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Late Graft Loss - Proceedings of the 28th Conference on Transplantation and Clinical Immunology, 3-5 June, 1996 (Hardcover, 1997 ed.)
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Late Graft Loss - Proceedings of the 28th Conference on Transplantation and Clinical Immunology, 3-5 June, 1996 (Hardcover, 1997 ed.)
Series: Transplantation and Clinical Immunology, 28
Expected to ship within 10 - 15 working days
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In all varieties of organ transplants, early results have
dramatically improved over the past two decades and failures due to
acute rejection are becoming rarer. Efficient immunosuppressive
regimens have been developed with the objective of very good
results at 1, 3 and 5 years. Successful transplants, however, are
significantly less frequent at 10 and 20 years, and many patients
require retransplantation. Many factors are involved in late graft
loss and it is now well recognized that, in addition to chronic
rejection, a number of non-immunologic factors play a prominent
role. In the case of renal transplantation, a reduced mass loss
(transplantation of a single kidney, sometimes from an aged donor,
ischemic injury and alteration of some nephrons in the case of
early acute rejection) will result in slowly progressing chronic
renal failure, even in the absence of any supplementary attack of
an immunological nature. The new treatments must be analyzed in the
light of their capacity to reduce these late failures. Several
preventive measures can also limit both immunologic and
non-immunologic factors of late transplant deterioration.
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