In this second volume, the Biennial Review of Infertility brings together the most up-to-date research and clinical information on male and female infertility, emerging assisted reproductive techniques, and controversial issues in reproductive medicine. This volume includes discussion of cutting-edge topics such as epigenetics, proteomics, and the role of the environment in fertility, as well as insightful evidence-based discussion of common clinical procedures. It is the cumulative effort of a preeminent panel of experts presenting each chapter in a clear and well-balanced manner. Created to provide an ongoing appraisal of current knowledge, the Biennial Review of Infertility stimulates communication amongst all those working to help couples resolve their infertility.

The prevalence of hypertension is almost three times as high as that of diabetes mellitus type 2, with both conditions being major risk factors for stroke, ischemic heart disease, cardiac arrhythmias, and heart failure. The exact prevalence of hypertension related to hormonal derangements (endocrine hypertension) is not known but estimated to affect less than 15% of hypertensive patients. Recent scientific discoveries have increased the understanding of the pathophysiologic mechanisms of hypertension. In Endocrine Hypertension, a renowned panel of experts provides a comprehensive, state-of-the-art overview of this disorder, discussing when to assign an endocrine cause in one of many conditions that may present with hypertension. The first part of Endocrine Hypertension is dedicated to adrenal causes. The second part of the volume concerns potential nonadrenal causes of hypertension, such as growth hormone excess or deficiency, primary hyperparathyroidism, vitamin D deficiency, testosterone deficiency, insulin resistance, obesity-associated hypertension, and the role of central mineralocorticoid receptors and cardiovascular disease. An important contribution to the literature, Endocrine Hypertension is an indispensable reference not only for endocrinologists, diabetologists, and adrenal investigators, but also for translational scientists and clinicians from cardiology, internal medicine, pediatrics, family medicine, geriatrics, urology, and reproductive medicine / gynecology.

Ethical rational, facts, and center techniques for choosing kidney donors all in one volume. This is the first book of its kind, devoted solely to preoperative issues for living kidney donors and those who counsel them. The eight chapters are devoted to vital areas that are comprehensively addressed by experienced professionals. The book presents a unified ethical and factual approach that is essential for all transplant centers to understand. It is a readable and understandable ethical foundation for living kidney donation that is free of jargon. It includes balanced, hard to find factual summaries that are essential for acceptable kidney donor counseling. As transplant centers increasingly turn to living kidney donors, this book is an essential step forward in the field.
The book will appeal to transplant physicians and surgeons, transplant coordinators and social workers, nephrologists who have patients on dialysis or who evaluate potential living kidney donors and to potential living kidney donors and their recipients. As a practical application of medical ethics to an important field, it will be of interest to medical ethicists as well.

In this book, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments.

New tools discussed are discussed. This book therefore serves as a guide to evidence-based clinical applications, and a preview of future possibilities.

Premature ejaculation (PE) is a common male sexual complaint, with a self-reported prevalence of 20 30% in observational studies. Over the past 10 20 years, our understanding of PE has evolved from the initial premise that it is a psychological disorder to the current recognition of an underlying biological and probably genetic predisposition in many cases. This new understanding has been accompanied by novel approaches to the assessment and treatment of patients with PE.

"Premature Ejaculation" is the first truly contemporary reference volume on the subject. It covers a broad range of aspects relevant to PE, including past and current definitions of the condition, the etiology of PE, its epidemiology, the impact of PE on both the patient and his partner, and the treatment of PE using pharmacotherapy and/or psychotherapy/cognitive behavioral therapy. The book is well illustrated and referenced, and the primary focus throughout is on evidence-based medicine.

This timely and authoritative volume will be of great value to sexual health physicians, andrologists, endocrinologists, urologists, psychiatrists, sexologists, psychologists, and other interested healthcare professionals."

In examining the preface of our first book, it is increases needed. The Deming philosophy empha apparent that the editorial comments made in sizes that quality is never fully achieved: process 1994 are even more pertinent in today's cost- improvement is never ending. constrained healthcare environment than when But, what is quality? Without defining, David first written. We repeat them in part. Garvin makes the point that "in its original form, This is a time in history when the concept of quality activities were reactive and inspecti- quality is reaching new highs in terms of public oriented; today, quality related activities have awareness. Articles describing quality, CQI, qual broadened and are seen as essential for strategic ity tools, critical success factors, failures, and success" 1]. How can the broad context of quality lessons learned appear in local newspapers, trade be applied to the diverse aspects of ESRD? journals, scientific periodicals, and professional Furthermore, although far from a new concept, publications on a daily basis, yet implementation Continuous Quality Improvement (CQI) has taken of a quality system in many hospital units is its place as a dominant theme in many industries. approached with caution and the basic tenants of CQI is more broadly applicable, both in concept quality systems and CQI continue to be misunder and execution, to service as well as manufacturi- stood. based operations."

This book approaches the classification, pathogenesis, diagnostic, therapy and surgery for kidney tuberculosis as well as male genital tuberculosis. The reader will find recent data on epidemiology, many interesting history cases with illustrations and new methods for the identification of Mycobacterium tuberculosis.

This book analyzes the basic science and treatment of male factor infertility with Dr. Silber's characteristic honesty and clear thinking. It describes finally what works and what doesn't work. It will inspire everyone in reproductive medicine (Gynecologists, Urologists, Embryologists and Endocrinologists) who wish to better understand male infertility.

Cardiovascular complications are not only responsible for more than half of our patients' mortality, they also represent the bulk of everyday problems in a dialysis unit. Yet, the space allocated to them in the major textbooks covers only 2-8% of their total content. The origins of this book lie in many years of day-to-day care of dialysis patients. It gradually became clear to the author that systematic application of well-known pathophysiological principles could improve patients' conditions beyond expectations. More importantly, it appeared that world literature was mainly concerned with evaluating risk factors and that efforts to improve prognosis were concentrated on urea removal. It is important, therefore, to notice that Volume Control', the central issue of this book, is not incorporated into the Adequacy' concept. While primarily intended for dialysis doctors, the author sincerely hopes that dialysis nurses, who carry the lion's share of day-to-day responsibility for dialysis patients, will also find this book a useful and practical guide to dialysis treatment.

Written entirely by surgical urologists, Surgical Management of Urolithiasis: Percutaneous, Shockwave and Ureteroscopy presents a comprehensive overview of the past, present, and future of surgical techniques, with a focus on educating urologists on the full spectrum of stone procedures. In addition to the technical issues, detailed complications are described. Basic as well as advanced techniques are presented in both a didactic and visual mode with representative endoscopic images and radiographs. Recent advancements which are not routinely a core component of surgical training programs are also covered in detail. Compact and extensively illustrated, Surgical Management of Urolithiasis: Percutaneous, Shockwave and Ureteroscopy is a unique and valuable resource in the field of surgical urolithiasis, essential both for those currently in training and for those already in clinical practice.

Sildenafil, for the treatment of erectile dysfunction, is one of the first products that has made its way successfully from basic NO (nitrous oxide) research, to clinical routine therapy. Sidenafil, part of the Milestones in Drug Therapy series, presents the major breakthroughs in the field of NO physiology and pharmacology that led to the development of the drug, as well as clinical applications in one source guide.

Written by leading experts in the field, each chapter covers aspects of clinical use and experience, pharmacokinetics, pharmacodynamics, biochemistry, and cultural science.

Seeing a patient die under his hands because there is no adequate treatment causes an emotion and a frustration in a doctor, which sometimes stimulates him to try to develop a new type of treatment. Seeing so many wounded young soldiers die due to renal failure in World War I incited the German doctor Georg Haas to try to develop an artificial kidney. He had to give up in despair in 1928. Ten years later doctor Willem Kolff saw a young man die in his ward in the University Hospital of Groningen due to renal failure. By that time two essential factors for an artificial kidney had become available: a drug to keep the blood from clotting outside of the body and an efficient dialysing membrane through which waste substances can pass from the blood into the dialysing fluid. Kolff succeeded in creating the rotating artificial kidney which he started using in the town hospital of Kampen in 1943. The rotation of this artificial kidney started a revolution that made it possible for thousands of kidney patients all over the world to keep on living - and sometimes to forget their disease for the time being. In addition it gave rise to the development of other artificial organs such as the heart-lung machine, the artificial heart and the artificial eye. Doctor Jacob van Noordwijk, the author of this book, was Kolff's first assistant in the treatment of the first 15 patients. How Kolff succeeded in spite of all the limitations imposed by the German occupation of the Netherlands and in spite of the absence of antibiotics and other medical tools which are common nowadays makes a story which may sound incredible. Yet it did happen and visitors to the town of Kampen can still see the hospital building where it all took place.

Kidney Transplants are the most frequently performed solid organ transplants. Pancreas transplantation offers unique survival and quality of life benefits to selected diabetics with or without concomitant renal failure. Usually, kidney and pancreas transplant recipients are managed by the same team of physicians and surgeons. Current textbooks dealing with kidney and pancreas transplantation are unfortunately usually in the form of introductory manuals or primers and lack crucial practical detail and scientific depth relevant to the practicing physician. The transplant physicians and surgeons at Cleveland Clinic have collaborated to produce a textbook devoted to kidney and pancreas transplantation that addresses the need for a work that is well grounded in scientific principles, quantitative clinical reasoning, clinical pharmacology, tested clinical practices and overall clinical applicability. Also addressed are key aspects in the initiation, maintenance and sustained growth of viable clinical programs in kidney and pancreas transplantation.

A concise, up-to-date review of the many new therapies available for the treatment of benign prostatic hypertrophy (BPH). The authors concisely evaluate the latest minimally invasive therapies, as well as time-tested surgical treatments, and review the medical therapies for BPH, namely a-adrenergic antagonists, 5-a reductase inhibitors, and their therapeutic combinations. Additional chapters examine the pathophysiology and natural history of BPH, its epidemiology, and the urodynamic evaluation of lower urinary tract symptoms. A perfect reference source for the practicing urologist seeking sound guidance on the best approach to his patients.

Rodney Appell, and a host of respected clinical experts comprehensively summarize the state-of-the-art in the diagnosis and treatment of both neurogenic and nonneurogenic urinary problems in males and females alike. Tailored for use by today's busy practicing urologists, as well as frontline physicians, this book provides the essential physiological background for classifying voiding dysfunctions, surveys the practical diagnostics for these dysfunctions, and reviews the available treatments, including pharmacologic therapy, electrical stimulation, and surgery. Informative, practical, and clinically relevant, Voiding Dysfunction: Diagnosis and Treatment brings to every physician's treatment room a first-class compendium of the latest scientific facts, the best methods of diagnosis, and the most appropriate and effective treatments for these disturbingly widespread disorders.

Eureka: General Surgery and Urology is an innovative book for medical students that fully integrates core science, clinical medicine and surgery. The book benefits from an engaging and authoritative text, written by specialists in the field, and has several key features to help you really understand the subject: Chapter starter questions - to get you thinking about the topic before you start reading Break out boxes which contain essential key knowledge Clinical cases to help you understand the material in a clinical context Unique graphic narratives which are especially useful for visual learners End of chapter answers to the starter questions A final self-assessment chapter of Single Best Answers to really help test and reinforce your knowledge The book starts with the First Principles chapter which clearly explains key concepts such as assessment of the patient fitness for surgery, patient consent and pain management. The Clinical Essentials chapter provides an overview of the symptoms and signs of surgical disease, investigations and management options. A series of disease-based chapters briefly describe, by system, relevant structure and function, history and examination and main surgical presentations, each chapter introduced by engaging clinical cases that feature unique graphic narratives. The Emergencies chapter covers the principles of immediate care in situations such as acute appendicitis. Finally, the Self-Assessment chapter comprises 80 multiple choice questions in clinical Single Best Answer format, to thoroughly test your understanding of the subject. The Eureka series of books are designed to be a 'one stop shop': they contain all the key information you need to know to succeed in your studies and pass your exams.

This booklet is for those suffering from exertion or 'stress' incontinence. It describes a new approach based on a planned series of exercises aimed at restoring the bladder. The anatomical causes of this type of incontinence are clearly explained and illustrated. There is no substitute for the self-discipline of exercises, but the book also deals with two other important points: correct breathing and balanced diet which will not lead to constipation or to being overweight. There is also a section on preparations for counteracting the incontinence that may result from pelvic surgery. Doctors and physiotherapists will be able to recommend this booklet to their patients.

Leading national and international urologists in the field of endourology describe standard and advanced endoscopic procedures for treating upper-tract pathology. The authors provide step-by-step instructions for the latest endoscopic procedures, ranging from upper urinary tract calculi and strictures to urothelial cancer. An accompanying DVD includes videos that clearly illustrate critical parts of the techniques and provide tips and tricks from the experts. Advanced Endourology: The Complete Clinical Guide offers practicing urologists and urology residents not only a comprehensive, illustrated guide to endourological techniques-particularly the more advanced procedures-but also a practical means to expand the range and scope of the procedures they perform.

In this volume, international experts discuss the following topics: molecular principles of the genesis of prostate cancer and the involvement of oncogenes and tumour suppressor genes; changes of cell-cell contacts; defects in androgen receptors and their effect on treatment with antiandrogens; drug resistance mechanisms and new therapeutic principles; and molecular diagnosis of prostate cancer.

This volume provides an up-to-date account of the achievements pertaining to the application of capsaicin and capsaicin-like molecules in the therapy of various human ailments such as pain, non-allergic rhinitis, obesity, tumors and gastrointestinal, dermatologic and urologic disorders. It discusses the basic functionsof the capsaicin receptor (TRPV1), its mechanisms of action and its role in physiological and pathological processes. The text focuses on the most recent progress in the use of capsaicin and capsaicin-like molecules as a therapeutic agent and highlights potential pharmaceutical implications of further TRPV1 research. The chapters are written by noted experts in their fields of endeavor. This book offers both clinicians and researchers valuable resource and reference material on the subject that will stimulate future research. "

Endourology has developed significantly in recent years as a result of rapid change in surgical techniques and instruments. This eighth volume in the series Recent Advances in Endourology brings together the latest clinical findings regarding various endourological treatment modalities and innovative materials. In the past 30 years, transurethral resection of prostate, bladder, and ureteral tumors has been dramatically refined. Transurethral microwave thermotherapy has emerged as a nonsurgical option for the treatment of benign prostatic obstruction. Percutaneous surgery has changed significantly with the miniaturization of the endoscope, while the needle ablation technique, which decreases pain and shortens hospital stays, has become the treatment of choice for small renal cell tumors. In this book, world-recognized experts outline their techniques clearly and concisely to provide an updated review of state-of-the-art endourological techniques.