Organogenesis of the kidney has been intensely studied for over a century. In recent years advances in molecular techniques have not only made great inroads into exploring the genetic regulation of this complex process but also began to unravel the molecular basis of many forms of congenital kidney disease. This book is a comprehensive study on these findings and the only book available with such in depth coverage of the kidney.
Key Features
* Hundreds of color figures depicting key events in all aspects of kidney development
* Full coverage of the genetic and cellular basis of kidney development
* Analysis of the genetic basis of the major congenital kidney diseases

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in diabetes, kidney and wound treatment. All chapters are contributed by pre-eminent scientists in the field and covers such topics as stem cells and cell therapy in the treatment of diabetes mellitus, kidney failure, wound and other skin aging diseases, characteristics of some kinds of stem/progenitor cells for therapy, future directions of the discussed therapies and much more. Pancreas, Kidney and Skin Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Dr. John Kellum has assembled an essential update on the topic of Nephrology as it relates to Critical Care Medicine. Articles include: Diagnostic criteria, Biomarkers for AKI, Sepsis-induced AKI,Drug-induced AKI, Cardio-renal syndrome,Surgery Associated AKI,Contrast-induced AKI, Principles of Fluid Therapy,Fluid composition and clinical effects, Renal replacement therapy, and Understanding acid-base.

Welcome.- Elliott F. Osserman In Memoriam.- The 1990 Guidelines for Nomenclature and Classification of Amyloid and Amyloidosis.- I Protein Aa/Saa and Secondary Amyloidosis.- The Human Saa Genes and Their Regulation by Cytokines.- Genetic Isofocusing Variant of Human Serum Amyloid A.- Sequence Analysis of a Third Human Saa Gene.- Human Serum Amyloid-A Protein: Variability Demonstrated by Cdna Sequencing and Expression Studies.- Abyssinian Cat Model of Aa Amyloidosis: Saa Gene Analysis.- Mink Serum Amyloid a Protein - Expression and Primary Structure of Amyloidogenic and Non-Amyloidogenic Isotypes.- Primary Structure of Two Rabbit Serum Amyloid a Proteins (Saa) Based on Cdna Sequence.- Biosynthesis and Processing of Saa by Mouse L-Cells Transfected with the Human Saag9 Gene.- Regulation of Serum Amyloid a (Saa) Synthesis in Hep 3B Cells by Cytokines and Corticosteroids.- Regulation of Saa Synthesis by Cytokines in a Human Hepatoma Cell Line.- Saa Secretion from Cytokine-Stimulated Human Hepatoma Cells Requires Hdl.- Interferon a Induces Tnf Elevations in Vivo. Correlation with Other Acute Phase React Ants.- Acute Phase Protein, Serum Amyloid a, Inhibits Il-1- and Tnf-Induced Fever and Hypothalamic Pge2 In Mice.- Human Recombinant TNF-? and Poly I. Poly C Induce Saa and Enhance Amyloidosis in Hamster.- The Physiology of the Acute Phase Serum Amyloid a (Saa) Response in Mice.- Mouse Saa3: Detection in Mouse Tissues with Specific Antibody.- Generation and Use of Site-Specific Antibodies Against Saa.- The N-Terminus is the Lipid-Binding Site of Saa: Supporting Evidence by Moabs.- Epitope Mapping of Amyloid-a Protein Using Monoclonal Antibodies.- Reactive (Aa) Amyloidosis in a 14 Year Old with No Predisposing Disease.- Induction of Amyloidosis in Mice: Preparation of Active Azocasein (Azo) and Effect of Endotoxin (Lps).- Serum Amyloid a (SAA) Induction in the Serum High Density Lipoproteins of the Syrian Hamster.- The Complete Primary Structure of Bovine Serum Amyloid Protein a (SAA) and of Tissue Amyloid Fibril Protein a (AA) Subspecies.- Degradation of Saa in Amyloid Fibrils by Elastase.- Evolutionary Aspects of Protein Saa.- Strain Specific Variation in Expression of Novel Mouse Apo-Saa Isoforms.- Saa Isotypes in Patients with Secondary Amyloidosis.- Differential Regulation of Human Serum Amyloid a Isoforms.- The Effect of SAA-Derived Fragment - SAA2-82 - On Platelet Aggregation.- Serum Amyloid a, An Acute Phase Protein, Inhibits Platelet Activation.- Serum Amyloid a (SAA)-Related Peptide Isolated from Synovial Fluid Modulates Superoxide Production by Human Neutrophils.- Antiplatelet Aggregation Activity of Serum Amyloid a (SAA) Related Peptides.- Effect of Purified Serum Amyloid a on Growth and Differentiation of Transformed Cells.- II Al Protein and Light Chain Related Amyloidosis.- Primary Systemic Amyloidosis (AL) In 1990.- Comparison of the Amino Acid Sequences of Ten Kappa I Amyloid Proteins for Amyloidogenic Sequences.- Characterization of a X Al Protein and Two Amyloidgenic X Bjp in Three Cases of Immunoglobulin Amyloidosis.- Biclonality in Amyloidosis Patient Mal: One Clone Producing an Amyloidogenic, the Other a Non-Amyloidogenic Kappa L-Chain.- Complete Amino-Acid Sequence of a Kappa Light Chain Fragment Isolated from the Urine of Amyloidosis Patient Mal.- Comparative Studies of Two al Chains of Kappa-III Light Chain Origin with and Without Attached Carbohydrate (Al So124 and Al 700).- Structural Studies of two Carbohydrate-Containing Al Chains (?II) Al NoV and Al Mc.- Complete Amino-Acid Sequence of Al-Bence-Jones Protein Pol of the Lambda I Subclass.- Complete Amino-Acid Sequence of Al-Lambda 1.1 Bence-Jones Protein Ezi.- Complete Amino Acid Sequence of A A Amyloid Fibril Protein Isolated from the Liver of Amyloidosis Patient Dia.- Systemic Al Amyloidosis In A Cat.- Experimental Production of Human Amyloidosis Al.- Al Amyloid, L-Chain and L&H-Chain Deposition Diseases: Comparison of Ig Synthesis and Tissue Deposition

This issue of Primary Care: Clinics in Office Practice, devoted to Nephrology, is edited by Dr. Samuel Snyder. Articles in this issue include: Secondary hypertension; Update on ACE/ARB/DRI; Workup of proteinuria; Diagnosis and evaluation of renal cysts; NSAIDs, COX2's and the kidney; The PCP/nephrologist partnership in advancing CKD; Nosocomial AKI; Geriatric patient with CKD; Hematuria workup; The kidney in obesity; and Renal transplant in the primary care setting.

Non-neoplastic diseases are the focus of coverage in this issue of Surgical Pathology Clinics. Topics include: Non-neoplastic diseases in kidney cancer; Nephrectomy for non-neoplastic causes; Autopsy renal pathology; Practical approach to kidney donation workup; Kidney allograft pathology; Renal infections; Amyloidosis - all subtypes; Histologic classifications in renal pathology - pros and cons; Renal molecular pathology; Emerging concepts and controversies in renal pathology. This issue is intended for surgical pathologists and those with clinical practices in diagnostic renal pathology and kidney research. Anthony Chang, whose clinical practice and research is focused on renal pathology, leads this issue.

Kidney anomalies are the most frequent abnormality detected on prenatal ultrasound. Some are inconsequential and others are life-threatening. All must be addressed by neonatologists. This edition of Pediatric Clinics of Perinatology covers these anomalies. In addition, it addresses a variety of other nephrology and urology issues that neonatologists confront. Some are rare and the chapter may then serve as an important resource. Others are common, and thus will provide updated information on diagnosis and management.

Interventional cardiologists are able to perform minimally invasive procedures, such as angioplasty and stenting, due to imaging technologies that allow them to see inside the heart and blood vessels without open surgery. Such imaging often requires injection of contrast media, which are generally safe, but for some patients with drug sensitivities or compromised kidney function, contrast-induced nephropathy (CIN) can result. CIN is a major complication that can increase in-hospital mortality. This issue of Interventional Cardiology Clinica addresses the management, treatment, and prevention of renal complications in the catheterization laboratory.

This book provides a comprehensive look at renal cell carcinoma, exploring its biology as well as current and future molecular targets for renal cancer carcinoma.

This issue of Clinics in Geriatric Medicine features expert clinical reviews on Renal Disease in Older Adults which includes current information on topics such as Anatomic/ Physiological Changes with Aging, Acute Kidney Injury in Older Adults, Electrolyte Problems in Older Adults, Glomerular Disease in Older Adults, Hypertension in Older Adults, Chronic Kidney Disease in Older Adults, End-stage Renal Disease in Older Adults, Decision Making in the Older Adult Patient with Advanced Kidney Disease, Obstructive Uropathy in Older Adults, Drug Dosing, Transplantation in Older Adults, and Slowing the Aging Process.

The treatment of hypertension has become the most important intervention in the management of all forms of chronic kidney disease. Chronic Kidney Disease and Hypertension is a current, concise, and practical guide to the identification, treatment and management of hypertension in patients with chronic kidney disease. In depth chapters discuss many relevant clinical questions and the future of treatment through medications and or novel new devices. Written by expert authors, Chronic Kidney Disease and Hypertension provides an up-to-date perspective on management and treatment and how it may re-shape practice approaches tomorrow.

Chronic Kidney Disease (CKD) is a recognized risk factor for cardiovascular events and death. The coexistence of CKD and heart failure is increasing in prevalence worldwide and requires a unique and subtle approach to patient management. The Kidney in Heart Failure focuses on the changes that occur in kidney physiology as a function of a failing heart. This comprehensive resource covers epidemiology, pathophysiology, management of kidney disorders and advances in nephropathy management. In addition, the latest therapies, common heart failure dilemmas and kidney disease markers are included. Each chapter is co-authored by a Nephrologist and Cardiologist, offering a unified perspective to these chronic conditions. This indispensible volume provides the reader with the depth-of-knowledge needed for assessing and treating the cardio renal patient.

The focus of this book is to provide a nephrology reference manual for the developing pediatrician and pediatric nephrologist. Its objective is not only to inform but also to teach -- one that inspires thinking in the reader. The contents and level of teaching in the manual are intended for trainees at four different levels: medical student, intern, resident and fellow. This handbook provides what other nephrology textbooks cannot -- a useful and practical guidebook that is written to teach at a level that is appropriate for various stages of learning. Each chapter focuses on a specific topic, followed by several patient cases, and with an answer and discussion of each case.