed the authors to devote much space to personal ideas, conveying the fascinating and sometimes conflicting nature of this field of medicine and, hopefully, stimulating further research.

Prostate cancer is by far the most common cancer in men and the second leading cause of death due to cancer. It comprises a mixed group of tumours displaying varying clinical behaviour: while some have a very aggressive course, others are rather indolent. Prevention of prostate cancer and discrimination between aggressive and indolent forms are important clinical goals and the acquisition of significant new evidence on means of achieving these aims makes this book particularly timely.A wide range of topics are covered by leading authorities in the field. The biology and natural history of prostate cancer are reviewed and the role of lifestyle and dietary factors, assessed. Detailed attention is paid to risk prediction biomarkers and to the role of novel high-throughput nucleic acid-based technologies in improving risk prediction and thereby allowing tailored approaches to cancer prevention. Potential means of chemoprevention of prostate cancer are also reviewed in depth, covering the very positive new data on the impact of aspirin as well as evidence regarding 5 -reductase inhibitors, DFMO and lycopene. Guidance is provided on the differentiation of aggressive from indolent disease and the policy and research implications of recent findings are examined. This book will be of interest to both clinicians and researchers."

Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Numerous cohort studies have already investigated multiple focal techniques, such as cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have demonstrated positive oncological outcomes with 70 to 90 % negative follow-up biopsy. These various ablative techniques have produced only minor side-effects concerning urinary function, a low rate of erectile dysfunction, and have demonstrated a limited rectal toxicity. As a result, the primary end-point has now shifted and a new strategy needs to be established for patient follow-up and for defining treatment failure. Written by international experts in the field, this book is mainly focused on new techniques, all of which are amply illustrated. Technical Aspects of Focal Therapy in Localized Prostate Cancer will be of great practical value to all urologists and oncologists.

Retrograde Ureteroscopy: Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Each volume is easily accessible through eBook format. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology, with all chapters describing the most recent techniques, reviewing the latest results, and analyzing the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic, minimally-invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides a quick references with over 4000 images that are appropriate for fellows and those teaching in the field.

Endoscopic Diagnosis and Treatment in Urinary Bladder Pathology: Handbook of Endourology contains five focused, review-oriented volumes that are ideal for students and clinicians looking for a comprehensive review rather than a whole course. Topics covered review both the endourological diagnosis and treatment of prostate, urethral, urinary bladder, upper urinary tract, and renal pathology. All chapters describe the most recent techniques, review the latest results, and analyze the most modern technologies. In the past ten years, the field of endourology has expanded beyond the urinary tract to include all urologic minimally invasive surgical procedures. Recent advancements in robotic and laparoscopic bladder surgery make this one of the fastest moving fields in medicine. As current textbooks are too time-consuming for busy urologists or trainees who also need to learn other areas of urology, this collection provides quick references and over 4000 images that are appropriate for fellows and those teaching in the field.

This book provides a comprehensive and up-to-date overview of all key issues related to kidney and urinary tract disease in full-term and premature newborns. Among the many topics addressed are fluid and electrolyte abnormalities, hydronephrosis, urinary tract infection, obstructive uropathy and renal replacement therapy. The approach throughout is clinically oriented, the aim being to provide the reader with hands-on guidance. Each chapter commences with a clinical case vignette and concludes with a take-home message highlighting key aspects of practical importance. In addition, however, informative reviews of the literature and the basic sciences are included. No other book currently on the market focuses solely on the newborn, and "Kidney and Urinary Tract Diseases in the Newborn" will be especially valuable to those undergoing fellowship training in neonatology or pediatric nephrology/urology.

Management of bladder cancer provides a single, comprehensive reference source that incorporates all the latest information regarding bladder cancer. The text covers epidemiology and natural history of bladder cancer as well as latest findings regarding the genetics and molecular biology of the disease. Diagnostic and staging evaluation of both non-muscle invasive and invasive bladder cancer is discussed. The text incorporates chapters summarizing new findings regarding markers for the diagnosis of bladder cancer and new diagnostic techniques to enhance traditional methods such as cystoscopy. Risk stratified treatment of non muscle invasive bladder cancer including various approaches to intravesical therapy are reviewed. Current guideline based approaches to management and new data regarding diagnosis and prognostication of muscle invasive bladder cancer is analyzed and summarized. The application of chemotherapy for muscle invasive and advanced disease is discussed and the evidence based application of multimodality therapy highlighted. Finally, gaps in current knowledge and areas for future research are highlighted. Ongoing important clinical trials which could imminently yield significant new knowledge is discussed. Authored by experts in their respective fields, Management of Bladder Cancer will serve as a easy and complete reference source for clinicians, researchers, individuals in training, allied health professionals and medical students in the fields of Urology, Medical Oncology, Radiation Oncology, Basic and Translational Science and Epidemiology.

Extensively revised and updated, the second edition of Essential Urology: A Guide to Clinical Practice provides support to primary care physicians through its review of common genitourinary problems. This edition continues to provide the primary care physician with tools to better recognize urological diseases as well as updated management strategies for these disorders. To enhance the theme of comprehensive care and family medicine, the volume is formatted according to the life cycle and the urological challenges, which may be detected and diagnosed by primary care physicians respective of the patient's stage in life, beginning with pregnancy and in utero diagnoses. Pediatric themes such as infection and voiding dysfunctions are followed by adult urological topics ranging from prostate diseases, nephrolithiasis, overactive bladder syndromes, incontinence and urological cancer screening. Three new chapters are added addressing male infertility/andrology and the growing demand for integrative and alternative medical care of urologic patients, as well as commonly encountered dermatological problems in the genital area. Essential Urology: A Guide to Clinical Practice, Second Edition is extremely comprehensive and yet, very accessible. It is authored by experts representing the spectrum of urological subspecialties, further enhancing the value of this unique work.

On Call in Urology is aimed at junior trainees working in urology. The book is written as a 'survival guide' detailing common presentations from primary care and the emergency department. It covers initial and further management of these cases and simple surgical procedures. The practical advice, photographs, and illustrations, as well as detailed procedural tips make this an ideal accompaniment to any junior doctor managing urology patients in emergency, ward and clinic settings. What's inside: * Essentials: Referrals, admissions, anatomy, radiology, drugs and instruments. * Emergency department: Renal colic, UTIs, catheterisation, trauma, pregnancy, paediatrics and more. * Ward: From the round to prescribing, catheters, irrigation, evaluating an acutely unwell patient and post-operative problems. * Clinic: Follow-ups, swellings, haematuria, raised PSA and other male UT symptoms. * Operating theatre: An introduction to getting set up in theatre and consent. * Practical procedures: Cannulation, cultures, gases, dipsticks, catheterisation and paraphimosis reduction.

In this third volume, the Biennial Review of Infertility brings together the most up-to-date research and clinical information on male and female infertility, emerging assisted reproductive techniques, and controversial issues in reproductive medicine. An impressive panel of contributors presents cutting-edge information in a clear and well-balanced manner. This volume includes hot topics in reproductive medicine including age and its impact on fertility, lifestyle factors and reproductive health, fertility preservation for cancer patients, reproductive tourism and a discussion of clinical research design. The expanded section on controversies allows for point/counterpoint discussion between experts with differing opinions on topics like safety of the ICSI procedure and the role of IUI in modern reproductive medicine. Created to provide an ongoing appraisal of current knowledge, the Biennial Review of Infertility stimulates communication amongst all those working to help couples resolve their infertility.

This volume provides new data about the molecular biology of CRPC and a review of the definition, staging and prognostic factors that define CRPC. The book features an in depth review of proven therapeutic options, including bone targeted therapies, immunotherapy, chemotherapy and hormonal based therapies. Combination therapy as well as novel targeted approaches presently under investigations are also reviewed. The text provides up to date guidelines and algorithms for the management of CRPC based on international guidelines presently available as well as evidence based medicine.

As a concise yet comprehensive summary of the current status of the field, "Management of Castration Resistant Prostate Cancer "serves as a very useful resource for physicians and researchers dealing with this challenging malignancy.

Since its first edition, Men's Health has established itself as the essential reference for practitioners across the spectrum of medicine - including those working in urology, andrology, cardiology, endocrinology, family practice and mental health. For this fully updated fourth edition the editors have again assembled an international team of expert authors to write on an encyclopedic range of topics, making this an invaluable resource for any health professional interested in maintaining and improving the health of their male patients. Comprehensive coverage of every aspect of men's health and the gender gap. Includes the latest research on cardiovascular risks. Assesses the specific issues concerning men and cancer. Examines the often overlooked aspects of mental health as it affects men. Incorporates new developments in metabolic medicine and men.

Since its first edition, Men's Health has established itself as the essential reference for practitioners across the spectrum of medicine - including those working in urology, andrology, cardiology, endocrinology, family practice and mental health. For this fully updated fourth edition the editors have again assembled an international team of expert authors to write on an encyclopedic range of topics, making this an invaluable resource for any health professional interested in maintaining and improving the health of their male patients. Comprehensive coverage of every aspect of men's health and the gender gap. Includes the latest research on cardiovascular risks. Assesses the specific issues concerning men and cancer. Examines the often overlooked aspects of mental health as it affects men. Incorporates new developments in metabolic medicine and men.

Male Infertility: Problems and Solutions provides a summary of state of the art developments in male infertility for both new and experienced practitioners. Written in a clear, concise and readable style, this volume allows the reader to obtain rapid answers to this challenging medical issue. Special emphasis is placed on diagnostic and treatment algorithms. Topics covered include interpretation of semen analysis and advanced testing, endocrine and genetic evaluation, diagnosis of azoospermia as well as an up-to-date interpretation and analysis of the many new therapies available for the treatment of male factor infertility. Male Infertility: Problems and Solutions provides rapid acquisition of pertinent background and development of management plans through the use of concise discussion and treatment algorithms and thus will be of great value to general urologists, gynecologists, primary care providers and allied health providers who manage infertility in both men as well as women.

This book presents the views of leading European experts on the diagnosis and management of testicular cancer, with coverage of current hot topics in the field. It opens by providing an overview of the recommendations in the most recent consensus paper from the European Germ Cell Cancer Consensus Group, which is based on interdisciplinary cooperation among urologists, medical oncologists, radio-oncologists, pathologists, and basic scientists. The remainder of the book focuses on areas of controversy in the diagnosis, treatment, and follow-up of testicular cancer. In each case the evidence base is discussed and results from the most recent studies are reviewed, drawing attention to new findings that might alter treatment recommendations. The treatment-related chapters cover a broad range of issues, including the best approach in patients with poor-prognosis and recurrent disease and those with long-term toxicities. Relevant aspects of survivorship care are also addressed. The book will help clinicians and practitioners to achieve the goals of minimizing therapy and its side-effects without reducing efficacy in low stage disease, improving the cure rate in advanced disease, and enhancing follow-up and long-term survivorship.

Practical Controversies in Medical Management of Stone Disease addresses areas of controversy regarding the evaluation and management of recurrent stone formers and provides the best available evidence to support or refute common common drug and dietary recommendations. Aimed at dispelling common myths about preventative stone treatment, this book provides practical recommendations for the diagnositic evaluation and treatment and recurrent calcium calcium stone formers, but addresses uric acid and cystine stone formers. Written by experts in stone disease, Practical Controversies in Medical Management of Stone Disease is a concise yet comprehensive resource that provides the best, current evidence supporting medical practices regarding kidney stone prevention. The book will be of value to anyone involved in the medical care of patients with kidney stones, including urologists, nephrologists, primary care physicians, and dieticians.

This book reveals the ever-present challenges of patient care at the forefront of medical knowledge. Syphilis and gonorrhoea played upon the public imagination in Victorian and Edwardian England, inspiring fascination and fear. Seemingly inextricable from the other great 'social evil', prostitution, these diseases represented contamination, both physical and moral. They infiltrated respectable homes and brought terrible suffering and stigma to those afflicted. Medicine, Knowledge and Venereal Diseases takes us back to an age before penicillin and the NHS, when developments in pathology, symptomology and aetiology were transforming clinical practice. This is the first book to examine systematically how doctors, nurses and midwives grappled with new ideas and laboratory-based technologies in their fight against venereal diseases in voluntary hospitals, general practice and Poor Law institutions. It opens up new perspectives on what made competent and safe medical professionals; how these standards changed over time; and how changing attitudes and expectations affected the medical authority and autonomy of different professional groups.

Hypertension: from basic research to clinical practice" contains a unique collection of selected chapters written by experts and enthusiasts engaged in research and treatment of hypertension, a condition that affects around a billion people in the world. The chapters describe fundamental researches at cellular and molecular levels to the science, and art of treatment of the condition in clinical practice. The topics included ranges from pathophysiology of hypertension, through monitoring of hypertension, to the treatment of hypertension in different patient categories. It contains essential background information as well as cutting edge research, and state of the art treatment alternatives in this broad field. From the beginners, and research students to the expert clinicians, and established scientists, everybody has something to learn from this book.

This volume provides practitioners with a practical, easy to read, well organized approach to the performance and analysis of urodynamics in order to optimize their usage clinically. Chapters are structured around specific types of patterns seen on urodynamic tracings. These urodynamic tracings are annotated and fully interpreted by the authors. Multiple examples of each type of tracing are provided with expert commentary. The expert commentary expands on the potential clinical significance of the tracing, provides a differential diagnosis, and, where appropriate, discusses its importance diagnostically, prognostically and the implications for clinical management. The text contains chapters on virtually all the relevant urodynamic findings and clinical conditions seen in practice, including lower urinary tract conditions in both adults and children, neurogenic and non-neurogenic dysfunction, and other commonly seen conditions such as lower urinary tract obstruction, vaginal prolapse, and detrusor overactivity. The material is also presented in a practical manner, with special consideration to the latest national and international guidelines. Written by authorities in the field, Rapid and Practical Interpretation of Urodynamics is a valuable resource that fills a key gap by providing a systematic method of interpretation of urodynamic tracings in an easy to understand textbook that will benefit urologic trainees and experienced urologists alike.

The authors aim to provide essential information on various clinical cases on urological cancers. The main messages are well referenced and the texts phrasing is written in a simple and user-friendly style. The book also contains summarizing tables and high quality original pictures. Several expert panels (American Urologists Association, European Association of Urologists, Association Francaise des Urologues, etc) are proposing guidelines aiming at providing detailed recommendations to the Urologists facing difficult urological scenarios and no significant discordance exist between them since they are all based on the existing published studies dealing with different aspects of the urological cancers.

Upper Tract Urothelial Carcinoma represents the first book of its kind to be dedicated solely to UTUC. It's aim is to improve understanding and eventually care of a disease that is greatly understudied and underappreciated, yet commonly dealt with by many medical and urologic oncologists. The volume features new data regarding genetic susceptibility, gene expression studies and causative factors; contemporary concepts and controversies regarding diagnosis and staging of UTUC; prediction tools and their value in treatment decisions within each disease stage and patient selection and treatment options such as endoscopic management, distal ureterectomy, radical nephroureterectomy and chemotherapy. Up-to-date information regarding boundaries of surgical resection, indication and extent of lymphadenectomy is covered as well as the role of perioperative/neoadjuvant chemotherapy in patients with high-risk UTUC. Upper Tract Urothelial Carcinoma will be of great value to all Urologists, Medical Oncologists and fellows in Urologic Oncology as well as upper level residents in training in Urology and Medical Oncology.

Modern science has shown that the widely held beliefs of clinicians about urinary tract infection (UTI) are wrong. A large body of meticulous, rigorous data, from different centres around the world makes this point. How can it be that doctors continue to practise in contradiction of what we now know? A few clinicians are now changing their approach with gratifying results so it is timely to encourage others to do likewise. Clinical guidelines have achieved such influence that most doctors feel compelled to follow them and may face censure if they do not. Regrettably the guidelines are mistaken and contradict the known science. The inertia of bureaucracy and the fear of antimicrobial resistance (AMR) do not help to encourage reflection. However, things are changing and the future should see new and better informed advice. It is a tragedy that these circumstances are leading to widespread suffering amongst many women, some men and children who experience untreated or inadequately treated infection that may plague them for years. This situation has to change. This book sets out the truth about this neglected field and explains the many errors that haunt the topic. The style makes the message accessible to all clinicians. The story is convincing, because the clinical stories that illustrate the text will be so familiar to practising clinicians, who have been baffled by their experiences. Above all, this book will help you and your patients by detailing an accessible, practical approach to resolving this difficult clinical problem in common practice. The scope of the book will cover: the history of the medicine of urinary tract infection (UTI); the urinary microbiome and what the microbes are really up to; the battles between the pathogens and the innate immune system; the truth about the tests and the criteria used to define UTI; antimicrobial resistance and the importance of Darwinian evolution; the science and ground-breaking research on UTIs; the use of antibiotics; successful treatment; supportive and other related treatments; ethics; the future; and, above all, the experiences of the patients.