An estimated 234,000 new cases of prostate cancer will be diagnosed in the United States this year, making it one of the most common cancers affecting American men; however, it can be a controversial disease to diagnose and treat now that there is research abounding for both "watchful waiting? and aggressive treatments. Dr. Oh supplies balanced information, with articles on: Prostate Cancer: To Screen or Not To Screen?; High Intensity Focused Ultrasound: Ready for Primetime?; The Case for Open vs. Robotic Assisted Laparoscopic Radical Prostatectomy; Primary and Salvage Prostate Cancer Cryotherapy; and? The Case for Open vs. Robotic Assisted Laparoscopic Radical Prostatectomy, to name a few. The state-of-the art information presented in this issue make is must-have for all urologists.

In spite of the fact that vasectomy is currently the most commonly utilized form of male contraception and it has been in use for more than 50 years, very little has been written regarding standards of practice, procedure, and follow up. This issue addresses these issues in such a way to allow the reader to evaluate what works best for their individual practice utilizing evidence-based medicine when it exists. It is not surprising in a society with a divorce rate of aproximately 50 % and an excess of 500,000 vasectomies per annum, that there is demand for vasectomy reversal. Approximately 6% of vasectomies are reversed. Although the most common indication for vasectomy reversal is remarriage, there are other indications. This issue addresses issues that are of concern when reversal is discussed with the patient seeking to restore his fertility.

Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.

This comprehensive and easy-to-read monograph is an authoritative update on clinical prostate cancer. It has been prepared by an international, multidisciplinary team at the invitation of the International Prostate Health Council think tank. A particular strength of the book is its presentation of the therapeutic options for patients with localized and advanced disease, including hormonal treatment.

Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, reviews new, valuable approaches to the treatment of prostate cancer in men. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics. The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers.

The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression. This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. The issues of racial differences in prostate cancer mortality, radiotherapy for the treatment of locally advanced prostate cancer, recombinant antibody candidates for treatment, taxane-based chemotherapy, lethal phenotypes, and novel and efficient translation clinical trials are also presented in great depth.

Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, provides readers with a general reference for prostate cancer from prevention to therapy and will be of value to clinicians, scientists, and administrators who strive to solve the cancer problem.

This book addresses the most pressing current questions in the management of urologic malignancies. The rapid advances in imaging and molecular markers are placed into a clinical context, with explanation of their effects on prognosis and treatment planning. Similarly, progress in immunotherapy is carefully examined, focusing in particular on the role of immune checkpoint inhibitors in both early- and late-stage urologic malignancies. Looking beyond the improvements in minimally invasive techniques for urologic cancers, the impacts of care coordination pathways and enhanced recovery after surgery protocols are reviewed. Readers will also find enlightening discussion of the decision algorithm for the treatment of early-stage, high-grade bladder cancer, taking into account evidence on the most advanced treatment options and the circumstances in which surgery may need to be expedited. The penultimate chapter discusses the Cancer Genome Atlas project for bladder cancer, and the book closes by considering contemporary medical and surgical management of testicular cancer.

Management of Penile Cancer provides a comprehensive and state-of-the-art overview of the major issues specific to the field of penile cancer. The sections of the book are structured to review the overall scope of issues of penile cancer, including diagnosis and staging, surgical approaches and the treatment of advanced disease. As multidisciplinary care is an integral part of the treatment of penile cancer, this book is unique in the inclusion of collaborating authors from a variety of integrated disciplines, including urology, radiation oncology, medical oncology and reconstructive surgery. Written by recognized experts in their field, Management of Penile Cancer is a unique and valuable resource in the field of penile cancer, both for those currently in training and for those already in clinical or research practice.

Recent research and clinical work have demonstrated that the rapid urologic innovation in minimally invasive treatment is creating exciting new horizons in endourology. This sixth volume in the series Recent Advances in Endourology brings that knowledge to a wider audience, focusing on the new concept of endourooncology, which is the merging of endourology and oncology. In the surgical treatment of urologic malignancies, bipolarization - that is, radical extended resection or organ-sparing surgery - is making remarkable advances. Further developments in sophisticated reconstructive surgery using robotic systems and image-guided ablation technology will allow surgeons to formulate minimally invasive, tailor-made procedures for each patient with urologic cancer. In this book, the current status and future prospects of these new technologies are reviewed, illuminating their roles in the future of endourooncology.

The book covers the complete field of testis cancer including the germ cell tumors and the stromal tumors, from epidemiology to new chemotherapeutic agents and schedules, throughout genetic features, risk factors, risk adapted treatments, role of different types of surgery and special clinical situations. Special attention is focused on fertility issues, late effects of the primary therapy and the economical aspects of the different treatment policies.

As a result of the third Consensus Conference, a consensual follow-up can be devised and a chapter dedicated to this controversial and not yet defined matter.

This book is the state-of-the-art reference text on testis cancer and is an essential resource for all urologists, medical oncologists and radio-oncologists.

The manual provides a complete overview of the clinical assessment, diagnosis and rehabilitation of pelvic floor dysfunctions. The book will help physical therapist students, practicing physical therapists or medical professionals to reinvent the world of pelvic floor rehabilitation with needful details about the anatomy, physiology, causes of pelvic floor dysfunctions, associated pathologies, types of pelvic floor muscle dysfunctions and sexual dysfunction in female and male along with different pelvic floor dysfunctions in female, male and pediatric population. This book also mentions different efficient techniques of pelvic floor evaluation, methodologies and treatment options for common pelvic floor muscles condition. A complete overview of functional anatomy, dysfunctions, causes, types of dysfunctions (hypertonus, hypotonus, incoordination, visceral), clinical assessment, diagnosis and rehabilitation of pelvic floor conditions in female, male and children. Evaluation and rehabilitation for conditions like vaginal laxity, urinary incontinence (stress urinary incontinence, urge urinary incontinence and mixed incontinence), pelvic organ prolapse, sexual dysfunction, pelvic pain, endometriosis, interstitial cystitis, vaginismus and dyspareunia in female. Evaluation and rehabilitation for conditions like erectile dysfunction, premature ejaculation, postvoidal dribbling, prostatitis, postprostatectomy rehabilitation and pelvic pain in male have been discussed. Evaluation and rehabilitation for conditions like enuresis and encopresis in children. Het's MMT, Het's SERF Assessment, Het's Ring Clock Assessment, Het's RR Scale and HPP guidelines. Most simplified practical approach to noninvasive, transvaginal and transrectal evaluation and rehab. Functioning of multiple types of biofeedback and rehabilitation devices like ultimate noninvasive, smart and extremely efficient technology PF360 for urogenital/urogynec/ anorectal rehabilitation. Basics of medical and surgical management of conditions related to pelvic floor dysfunctions.

This book describes up-to-date information on the pathogenesis and molecular biology of human papillomaviruses and describes the mechanistic role of the viruses in epithelial cancers. Included in the book are chapters on the epidemiology of human papillomaviruses, the factors that control replication and transcription and the viral proteins, which are involved in modulating the biology of the host cell leading to cancer. Details of the immune response to the viruses and potential vaccine strategies are discussed.

The thoroughly updated and revised third edition of Management of Prostate Cancer provides concise and authoritative guidance to today's best therapeutic regimens for the diagnosis and treatment of prostate cancer. Highlighting the latest major advances in the field, the book includes chapters on the most controversial areas of prostate cancer - screening, chemoprevention, and active surveillance; updated chapters on genetic risk and progression, biopsy schemes, treatment of complications, and comparative treatment outcomes for surgery; and new chapters on risk factors, new markers, nomograms, and focal therapy. This volume also features overviews of new and emerging drugs and treatment paradigms for castrate resistant disease, advances that promise to extend life and perhaps even cure a subset of men with metastatic disease. With its comprehensive illustrations and contributions from renowned experts in the field, Management of Prostate Cancer, 3rd Edition is an invaluable resource for practitioners in the treatment of prostate cancer.

This book is a comprehensive guide to imaging techniques for the diagnosis and management of genitourinary disorders. Divided into five key sections, the text covers diagnostic imaging of the urinary tract and the genital tract in both men and women. This fourth edition has been fully revised to provide clinicians with the latest advances and techniques in the field. New chapters on radiological anatomy and novel imaging techniques have been included. Latest guidelines and systematic-algorithms are covered to assist understanding and simplify diagnostic reporting. Radiological images, diagrams and figures further enhance the thorough text. Key points Comprehensive guide to diagnostic imaging techniques for genitourinary diseases and disorders Fully revised, fourth edition detailing latest advances in the field Includes new chapters on radiological anatomy and novel imaging techniques Previous edition (9788184486827) published in 2009

This book provides an overview of the current state-of-art in combining advances in biomedical imaging with intraoperative navigation and preoperative planning for urologic surgery. These advances hold great promise in improving diagnostic and therapeutic urologic interventions to improve patient outcomes. Leading experts in this exciting emerging field covers early clinical and pre-clinical applications of optical, ultrasound, cross-sectional and computer-assisted imaging in urologic surgery.

"Advances in Image-Guided Urologic Surgery" provides a unique and valuable resource for audience with clinical and research interest in minimally invasive surgery, endourology, urologic oncology, imaging and biomedical engineering.

Invasive bladder tumors affect the muscle wall, and have a propensity to metastasize and spread to other areas of the body, and are more likely to be fatal. This book presents state-of-the-art diagnoses and treatments available for bladder cancer that has metastasised into the body. A thorough review of current practice is presented in a full color volume with more than 40 tables and 50 illustrations. The book offers a comprehensive review of the subject, covering epidemiology, screening, diagnostic factors, surgery, chemotherapy and post-operative monitoring. Most chapters are jointly written by a basic researcher and a clinician.

This book is the new edition of this comprehensive guide to the medical and surgical management of kidney stones. Divided into three main sections, the text begins with discussion on the basic formation of kidney stones, followed by mineral metabolism and diseases that lead to the formation of stones, with the final section describing surgical management techniques. The second edition has been thoroughly revised and expanded with new topics including imaging methods, non invasive surgical techniques, and management in special cases such as pregnancy. This new edition also includes discussion on stones in children. With an internationally recognised author team led by US-based specialists, this 900-page text is highly illustrated with clinical photographs and diagrams. Previous edition published in 1995. Key Points Comprehensive guide to medical and surgical management of kidney stones Fully revised second edition, with many new topics Highly illustrated with clinical photographs and diagrams over 900 pages Internationally recognised, US-based author team

This book describes the anatomy, embryology, and radiology of the urinary tract, and the surgical techniques for detailed genitourinary (GU) organ reconstruction. The ethical aspect and care of the patient during surgery is described in depth for broader understanding. Nearly 1,700 images and over 1,500 coloured illustrations have been drawn to describe the each surgical step as clearly and easily possible. First comprehensive pediatric urology surgery book, with detailed surgical steps, in this decade. Online clinical pictures with corresponding printed line diagrams for better understanding. Covers a wide range of topics in pediatric urology and reconstruction. Contributions from international authors with expertise in the field.

This thesis focuses on the synthesis and vaccine evaluation of the prostate tumor- associated carbohydrate antigen RM2. The author first presents the use of the [1+2+3] one-pot sequential strategy to successfully synthesise the RM2 antigen and its analogues as single stereoisomers in every glycosylation step, producing good yields and stereoselectivity. He then introduces the conjugation of the synthetic RM2 antigen to the carrier protein CRM197 in an average number of 1-10 to create the prostate cancer vaccine candidate, which is combined with -galactosylceramide C1, its analogue C34, or Alu. The results of the vaccination studies in mice are also described and indicate that the strongest anti-RM2 antigen titer is exhibited when one molecule of diphtheria toxin (DT) is conjugated with an average of 4.7 molecules of RM2 antigen (DT-RM4.7) and adjuvanted with the glycolipid C34. More importantly, the induced mouse antibodies mediate the effective complement-dependent cytotoxicity (CDC) against the prostate cancer cell line LNCap. The study presented in this thesis is the first ever to successfully synthesize this complex glycan molecule. Owing to the steric hindrance of the adjacent sialyl moiety, the introduction of two sialic acid units to the compact and rigid 3,4 di branched galactoside unit is very challenging and the -selective and efficient glycosylation of the galactosamine moiety at the 4-position of di branched galactose is also problematic.

This book will enable the reader to gain a sound understanding of contemporary and futuristic evidence-based interventions and assessment procedures for pelvic floor disorders. It gathers the experiences of some of the most important experts on electrical stimulation techniques, offering a multidisciplinary and problem-oriented approach organized according to therapeutic goals. Interventions are recommended that are consistent with theory and display clinical efficacy for specific disorders, including urinary incontinence or retention, fecal incontinence, constipation, pelvic pain, sexual dysfunction and neurological diseases involving the pelvic floor. All of the surgical or rehabilitative techniques requiring electrical stimulation for the treatment of these disorders are explored and essential background information is provided on functional anatomy, neurophysiology and concepts in electrotherapy. This volume will be a very useful tool for urologists, general or colorectal surgeons, gynecologists and anesthesiologists and also physiotherapists and alternative medicine practitioners (a specific chapter focuses on electroacupuncture). It will assist in their clinical practice as they seek to help the very many patients who suffer from any of the wide range of functional pelvic floor disorders.