Despite the rising popularity of the minimally invasive laparoscopic option, open nephron-sparing surgery is still seen by many experts as the 'gold standard' for open surgery for kidney tumors and should remain the first choice for many patients. This challenges the idea that less-invasive therapies are always more desirable than open surgery. While laparoscopic nephron-sparing surgery may be a more attractive option for treating small, easily accessible kidney tumors, for large tumors this is not always the case. Nephron-sparing surgery is a outstanding text that analyses all forms of surgery, open or laparoscopic, as well as providing a backdrop on renal cell carcinoma in general, and the complications and outcomes following surgery that both surgeon and patient will face. Featuring 100 colour photos, the text includes chapters on: Imaging renal masses: current status Open nephron-sparing surgery for renal cell carcinoma Minimally invasive approaches for renal cell carcinoma: an overview Laparoscopic partial nephrectomy Controversies in nephron-sparing surgery Renal cell carcinoma: long-term outcome following nephron-sparing surgery Dr Sasidharan and Professor Soloway have created a superb text covering all aspects of nephron-sparing surgery that should provide excellent guidance for all those who are just beginning to perform nephron-sparing surgery or act as an aide-memoire for those familiar with nephron-sparing surgery.

The last few years have seen major advances in all aspects of the understanding and treatment of kidney cancer, particularly the commonest variant clear cell carcinoma of the kidney. This book brings the reader up to date with these developments, covering aetiology, epidemiology, pathogenesis, prognostic factors, presentation, interventional radiology, minimally invasive surgery, surgery for locally advanced tumours and for metasatic disease, adjuvant medical therapies, therapies for advanced disease, radiotherapy and palliation of symptoms. Each chapter is written by acknowledged experts in the field. The reader gains an excellent idea of the state of the art in the treatment of kidney cancer in an accessible format.

Formulated by members of the International Scientific Committee of Radionuclides in Nephro-urology (ISCORN), Functional Imaging in Nephro-urology is not a textbook on uronephrology or radionuclides in nephro-urology, or even a book on new techniques in imaging. What the editor and authors provide here is a unique opportunity to evaluate the strategic management techniques (both diagnosis and follow-up) of a number of uronephrological entities.
Demonstrating the experience of the authors in using various imaging modalities, and detailing the benefits and controversies which are associated with their clinical applications, this text presents management strategies based on the patient, the choice of modality, and cost implications.
Detailed, well-referenced and highly illustrated, this is an important book for radiologists, nephrologists and urologists working with children and adults, specialists in renal nuclear medicine, and pediatricians.

With detailed contributions and research from experts, this reference supplies an abundance of information on acid-base physiology, disorders of acid-base equilibrium, and the management and treatment of these disorders in clinical practice. A unique and timely resource, this guide provides a large number of tables, references, and figures to illustrate the relationship between the underlying physiology and diagnosis of acid-base disorders. Reviewing current information on the pathophysiology of acid-base disorders from both a molecular and integrative perspective, the book provides straightforward guidelines for the diagnosis and management of disturbances of acid-base homeostasis.

A much-needed, up-to-date guide to the clinical management of kidney disorders in children and adolescents, this text presents the essentials of diagnosis and treatment in this important field, with an indication of when referral to, or consultation with, the pediatric nephrologist is needed.

With a team of international contributors who have had a significant global impact on the development of pediatric nephrology, this user-friendly resource takes the findings of specialists to a much wider audience in training and in primary care.

This text, the proceedings of the 32nd International Conference on Transplantation and Clinical Immunology, held in Lyon, France, on May 25-26, 2000, addresses novel issues in terms of changing indications for transplantation in the management of organ failure, whether humans will remain the only source for organ procurement, prospects for engineering in organ replacement, and whether transplantation will remain the most appropriate approach to organ failure. Some promising treatments are approached, such as enzymic and biochemical replacement, gene therapy, tolerance induction, stem cell transplantation, and xenotransplantation. In addition to the constant improvement in conservative management of organ failure in general, ongoing research in selected fields is reported in the proceedings, such as: liver transplantation vs artificial liver; novel dialysis strategies vs evolving immunosuppression in kidney transplantation; islets transplantation and external implantable insulin pumps vs pancreas transplantation in diabetic patients and circulatory assistance and intramyocardial myoblast injection vs heart transplantation. Pivotal experience in selected emerging transplantations is included, that is, small bowel, limb, skin and neuronal transplantation. Such fascinating perspectives raise medical, economical, and ethical problems which are discussed in this book.

This book provides a current understanding of Continuous Renal Replacement Therapies (CRRT) techniques with a focus on drug dosing in critically ill children receiving CRRT. Strategies include the role of therapeutic drug monitoring, effect of CRRT on drug pharmacokinetics, variations in the drugs properties, newer kidney injury biomarkers and simple and easy methods for estimating drug clearance. The conclusion of this book features case reports focused on the patients' symptoms and laboratory data as they present in clinical practice and the type of CRRT modality needed to provide quality, safety, and cost-effectiveness of patient care. Pediatric Continuous Renal Replacement Therapy will expand the clinical knowledge and experience of practicing nephrologists and other professionals involved in the care of children suffering from Acute Kidney Injury (AKI) to improve and sustain their quality of life.

Diabetes and the Kidney provides endocrinologists and nephrologists of all levels with expert clinical diagnosis and management guidance for this extremely common diabetic complication.

Practical and accessible, chapters contain text features such as case histories, potential pitfall boxes, key points, management algorithms, and useful weblinks to fully engage the reader and provide expert guidance to help clinicians best manage their patients. In addition, all relevant international society guidelines and recommendations are fully included.

After an initial analysis of the epidemiology and pathogenesis of kidney complications in diabetes, it quickly moves on to the following core sections:

- Special Situations, Risk factors and Complications - examining diabetic nephropathy in relation to each other diabetic complication, ie cardiovascular disease- Prevention and Therapy - focusing on the most up to date information regarding prevention, diagnosis, treatment, and management of kidney disease in diabetes.

Expertly edited, and with contributions from an experienced international team, Diabetes and Kidney Disease will be the perfect tool to consult when managing diabetic patients with associated kidney problems.

The present volume provides overviews of aging and changes in renal function over time; it devotes chapters to renal parenchymal disease and urinary tract infections; and the sections on geriatric urology cover urinary incontinence and urinary-tract neoplasm, including prostatic cancer. The book summarizes current information on renal replacement therapy in the elderly and reviews such important topics as hemodialysis, peritoneal dialysis, fluid and acid-base abnormalities as they are seen in older patients, and transplantation in the elderly. Concerning medical care of older nephrology patients, the contributors have reviewed the management of hypertension, current understanding of glomerular disease, current approaches to the diabetic with renal disease, and use of antineoplastic and antimicrobial therapy, all in these special patients. They discuss the prevention of renal failure in older patients, both in diagnostic and therapeutic aspects, and examine sexual dysfunction and indications for surgery in the older patient with obstruction. Finally, the text examines such ethical issues as the use of advanced directives and the allocation of scarce resources.

For more than 30 years, the highly regarded Secrets Series (R) has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Hypertension Secrets, 2nd Edition, offers practical, up-to-date coverage of the full range of essential topics in this dynamic field. This highly regarded resource features the Secrets' popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style - making inquiry, reference, and review quick, easy, and enjoyable. The proven Secrets Series (R) format gives you the most return for your time - succinct, easy to read, engaging, and highly effective. Covers the full range of pathophysiology, natural history, and diagnosis and management of hypertension for in-training or practicing professionals. Fully revised and updated, including protocols and guidelines that are continuously evolving and that increasingly dictate best practices. Includes chapters on obstructive sleep apnea; drug- or alcohol-induced hypertension; hypertension and diabetes, the obese individual, African Americans, the elderly, thyroid disorders, and pregnancy; and the role of device therapy. Top 100 Secrets and Key Points boxes provide a fast overview of the secrets you must know for success in practice and on exams. Bulleted lists, mnemonics, practical tips from global leaders in the field - all providing a concise overview of important board-relevant content. Portable size makes it easy to carry with you for quick reference or review anywhere, anytime. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

For more than 30 years, the highly regarded Secrets Series (R) has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Nephrology Secrets, 4th Edition, features the Secrets' popular question-and-answer format that also includes lists, tables, and an easy-to-read style - making reference and review quick, easy, and enjoyable. The proven Secrets (R) format gives you the most return for your time - concise, easy to read, engaging, and highly effective. Covers the full range of essential topics in nephrology for in-training or practicing professionals. Written and fully updated by global experts and thought leaders in nephrology. Top 100 Secrets and Key Points boxes provide a fast overview of the secrets you must know for success in practice and on exams. Portable size makes it easy to carry with you for quick reference or review anywhere, anytime. New chapters on home dialysis, onco-nephrology, and palliative care nephrology. Fully updated throughout, with clear illustrations, figures, and flow diagrams that expedite study and review. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

This book details protocols on classical methods and very modern ex vivo mammalian developmental kidney model systems. Chapters focus on generation of mosaic embryonic kidneys, culture of the kidney tissues ex vivo, embryonic kidney progenitor cell, 3Dkidney model cell line based cultures, programming the kidney cell fates in human pluripotent cells, protocols to target the functional players in kidney ontogenesis, 4D and 3D ex vivo imaging, drosphila, and computational approaches to kidney ontogenesis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Kidney Organogenesis: Methods and Protocols aims to ensure successful results in the further study of this vital field.

The need for adequate means by which to improve urine output is very old. Even in the "Scuola Salernitana," the oldest medieval medical school in Western Europe, about 1000 years ago it was taught how to improve urine output. The list of known "diuretica" included herbs, plants, roots, vegetables, in particular asparagus, fennel and carrot. The first diuretic drugs, however, were mercurial compounds. Thus, calomel, mercurous chloride, was initially used as a diuretic in the sixteenth century by Paracelsus, being one of the ingredients of the so-called "Guy's Hospital pill." But calomel had a cathartic effect so that it was replaced by organic mercurial compounds. These diuretics were clearly toxic. After the discovery of the car bonic anhydrase, in the early 1930s, and the introduction of sulfanilamide as a chemotherapeutic agent, it was observed that this drug was inhibiting carbonic anhydrase in vitro and urinary acidification in vivo thereby causing metabolic acidosis; urine output, however, appeared to increase. Subsequent studies led to the synthesis of more potent analogs, in particular acetazolamide. Studies on car bonic anhydrase inhibitors led to the synthesis of benzothiadiazides which disclosed much less inactivating action on carbonic anhydrase and much more diuretic effect through an inhibition of tubular transport of sodium and chloride. Chlorothiazide was the first member of this class of diuretics. Thiazides are still used in clinical practice."

Put the world's most well-known kidney reference to work in your practice with the 11th Edition of Brenner & Rector's The Kidney. This two-volume masterwork provides expert, well-illustrated information on everything from basic science and pathophysiology to clinical best practices. Addressing current issues such as new therapies for cardiorenal syndrome, the increased importance of supportive or palliative care in advanced chronic kidney disease, increasing live kidney donation in transplants, and emerging discoveries in stem cell and kidney regeneration, this revised edition prepares you for any clinical challenge you may encounter. Extensively updated chapters throughout, providing the latest scientific and clinical information from authorities in their respective fields. Lifespan coverage of kidney health and disease from pre-conception through fetal and infant health, childhood, adulthood, and old age. Discussions of today's hot topics, including the global increase in acute kidney injury, chronic kidney disease of unknown etiology, cardiovascular disease and renal disease, and global initiatives for alternatives in areas with limited facilities for dialysis or transplant. New Key Points that represent either new findings or "pearls" of information that are not widely known or understood. New Clinical Relevance boxes that highlight the information you must know during a patient visit, such as pertinent physiology or pathophysiology. Hundreds of full-color, high-quality photographs as well as carefully chosen figures, algorithms, and tables that illustrate essential concepts, nuances of clinical presentation and technique, and clinical decision making. A new editor who is a world-renowned expert in global health and nephrology care in underserved populations, Dr. Valerie A. Luyckx from University of Zurich. Board review-style questions to help you prepare for certification or recertification. Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

Concise, thorough, and easy to use, Handbook of Nephrology and Hypertension 7th Edition, provides authoritative guidance on diagnosing and treating patients with a wide range of kidney disorders and hypertension, including coverage of dialysis and transplantation. Lead editor Dr. Christopher Wilcox and his team of section editors Drs. Michael Choi, Limeng Chen, Winfred N. Williams, and Mark S. Segal oversee a group of expert authors, both faculty and fellows, who focus on common problems and challenges in this complex field. Brief, focused chapters contain abundant figures and algorithms and have been updated to reflect new findings in renal cystic diseases, new drugs used for hypertension, transplantation and renal protection, and much more. Includes new chapters on Urinalysis and Hematuria, Hypertensive Nephropathy, Drug Use in Kidney Disease, Resistant and Secondary Forms of Hypertension, and Medical Reimbursement and Economics of Nephrology Practice Contains dedicated chapters on drugs for edema, hypertension, and glomerulonephritis, as well as drugs pertaining to renal transplant, covering how to select and use drugs, doses, and adverse effects, and how prescribing should be altered in patients with renal insufficiency Features a new four-color design and more figures and algorithms throughout Shares the experience and knowledge of distinguished international authors from top universities in both the U.S. and China, with many chapters co-authored by a faculty and a fellow Enrich Your eBook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech.