This book covers several aspects of inhalation toxicology ranging from inhalation drug abuse to battlefield chemical inhalation lung injury, and emphasizes pathophysiology and therapy.

Understanding Human Anatomy and Pathology: An Evolutionary and Developmental Guide for Medical Students provides medical students with a much easier and more comprehensive way to learn and understand human gross anatomy by combining state-of-the-art knowledge about human anatomy, evolution, development, and pathology in one book. The book adds evolutionary, pathological, and developmental information in a way that reduces the difficulty and total time spent learning gross anatomy by making learning more logical and systematic. It also synthesizes data that would normally be available for students only by consulting several books at a time. Anatomical illustrations are carefully selected to follow the style of those seen in human anatomical atlases but are simpler in their overall configuration, making them easier to understand without overwhelming students with visual information. The book's organization is also more versatile than most human anatomy texts so that students can refer to different sections according to their own learning styles. Because it is relatively short in length and easily transportable, students can take this invaluable book anywhere and use it to understand most of the structures they need to learn for any gross anatomy course.

This book examines several recent, major developments in the field of nutritional pathology, providing enhanced, current understanding of the role that altered or disturbed nutrition plays in the pathogenesis of disease. It is intended for students in pathology, nutrition, and biochemistry.

This fourth edition presents an updated and expanded text and illustrations to reflect continued morphologic, immunophenotypic, and especially molecular advances in the field of neoplastic hematology, mostly due to the rapidly expanding application of next-generation sequencing. Those advances not only allow a more reliable diagnosis of the majority of tumors and identification of early changes such as monoclonal B-cell lymphocytosis or clonal hematopoiesis of indeterminate potential (CHIP), but also in many cases identify mutations or phenotypic changes in tumors that can be targeted by mutation-specific or antigen-specific drugs. This edition incorporates the updated WHO classification of hematopoietic tumors and new immunophenotypic and molecular markers to provide a thorough pathologic overview of hematologic neoplasms while focusing on flow cytometric features. Special emphasis has been put on hematological neoplasms with crucial clinical significance such as acute promyelocytic leukemia, other acute leukemias, and difficult areas in flow cytometry. Flow cytometric features in AML, MDS, CMML, CLL and measurable residual disease were significantly expanded. There are many new comparative tables, illustrations, and diagrams of algorithmic approaches.

Cardiovascular Pathology, Fifth Edition provides a comprehensive treatise on the pathology of cardiovascular diseases, combining presentations of detailed pathology of cardiovascular diseases coupled with contemporary insights into etiology and pathogenesis. Twenty-two chapters cover general topics, including cardiovascular genetics, heart failure, and transplantation, and specific congenital and acquired cardiovascular diseases, therapeutic interventions, and forensic aspects. New chapters address the scope of practice and training in cardiovascular pathology, with a focus on major diagnostic approaches used in contemporary practice and research in cardiovascular pathology, and a perspective on the field of cardiovascular regenerative medicine linked to the basic pathobiology of cell-based therapy. The book provides a unique combination of details of pathological anatomy essential for pathologists involved in the evaluation of cardiovascular specimens and cardiovascular diseases, and is an excellent reference for anyone interested in the natural history and therapeutic advances in the cardiovascular field.

This guide to dermatopathology is a general overview helping readers review the histopathology of dermatological conditions. The book discusses superficial perivascular, interface, spongiotic, and psoriasis form dermatitis. It also examines lymphohistiocytic infiltrate, leukocytoclastic vasculitis, panniculitis, and folliculitis. Additional chapters cover nodular and diffuse dermatitis and bullous and vesicular dermatitis. The book describes the dermatopathology hierarchy infrastructure and provides a glossary of terms. Established practitioners as well as trainees will find this an ideal resource for revision and for recertification in the topic. Each entry follows a similar format with includes information on epidemiology, pathophysiology, clinical features, special studies, and clinical variants, histological features, histological differential and Good Things to Know.

Everything you need to know about Pathophysiology at a Glance! From the publishers of the market-leading at a Glance series, and from the authors of the successful Fundamentals of Applied Pathophysiology textbook comes the ideal revision guide for all the key diseases and conditions that nursing and healthcare students need to be aware of. Combining superb illustrations with accessible and informative text, this book is perfect for all nursing and healthcare students, and anyone who is looking for an overview of pathophysiology. Pathophysiology for Nurses at a Glance covers all the key diseases and disease processes affecting each body system, and key concepts encountered from the start of the pre-registration nursing or healthcare course. Key features: * Superbly illustrated, with full colour illustrations throughout * Written specifically for nursing and healthcare students with all the information they need * Self-assessment questions provided for each chapter Pathophysiology for Nurses at a Glance is ideal for nursing and healthcare students as well as qualified practitioners, providing a comprehensive yet accessible overview of human pathophysiology.

This book provides an overview of Asphyxial Deaths which includes hanging, strangulation, choking, smothering, gagging, drowning, aspiration, mechanical and chemical asphyxiants, etc. Postmortem examination often leads to doubts as a clear distinction between the different type of asphyxia cannot be made easily. Forensic and physiological aspects are discussed with the help of illustrative cases. The author discusses the different aspects of asphyxia deaths and substantiates multiple case studies to establish a scientific approach that can act as a guideline to the autopsy surgeon in providing a precise opinion and clarify doubts for the judiciary involved in such criminal justice cases. Key Features * Presents individual case studies of Asphyxial deaths. * Covers the guidelines to be followed by the autopsy surgeons in different cases. * Discusses the physiological aspects of Asphyxial deaths in detail. * Illustrates the cases in a stepwise manner with more than 350 colored photographs of postmortem examination.

In endocrine pathology, surgical pathologists often concentrate on neoplasms at the expense of nonneoplastic disease processes. This is unfortunate as nonneoplastic endocrine disorders are many times more common in the population. As in all fields of medicine, nonneoplastic endocrine diseases can closely mimic the neoplastic; an awareness of all aspects of pathology underpins routine clinical practice. This Fifth Series Fascicle offers pathologists and clinicians an opportunity to develop an increased understanding of nontumor endocrine pathology in order to inform patient care.

Greenfield's is the world’s leading neuropathology reference. It provides a comprehensive account of the pathological findings in neurological disease, their biological basis, and their clinical manifestations. The two volume work provides a remarkable text which is clear, comprehensive and precise with exceptional illustrations. The tenth edition features fully updated sections covering CNS tumours, neurodegeneration, skeletal muscle, epilepsy, paediatric and forensic neuropathology.Expert coverage from an international team of Editors and contributors ensures authoritative and up to date content. The two volume set includes a downloadable and easily used e-version. This is a tried and tested reference for scientists, clinicians, researchers, and students who wish to learn more about neurological disease.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of bone pathology, it incorporates the most recent clinical, pathological, and molecular knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, Diagnostic Pathology: Bone is a one-stop reference for accurate, complete surgical pathology reports, ideal as a day-to-day reference or as a reliable training resource. Includes a wide range of nonneoplastic and neoplastic entities in bone pathology that enhance diagnostic accuracy and provide the biological basis for optimal treatment of patients with bone tumors and nonneoplastic conditions Reflects updates from the 5th Edition of the WHO Classification of Tumors of Soft Tissue and Bone Brings you fully up to date with recent advances in nonneoplastic orthopaedic specimens, including osteoarthrosis, osteonecrosis, pathology of intervertebral discs and menisci, non-infectious inflammatory arthritis, crystal deposition diseases, and common metabolic disorders Features new chapters covering growth and development, radiologic approach to bone tumors, and synovial tumors Contains thousands of extensively annotated images, including gross pathology photographs, histopathology photomicrographs, immunohistochemistry, FISH, correlative radiologic imaging, and full-color illustrations Features a templated, highly formatted design; concise, bulleted text; diagnostic pearls, key facts in each chapter; and an extensive index for easy reference Provides an excellent resource at the point of care for physicians in pathology, radiology, and orthopaedics, as well as medical and radiation oncologists who treat bone tumors Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

There have been numerous significant developments in the diagnosis and treatment of ophthalmic tumors since the last edition of Tumors of the Eye and Ocular Adnexa. This fascicle in the Fifth Series of the AFIP Atlases of Tumor and Non-tumor Pathology includes these developments as well as abundant images to depict ophthalmic pathology. In this richly illustrated volume, the authors emphasize that the pathology of ophthalmic tumors must address not only how to make a correct diagnosis, but also how to guide the ophthalmic surgeon to a treatment plan for the disease while simultaneously preserving a patient's vision.

Quality refers to the amount of the unpriced attributes contained in each unit of the priced attribute. Leffler, 1982 Quality is neither mind nor matter, but a third entity independent of the two, even though Quality cannot be defined, you know what it is. Pirsig, 2000 The continuous formulation of good practices and procedures across fields reflects the importance of the recognition and maintenance of "quality" for nearly every profession. The widespread introduction of point-of-care testing, centralization of activities in large core laboratories, and the increase in number and complexity of diagnostic testing worldwide has driven changes in the organization of laboratory diagnostics over the past decades. As such, laboratory diagnostics, continuously catching up to updated techniques and complex procedures, need to stay vigilant about safety and good practices adjustments. Although widely defined and quantified, the concept of quality is an intrinsic feature of the human psyche and decision making. Written to improve laboratory work, Quality Assurance in the Pathology Laboratory examines: Quality assurance of quantifiable methods applied in laboratory medicine and toxicology Quality aspects of emerging disciplines including personalized therapy and virtopsy Regulatory and logistic instrumentation that ensure quality in laboratory methods Professional education at the graduate and postgraduate levels Laboratory diagnostics substantially contributes to clinical decision making by providing valuable information for the screening, diagnosis, therapeutic monitoring, and follow-up of most-if not all-human disorders. Providing general insights into the quality assurance aspects of pathology and laboratory medicine, this book aids in improving laboratory work and, at the same time, shows the possibilities and limits of all logistic and legal tools related to quality issues.

This comprehensive and authoritative reference covers all aspects of the group of disorders collectively known as the lymphoid neoplasms. The reader is taken through a description of its normal cellular origins and the molecular genetic abnormalities that can lead to this group of conditions, a section of the book that has been considerably strengthened for this third edition, to the environmental factors that may be relevant to disease development, and, finally, to the pragmatic aspects of disease management. The authors synthesise for the reader apsects of current knowledge and likely future developments, and direct them to the appropriate resources should they wish to pursue particular avenues of scientific or literature research.

The autopsy is a central component of postgraduate training in pathology and remains an important part of medical practice today. Pathologists are now expected to possess a higher level of knowledge and understanding of the autopsy, the law surrounding it, and its clinical value, in an increasingly scrutinized and legislated environment. Autopsy practice can no longer be viewed in the absence of external contextual issues: it is vital that pathologists have solid grounding not only in standard technique, but also in such matters as personal health and safety to obtaining informed family consent, before undertaking an autopsy procedure. This new and revised edition of The Hospital Autopsy presents a clear and systematic approach to safe and effective modern autopsy practice. Like the extremely popular second edition, it begins by discussing issues of consent and mortuary design before going on to comprehensively cover external examination, evisceration, dissection of internal organs, and report writing. In this edition, new chapters have been added on the radiological autopsy, religious attitudes to autopsy, and the implications of high-risk infections for autopsy practice. Specialist techniques are covered in depth, and chapters are devoted to complex issues including perinatal autopsies, maternal deaths, and neuropathological examinations. The Hospital Autopsy, Third Edition, is sure to be an indispensable resource for pathologists in training, as well as a useful refresher for practicing pathologists and autopsy technicians.

Anatomy and pathology are key areas in medical training, but the amount medical students have to learn within them can seem overwhelming. This book helps students gain a firm grasp of the facts they must know before they enter their clinical years. It encompasses the core basics of the major organ systems in the body and presents them in a memorable, easy-to-read form. The book covers the background and knowledge that are clinically relevant to, and commonly encountered in, end-of-semester exams and provides a solid preparation for clinical years. It is an excellent resource for all medical students wishing to gain and retain anatomy and pathology knowledge in a time-effective manner.

Stillbirth remains a sufficiently frequent outcome of pregnancy to pose great problems for clinicians, who have to treat extremely distressed patients. This concise but comprehensive book from an international team of contributors sets out clear guidelines for clinical procedures and patient management for the obstetrician, as well as the gynecologist and the gynecologic pathologist.

Once the existence of free radicals was proven, an avalanche of studies on free radical-mediated biological processes ensued. The study of reactive oxygen and nitrogen species (ROS and RNS) is center stage in biological free radical investigations. Written by a biochemist, Signaling Mechanisms of Oxygen and Nitrogen Free Radicals discusses the regulatory functions of ROS and RNS in physiological and pathophysiological states. An exploration of the main questions of signaling mechanisms of reactive oxygen and nitrogen species in enzymatic processes, this book draws attention to the chemical mechanisms of these reactions. It elucidates the differences between signaling functions and damaging effects of ROS and RNS in biological systems. The text also covers free radical signaling processes catalyzed by enzymes, producers of superoxide and nitric oxide that are able to use produced ROS and RNS as signaling species in their own catalytic processes. It then examines ROS and RNS signaling produced by mitochondrial enzymes. The author explores signaling functions of ROS and RNS in enzymatic heterolytic reactions, supplying important data on ROS and RNS signaling in the catalysis by the enzymes which do not produce free radicals by themselves. He provides information on signaling by reactive oxygen and nitrogen species in apoptosis and aging/senescence and concludes with coverage of mechanisms of free radical signaling in enzymatic processes. The book provides new understanding of signaling functions in living organisms related to cardiovascular processes, cancer, inflammation, hereditary diseases, and their regulation of physiological functions such as development, aging, and senescence. This information can support the development of new drugs and novel treatment methods.

Once students have learned the principles behind basic pathology and the mechanisms of disease, they must then consolidate their knowledge by putting those principles into clinical practice. Providing a practical learning experience, this volume presents fifty structured clinical scenarios. Each case is based on a clinical situation that pulls together the key pathological, radiological, and clinical aspects of a condition. Questions and answers highlight diagnostic avenues and provide an effective way of testing assimilation of the material. Students can set their own level of challenge and build their clinical understanding by delving into a cluster of cases covering related topics, or instead emphasize one of the five main themes: symptoms, signs, investigations, treatment, and overall management. Ample illustrations supplement the text, which blends typical clinical case presentations with narrative-style and imaging-based cases.

"Practical Ultrasound in Anesthesia, Critical Care and Pain Management" is a stand alone comprehensive reference that covers every aspect of ultrasound for the practicing anesthesiologist. Beginning with a background on the physics of equipment and practical applications, this text walks the specialist through subjects like needle visualization, teaching, training, accreditation, and getting the best out of your ultrasound equipment.

With high resolution ultrasound photographs "Practical Ultrasound in Anesthesia, Critical Care and Pain Management "covers topics that explore: vascular access nerve blockades echocardiography transesophageal echocardiography - evaluation of the valves basic echo doppler transesophageal doppler trans-cranial doppler the respiratory system

Also included is a fully developed CD that includes high resolution video clips of actual ultrasound examples, organized in an easy cross reference fashion for the busy clinician.

Used by generations of physicians who encounter patients with dermatological diseases, Lever's Dermatopathology: Histopathology of the Skin comprehensively covers skin disease in which histopathology plays an important role in diagnosis. The updated 12th Edition, edited by Drs. David E. Elder, Rosalie Elenitsas, George F. Murphy, Misha Rosenbach, Adam I. Rubin, John T. Seykora, and Xiaowei Xu, maintains the proven, clinicopathologic classification of cutaneous disease while incorporating a "primer" on pattern-algorithm diagnosis. It features larger images throughout, as well as thoroughly revised content with new diseases and new information on pathophysiology and molecular pathogenesis-all in an easy-to-navigate, highly readable format. More than 2,000 larger, full-color illustrations, including photomicrographs and clinical photographs, help you visualize and make the most of the clinical diagnostic process Clinical Summaries provide a concise clinical review before presenting histologic features, and Principles of Management sections summarize today's complex treatment modalities in one convenient place Ultrastructural, immunohistochemical, and molecular techniques are discussed where they have value in identifying particular diseases Numerous tables summarize or compare and contrast similar groups of diseases A chapter dedicated to algorithmic classification of skin diseases according to histologic pattern features helps you develop a differential diagnosis for unknown cases An outstanding resource for dermatopathologists, pathologists, and dermatologists in training, practice, and teaching Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This fully updated edition explores the latest techniques to study the challenging, and at times dangerous, genus of bacteria known as mycobacteria with basic methods that are still required for mycobacteriology along with the newer or improved methods that have been developed. The volume features chapters on the basics of DNA isolation, protein isolation, and lipid isolation, as well as more sophisticated techniques for isolation of ribosomes, and continues with sections involving analyzing subcellular fractions, culture methods, sequencing technology, in vitro models, molecular methods, as well as drug discovery applications. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Mycobacteria Protocols, Fourth Edition serves as an ideal guide for those starting out with their mycobacteria research and also for those who have worked with it for decades.

Until recently, innate immunity was regarded as a relatively nonspecific system designed to engulf and destroy pathogens. However, new studies show that the innate immune system is highly developed in its ability to discriminate between self and foreign entities. Understanding this mechanism can lead to therapeutic strategies based on manipulation of this previously unexploited branch of the immune system.
Drawing on the research of leading experts, Nucleic Acids in Innate Immunity provides insight in this new area of immunology. The book begins by explaining the roles of nucleic acids in immunity, describing the mechanism of discrimination based on pattern-recognition receptors (PRRs), including Toll-like receptors (TLRs), Nod-like receptors (NLR), and RIG-I-like receptors (RLR). Chapters discuss how these PRRs recognize and respond to pathogen-associated molecular patterns (PAMPs) by activating specific signaling pathways.
The second section focuses on the therapeutic applicationsof immunomodulatory DNA by manipulating released pathogenic nucleic acids as immune system stimulants. The book introduces novel therapeutics developed to prevent or treat infectious diseases, allergic disorders, and cancer, as well as clearing unnecessary or abnormal host molecules.
The final section addresses how the immune system discriminates self and non-self RNA. Recent findings that host (self) nucleic acids are not inert in the immune system beg the question of exactly what elements within DNA or RNA are recognized by the innate immune system. Contributions review recent advances to understand innate immune recognition of nucleic acids and describe the resulting immune modulation.
Providing a comprehensive review of nucleic acid recognition and regulation by the innate immune system, this seminal work reveals new directions for future research in immune modulation.

Pathology of Sharp Force Trauma illustrates and details sharp force trauma as seen in forensic pathology case work as well as in the clinical setting, outlining how one informs the other in interpreting such trauma for medico-legal purposes. For the purposes of discussion, the author defines sharp force trauma as: "The application of force to produce an injury which results in a clear division or separation of the skin and underlying tissues". Sharp force trauma may be caused by all manner of implements with a sharp edge and/or pointed end, whether or not they have been produced for use as a weapon, and includes knives, broken glass, scissors and many others, to name but a few. Certain tools, such as axes or machetes, combine a sharp edge with heavy weight and produce injuries with both sharp and blunt impact elements. In many countries, with the exception of those where firearms are readily available, sharp force trauma-particularly the use of knives-is the most common method of homicide and a frequent source of morbidity seen in emergency departments. Also, there has recently been an alarming upsurge in the use of knives in gang-related assaults and in terrorist incidents. As such, the book takes a comprehensive approach in explaining the different aspects of such trauma, most importantly the manner in which the victim has died. This includes cases of homicide, suicide or accident, indicating the type of weapon responsible, explaining how it was used, and presenting other such information to the investigation of such cases. Features: * Includes over 400 full-color graphic and illustrative images throughout * Addresses all aspects of the investigation including trauma, crime scene findings, post-mortem examination, characteristics of injuries and categorization into homicide, suicide or accident * Covers the biomechanics of knife trauma and tool mark examination techniques to identify implements used * Illustrates penetrating injuries caused by pointed implements which have linear components, such as arrows, nails, spears, stakes and others * Details cutting, penetrating, and other sharp force injuries resulting from medical intervention in a healthcare environment, such as might occur during surgical procedures * Examines sharp injuries caused by domesticated and wild animals * Written by one of the premier forensic pathologists in the world with over 40 years of first-hand case experience Pathology of Sharp Force Trauma is the first substantive book published in English to look exclusively at this subject. Although primarily intended for pathologists and clinicians who are involved in the examination of such injuries in the post-mortem room or in a hospital environment, it will also be of interest to medical examiners, police and criminal investigators, attorneys and legal professionals, personnel in other forensic disciplines, and all doctors and medical students with an interested in trauma and its management.

Since the first edition of Identification of Pathogenic Fungi, there has been incredible progress in the diagnosis, treatment and prevention of fungal diseases: new methods of diagnosis have been introduced, and new antifungal agents have been licensed for use. However, these developments have been offset by the emergence of resistance to several classes of drugs, and an increase in infections caused by fungi with innate resistance to one or more classes. Identification of Pathogenic Fungi, Second Edition, assists in the identification of over 100 of the most significant organisms of medical importance. Each chapter is arranged so that the descriptions for similar organisms may be found on adjacent pages. Differential diagnosis details are given for each organism on the basis of both colonial appearance and microscopic characteristics for the organisms described. In this fully updated second edition, a new chapter on the identification of fungi in histopathological sections and smears has been added, while colour illustrations of cultures and microscopic structures have been included, and high quality, four colour digital images are incorporated throughout.