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This book gives a complete description of online hemodiafiltration, in five sections. It is unique in the systematic and complete way in which hemodiafiltration is described. Each chapter is completed by a point-to-point summary of essential information, in a separate text box. Part of the book is dedicated to the theoretical background of convective clearance. In this part, safety issues and quality control is reviewed (especially on the quality of water for dialysis and substitution fluid), as well as equipment (both dialyzers and machines) with which this treatment can be performed. As recently the results of several randomized controlled trials were available, the effect of hemodiafiltration on hard clinical end points (mortality and morbidity) is discussed in detail. This has not been done before, as the most recent book/journal on hemodiafiltration was published in 2011, before the results of the 3 randomized controlled trials were published. Furthermore, the methodological quality of the trials is discussed by an expert, in order to help the readers in their judgment of the trials Part of the book concentrates on the effect of the treatment on several biomarkers and uremic toxins. Several clinically relevant issues is discussed separately, such as the prescription of anticoagulation during the treatment, drug prescription and clearance for patients treated with hemodiafiltration, and hemodynamic stability. Finally, a practical guide on how to perform the treatment is provided. In this unique section, seemingly simple but important details of hemodiafiltration-treatment is discussed, such as the importance of needle size for blood flow rates, the difference between filtration fraction and substitution ratio, the different targets that can be set and how to reach them. As most literature is mainly focused on theoretical issues, this unique feature really will help the field to perform hemodiafiltration, and answer practical questions.
Expert Opinions in Female Pelvic Medicine and Reconstructive Surgery covers a range of female urologic disorders, using a case-based approach to provide timely guidance on diagnosis and management. Forty cases of varying complexity are introduced by the editors and illustrated where appropriate by clinical findings. One or two expert reviewers then present their protocols for the management of each case, and their projected prognosis. Sometimes these views may diverge, as they do in practice. In all cases therefore, the editors add a final commentary to those of the expert reviewers, to summarise current management protocols and guide the reader towards an optimum treatment plan. Presents 40 urological cases Expert reviewers present their protocols for each case and the editors summarise the current management procedures Clinical findings are presented with images and urological graphs Provides an expert guide to the diagnosis and management of female urologic disorders
Spermatogenesis involves the coordination of a number of signaling pathways, which culminate into production of sperm. Its failure results in male factor infertility, which can be due to hormonal, environmental, genetic or other unknown factors. This book includes chapters on most of the signaling pathways known to contribute to spermatogenesis. Latest research in germ cell signaling like the role of small RNAs in spermatogenesis is also discussed. This book aims to serve as a reference for both clinicians and researchers, explaining possible causes of infertility and exploring various treatment methods for management through the basic understanding of the role of molecular signaling. Key Features Discusses the signaling pathways that contribute to successful spermatogenesis Covers comprehensive information about Spermatogenesis at one place Explores the vital aspects of male fertility and infertility Explains the epigenetic regulation of germ cell development and fertility Highlights the translational opportunities in molecular signaling in testis
Overactive Bladder: Practical Management provides urologists, gynecologists and other health practitioners with a comprehensive clinical guide to this very common problem, resulting in a perfect resource to consult time and time again. Beginning with an introductory section covering the definition and pathophysiolgy of OAB, it then moves on to cover evaluation, first-line management, second-line management and finally surgery. Well-illustrated throughout, each chapter begins with a key points box outlining the most important take-home messages. Also included are clear management algorithms to aid decision-making, 'Do's and Don't' boxes to help avoid errors made, key references to the top journal articles, and the very latest guidelines from the EAU, AUA and other major urology societies. Chapters are written by the top names in the field and the entire book is expertly edited by Jacques Corcos, John Heesakkers and Scott MacDiarmid. The result is a consistent, comprehensive and fully up to date approach to OAB, providing urologists managing patients with this condition with rapid access, specialist clinical guidance.
Das Standardwerk der urologischen Onkologieaktualisiert in 6. Auflage
Die Uroonkologie" bietet dem Leser vollstandige und umfassende Information zu allen Bereichen des Themas:
alle Grundlagen fur eine erfolgreiche Therapie von Molekularbiologie uber Studienplanung bis zu alternativen Therapieansatzen,
alle Details zur Diagnostik, Indikationen, Durchfuhrung und Ergebnis der verschiedenen Therapieansatze aller urologischen Tumorerkrankungen.
Zusammenfassende Bewertung der Therapien am Ende jedes Kapitels.
NEU: Neugliederung des Inhalts zur besseren Orientierung mit neuen und komplett uberarbeiteten Kapiteln zu Themen wie:
. Inkontinente- und Rektale Harnableitung
. Komplikationsmanagement bei Immun- und Chemotherapie
. Sexualitat und Krebs
Eine praxisnahe, klare Sprache, viele Tabellen und instruktive Abbildungen erleichtern das Lesen. Zahlreiche Therapie- und Nachsorgeschemata sorgen fur eine schnelle Orientierung und ermoglichen die direkte Umsetzung in die tagliche Praxis.
Als Autoren wirken die anerkannten deutschsprachigen Experten zum Thema.
Rubben: Uroonkologie - Das Buch, an dem kein onkologisch tatiger Urologe vorbeikommt "
Male Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia provides urologists of all levels with a practical, highly clinical guide to the variety of different symptoms and problems concerning the male lower urinary tract, including benign prostatic hyperplasia, one of the conditions that urologists most regularly encounter. Evidence-based throughout and written by the world's leading experts in the topic, it comprehensively reviews the very latest in diagnostics and imaging, patient phenotyping, genetic studies, medical and surgical therapies, and lifestyle management in order to help clinicians best manage their patients. Highlights include chapters on: * Alpha-Adrenergic Antagonists for Lower Urinary Symptoms Secondary to Benign Prostatic Hyperplasia * Phosphodiesterase Type 5 inhibitors for Male LUTS * Combination Medical Therapy for Male LUTS * Open Simple Prostatectomy * Minimally Invasive Therapies * Monopolar and Bipolar Transurethral Resection of the Prostate * GreenLight Laser Therapy Containing pitfall boxes and key points throughout to aid quick and easy understanding of the key information, this excellent book is an essential read for the modern-day urologist.
Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research ?ndings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.
Sexual dysfunctions in men, such as erectile dysfunction, ejaculatory disorders, and low sexual desire, are typically sources of significant distress for men. This book, being published with a companion volume on Sexual Dysfunction in Women, provides general therapists with practical, yet succinct evidence-based guidance on the diagnosis and treatment of the most common male sexual disorders encountered in clinical practice. It assumes that mental health professionals and other clinicians without expertise in the field of sex therapy have much to offer these men by combining a multidisciplinary understanding of issues surrounding sexual problems with their general clinical knowledge and expertise. With tables and marginal notes to assist orientation, the book is designed for quick and easy reference while at the same time providing more in-depth understanding for those desiring it. The book can serve as a go-to resource for professional clinicians in their daily work and is an ideal educational resource for students and for practiceoriented continuing education.
Transitional Urology is designed to fill a critical gap that exists in the published literature by comprehensively addressing the urological challenges facing adolescents and adults with complex congenital anomalies of the genitourinary system. It provides a valuable resource to pediatricians and pediatric urologists facing urological management issues beyond their expertise in their aging patients as well as technical guidance to adult urologists who may have had little or no experience caring for patients with a congenital condition. This work will service as a field guide to congenitalism, providing a "how to" approach to guide the urologist using real clinical examples for the most common and challenging urological problems encountered. It also provides a framework for the transition process from pediatric to adult-centered care, with a special emphasis on the multidisciplinary nature needed to provide patient-centered care. Specific conditions that require special consideration, including myelomeningocele, exstrophy, posterior urethral valves, and hypospadias are highlighted. Topics considered common in the general urology practice- like infertility and sexual dysfunction are addressed within the context of patients with neurological or anatomical complexity. In addition, this text reviews urological complaints for which basic clinical algorithms are well-established within the context of a congenitally-abnormal bladder. Chapters discuss how and when special testing like video urodynamnics and positional fluoroscopy may be warranted to provide critical diagnostic guidance. The text also review how typical age-related urological phenomena, like elevated PSA, hypogonadism, and BPH, may present in this subset of patients and how treatment of these conditions may be different than the general population.
Sexually transmitted infections remain a global health concern with the World Health Organization reporting over 340 million new cases of bacterial and protozoal STI every year, worldwide. They are frequently associated with a significant degree of medical and psychological morbidity. This full-colour pictorial guide is a unique, single volume compilation of common diseases in genito-urinary medicine. It covers a wide range of ailments from sexually transmitted infections to dermatological conditions affecting the genito-urinary system. Each high-quality image is accompanied by a clear, concise description to aid diagnosis. As well as providing a diagnostic tutorial for trainees in genito-urinary medicine, this book is a reference for any healthcare professional encountering these diseases. Candidates for the Diploma of Genito-urianry Medicine and the Knowledge Based Assessment in Genito-Urinary Medicine will find this visual compendium invaluable.
"A Doody's Core Title 2012"
"Emerging Cancer Therapeutics" is a trinary, hard cover, periodical that is designed to provide an up-to-date evidence-based review of a dedicated emerging cancer therapy topic of interest to clinicians and scientists who are involved in the care of patients receiving cancer treatment. It will serve as both a reference and instructional tool for students, housestaff, fellows, practicing clinical oncologists, radiation oncologists, surgical oncologists, cancer biologists, and interdisciplinary colleagues throughout the oncology spectrum.
With contributions from experts across the United States and Canada, "Prostate Cancer" details the current management of prostate cancer and reviews new therapies in development for prostate cancer, with an emphasis on castration-resistant prostate cancer (CRPC). Coverage includes discussion of multiple new agents that have been shown to impact overall survival or improve skeletal-related events in metastatic CRPC as well as articles covering new data on screening and prevention, integration of surgery and radiation with newly emerging medical therapies, and coverage of the newest developments in immunotherapy. This book is a valuable tool for clinicians, nurses, researchers, medical students, residents, and fellows.
Included in "Prostate Cancer"
Designed to provide a comprehensive and state-of-the-art overview of the use of urologic catheters and devices in clinical practice. Sections of the book have been structured to review the overall indication for the use of urologic catheters and devices, types available, complications and management. This text fills a critical need for resource materials on these topics. The book also includes highly practical presentations and of typical patients with catheters or devices seen in the clinical practice of geriatric urology, all in the form of case presentations with expert analysis and editorial commentary. Highlighting the integrated multidimensional aspects of care for urology patients, this book is unique in the inclusion of collaborating multidisciplinary authors who are all recognized experts in their field. Written entirely by urologic specialists, Clinical Application of Urologic Catheters, Devices and Products provides a unique and valuable resource in the field of practicing urology, for urologists, nurse practitioners, physician assistants, and for those currently in training.
In this volume, undisputed leading experts from Europe and beyond come together to cover the field of andrology in its entirety, providing a guide that will be of value to urologists and other physicians in their daily clinical practice. It is designed for a wide audience, including both those coming into contact with andrological issues for the first time and more experienced readers requiring updated guidelines and advice on the most controversial and thorny issues. A wide range of topics is covered, including male genital abnormalities, disorders of pubertal development, gender identity disorders, Peyronie's disease, sexual dysfunction, hypogonadism and infertility, urogenital infections, urogenital cancers, and andrological emergencies. Clinical Andrology will prove an invaluable quick consulting tool, rigorous in its scientific content but at the same time easy to read and rich in images and tables.
Bladder injection of onabotulinumtoxinA for the treatment of urinary incontinence due to neurogenic detrusor overactivity has recently been approved by regulatory agencies in several EU countries and by the FDA in the United States. This is the first book to focus on the practical application of botulinum toxin (BoNT) in the genitourinary tract. It covers in detail applications of BoNT in the bladder and the prostate and pelvic floor, with reviews of the latest clinical series and techniques in both adults and children. Appendices containing easy-to-read instructions for patients undergoing bladder and prostate BoNT injections are included, in addition to procedural guidelines for nursing staff. The book is written in a concise, clinically relevant style by two leading pioneers in the field, who were the first to undertake comprehensive basic research into the mechanisms underlying the efficacy and potential uses of BoNT within the lower urinary tract.
Kidney stone is a significant disease with a 12-15% prevalence in the United States. Patients with a history of stones have a 50% risk of making another stone in 5 years or 80% risk in their lifetime. The goal of this book is to educate the reader on the nuts and bolts of stone disease and to provide new and updated information to help them tackle this painful disease.
Management of bladder cancer provides a single, comprehensive reference source that incorporates all the latest information regarding bladder cancer. The text covers epidemiology and natural history of bladder cancer as well as latest findings regarding the genetics and molecular biology of the disease. Diagnostic and staging evaluation of both non-muscle invasive and invasive bladder cancer is discussed. The text incorporates chapters summarizing new findings regarding markers for the diagnosis of bladder cancer and new diagnostic techniques to enhance traditional methods such as cystoscopy. Risk stratified treatment of non muscle invasive bladder cancer including various approaches to intravesical therapy are reviewed. Current guideline based approaches to management and new data regarding diagnosis and prognostication of muscle invasive bladder cancer is analyzed and summarized. The application of chemotherapy for muscle invasive and advanced disease is discussed and the evidence based application of multimodality therapy highlighted. Finally, gaps in current knowledge and areas for future research are highlighted. Ongoing important clinical trials which could imminently yield significant new knowledge is discussed. Authored by experts in their respective fields, Management of Bladder Cancer will serve as a easy and complete reference source for clinicians, researchers, individuals in training, allied health professionals and medical students in the fields of Urology, Medical Oncology, Radiation Oncology, Basic and Translational Science and Epidemiology.
Treatment of Benign Prostatic Hyperplasia: Modern Techniques is an up-to-date review of modern techniques used to treat benign prostatic hyperplasia. It provides a comprehensive review of both office and operating room based techniques. Both electrosurgical and laser based techniques are covered. These include high powered 532 nm laser photoselective laser vaporization of the prostate (PVP), holmium laser enucleation/ablation of the prostate (HoLEP/HoLAP), and Bipolar Electrovaporization of the Prostate (Bipolar EVP/Bipolar TURP). In addition, a comprehensive review of office based techniques and future therapies currently being developed is presented. Each of these techniques are presented in a balanced fashion with a focus on modern literature. Treatment of Benign Prostatic Hyperplasia: Modern Techniques will be of great value to Urologists, Urology Residents, Iternists, and Family Practitioners.
This issue of Radiation Medicine Rounds examines the latest advances in the use of radiation medicine in treatment of prostate cancer Prostate cancer is the most common cancer in males and radiation therapy is a major tool in the management of the disease. This issue of Radiation Medicine Rounds includes reviews of all major recent advances in treatment of favorable, intermediate and high-risk prostate cancer as well as newer modalities such as brachytherapy, stereotactic body radiation therapy, and proton beam radiotherapy. Articles also review current knowledge in the areas of new biomarkers, risk stratification, and risk stratification. This issue of RMR will provide the practitioner with a full current overview of the present best practices and recent research in management of this complex and challenging disease. Radiation Medicine Rounds features:
This book demonstrates knowledge on tissue-based procedures for stress urinary incontinence and other pelvic floor related topics. As the field shifts away from using synthetic material for repair, this work presents a new perspective on native tissue repair from the opinions and research of the authors. Written by a panel of expert authors in the field, this text provides high quality, focused information that is complimented by illustrations and videos. With established track records the authors illustrate how to perform the procedure vaginally or through open surgery, and inclusion of live surgeries via online video, makes this an invaluable tool for busy surgeons and specialists interested in pelvic floor reconstruction.
Research on testosterone is increasing in many senses; however there is still much controversy regarding its physiology and clinical use. This book addresses these topics, providing a broad over view about testosterone, from its basic fea tures to the most recent evidence of clin ical applicability. Also, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. Although not essential for survival, testosterone represents the essence of male biological function, being the important testicular androgen in men. Low serum testosterone levels are asso ciated with cardiovascular morbidity, meta bolic syndrome, type 2 diabetes mellitus, atherosclerosis, osteoporosis, sarcopenia, and mortality. Conversely, increased serum levels of testosterone may lead to deleteri ous events. In general, there is increasing evidence that serum testosterone is a major biomarker status of men's health in general. Testosterone: From Basic to Clinical Aspects is an indispensable reference for all those who seek state-of-the-art knowledge regarding this hormone, from basic issues (including pharma cology and physiology) through clinical aspects (related diseases and supplementation ther apy).
Discusses the practical pathologic diagnoses of tumours and tumour-like diseases of the prostate gland, seminal vesicles, penis, and scrotum. The authors follow the tradition of the preceding three editions by emphasising pathologic gross and light microscopic diagnostic features and differential diagnoses. They also discuss relevant clinical features, including concise sections on the clinical presentation and the clinical meaning of the pathologic diagnosis in terms of prognosis and treatment. The immunohistochemical and molecular pathologic studies that are of current value in diagnosis are clearly presented. The high-quality images follow the rich tradition of the previous editions to depict the spectrum of tumour morphology from cases mainly from the files of institutions such as The Johns Hopkins Hospital, Barnes-Jewish Hospital, and Instituto de Patologia e Investigacion. This Atlas will be of great value in the field of pathology of the prostate gland, seminal vesicles, penis, and scrotum for years to come.
The basic anatomy and physiology of the urinary tract, the validity of animal models and other methodological considerations as well as a range of potential therapeutic targets are comprehensively reviewed by leading international experts, making this a unique reference source for basic scientists and research-minded clinicians alike
This book provides an overview of research and practice dealing with the specific needs of gay and bisexual men living with prostate cancer, as well as the special psychosocial needs of their partners. The intention is twofold: to provide insight into the unique experiences and concerns of gay or bisexual men living with prostate cancer in order to inform and assist future research, clinical practice and supportive care, and policy; and to ensure that the needs of gay and bisexual men are recognized and advanced on the mainstream prostate cancer agenda. Featuring both cutting-edge research and powerful portraits of gay and bisexual men living with prostate cancer, this book will be indispensable for health care, oncology, and mental health practitioners who seek to address their specific experiences and challenges.
This book, now in an extensively revised second edition, provides an exhaustive review of the state of the art in the management of prostate cancer, from screening to treatment, with emphasis on a multidisciplinary approach. The editors are very excited about the outstanding new or updated contributions from the different expert authors. The opening chapters address basic aspects including epidemiology, pathology, biology, genetics, and chemoprevention. The role of individual and mass screening is carefully appraised, and extensive attention is devoted to diagnosis and clinical work-up by means of recently implemented investigations such as multiparametric MRI and choline PET-CT. The use of active surveillance is examined in detail. Subsequent chapters discuss the different therapies that may be employed: open and minimally invasive, including robot-assisted, radical prostatectomy, the various forms of radiation treatment, high-intensity focused ultrasound, cryotherapy, hormonal manipulations, chemotherapy, targeted therapies, and immunotherapy. Up-to-date results from practice-changing phase III randomized clinical trials are included and special insights are provided into the interpretation of results and the patient's perspective.
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