This volume presents chapters by leading figures researching the various pathways by which stress may interfere with health maintenance and contribute to disease etiology and progression. Their work focuses on direct effects of stress on the immune and endocrine systems, on behavioral factors in diseases such as cancer and diabetes, and with the general role of stress in illness processes.

This volume is an outstanding collection of papers written by Jungian analysts from different schools of analytical psychology on various aspects of psychopathology. The subjects covered include depression, anorexia, schizoid personality, narcissistic personality disorder, borderline personality disorder, mania, psychosis, paranoia, masochism, fetishism, transvestism, perversion, marital dysfunction, survivor syndrome, and old age.The contributors, who include some of the most creative and distinguished clinicians in the Jungian world today, are: B. Bosnack, Gustav Dreifuss, Alan Edwards, Michael Ford Ham, C. T. Frey-Wehrlin, Rosemary Gordon, Judith Hubback, Peer Hultberg, Mario Jacoby, Thomas Kirsch, F. Langegger, Rushi Ledermann, Fred Plaut, Joseph Redfearn, Ch. Robinson, Nathan Schwartz-Salant, Eva Seligman, Anthony Storr, Mary Williams, and Luigi Zoja.The book is intended to appeal beyond the Jungian community, and the editor's introductory remarks which precede each paper highlight (and where necessary explain) concepts and attitudes that seem special to analytical psychology. In this way, psychoanalytically and eclectically oriented practitioners can make full use of the book.

Agrios' Plant Pathology, Sixth Edition is the ultimate reference in the field. Here, Dr. Richard Oliver provides a fully updated table of contents with revised and new chapters and invited contributors from around the globe. Building on his legacy, this new edition is an essential read for students, faculty and researchers interested in plant pathology. Sections outline how to recognize, treat and prevent plant diseases and provide extensive coverage on abiotic, fungal, viral, bacterial, nematode and other plant diseases and their associated epidemiology. A large range of case studies take a deep dive into the genetics and modern management of several plant species.

Modernize your approach to graft biopsies, diagnosis and pathogenesis in transplantation pathology, with the second edition of this specialized textbook. Reach the latest classification schemes, combining both anatomic and clinical pathology, and gain a comprehensive understanding of detailed pathological processes, affecting both host and graft. Following publication of the first edition in 2009, technological advances in understanding of transplant immunology and physiology have enhanced many aspects of pathological diagnoses. This edition bridges key knowledge gaps in pathophysiologic mechanisms and constantly evolving clinical protocols, facilitating strong support for the pathologist, clinician, and student. Authored by leading experts in transplantation medicine, this multimedia guide boasts richly illustrated images, underscoring vital diagnostic features for busy readers. Addressing topics such as the immunopathology of graft rejection, laboratory medicine and dermatological complications in transplantation, this textbook engages with a variety of underlying pathogeneses, taking into account current laboratory and clinical findings, worldwide.

Eighteen contributions consider various aspects of pulmonary vascular control and the pulmonary vasculature's response to injury and disease. They discuss recent advances in molecular biology to cell proliferation, interactions between the endothelium and smooth muscle, and the etiologies of various

The most comprehensive reference book on diagnosing cutaneous hematologic disorders available, Hematopathology of the Skin: Clinical and Pathological Approach, 2nd Edition, provides interdisciplinary guidance from more than 40 global experts in the fields of dermatopathology, dermatology, hematopathology, and hemato/oncology. Edited by Dr. Alejandro A. Gru, Dr. Alistair Robson, and Dr. Andras "Andras" Schaffer, this concise yet comprehensive reference features a logical, consistent format heavily illustrated with high-quality clinical and pathological images throughout. Unparalleled in scope, it is a well-written, easy-to-follow resource for clinicians who care for patients with cutaneous hematologic neoplasms. Emphasizes cutaneous inflammatory conditions and reactive lymphoproliferations that resemble hematologic malignancies and often cause diagnostic dilemmas Includes new editorial board member Dr. Alistair Robson, a globally recognized world expert on skin lymphomas Uses a consistent chapter format that covers disease definition; clinical, histological, immunophenotypic, and genetic findings; detailed molecular and immune pathogenesis; detailed differential diagnoses; and a capsule summary Features hundreds of high-quality clinical and pathological images, tables, and figures that clearly explain key concepts Follows the classification guidelines of the World Health Organization and European Organization for Research and Treatment of Cancer (EORTC) Contains the most recent (2022) updates to WHO and EORTC classifications as well as an increased number of international contributing authors Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Soft tissue sarcomas represent a heterogeneous group of rare malignancies, widely regarded as one of the most diagnostically challenging. Drawing on their collective experience gleaned from over 30,000 cases, this book offer practical guidance from leading experts in soft tissue pathology. Exploring topics with clinical, immune-histochemical and molecular correlation, chapters are organised in a clear, morphological structure. This valuable resource includes diagnostic clues for practitioners of all levels to override the challenges and pitfalls in patient diagnosis. Featuring a range of high-quality illustrations, the focus is on sarcomas, lesions of intermediate malignancy, and benign tumours, whilst also providing support in emphasizing the differences between these and pseudosarcomas. Readers can gain confidence in minimizing diagnostic errors, with this pattern-based, wide-ranging approach. This book includes entry to an online version on Cambridge Core, which can be accessed via the code printed on the inside of the cover.

The 10th edition of Porth's Pathophysiology: Concepts of Altered Health States continues a legacy of excellence by providing comprehensive, nursing-focused coverage designed to help grasp both the physical and psychological aspects of altered health. The book's unique emphasis on "concepts" of altered health states, as opposed to factual descriptions of diseases and disorders, helps students grasp both the physical and psychological aspects of altered health. The Tenth Edition maintains its comprehensive depth with over 1,100 illustrations to show students the complex pathophysiology. In addition, over 40 advanced 3D narrated animations that address the most clinically relevant and difficult to understand disorders, engaging unit-opening case studies that reinforce critical thinking and set the tone for the content to come, and a wide range of built-in study tools. Porth's Pathophysiology: Concepts of Altered Health States is designed to make pathophysiology an exciting exploration that relates normal body functioning to the physiologic changes that occur as a result of disease, as well as the body's remarkable ability to compensate for these changes. Indeed, it is these changes that represent the signs and symptoms of disease. Students develop a strong understanding of pathophysiology concepts with the easy-to-follow narrative that builds concepts on one another, defines words as content is presented, and reviews concepts from physiology, biochemistry, physics, and other sciences along the way. Key Features of 10E: *NEW* A new unit on Emergency Medicine . The new chapters in this section are: Bioterrorism, Emergency Psychological Issues, Burns, and Shock. The purpose of this unit is to introduce pathophysiology issues that appear in an Emergency Room or Emergency situation and are not covered elsewhere in the book. *NEW* Unfolding Patient Stories: This edition includes even more cases studies with the introduction of unfolding vSim vignettes called Unfolding Patient Stories. It is not necessary to have a vSim product to use this feature. These unfolding vignettes are designed to start conversations in the classroom by using vSim patients in the book. The vignettes are completely standalone cases but if a school is using vSim then student will be familiar with the patient. Unit opener Case Studies: Prepare for clinical practice with 14 unit-opening case studies that put a real face on pathophysiology and help you relate the clinical presentation to the underlying pathophysiology. Full-color Art: Increase your understanding of key concepts with the full-color art program comprised of over 1,100 illustrations showing the clinical manifestations of diseases and disease processes. Review exercises: Reinforce your understanding of key content with chapter-ending review exercises. Objectives and Summaries: Deepen your understanding by pausing and reviewing salient points using the easily-identified section-opening Objectives and section-ending Summaries . Key Concept Boxes: Retain and apply text information using the information in the boxes help you incorporate key information into a larger conceptual unit, rather than memorizing a string of related and unrelated facts. Lab References : Easily access useful references including lists of common suffixes and prefixes, normal laboratory values in both conventional and SI units, and a comprehensive glossary. Animations: Master the most clinically relevant and difficult to understand disorders with over 40 advanced 3D narrated animations.

Dr Geoffrey Garrett was for over 30 years a Home Office pathologist. This is his personal memoir, in conjunction with crime journalist Andrew Nott, of many infamous, unusual and heartbreaking cases and a fascinating history of his professional life, giving a unique insight into a pathologist's work. Beginning with a no-holds-barred account of the basic methodology of a post-mortem examination, the book chronicles many memorable cases, including: The discovery of a preserved body on the Yorkshire moors later identified as the first victim of the Moors Murderers The murders of three policemen plus the apprehension of a murderer who turned out to be a policeman's son An examination of sex crimes The Moss: a seminal piece on Manchester's 'Bronx' - Dr Garrett reveals life in the ghetto, the drug gangs and how they operate How a man's face, burned beyond recognition, was reconstructed to help solve a murder Plus examples of many other baffling crimes which were resolved on the pathologist's table.

Hormonal influences, both natural and iatrogenic, are implicated in the most frequent health issues of women. Endometrial cancer is now the most common gynecologic cancer in the United States and the industrialized world. This cancer is strongly related to hormonal and metabolic factors. In addition, breast cancer treated with hormone therapy (Tamoxifen) may, in some cases, be associated with uterine pathology. Hormone therapy is used to improve the physiological effects and counteract abnormal and deleterious effects of "natural" hormonal activity. Millions of women receive hormone therapy at some point of their life: using oral contraceptives, reproductive technology, treatment for post-menopausal symptoms, among other uses. This book addresses a range of women's health issues, from fertility to neoplasms, and their relationship with natural and iatrogenic hormonal effects. Chapters include clinical and pathological descriptions, theoretical and practical medical issues, and original studies and cases. Controversial issues in certain hormone therapies are presented with updated concepts based on clinical studies and novel statistical methods. The book will be useful for specialized and general physicians, oncologists, endocrinologists, researchers, medical students, and others in the field of women's health.

Saliva as a unique sample for health assessment is gaining attention among researchers of different fields in the last 20 years; being reflected in an impressive increase in the number of papers published studying saliva from different biological aspects in human and veterinary species. Once deemed merely a digestive juice is now considered a biological fluid capable of communicating information about physiopathological processes occurring in organisms, since saliva has been shown to contain molecular and bacterial compounds that can change in response to local and systemic pathologies. Furthermore, the interest of saliva as a diagnostic, prognostic and monitoring biofluid is forced by its non-invasive nature being of easy and inexpensive sampling, involving only minimal discomfort and allowing the collection of multiple/repeated specimens at anytime, anywhere and without need for specialized staff. In this contributed volume, the authors bring together, summarize and reflect the generated knowledge about saliva as a source of biomarkers for health and welfare evaluation in humans and animal models. This volume also highlights the importance of confounding factors, such as sampling methods, flow, total protein content, contamination, or storage. This book will serve as a manual for graduates, practitioners and researchers by providing general ideas about the possibilities and utilities of saliva in clinical practice or investigation, and indicating the main cautions each should have in mind before saliva usage.

This accessible book examines poisoning in various contexts of international conflict. It explores the modern-day use of poison in warfare, terrorism, assassination, mass suicide, serial poisoning within healthcare, and as capital punishment. It examines a broad range of international cases from the Americas, Europe, Japan, India and more in relation to Situational Crime Prevention and its theoretical precursors, in order to explore potential prevention strategies and the ways in which perpetrators circumvent them. Case studies include analysis of attempts on the lives of Sergei and Yulia Skripal, the Tokyo subway attacks, the crimes of Dr. Harold Shipman and the Heaven's Gate and Jonestown cults. For each, the means, motive, opportunity, location, and perpetrator-victim relationship is examined. This accessible book speaks to students of criminology and those interested in penology, careers in criminal justice, homicide detectives, anti-terrorism personnel, forensic pathologists and toxicologists.

Key Features: • Discusses the clinical and applied aspects of forensic medicine through illustrative case scenarios and reports. • Addresses the needs of clinicians and forensic medicine specialists in writing medico-legal reports for specific cases. • Provides evidence-based solutions to medicolegal and ethical dilemma faced during routine practice.

From JFK to Marilyn--the morbid, medical, and mysterious facts behind the most famous celebrity deaths. When a life ends tragically whether by violence or accident, pathologists perform an autopsy to determine the cause of death. It is a methodical, morbid, and necessary task. These autopsy reports, often filled with medical terminology and intriguing diagrams of the bodies we knew so well from their lives on the big screen, offer an unusual insight into the nature of death itself. The reports you'll find here provide a fascinating glimpse into the underworld that hovers just beyond the reach of the living. Includes the autopsy files or transcriptions from dozens of famous people including: Presidents: Abraham Lincoln and John F. Kennedy Politicians: Simon Bolivar, Adolf Hitler, Vladmir Lenin, and Malcolm X Assassins and Criminals: Lee Harvey Oswald, Jesse James, and Bonnie and Clyde Musicians and Movie Stars:Elvis Presley, Marilyn Monroe, Notorious B.I.G., Janis Joplin, Whitney Houston, and Ludwig Van Beethoven In a world more obsessed with celebrity than ever before, these reports are a sobering reminder of how fleeting real fame can be--and how destructive and dangerous as well. Skyhorse Publishing, as well as our Arcade imprint, are proud to publish a broad range of books for readers interested in history--books about World War II, the Third Reich, Hitler and his henchmen, the JFK assassination, conspiracies, the American Civil War, the American Revolution, gladiators, Vikings, ancient Rome, medieval times, the old West, and much more. While not every title we publish becomes a New York Times bestseller or a national bestseller, we are committed to books on subjects that are sometimes overlooked and to authors whose work might not otherwise find a home.

This second edition expands upon the previous volume with additional emphasis on recent innovation in basic renal research and has a more holistic approach on associated disorders such as complications associated with peritoneal dialysis, ischemic acute kidney injury, the sympathetic nervous system, and vascular calcification. The book is divided into five parts: Part I provides a number of in vitro, in vivo, and ex vivo models of kidney disease and associated complications; Part II looks at recent advances in imaging techniques; Part III covers recent developments in studying metabolism in renal ischemia and reperfusion; Part IV addresses study and measurement of vascular calcification; and Part V explores analytical techniques that are both topical and of widespread relevance to the study of experimental renal disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Kidney Research: Experimental Protocols, Second Edition is a valuable collection of protocols useful to new and experienced researchers who are interested in the field of Nephrology.

This authoritative volume examines immunohistochemical methods aimed at investigating the toxicologic pathology of rodent, non-human primate and aquatic animal tissues. Eleven comprehensive chapters provide pathologists and researchers in various sub-disciplines of toxicology with a comprehensive review of the methods and approaches for immunohistochemical staining in various target tissues. It explores the tissue-antigen and antibody-specific problems that may be encountered during the staining procedures and provide potential avenues for resolving various methodological issues. Special attention is paid to the latest enhancement procedures for antigen retrieval and visualization as well as image analysis and antigen quantification. Written by leading researchers in toxicology and pathology, this book is a significant resource for toxicologists and pathologists working with rodents, monkeys and aquatic animal tissues.

This innovative text explores the cellular transport of organic cations, from functional and structural properties to pharmacological implications and psychiatric developments. The authoritative chapters introduce organic cation transporters and then proceed to discuss their mechanisms such as binding of substrates and inhibitors; their drug dispositions and toxicity; their relationships to genetic and pathophysiological variability; and their roles in endocrine, metabolic, and neurological systems. The final chapters delve into the use of animal models for the study of organic cation transporter function and their possible use in environmental cycling of pharmaceutical residues. This comprehensive volume unites integrative transporter physiology with structural and molecular biology, genetics, pharmacology and pathophysiology, offering a holistic approach to utilizing this novel technique in physiological contexts. It will prove invaluable reading for researchers and students in various areas of integrative, organ, cell and molecular physiology as well as pharmacologists and neurologists.

The books Molecular Diagnostics Part 1 and 2 provide a comprehensive and practical overview of the state-of-the-art molecular biological diagnostic strategies that are being used in a wide variety of disciplines. The editors and experts in their respective fields have combined their knowledge to write these two books. Many years of experience in the development, application and quality control of molecular diagnostic methods is reflected herewith. Molecular Diagnostics Part 1 is dedicated to the theoretical backgrounds of the technologies often applied in molecular diagnostics, in which nucleic acid amplification methods (such as real-time PCR), sequencing and bioinformatics are the basic tools. The assay design and -development, combined with items of trouble-shooting are described in detail. As a foundation of reliable molecular diagnostic assays, the quality control required for validation, implementation and performance of molecular diagnostic assays is thoroughly discussed. This book also provides extensive information for those working with molecular techniques in a wide variety of research applications using conventional and real-time PCR technology, Sanger and high throughput sequencing techniques, and bioinformatics. Molecular Diagnostics Part 2 highlights the applications of the molecular diagnostic methods in the various diagnostic laboratories, comprising: - Clinical microbiology - Clinical chemistry - Clinical genetics - Clinical pathology - Molecular hematopathology - Veterinary health - Plant health - Food safety Both full-colour and well-illustrated books are particularly valuable for students, clinicians, scientists and other professionals who are interested in (designing) molecular diagnostic methods and for those who wish to broaden their knowledge on the current molecular biological revolution. The information in the books highlights the trend of the integration of multiple (clinical) disciplines into one universal molecular laboratory.

This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.

The clinical laboratory is often known as a "black box" to nurses, physicians, and surgeons, but this concise book removes the veil by covering all the pertinent aspects of the clinical laboratory. This book bridges between medicine and chemistry by offering an overview to a clinical laboratory's structure and function, the importance of laboratory utilization and test ordering, as well as pre-analytical, analytical, and post-analytical issues of importance to recognize in any clinical laboratory. An interactive FAQ and a detailed index are also available.

This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis. Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes. In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli. Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors. In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis. New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment.

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

An overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.

THE SUNDAY TIMES BESTSELLER A RADIO 4 BOOK OF THE WEEK CHOSEN AS A BOOK OF THE YEAR BY THE TELEGRAPH AND THE NEW STATESMAN "A marvellous book" Rev Richard Coles "Gripping... filled with compassion." Sunday Times "Remarkable... hopeful and uplifting." Mail on Sunday "An antidote to despair" Daily Mirror "Enthralling... vivid and humane" Observer "Exemplary" New Statesman When a plane crashes, a bomb explodes, a city floods or a pandemic begins, Lucy Easthope's phone starts to ring. Lucy is a world-leading authority on recovering from disaster. She holds governments to account, supports survivors and helps communities to rebuild. She has been at the centre of the most seismic events of the last few decades, advising on everything from the 2004 tsunami and the 7/7 bombings to the Grenfell fire and the war in Ukraine. Lucy's job is to pick up the pieces and get us ready for what comes next. Lucy takes us behind the police tape to scenes of chaos, and into government briefing rooms where confusion can reign. She also looks back at the many losses and loves of her life and career, and tells us how we can all build back after disaster. When the Dust Settles lifts us up, showing that humanity, hope and humour can - and must - be found on the darkest days.

This book will enable practitioners to understand the many complex intricacies of immunohistochemistry (IHC) and make best use of this powerful analytical tool. Providing a thorough grounding in the fundamentals of immunohistochemistry, the book includes several chapters on robotics and automation technology, giving key information on the design of machines and tips to maximise workflow efficiencies. The relationship between IHC and molecular pathology is explained clearly, demonstrating the increasing impact on personalized medicine and targeted therapies for cancer patients. The staining protocol is deconstructed, allowing the reader to adapt it for a variety of diagnostic and research applications. Written by experts at the forefront of hospital immunohistochemistry, there is a strong emphasis on practical guidance on a range of techniques as well as troubleshooting of common problems driven by the authors' experiences. Extensively illustrated with high-quality colour images, this is an invaluable resource to all pathology practitioners utilising the technique.