With increasing emphasis on the early diagnosis and management of urologic tumours, it is imperative that the practising urologist comprehend the relevance of the morphology for the clinical diagnostic and therapy. Moreover, the clinician should be fully informed of the importance of modern morphological methods for the diagnosis and management of urological tumours. Not only is this highly illustrated text a necessary adjunct in the attending urologist's armamentarium, it will also satisfy the needs of residents in pathology or even of pathologists, who are not daily faced with urological tumours. The structure of the chapters follows a uniform schema: short introduction with the definition of the tumour/ tumours, clinical history epidemiology, aetiology, gross morphology, microscopy, tumour genetics, importance of ancillary methods for the diagnosis, differential diagnosis, principles of grading and staging, morphological prognostic factors, and clinical course. The tables showcase the latest WHO histological classification of the tumours of the single organs, the integral (or complete) form of the latest TNM staging version, and the principles of the international accepted grading systems (kidney, bladder, prostate, penis ). A short chapter is devoted to handling procedures for surgical specimens and biopsies by clinicians.

Radical prostatectomy involves the surgical removal of the entire prostate gland and the seminal vesicles. Recently the open operation has been challenged by laparoscopic and robotic techniques. However, making the transition to this new technology is not an easy option. Avoiding surgical complications such as incontinence and ensuring continued erectile function following the procedure requires good surgical technique by whatever means. The editors and their distinguished team of contributors from around the world offer the reader their guidance based on personal experience and best surgical practice. Radical Prostatectomy is required reading for all those performing radical prostatectomy by open, laparoscopic or robotic techniques.

Overactive bladder (OAB) affects millions of men and women daily. Given the symptoms of sleep loss, depression, and a lower quality of life than even those with diabetes mellitus, effective and beneficial treatment is a must for these people. Drs Kreder and Dmochowski, both recognized experts on voiding dysfunction and urodynamics, have assembled a distinguished team of experts from around the globe to share with the reader, whether qualified or in-training, their perspectives based both on best practice and personal experience in evaluating and managing the overactive bladder. This seminal work should guide the reader in daily practice.

The successful practice of reproductive medicine requires the coordinated efforts of many medical professionals. Male Reproductive Dysfunction: Pathophysiology and Treatment describes the most significant advances towards the improved overall understanding of male reproductive dysfunction and provides practical strategies for the assessment and management of these conditions. The book discusses normal anatomy and physiology of the male reproductive system. It examines psychological and social influences, and the pathophysiology that can affect the male reproductive system from infancy through adulthood. It provides clear guidelines and algorithms for the assessment of male hypogonadism and infertility, from relevant history and physical exam findings to the proper interpretation of laboratory results. The book examines imaging technology and the currently available treatment strategies for male hypogonadism and infertility. Additional topics include immunological factors, the preservation of fertility in males with cancer, and the treatment of men with spinal cord injury and other neurologically disabling diseases.

Divided into eleven detailed sections, this reference displays the expertise and research of specialists from leading urology centers around the world and offers authoritative chapters on the entire spectrum of urologic laparoscopy. The chapters cover methods in patient selection, peri-operative management, and complication avoidance; step-by-step descriptions of specific techniques; and the pros and cons of each procedure for a clear grasp of the many principles and practices currently utilized in the field.
Placed alongside the Atlas of Laparoscopic Urology with DVDs, this set will likely become the standard reference text in the field of urologic laparoscopic surgery.

A dedicated guide to the basics of urology available in a handy, useable format. A straightforward presentation of practical knowledge and bedside skills. Written by residents and attending physicians at the world famous Brady Institute of Urology at Johns Hopkins University Hospital and marketed using the name of the Brady Institute of Urology. While comprehensive textbooks are essential to the practice of urology, equally important are readily accessible manuals that students, residents, trainees and even experienced urologists can carry with them in their pockets or on PDAs. Filling a gap in the market for a definitive pocket urology reference guide, this easy-to-use text covers the key topics in the field, with an emphasis on the straightforward presentation of practical knowledge and bedside skills. Written by residents and attending physicians at the world famous Brady Institute of Urology at Johns Hopkins University Hospital, this is a much-needed, highly useful handbook for those in the field.

The only guide to focus primarily on current molecular methods of diagnosis and early stage evaluation, this reference presents the latest techniques and technologies for dementia identification and evaluation, including neuropathological strategies, neuropsychological tests, biomarkers, CT, MRI, functional MRI, PET, and SPECT. Offering practical care and examination guidelines, each chapter provides findings that are particularly relevant for the assessment of disorders such as Alzheimer's disease, dementia with Lewy bodies, vascular dementia, and fronto-temporal dementia.

Bladder cancer is the fifth most common cancer of American men and the eighth most common cancer of American women, with sixty thousand new cases of the disease diagnosed each year in the US alone. Disease prevalence is high in western nations due to the predominance of the chronic relapsing form of cancer that occurs in these countries (USA prevalence estimated to be 600,000; NCI-SEER database), and this single fact makes bladder cancer one of the most expensive cancers to treat. expertise of an international community of experts in the area. All aspects of disease biology, diagnosis and treatment are addressed. Appropriate for scholars and students of medicine at all levels, it promises to become a key text in the field.

Providing a detailed coverage that is impossible in broader-based textbooks, "Urogenital Ultrasound, Second Edition", is a comprehensive study of genitourinary ultrasound that has been completely revised to keep up-to-date with this rapidly changing field. Reflecting the obviously visual nature of ultrasound imaging, "Urogenital Ultrasound, Second Edition" contains more than 1,000 images, including those from more technically advanced ultrasound machines than were in the first edition. Aiding the reader in recognizing various disease states and recommending effective therapeutic or surgical measures, this new edition also covers all recent developments, explained in a pragmatic style that is easily read and understood.

Written by over 250 of the world's leading urologists and uro-oncologists from the USA, Canada, UK, Austria, Belgium, Finland, France, Germany, Ireland, Italy, the Netherlands and Singapore, who tackle prostate cancer on a daily basis, this comprehensive and fully up-to-date illustrated text reference covers the etiology, pathophysiology, diagnosis, management and treatment of early and advanced prostate cancer. advanced non-surgical procedures, Prostate Cancer: Principles and Practice focuses on the following key areas: * the pathology and etiology of prostate cancer assessing the prostate, whether qualified or in training.

Formulated by members of the International Scientific Committee of Radionuclides in Nephro-urology (ISCORN), Functional Imaging in Nephro-urology is not a textbook on uronephrology or radionuclides in nephro-urology, or even a book on new techniques in imaging. What the editor and authors provide here is a unique opportunity to evaluate the strategic management techniques (both diagnosis and follow-up) of a number of uronephrological entities.
Demonstrating the experience of the authors in using various imaging modalities, and detailing the benefits and controversies which are associated with their clinical applications, this text presents management strategies based on the patient, the choice of modality, and cost implications.
Detailed, well-referenced and highly illustrated, this is an important book for radiologists, nephrologists and urologists working with children and adults, specialists in renal nuclear medicine, and pediatricians.

Contents:
1. Introduction 2. Ultrasound Principles and Anatomy of the Prostate 3. Effect of Radiology on Prostate Histopathology and Assessment of Residual Cancer 4. What Should You Ask Your Pathologist When Contemplating Minimally Invasive Therapy 5. Detailed Mapping of Prostate Carcinoma Foci: Implications for Prostate Brachytherapy 6. Treatment Decisions: Surgery vs. Brachtherapy a Urologist's Perspective 7. Treatment Decisions: a Patient's Perspective on Prostate Brachytherapy 8. Principles of Prostate Brachytherapy Isotope Decisions 9. Use of Artificial Neural Networks in the Clinical Staging of Prostate Cancer: Implications for Prostate Brachytherapy 10. What Do Whole Mount Radical Prostatectomy Specimens Teach Us About Extracapsular Disease. Implications for Prostate Brachytherapy 11. Can Permanent Implants Address Extracapsular Disease, Can Extraprostatic Extension be Treated by Prostate Brachytherapy? An Analysis Based on Postimplant Dosimetry 12. Evaluating the Role of Neoadjuvant Deprivation for Patients Undergoing Prostate Brachytherapy 13. Impact of Hormonal Therapy on Pubic Arch Interference 14. Pre Implantation Urologic Considerations 15. Selection of Equipment for Prostate Brachytherapy 16. Advances Beyond Biplanar Ultrasound for Permanent Prostate Implants 17. What to Look for When Choosing Treatment Planning Software for Prostate Brachytherapy 18. A Comprehensive Review of Prostate Cancer Brachytherapy: Defining an Optimal Technique 19. Planning an Implant: Preplanning Versus Intraoperative Planning 20. Point Kernels and Superposition Methods for Scatter Dose Calculations in Brachytherapy 21. Treatment Planning for High Dose-rate Prostate Brachytherapy 22. High Dose-rate Afterloading Iridium-192 Prostate Brachytherapy 23. Use of Conformal High-dose Rate Brachytherapy for Management of Patients with Prostate Cancer: Optimizing Dose Escalation 24. The Role of High Dose Rate Prostate Brachytherapy in the Management of Prostate Cancer, Treatment Planning and Results from Memorial Sloan-Kettering Cancer Center 25. Modified Uniform Seed Loading for Prostate Brachytherapy: Rationale, Design and Evaluation 26. Treatment Planning and the Seattle Prostate Institute Approach to Treatment Planning for Permanent Implants. 27. Surgical Tips: Improving Ultrasound Imaging During Interstitial Implant 28. Intraoperative Technique 29. Intraoperative Technique Using Pd-103 30. Intraoperative Technique with Biplane Ultrasound and Fluoroscopic Guidance for Optimal Seed Placement 31. Performing a Prostate Implant Under Local Anaesthesia 32. A Prospective Multi-center Study of Transperineal Prostatic Block for Transurethral Needle Ablation (TUNA) of the Prostate 33. Improvement of Transperineal Implant Dosimetry by Intraoperative Cystoscopic Confirmation of Prostate Anatomy Nursing Management of Prostate Brachytherapy Patients 34. Management of Patients Receiving Transperineal Palladium-103 Prostate Implants 35. Prevention of Perineal Hematoma Using the Perineal Pressure Application Device (PPAD) After Prostate Brachytherapy 36. The Role of a Needle Manipulator/ruler in 1125/Pd 103 Preloaded Needle Implants of the Prostate 37. Defining a Quality Prostate Implant 38. Options for a Suboptimal Permanent Prostate Implant 39. Long-term Results. Radiation Oncologist's Perspective 40. Biochemical Outcome After Radical Prostatectomy, External Beam Radiotherapy or 125I Prostate Brachytherapy for Low and Intermediate Risk Prostate Cancer Patients 41. Acute and Chronic Toxicity After IMRT/HDR for Patients S/P TURP, Large Glands, High IPS Scores: Patient Selection, OR Technique, Treatment Planning, Inpatient Management, Catheter Movement and QOL Assessment Long-term Results. A Urologist's Perspective 42. The Intermediate Risk Disease Patient: Is There an Advantage for External Beam Radiotherapy and Implant? 43. Experimental Evaluation of the Rtog Recommendation for Permanent Prostate Brachytherapy Implants 53. Dosimetric Analysis of Urinary Morbidity Following Prostate Brachytherapy (125i vs. 103pd) Combined with External Beam Radiation Therapy 54. Lessons from the Learning Curve Erectile Function Following Prostate Brachytherapy 55. Rectal Complications after Permanent Seed Implants Sexual Dysfunction after Permanent Implant 56. Management of Voiding Dysfunction Following Implantation 57. Transient Elevation of Serum Prostate

Extensively illustrated for clear navigation and understanding of anatomical sites, surgical techniques, and reconstructive procedures, this reference studies the surgical and non-surgical evaluation and management of various disorders affecting female urinary and pelvic health. Exploring a topic of increasing importance, this guide: * provides detailed instruction on the preparation and performance of various surgical procedures * contains practical approaches and techniques for all urologists and gynecologists involved in female pelvic health and reconstructive surgery * studies the anatomy of pelvic support, the epidemiology of urinary incontinence, and quality of life issues relating to incontinence. With valuable recommendations, guidelines, and best practices from over one hundred skilled authorities, this text provides expert guidance in the treatment of urinary incontinence, pelvic organ prolapse, and other dysfunctions.

Excerpted from the Textbook of the Neurogenic Bladder, Essential Guide to the Neurogenic Bladder provides information on two topics essential to the practicing clinician: evaluation and treatment. Giving the reader easy access to the diagnostic armamentarium, this well-illustrated text provides the examining physician with excellent guidelines for conducting thorough, efficient, and beneficial examinations of both adults and children using a variety of instruments and tests. Both surgical and non-surgical treatment options are written by experts from around the globe and should invariably help the reader to choose the best treatments for optimal results.

This book provides andrologists and other practitioners with reliable, up-to-date information on all aspects of male infertility and is designed to assist in the clinical management of patients. Clear guidance is offered on classification of infertility, sperm analysis interpretation and diagnosis. The full range of types and causes of male infertility are then discussed in depth. Particular attention is devoted to poorly understood conditions such as unexplained couple infertility and idiopathic male infertility, but the roles of diverse disorders, health and lifestyle factors and environmental pollution are also fully explored. Research considered stimulating for the reader is highlighted, reflecting the fascinating and controversial nature of the field. International treatment guidelines are presented and the role of diet and dietary supplements is discussed in view of their increasingimportance. Clinicians will find that the book s straightforward approach ensures that it can be easily and rapidly consulted."

Contents:
Preface I. Introduction 1. Urological Stents: Material, Mechanical and Functional Classification 2. Evaluating New Medical Technologies: Issues and Opportunities II. History of Stents 3. History of Ureteral and Urethral Stenting 4. The Double-J: Then and Now 5. History of Wallstent 6. From Prostakath to Memokath 7. History of UroCoil and ProstaCoil 8. History and Status of Bioabsorbable and Biodegradable Materials in Urology 9. Radiation Protection of Patients and Personnel During Urological Stenting III. Stent Materials 10. Characteristics of Materials Used in Implants: Metals 11. Characteristics of Materials Used in Implants: Polymers 12. Bioabsorbable Materials in Urology IV. Evaluation of Stents 13. Methods of Testing the Biocompatibility of Implantable Medical Devices 14. Elasticity of Radiopaque Ureteral Stents V. Infection and Encrustations on Stents 15. Surface Modification of Polymeric and Metal Stents Coming Into Contact with Blood or Urine 16. Encrustation and Microbial Adhesion on Stents: Current Understanding of Biofilm 17. Bacterial Adherence to Hydrophilic-coated Polymer Stents 18. Bacterial Adhesion to Biogradable Stents 19. Urinary Tract Infection in Patients with Urethral Stents 20. How to Prevent Encrustations on Metallic Stents VI. Ureteral Stents: Urological Diseases 21. Optimal Management of the Obstructed Kidney 22. Double-J (JJ) Stents Versus Nephrostomy Tube Drainage 23. Tricks for Stenting the Obstructed Ureter 24. Non-refluxing Ureteral Stents 25. Use of Pyelo-ureteral DD Stents in Children 26. Design Faults in Currently Available Ureteric Stents 27. Minimally Invasive Ureteric Stent Retrieval 28. Endo-urological Evaluation and Management of the 'Forgotten' Indwelling Ureteral Stent 29. UPJ Stenosis: Is Surgery Better Than the Endoscopic Approach? 30. Stenting After Antegrade and Retrograde Endopyelotomy 31. Stenting After Endopyelotomy in Children 32. ESWL: To Stent or Not To Stent? 33. Uretero-intestinal Stricture Stenting 34. Metallic Stents in the Management of Ureteric Obstruction 35. A Stent/Nephrostome for the Management of Post-renal Transplantation Complications. 36. Recanalization of Metal Ureteral Stents Obliterated by Proliferative Tissue 37. Patient Information About Ureteric Stents: Development of A Validated Booklet VII: Ureteral Stents: Non-urological Diseases 38. Temporary Ureteral Stenting for the Management of Symptomatic Hydronephrosis During Pregnancy 39. Stenting in Benign Gynaecology and Gynaecological Oncology 40. Endo-urological Management of Iatrogenic Ureteral Injuries 41. Reinforced Endo-ureteral Stent in Tumour-induced Hydronephrosis 42. Double-pigtail Stent with Radiopaque Removable Sheath 43. Use of Self-expanding Metal Stents in Ureteral Obstruction Due to Malignant Pelvic Disease VIII: Prostatic Stents in Benign Prostatic Hyperplasia 44. The Memokath Thermoexpandable Prostate Stent 45. Intra-urethral Catheter (IUC) in the Treatment of Prostatic Obstruction 46. Clinical and Cost Comparison of Long-term Catheterization and Memokath Prostatic Stenting 47. ProstaCoil in Non-surgical Management of BPH 48. Urolume Stents in the Management of Benign Prostatic Hypertrophy 49. Urolume Endoprosthesis as an Alternative Treatment of BPH in Inoperable Patients 50. Anatomical Limitations of the Prostatic Urethra in Using Cylindrical Stents 51. Is There a Role for Permanent Stents in the Treatment of BPH? 52. Temporary Prostatic Stenting Using the Barnes Stent 53. Role of Temporary Stents After Minimally Invasive Treatments for Benign Prostatic Hyperplasia 54. Use of Biodegradable Stents After Visual Laser Ablation of the Prostate IX. Prostatic Stents in Prostate Cancer 55. Relief of Bladder Outlet Obstruction Caused by Prostate Cancer Using a Long-term Intra-urethral Stent (ProstaCoil) 56. Permanent Prostatic Stent in the Management of Obstructive Prostate Cancer in High-risk Patients 57. External Irradiation for Prostate Cancer in Patients with Urethral Stents X. Stents in Urethral Strictures 58. Stenting After Urethral Surgery 59. Appropriate Stenting in Hypospadias Surgery 60. How Do Temporary Urethral Stents Work in Recurrent Urethral Strictures? 61. Long-term Results of Urolume Stents in Recurrent Urethral Strictures 62. Role of Permanent Stents in the Management of Complex Urethral Strictures 63. Treatment of Recurrent Anastomotic Stenoses After Radical Prostatectomy or Radical Cystoprostatectomy and Orthotopic Bladder Replacement with Temporary Stents 64. Histological Changes Associated with Stenting the Urinary Tract XI. Stents in Detrusor-Sphincter Dyssnergia 65. Memokath Stent in the Treatment of Detrusor External Sphincter Dyssynergia Following Spinal Cord Injury 66. Complications Related to Sphincter Stents Used for the Management of Detrusor-sphincter Dyssynergia XII. Vascular Stents 67. Metal Stents for the Treatment of Atherosclerotic Renovascular Disease 68. Indications for Stent Placement in Haemodialysis Fistulas and Grafts 69. Stent Grafts in Endovascular Management of Iliofemoral Venous Occlusions Caused by Urologic Pelvic Malignancies XIII. The Future 70. Extra-anatomical Urinary Diversion 71. Polymeric Endoluminal Paving: local Endo-urological Polymer Systems for Support, Barrier Creation and Site-specific Drug Delivery

Key Topics in Urology gives a broad, up-to-date understanding of common urological conditions. Each topic addresses the mode of presentation, management and outcome of these conditions. As well as being relevant for specific examinations, the book provides a review of conditions frequently encountered by the on-call registered medical practitioner who may not have specific training in urology. This book is essential revision guide for the MRCS and FRCS examinations and a useful reference source for higher surgical trainees without training in urology, GPs and nurses.

This up-to-the-minute reference provides comprehensive coverage of the male and female sphincteric mechanisms and their connection to the pelvic floor as well as upper and lower urinary tract function-emphasizing modern approaches to the epidemiology, diagnosis, and treatment of abnormalities including incontinence, hypertonicity, retention, dyssynergia, and the overactive sphincter. Highlights state-of-the-art clinical, urodynamic, electrophysiological, and imaging techniques such as ultrasonographic explorations of the female urethra! Detailing lifestyle interventions, physiotherapy, disposable devices, and pharmacological therapeutics, The Urinary Sphincter covers -observations in embryology and infancy that contribute to pathological phenomena in adults -genital prolapse in females -recent developments in the engineering and the mechanisms of action of artificial sphincters, stents, and slings, as well as surgery, injectible techniques, and various sling procedures -neuromodulation and neurostimulation of urethrovesical function -contemporary surgical approaches for coordinated bladder function -reports from the International Continence Society on the methodology, standardization of terminology, and complications related to urethrovesical function and dysfunction -and more! Furnishing practical algorithms and nearly 3000 useful references, tables, equations, photographs, and drawings, The Urinary Sphincter is an invaluable and authoritative source for urologists, gynecologists, neurologists, physiatrists, physiologists, pharmacologists, physiotherapists, and medical students in these disciplines.

Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling. Key Features Discusses the signaling pathways that contribute to successful spermatogenesis Covers comprehensive information about Spermatogenesis at one place Explores the vital aspects of male fertility and infertility Explains the epigenetic regulation of germ cell development and fertility Highlights the translational opportunities in molecular signaling in testis

Providing a comprehensive review of the interactions between exercise and human reproduction, this unique text focuses on both the positive and negative consequences of sport and physical activity on male and female fertility and infertility and the biological mechanisms and processes behind them. Beginning with a review of the structure and function of the male and female reproductive systems as well as fertilization and gestation, the discussion then turns to the physiology and endocrinology of sport and exercise, which is further elaborated in subsequent chapters on the impact of physical activity, hormonal changes, pathologies, and consequences of drug use for active men and women. Additional chapters address related topics, such as the impact of sport on young athletes and developing reproductive potential, physical activity and pregnancy, the use of oral contraceptives in athletes, oxidative stress, and the impact of nutritional deficiencies on athletes' fertility, with a final chapter providing recommendations and therapeutic guidelines for exercise-related reproductive disorders. Covering everything from the fundamental principles of sports physiology and human reproductive potential to the interaction between physical exercise and the endocrinology of the reproductive system, Exercise and Human Reproduction is an authoritative resource for helping clinicians understand how the reproductive system adapts to activity and exercise and offers strategies to avoid potential harm to human reproduction.

The purpose of this book is to provide a contemporary overview of the causes and consequences of prostate cancer from a cellular and genetic perspective. Written by experts in the fields of epidemiology, toxicology, cell biology, genetics, genomics, cell-cell interactions, cell signaling, hormone signaling, and transcriptional regulation, the text covers aspects of prostate cancer from disease initiation to metastasis. Chapters explore in depth the cells of origin for prostate cancer, its genomic subtypes, neural transcription factors in disease progression, epigenetic regulation of chromatin, and many other topics. This book distinguishes itself from other texts on prostate cancer by its focus on cellular and genetic mechanisms, as opposed to clinical diagnosis and management. As a result, this book will be of broad interest to basic and translational scientists with familiarity of these topics, as well as to trainees at earlier stages of their research careers.

This volume provides a comprehensive review and detailed description of surgical techniques for prostate cancer surgery. All aspects are covered, including surgical anatomy and methods of transrectal ultrasound guided prostate biopsies, step-by-step approach techniques for radical prostatectomy, and the latest data on outcomes. Furthermore, limitations as well as tips and tricks are detailed in addition to management of common complications. Lastly, with the increasing use of ablative therapy and brachytherapy, the mechanism of action as well as the keys to obtaining optimal outcomes are illustrated. Surgical Techniques for Prostate Cancer is a concise and valuable resource to surgeons that documents the different approaches to prostate cancer surgery.