The 'Year Book of Urology' brings you abstracts of the articles that reported the year's breakthrough developments in urology, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice.

Male genital disorders represent a common issue in medical practice, especially in the dermatological setting. Correct clinical evaluation of these disorders is essential when addressing the diagnosis, which in some cases may require histopathological confirmation. Depending on the disease, early diagnosis may be not only lifesaving, but also of fundamental importance to the planning of successful treatment. This atlas introduces the most common penile diseases, along with more rarely encountered ones. It provides invaluable guidance on clinical diagnosis by highlighting prominent clinical features and presenting particular videodermatoscopy findings when these are indicative of the diagnosis. In addition, for each condition the most appropriate treatment is proposed, taking into account recent therapeutic advances of proven benefit.

This book aims to provide an up-to-date review of the literature in each of the major areas relating to the management of older urological cancer patients, and makes recommendations for best practice and future research. The authors come from a broad geographic spread including the UK, mainland Europe and North America to ensure a worldwide relevance.

Genitourinary Imaging - A Case Based Approach is a user friendly, portable guide that offers a comprehensive coverage of the subspecialty with an emphasis on all modalities. As subspecialty practice has become the norm in radiology, it becomes increasingly important to keep abreast of the latest information within the specialty that one is practising. The case based nature of this book, with modality independent content, allows the reader to assimilate practice specific information with ease. Full color images with tabular salient points, imaging algorithms and evidence based criterion support the text. Key points provide succinct explanations of the disease and an appropriate differential diagnosis, as well as providing a brief description of therapy and prognosis. Genitourinary Imaging - A Case Based Approach is aimed at residents and training and practicing genitourinary radiologists.

The book will serve as on demand reference for consultation when one is faced with such special scenario in the field of endourology. It s easy to read and easy to understand format should give an easy access to all chapters right from the beginning, so there is no need to read previous chapters for understanding the current one.

Furthermore it will serve as a textbook for problem oriented approach, which will be an interesting and attractive method of teaching. "

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels.

Ultrasound is a modality with broad applications in the imaging of the genitourinary tract.? Reviewed are the uses of US imaging the kidneys, prostate, scrotum, and bladder.? Also included are reviews of fetal genitourinary abnormalities, urinary tract infection, and tuberculosis.? The issue is rounded out with articles on contrast agents and on US-guided interventions.

Drs. Stoffel and McGuire have developed an issue that supplies urologists with state-of-the-art reviews devoted to the adult neurogenic bladder.? Among the stand-out articles are Bladder Rehabilitation: Goals and Practice; Pharmacologic Therapy for the Neurogenic Bladder; Multiple Sclerosis and the Neurogenic Bladder; Spinal Cord/Brain Injury and the Neurogenic Bladder; Botulinum Toxin Injections; Neuromodulation in the Neurogenic Bladder; Augmentation Cystoplasty for Improving Bladder Storage/Compliance; Myelodysplasia and the Adult Neurogenic Bladder; Tissue Engineering/Regeneration; Urologic Complications of the Neurogenic Bladder; and Urodynamics in Neurogenic Bladder.

Pelvic Floor Dysfunction is reviewed in this issue of Obstetrics and Gynecology Clinics, guest edited by Dr. Joseph Schaffer. Authorities in the field have come together to pen articles on Anatomy of the Pelvic Floor Dysfunction; Epidemiology of Pelvic Floor Dysfunction; Clinical Approach and Office Evaluation of the Patient with Pelvic Floor Dysfunction; Pathophysiology of Urinary Incontinence, Voiding Dysfunction, and Overactive Bladder; Behavioral Management of Urinary Incontinence, Voiding Dysfunction, and Overactive Bladder; Pharmacologic Management of Urinary Incontinence, Voiding Dysfunction, and Overactive Bladder; Surgery for Urinary Incontinence and Overactive Bladder; Pathophysiology of Pelvic Organ Prolapse; Non-Surgical Management of Pelvic Organ Prolapse; Vaginal Surgery for Pelvic Organ Prolapse Repair; Abdominal, Laparoscopic, and Robotic Surgery for Pelvic Organ Prolapse Repair; Use of Mesh and Materials in Pelvic Floor Surgery; Obliterative Surgery for Pelvic Organ Prolapse Repair; Pathophysiology of Anal Incontinence, Constipation, and Defecatory Dysfunction; Evaluation and Treatment of Anal Incontinence, Constipation, and Defecatory Dysfunction Pathophysiology of Pelvic Floor Related Pelvic Pain; and Evaluation and Treatment of Pelvic Floor Related Pelvic Pain.

A growing majority of women in the western hemisphere have been delaying initiation of childbearing to later in life. Consequently, more women in their late 30s to early 40s are attempting to get pregnant for the first time than ever before. Since the incidence of most cancers increases with age, delayed childbearing results in more female cancer survivors interested in fertility preservation. In this book, the editors provide strategies for fertility preservation in women and men who require gonadotoxic treatment. In addition, epidemiologic, ethical, medico-legal, psychologic, and social aspects of fertility preservation are discussed. Using a format that combines concise scientific background with practical methodological information and easy-to-grasp algorithms, the chapters all conform to a uniform structure, including a brief abstract, keyword glossary, step by step protocol of laboratory procedures, key issues in commentary and a list of references. The result is a unique, practical reference guide for reproductive endocrinologists, urologists, embryologists, reproductive scientists, and oncologists.

Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.

Andrology is the fastest growing subspecialty in urology and has recently achieved remarkable advances in the understanding of the erectile mechanism and in reproductive medicine. Male Infertility and Sexual Dysfunction presents all the current avenues of treatment with emphasis on multidisciplinary considerations. Chapters are written by select international authorities presenting indepth coverage of their areas of expertise. Each topic will cover the background, anatomy, physiology, diagnosis, classification, and treatment (medical and/or surgical). Part I focuses on the study of male infertility and includes discussions of the basic sciences, office evaluation, laboratory and imaging techniques, and the use of testicular biopsy. This is followed by specialized chapters dealing with immunologic infertility, genital inflammation, reactive oxygen species, medical management, sperm processing and preventive adolescent andrology. Part II reflects a more diverse format in the coverage of sexual dysfunction and includes discussions of androgen insufficiency, nocturnal penile tumescence studies, neurotransmission, penile neurology, premature ejaculation, psychogenic impotence and the latest medical, noninvasive and surgical treatments.

Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, reviews new, valuable approaches to the treatment of prostate cancer in men. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics. The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers.

The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression. This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. The issues of racial differences in prostate cancer mortality, radiotherapy for the treatment of locally advanced prostate cancer, recombinant antibody candidates for treatment, taxane-based chemotherapy, lethal phenotypes, and novel and efficient translation clinical trials are also presented in great depth.

Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, provides readers with a general reference for prostate cancer from prevention to therapy and will be of value to clinicians, scientists, and administrators who strive to solve the cancer problem.

Foreword; B.H. Scribner. Preface; R. Gokal, K.D. Nolph. 1. Historical Development and Overview of Peritoneal Dialysis; R. Gokal, K.D. Nolph. 2. Peritoneal Ultrastructure; J. Dobbie. 3. Peritoneal Circulation; R. White, D.N. Granger, R. Korthius. 4. Peritoneal Physiology -- Transport of Solutes; R.T. Krediet, B. Rippe. 5. Peritoneal Lymphatics; R. Khanna, R.A. Mactier. 6. Ultrafiltration with Colloid Osmosis; J.K. Leypoldt, C. Mistry. 7. Peritoneal Pharmacokinetics and Pharmacological Alterations of Peritoneal Transport; P. Hirszel, N. Lameire, M. Bogaert. 8. Solutions and Systems; J. Winchester, G. LaGreca, M. Ferriani. 9. Peritoneal Dialysis Access and Exit Site Care; Z.J. Twardowski. 10. Placement Procedures for Peritoneal Access; S. Ash, W.K. Nichols. 11. Organization of a Peritoneal Dialysis Program -- Nurses' Role; B. Prowant, L. Uttley. 12. Continuous Ambulatory Peritoneal Dialysis; G.E. Digenis, N.V. Dombros, J.W. Moncrief, D.G. Oreopoulos, R.P. Popovich. 13. Automated Peritoneal Dialysis; J.A. Diaz-Buxo, W. Suki. 14. Adequacy of Peritoneal Dialysis; P. Keshaviah, K. D. Nolph. 15. Nutritional Management of Patients on Peritoneal Dialysis; J. Bergstrom, J. Kopple, B. Lindholm. 16. Peritonitis; W. Keane, S.I. Vas. 17. Host Defence and Effects of Solutions on Peritoneal Cells; G. Coles, S. Lewis, J.D. Williams. 18. Calcium Phosphate and Renal Osteodystrophy; R. Gokal, A. Hutchison. 19. Other Complications of Peritoneal Dialysis; J.M. Bargman. 20. Pediatric Peritoneal Dialysis; S.R. Alexander, J.W. Balfe, E. Harvey. 21. Peritoneal Dialysis in Diabetics; R. Khanna. 22. Peritoneal Dialysis in the Elderly; A. Nissenson. 23. Quality of Life and Cost Effectiveness; R. Gokal. 24. Outcome of Peritoneal Dialysis -- Comparative Studies; R. Maiorca, G. Cancarini. 25. Registry Results; K.D. Nolph. 26. Use of Peritoneal Dialysis in Special Situations; S. Prichard, J.M. Bargurar. 27. Intraperitoneal Chemotherapy; R. Dedrick, M.F. Flessner. Index of Subjects.

This comprehensive and easy-to-read monograph is an authoritative update on clinical prostate cancer. It has been prepared by an international, multidisciplinary team at the invitation of the International Prostate Health Council think tank. A particular strength of the book is its presentation of the therapeutic options for patients with localized and advanced disease, including hormonal treatment.

This book addresses the most pressing current questions in the management of urologic malignancies. The rapid advances in imaging and molecular markers are placed into a clinical context, with explanation of their effects on prognosis and treatment planning. Similarly, progress in immunotherapy is carefully examined, focusing in particular on the role of immune checkpoint inhibitors in both early- and late-stage urologic malignancies. Looking beyond the improvements in minimally invasive techniques for urologic cancers, the impacts of care coordination pathways and enhanced recovery after surgery protocols are reviewed. Readers will also find enlightening discussion of the decision algorithm for the treatment of early-stage, high-grade bladder cancer, taking into account evidence on the most advanced treatment options and the circumstances in which surgery may need to be expedited. The penultimate chapter discusses the Cancer Genome Atlas project for bladder cancer, and the book closes by considering contemporary medical and surgical management of testicular cancer.

Management of Penile Cancer provides a comprehensive and state-of-the-art overview of the major issues specific to the field of penile cancer. The sections of the book are structured to review the overall scope of issues of penile cancer, including diagnosis and staging, surgical approaches and the treatment of advanced disease. As multidisciplinary care is an integral part of the treatment of penile cancer, this book is unique in the inclusion of collaborating authors from a variety of integrated disciplines, including urology, radiation oncology, medical oncology and reconstructive surgery. Written by recognized experts in their field, Management of Penile Cancer is a unique and valuable resource in the field of penile cancer, both for those currently in training and for those already in clinical or research practice.

The book covers the complete field of testis cancer including the germ cell tumors and the stromal tumors, from epidemiology to new chemotherapeutic agents and schedules, throughout genetic features, risk factors, risk adapted treatments, role of different types of surgery and special clinical situations. Special attention is focused on fertility issues, late effects of the primary therapy and the economical aspects of the different treatment policies.

As a result of the third Consensus Conference, a consensual follow-up can be devised and a chapter dedicated to this controversial and not yet defined matter.

This book is the state-of-the-art reference text on testis cancer and is an essential resource for all urologists, medical oncologists and radio-oncologists.

Recent research and clinical work have demonstrated that the rapid urologic innovation in minimally invasive treatment is creating exciting new horizons in endourology. This sixth volume in the series Recent Advances in Endourology brings that knowledge to a wider audience, focusing on the new concept of endourooncology, which is the merging of endourology and oncology. In the surgical treatment of urologic malignancies, bipolarization - that is, radical extended resection or organ-sparing surgery - is making remarkable advances. Further developments in sophisticated reconstructive surgery using robotic systems and image-guided ablation technology will allow surgeons to formulate minimally invasive, tailor-made procedures for each patient with urologic cancer. In this book, the current status and future prospects of these new technologies are reviewed, illuminating their roles in the future of endourooncology.

This book provides an overview of the current state-of-art in combining advances in biomedical imaging with intraoperative navigation and preoperative planning for urologic surgery. These advances hold great promise in improving diagnostic and therapeutic urologic interventions to improve patient outcomes. Leading experts in this exciting emerging field covers early clinical and pre-clinical applications of optical, ultrasound, cross-sectional and computer-assisted imaging in urologic surgery.

"Advances in Image-Guided Urologic Surgery" provides a unique and valuable resource for audience with clinical and research interest in minimally invasive surgery, endourology, urologic oncology, imaging and biomedical engineering.

This thesis focuses on the synthesis and vaccine evaluation of the prostate tumor- associated carbohydrate antigen RM2. The author first presents the use of the [1+2+3] one-pot sequential strategy to successfully synthesise the RM2 antigen and its analogues as single stereoisomers in every glycosylation step, producing good yields and stereoselectivity. He then introduces the conjugation of the synthetic RM2 antigen to the carrier protein CRM197 in an average number of 1-10 to create the prostate cancer vaccine candidate, which is combined with -galactosylceramide C1, its analogue C34, or Alu. The results of the vaccination studies in mice are also described and indicate that the strongest anti-RM2 antigen titer is exhibited when one molecule of diphtheria toxin (DT) is conjugated with an average of 4.7 molecules of RM2 antigen (DT-RM4.7) and adjuvanted with the glycolipid C34. More importantly, the induced mouse antibodies mediate the effective complement-dependent cytotoxicity (CDC) against the prostate cancer cell line LNCap. The study presented in this thesis is the first ever to successfully synthesize this complex glycan molecule. Owing to the steric hindrance of the adjacent sialyl moiety, the introduction of two sialic acid units to the compact and rigid 3,4 di branched galactoside unit is very challenging and the -selective and efficient glycosylation of the galactosamine moiety at the 4-position of di branched galactose is also problematic.

The thoroughly updated and revised third edition of Management of Prostate Cancer provides concise and authoritative guidance to today's best therapeutic regimens for the diagnosis and treatment of prostate cancer. Highlighting the latest major advances in the field, the book includes chapters on the most controversial areas of prostate cancer - screening, chemoprevention, and active surveillance; updated chapters on genetic risk and progression, biopsy schemes, treatment of complications, and comparative treatment outcomes for surgery; and new chapters on risk factors, new markers, nomograms, and focal therapy. This volume also features overviews of new and emerging drugs and treatment paradigms for castrate resistant disease, advances that promise to extend life and perhaps even cure a subset of men with metastatic disease. With its comprehensive illustrations and contributions from renowned experts in the field, Management of Prostate Cancer, 3rd Edition is an invaluable resource for practitioners in the treatment of prostate cancer.

Death on Hemodialysis: Preventable or Inevitable? presents the transactions of the Brooklyn meeting, held in April 1993, including an analysis by Scribner and Schreiner and an introduction by Edmund Bourke. Authors include the heads of dialysis registries for Japan, Europe, and the United States, as well as protagonists of dialyser reuse and short dialysis times. Enthusiasts championed the determination of adequacy of dialysis by formulae or by clinical assessment. All chapters are direct and forceful. The reader will be able to judge the data on what are key controversies in planning dialysis protocols and schedules.

Invasive bladder tumors affect the muscle wall, and have a propensity to metastasize and spread to other areas of the body, and are more likely to be fatal. This book presents state-of-the-art diagnoses and treatments available for bladder cancer that has metastasised into the body. A thorough review of current practice is presented in a full color volume with more than 40 tables and 50 illustrations. The book offers a comprehensive review of the subject, covering epidemiology, screening, diagnostic factors, surgery, chemotherapy and post-operative monitoring. Most chapters are jointly written by a basic researcher and a clinician.

This book is the new edition of this comprehensive guide to the medical and surgical management of kidney stones. Divided into three main sections, the text begins with discussion on the basic formation of kidney stones, followed by mineral metabolism and diseases that lead to the formation of stones, with the final section describing surgical management techniques. The second edition has been thoroughly revised and expanded with new topics including imaging methods, non invasive surgical techniques, and management in special cases such as pregnancy. This new edition also includes discussion on stones in children. With an internationally recognised author team led by US-based specialists, this 900-page text is highly illustrated with clinical photographs and diagrams. Previous edition published in 1995. Key Points Comprehensive guide to medical and surgical management of kidney stones Fully revised second edition, with many new topics Highly illustrated with clinical photographs and diagrams over 900 pages Internationally recognised, US-based author team