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Fully updated for the second edition, these handy pocket-sized study cards remain an innovative and versatile revision solution. Containing vital techniques and tips, the study cards condense revision into short essential bursts. Ideal for revising quickly on the move, students can also use them when carrying out examinations, or as a reminder before ward rounds and teaching sessions. Arranged into clear sections, the cards allow the reader to find and digest topics easily, whilst full colour illustrations aid quick and confident diagnoses. Taking a system-based approach, the set covers all essential diseases and syndromes in just 166 double-sided cards. Each card first describes the clinical examination and symptoms, before covering the need-to-know essentials: aetiology, indications, differential diagnoses, complications and suitable investigations. The final part of each card covers the treatment or management of the disease.
Kidney transplantation from a living donor provides the best chance for successful renal replacement therapy. However patient's safety remains of paramount importance and complications are unacceptable. Laparoscopic donor nephrectomy (LDN) has been proven to have a lower surgical mortality and morbidity as well as a lower blood loss, a shorter hospital stay, and a better cosmetic result compared to the open procedure. This has resulted in LDN being considered the standard in many centers. Robot-Assisted Laparoscopic Donor (RALD) nephrectomy is a new trend developed in the last decade. Robotic assistance is increasingly popular worldwide, because it offers optimal operative conditions to the urological surgeon and a shorter learning curve than the standard laparoscopy.
This book presents a comprehensive and instructive management plan for physicians who care for CKD patients. Basic aspects of CKD, clinical assessment, evaluation and management of risk factors, cardiovascular disease in the context of CKD, assessment and management of CKD complications, special circumstances in CKD patients, and the path to renal replacement therapy are all thoroughly covered. Diagnostic and therapeutic approaches are presented according to the latest staging system for CKD, with patient care being discussed separately for each disease stage. The proposed management plan is both "best available evidence based" and "practice based." The book also recognizes the needs of busy clinicians by including helpful boxes summarizing the evidence on diagnostic and therapeutic issues and practice pearls based on guidelines. The authors are recognized experts from across the world, ensuring global coverage of the problem, and most have participated in writing guidelines on CKD.
This manual will meet the everyday needs of the wide range of medical professionals who play a role in the treatment of children referred to hospital because of renal disease. It is an easy-to-use, portable guide that will assist pediatricians, residents, and trainees in making prompt first-level management decisions. It will also prove invaluable for the adult nephrologists who care for children in many developing countries, and will serve as a teaching guide for experts when training non-subspecialists. Individual sections are devoted to the evaluation of renal disease; fluid, electrolyte, and acid-base disorders; glomerular diseases; tubular disorders; congenital, inherited, and urological disorders; consequences of renal disease; and miscellaneous topics. The text is in a bulleted format with tables and algorithms wherever possible, making it straightforward and easy to read. An appendix includes further important information such as normal values, drug dosages, and drug nephrotoxicity.
The aim of this guide is to provide clinicians with practical reference for the management of hypertensive patients with other cardiovascular risk factors, which originate from impaired metabolic functions. With the aid of carefully selected, paradigmatic case studies, the physician will find sound advice for the best approach to common but often under-recognized clinical situations, and answers to practical questions that arise when a specific condition is not directly addressed in the guidelines. Question-and-answer sections will help the reader to identify at a glance the most complex steps in the diagnostic and therapeutic process. In a "real world" clinical setting, the hypertensive patient rarely presents with hypertension as the only cardiovascular risk factor, and is more likely to be affected by other metabolic risk factors, such as impairment of lipid metabolism, glucose homeostasis, and purine metabolism, and by overweight or obesity. These cases will serve as a basis for analyzing best practice, highlighting problems in diagnosis and treatment, and selecting the most appropriate management of patients with metabolic risk factors in everyday practice.
This book discusses the latest findings on the pathogenesis and treatment of IgA nephropathy. It particularly focuses on recently recognized initiation and progression factors and the varying treatment strategies in different regions, such as Asia, Europe, and the United States. More than 40 years have passed since Dr. Jean Berger first described primary IgA nephropathy ("Nephropathy with mesangial IgA-IgG deposits") as a new disease entity. Immunohistopathologically, IgA nephropathy is characterized by the granular deposition of IgA (IgA1) and C3 in the glomerular mesangial areas with mesangial cell proliferation and the expansion of mesangial matrices. It is clear that IgA nephropathy is one of the most common types of chronic glomerulonephritis in the world. This disease may lead to end-stage kidney disease, with its enormous economic impact on healthcare everywhere. Efforts by many investigators around the world have gradually clarified various aspects of the pathogenesis and treatment of IgA nephropathy. However, there are many controversial strategies for the treatment of patients with IgA nephropathy throughout the world, as there are several limitations for treatment in each country. This volume provides nephrologists everywhere with an overview and comparison of both global and regional findings in basic and clinical fields in IgA nephropathy. It covers genetic variation, aberrant IgA1 production, and classification etiology, guidelines, and treatment goals, with all chapters written by top international researchers.
"Fundamentals of Renal Pathology" is a compact and up-to-date resource on the basics of renal pathology that will be of particular value for residents and fellows in training in renal pathology, general pathology, and nephrology, but will also serve as a handy reference for the more experienced. This second, revised and updated edition of the book offers an integrated approach based on contributions from established experts in the field. Key diseases are discussed within the context of clinical presentations, with the emphasis on clinicopathological correlation and differential diagnosis. Topics discussed include glomerular diseases with nephrotic or nephritic syndrome presentations; systemic and vascular diseases affecting the kidney, including diseases affecting the renal transplant; tubulointerstitial diseases; and plasma cell dyscrasias and associated diseases. Well-chosen color illustrations and electron micrographs enhance and complement the text.
This guide is structured to assist physicians in the management of those hypertensive patients who present with specific comorbidities, such as diabetes, systolic dysfunction, obesity, renal disease, or previous cardiac events, often associated with hypertension. The clinical cases contained in this book have been selected to provide a paradigmatic set of scenarios frequently encountered in daily clinical practice, and will serve as an easy-to-access tool in applying general guidelines to individual patients, particularly in the choice of the most appropriate antihypertensive therapy. Treatment of hypertension with associated clinical conditions require specific therapies and combinations of drugs, which are necessarily different from one comorbidity to another. By discussing exemplary cases that may better represent clinical practice in a "real world" setting, and analyzing step by step the diagnostic and therapeutic process, this book will assist cardiologists and physicians in selecting the diagnostic tools and forms of treatment best suited to the individual patient and the particular cardiovascular risk profile.
Owing to demographic trends and medical progress, the number of patients requiring renal replacement therapy is increasing steadily. Longer survival on hemodialysis also means that surgeons have to face more complex and challenging situations regarding life-sustaining access vessels. This book offers a comprehensive overview of up-to-date knowledge on vascular access surgery. Written by a senior author with more than 30 years of experience and by expert contributors, it covers both surgical and theoretical aspects. The author shares his expertise in a hands-on approach, and presents his views on the difficulties that every clinician may encounter. The various options for vascular access creation are carefully reviewed. Detailed descriptions and numerous accompanying illustrations of AV fistulas, AV prosthetic grafts, and arterioarterial grafts are provided, and a chapter is also devoted to the use of central venous catheters. Potential complications and their management are explained in depth, and advice is offered on how to deal with special patient groups requiring extra attention. Separate chapters on fluid dynamics (drawing on the author's own research) and vascular pathology cater for the needs of those with a particular interest in the pathophysiological principles.
"Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis" provides a comprehensive review of cytology and all the morphologic correlates, including their respective limitations, related to a broad spectrum of renal neoplasms with special emphasis on cyto-histo correlation. The book also discusses related usual radiologic appearances, gross features and possible targeted therapies where appropriate. The volume features an integrated approach that provides step-by-step guidance in the morphologic evaluation of renal neoplasms. Furthermore, all chapters are written by experts who deal with this type of specimen in their daily practice and have insights into the pathology as well as the clinical aspects of these tumors.
Illustrated with high quality color microphotographs and formatted for ease of use in the lab, R"enal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis"is a helpful guide to everyday pathology practice, especially for pathologists who rarely encounter this type of specimen."
Nearly all patients with chronic kidney disease (CKD) have at least one significant dermatologic manifestation. This all-inclusive reference covers the wide array of cutaneous manifestations attributable to CKD, kidney transplantation and the pharmacological aspects of the disease process. Each chapter provides pathobiology, extensive clinical discussions, full-color images and in-depth treatment options. Dermatological Manifestations of Kidney Disease helps the practitioner, nephrologist, resident and student recognize, appropriately evaluate and treat these conditions more effectively.
This volume, written by well-known experts in the field, covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer's series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg-Strauss syndrome). This volume will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these diseases.
If you want to know more about chronic kidney disease (CKD), this introductory booklet is for you. Many people have CKD, but most of them feel perfectly well and will never develop kidney failure. However, your kidneys have important jobs in the body. They clean your blood, regulate the chemical balance of your body and keep your blood pressure normal. So if there is anything wrong with your kidneys, your blood pressure may rise. High blood pressure increases your chances of having a heart attack,heart failure or a stroke. This is why it is important to look after yourself if the doctor discovers you have CKD. This booklet tells you how to take control of your body and protect your circulation. At the end of the booklet, you will find a `jargon busting' section to help explain medical terms. There is also information about finding out more, either from books or online.
This booklet is an introduction to home haemodialysis. Haemodialysis is a treatment for kidney failure that uses a machine to filter the blood through an artificial kidney. Haemodialysis can be done in hospital or renal unit, but there are many differences between home and hospital treatments and different things to think about. So this booklet is to give you and your family more information about having dialysis at home. This can be useful to allow you to be involved and in charge of making choices about the type of dialysis you might have. To understand the information here fully, it's good to know a bit about kidney failure dialysis first. There are other places where you can get information; some of these are listed near the end of the booklet.
Overcome the toughest clinical challenges in nephrology with Brenner & Rector's The Kidney -- the most well-known nephrology resource in the world. A diverse team of more than 200 international contributors brings you the latest knowledge and best practices on every front in nephrology worldwide. From basic science and pathophysiology to clinical best practices, Brenner & Rector's The Kidney is your go-to resource for any stage of your career. Review of the basic science that underpins clinical nephrology, comprehensive selection of the most important bibliographical sources in nephrology, and Board Review-style questions help you prepare for certification or recertification. Coverage of kidney health and disease from pre-conception through fetal and infant health, childhood, adulthood, and into old age. Expanded sections and chapter on global perspective and ethical considerations. Uniform terminology and nomenclature in line with emerging consensus in world kidney community. More than 700 full-color high-quality photographs as well as carefully chosen figures, algorithms, and tables to illustrate essential concepts, nuances of clinical presentation and technique, and decision making provide a visual grasp and better understanding of critical information. Internationally diverse, trusted guidance and perspectives from a team of well-respected global contributors. An editorial team headed by Dr. Skorecki and handpicked by Dr. Brenner ensures the ongoing adherence to previous standards of excellence. All chapters have been extensively updated or entirely rewritten by authorities in their respective fields. The latest clinical information including recent clinical trials, genetic causes of kidney disease, cardiovascular and renal risk prediction in chronic kidney disease, new paradigms in fluid and electrolyte management, and pediatric kidney disease, keep you current with the rapid development of care and research worldwide. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices. The must-have resource for mastering all areas of nephrology, extensively revised and with new global experts. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. A complete guide to every aspect of interventional nephrology-an essential text for students, residents, fellows, and clinicians A Doody's Core Title for 2017! This timely resource examines all relevant aspects of interventional nephrology, from the history of nephrology to the principles governing the latest vascular access techniques. Heavily illustrated with full-color procedural drawings and featuring an easy-to-follow design, the book includes contributions from many leading authorities in the field whose insights combine to form an unprecedented, clinically rigorous survey of interventional nephrology. Interventional Nephrology opens with an instructive look at the origins of hemodialysis access; an overview of the history of interventional nephrology in the U.S. and abroad; and clinically relevant coverage of vascular access outcomes. The high-yield coverage continues with a probing assessment of ethics, public policy, and practice guidelines, illuminating such pivotal topics as industry partnerships and conflicts of interest. The principles that support interventional nephrology techniques are also extensively reviewed, encompassing everything from vascular mapping to peritoneal dialysis catheter removal, while the following section delves into the key surgical aspects of vascular access. Finally, the book provides useful perspectives on how political and policy affairs impact current practice. FEATURES Illustrated with precise full-color drawings and radiographs that highlight both normal and vascular anatomy and clarify the management of vascular access problems Streamlined design and helpful pedagogy, including chapter-opening learning objectives, numerous tables, and concept-clarifying figures Complete overview of the core principles underlying interventional nephrology practice and techniques, covering vascular mapping, monitoring and surveillance of arteriovenous access, venous angioplasty, tunneled catheters, renal ultrasonography, and much more Discussion of vascular access in special populations and the role of pharmacologic agents in preserving vascular access provides evidence-based insights that are pertinent to the everyday practice of interventional nephrology In-depth emphasis on the surgical aspects of vascular access reviews sites, types, and creation of arteriovenous fistulae; secondary arteriovenous fistula; and surgical options for vascular anomalies Forward-thinking coverage of basic and translational science considers future directions in vascular access science; flow dynamics, maturity, and access failure; neointimal hyperplasia; pharmacologic prevention of access dysfunction; and device innovation
This practical guide provides the reader with answers to important clinically relevant questions regarding the evaluation and management of acute kidney injury (AKI). All aspects of critical care nephrology are covered, from pathophysiology and diagnosis to prevention and treatment. The questions considered relate to a wide range of issues, such as: How do I diagnose AKI? How can I protect the kidney in clinical practice? How do I manage patients with AKI? When should I initiate and how do I perform renal replacement therapy (RTT)? Which type of RTT is most appropriate for my patient? Should I give specific nutrients? In addition to providing practical guidelines and treatment algorithms, the book includes calculators for continuous RRT and anticoagulant dosing. The authors are internationally renowned experts in the fields of Intensive Care Medicine and Nephrology and all contributions are written in a clear and concise style and have been peer reviewed. Acute Nephrology for the Critical Care Physician will serve as a very useful source for intensivist internists, anesthesiologists and nephrologists involved in the management and treatment of critically ill patients at risk of or affected by AKI.
This issue of Emerging Cancer Therapeutics provides a comprehensive review for practitioners on the current status of renal cancer treatment. Renal cancer treatment has undergone major changes over the course of the past few years and "Renal Cancer" addresses current best practices in the light of the most recent evidence. All of the chapters are written by international experts in the field, address the common clinical scenarios in renal cancer and are multidisciplinary in scope covering surgical, medical, and radiation therapy. Chapters examining emerging and novel therapeutic targets, the management of both CNS, and skeletal metastases in renal cancer round out the coverage. Emerging Cancer Therapeutics features:
Editorial board of nationally recognized experts across the spectrum of Cancer Therapeutics In-depth, up-to-date expert reviews and analysis of major new developments in all areas of Cancer Therapeutics Issues edited by an authority in specific subject area Focuses on major topics in Cancer Therapeutics with in-depth articles covering advances in clinical and translational research developments, as well as clinical applications and experience Emphasizes multidisciplinary approaches to research and practice
This issue is a dedicated supplement published in addition to the regular issues of 'American Journal of Nephrology' focussing on one specific topic. 'American Journal of Nephrology' is a well-respected, international peer-reviewed journal in nephrology. Supplement issues are included in the subscription.
This book describes the techniques, strategies, and drugs that have been demonstrated by at least one paper published in a peer-reviewed journal to significantly influence survival in patients with or at risk for acute kidney injury. Each chapter focuses on a specific intervention. The scope is accordingly wide, with coverage of topics as diverse as the type, timing, and dose of renal replacement therapy (RRT), anticoagulation and specific indications for RRT, perioperative hemodynamic optimization, fluid balance, diuretics, colloids, fenoldopam, terlipressin, N-acetylcysteine, and vasopressin. A variety of settings are considered, including critically ill patients, cardiac surgery, and hepatic and hematologic disorders. The topic selection was made using a democracy-based approach in which hundreds of specialists from dozens of countries expressed, via the web, whether they agreed with these topics and whether they used the techniques in their daily clinical practice. The clear text is supported by "how to do" sections and "key point" boxes that provide easily accessible practical information. The book will be of interest for a wide variety of specialists, including intensivists, nephrologists, emergency doctors, and anesthesiologists.
This volume focuses on cadmium (Cd) exposure, its effects on human health, the mechanism of Cd accumulation and the development of mitigation technologies. Further, it discusses clinical, epidemiological, agricultural, toxicological, and biochemical aspects of Cd pollution and presents recent biochemical studies on molecular mechanisms of Cd cytotoxicity and cellular transport as well as the mechanism of Cd-induced disturbances in phosphorus (P) metabolism. It also provides insights into the pathophysiology of itai-itai disease, a serious condition caused by Cd pollution. Cadmium -New Aspects in Human Disease, Rice Contamination, and Cytotoxicity- is a valuable resource for scientists involved in heavy metal toxicology, botanical sciences, and regulatory sciences. Addressing the features of Cd pollution in the past and in the present, as well as future perspectives, this is a must-have book for students, researchers and practitioners interested in global and local metal pollution.
This comprehensive, easy to read reference addresses the clinical implications of congenital anomalies of the kidney and urinary tract (CAKUT) in children. Authored by a panel of internationally recognized pediatric nephrologists and urologists, chapters discuss clinical presentation, workup, interpretation of imaging studies, genetics, prenatal diagnosis, prevention and treatment of various anomalies to help the practitioner understand, diagnose and manage CAKUT. Tables, figures, algorithms and an extensive appendix listing conditions and syndromes associated with CAKUT are featured to assist physicians in the differential diagnosis and workup of different conditions.
This book provides a comprehensive review of diagnosis and treatments of renal cell carcinoma (RCC) for practitioners and researchers with an interest in this disease. A major aim of the book is to present the most important and most recent advances in molecular bases and targeted therapy for this neoplasm. The remarkable resistance to chemotherapy and radiotherapy and the minimum contribution of cancer genes that commonly mutate in other adult epithelial cancers have made RCC highly distinct from other types of solid neoplasms. In the past decade, however, treatment options for RCC have been expanding and moving quickly toward laboratory-based and molecular-targeted therapies. Advances in RCC therapy also have brought novel treatment options to other types of cancer, such as a TKI for hepatocellular carcinoma and gastrointestinal tumors, as well as mTOR inhibitors to progressive neuroendocrine tumors of pancreatic origin and to breast cancer, suggesting that RCC is no longer an "orphan disease" in the field of molecular oncology. Additional topics covered in the book include pharmacokinetics and pharmacodynamics in molecular-targeted agents and the putative mechanism of resistance to anti-angiogenic agents, such as intratumoral heterogeneity or cancer stem cell population. This volume provides the latest and most useful information for all readers who are eagerly devoted to curing renal cell carcinoma.
In this chapter, the term 'renal osteodystrophy' will be used in a generic sense to include all the clinical syn- dromes of skeletal disease and altered calcium (Ca) and phosphorus (P) homeostasis resulting from chronic renal failure (CRF). The skeletal pathology can include osteitis TAHQgT 0BQAN8 fibrosa and other features of secondary hyperparathy- OUT roidism, osteomalacia, aplastic or adynamic bone disease, PARATHVnOO QLAND osteoporosis, osteosclerosis, and in children, retardation of growth. Emphasis will be placed on the manifestations Figure I. Schema showing the conversion of vitamin D3 (D3) of these syndromes that occur in patients on maintenance to 25-hydroxyvitamin D3 (25(OH)D3 or calciferol) in the liver dialysis with a consideration of pathogenesis, prevention and subsequently to 1,25 dihydroxyvitamin Dj (l,25[OH)2D3 and management. or calcitriol) in the kidney. Vitamin D through a specific action on collagen metabolisnh. There The term, vitamin D, is used to include vitamin D, or are also cellular receptors for calcitriol in the parathyroid cholecalciferol, the naturally occurring sterol present in glands, pancreas, kidneys, and salivary glands, although animals, and vitamin D, or ergocalciferol, a sterol gener- its action in these tissues are uncertain. Recently, calcitriol ated through the ultraviolet irradiation of plant precursors.
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