Diagnosing and treating hair disorders is still a subject that is rarely or only superficially covered in residency training. Hence, dermatopathologists and clinical dermatologists often find a gap in their knowledge. A new edition of an acclaimed text, An Atlas of Hair Pathology with Clinical Correlations, Second Edition bridges this gap and serves as a primer, an atlas, and a reference. Features: Supplies basic information on anatomy Examines clinical features that provide a clinical / pathological correlation Details the practical processes of evaluating specimens Includes new photographs demonstrating basic and advanced histologic features of hair disease Explores several new diagnoses Disorders in this edition include senescent balding, loose anagen hair syndrome, psoriatic alopecia, and psoriatic alopecia, and chemotherapy-induced alopecia. The book also contains a glossary of terms related to hair pathology.

This title includes a number of Open Access chapters. The book provides a comprehensive perspective on the subject of obesity epidemiology, pathophysiology, and management of obesity. The chapters provide a better understanding of obesity and obesity-related diseases and offer an integrative framework for individualized dietary and exercise programs, behavior modification, pharmaceutical approaches, surgery, and population interventions to reduce the growing epidemic of obesity.

Nearly ten years after the first edition of Water-Related Death Investigation: Practical Methods and Forensic Applications, water death cases continue to be improperly investigated. The pathologist's report can determine the cause of death as a drowning, but the manner of death is the most challenging to prove. The report will not determine if a victim jumped into the water to commit suicide, fell into the water accidentally, or was pushed in as a homicidal act. Many drowning cases do not reflect injury to the body, so evidence collected at the scene plays a vital role. The importance of an on-scene body assessment cannot be overemphasized. Often, the body evidence begins to change rapidly upon recovery and may not be present during an autopsy. Written statements on the scene are an effective tool to use to determine the accuracy of information given to arriving officers. These statements need to be written by the witnesses themselves as well as the reporting person. The "Show Me" technique can also help reveal discrepancies in a person's version of what occurred as well as aid in providing the most details to an incident as is humanly possible. This second edition includes updated information on the latest technology to assist water death investigators. Parabon Snapshot can help determine the faceless identity of skeletal remains and help locate potential suspects using the science of DNA. Drones can aid in locating missing persons as well as human remains, even months after death. Updated information is provided regarding fingerprints from submerged objects, and Carbon-14 can help determine the origin of a found corpse. Key Features: Thoroughly reviews the physiological aspects of drowning Reveals the investigative characteristics inherent to various scenes of water-related deaths Highlights certain "red flag" indicators that may point to foul play or scene staging Outlines autopsy protocols, trial preparation, and expert witness testimony Provides numerous case studies and numerous illustrations to further clarify key points presented in the text Coauthored by a Master Water Death Investigator and an experienced forensic pathologist, Water-Related Death Investigation: Practical Methods and Forensic Applications, Second Edition merges the essentials of evidence collection and field investigation with autopsy best practices and laboratory testing. It will continue to serve as a valuable resource for the various professionals involved in these cases.

Death Investigation: A Field Guide, Second Edition is updated and expanded to include a chronological analysis of the death scene investigative process from the first notification to the autopsy and final report. This book is written for the standpoints of a forensic pathologist and a forensic toxicologist emphasizing essential elements of the death investigation and how the results impact the final cause and manner of death. Topics discussed include how to assess the body at the scene and how to properly investigate natural and unnatural deaths. The book discusses various means and causes of deaths, demonstrating how death manifests in various parts of the body. A section on traumatic injuries examines and illustrates with color photographs blunt force, sharp force, gunshot wounds, and a host of other injuries that the investigator is likely to confront. Natural death conditions and disease are discussed in a separate chapter devoted to the most common manner of death. The Second Edition is fully updated with new added sections which cover forensic toxicology, statutory responsibilities, documentation and photography of the scene, DNA identification and possible contamination issues, decomposition, managing and utilizing electronic medical records, anaphylaxis and allergic reactions, infectious diseases such as Covid-19, acute peritonitis, and more. Despite including over 200 full-color photos, the book retains a succinct, handy format that is invaluable to those facing, and tasked with investigating, the reality of death on a day-to-day basis. Death Investigation: A Field Guide, Second Edition continues to serve as an invaluable resource for Crime Scene Investigators (CSIs), coroners, Medical Death Investigators (MDI), and medical examiner professionals.

Crime scene reconstruction (CSR) is today's hot topic. The immense proliferation of television, print, and electronic media directed at this area has generated significant public interest, albeit occasionally encouraging inaccurate perceptions. Practical Crime Scene Analysis and Reconstruction bridges the gap between perception and reality, helping readers understand the nature of the scientific method and teaching the proper application of its components. A proven methodology The book begins by recounting the history of crime scene analysis and exploring fundamental principles. Then the authors introduce their proven methodology, known as Event Analysis. This technique defines specific actions, discusses the order of those actions, and offers significant insight into determining what did or did not happen in the course of the incident under investigation. Using case studies and more than 200 color photos, the book demonstrates this method and how it can be used to explain clues that would otherwise be puzzling or ambiguous. Practical advice from the crime scene to the courtroom The authors show how to resolve significant questions that arise in the course of CSR through the use of an event analysis worksheet. The book also discusses crime scene protocol, bloodstain pattern analysis, gunshot investigation, and forensic pathology and the human body. The final chapters provide instruction on writing crime scene reports, discuss ethical issues, and give advice on courtroom presentation. Includes color photos demonstrating the science of CSR on: Superposition Timing and sequence Bloodstain analysis Ballistics Wound patterns

"Biomedical Science in Professional and Clinical Practice" is essential reading for all trainee biomedical scientists looking for an introduction to the biomedical science profession whether they are undergraduates following an accredited biomedical sciences BSc, graduate trainees or experienced staff with overseas qualifications. This book guides trainees through the subjects, which they need to understand to meet the standards required by the Health Professions Council for state registration. These include professional topics, laws and guidelines governing clinical pathology, basic laboratory techniques and an overview of each pathology discipline. It helps trainees at any stage of training and in any pathology discipline(s) to think creatively about how to gather evidence of their understanding and professional competence. By referring to specialist sources of information in each area, it helps students to explore particular topics in more depth and to keep up to date with professional and legal changes. It is also of value to any Training Officers who are looking for ideas while planning a programme of training for a trainee biomedical scientist.

The book includes basic principles of working in the pathology laboratory including laws and regulations, which must be observed, such as health and safety, data protection and equal opportunities laws and guidelines. Practical exercises are included throughout the book with examples of coursework, suggestions for further exercises and self -assessment. Summary boxes of key facts are clearly set out in each chapter and ideas for group/tutorial discussions are also provided to enhance student understanding.

This book provides a comprehensive overview of the fast-evolving subject of clinical application of cancer therapeutic biomarkers. The second edition captures significant progress of cancer immunotherapy and emphasizes the genetic basis for selective cancer treatment. It covers an in-depth insight on biomarkers across a broad area of cancer research and oncology with a wealth of integrated genetic and molecular information about specific therapies by a multidisciplinary team of internationally recognized experts. Each chapter focuses on a class of targeted, immunologic, or chemotherapy agents and their companion biomarkers that predict response, benefit or resistance, and severe adverse event. The book will serve as a handbook for health professionals and scientists on the current applicable biomarkers in the management of cancer. The vision into the systemic classification and statistical consideration of therapeutic biomarkers summarized by the book editors and chapter authors will help advance precision medicine-a precisely tailored cancer treatment strategy for cancer patient care.

Prepare for your future nursing career with Essentials of Pathophysiology: Concepts of Altered Health States . This clear, readable, and student-friendly text delivers "need to know" disease content along with the essential foundation in science that students need to succeed in their future careers. Approaching the topic as an exploration of pathophysiology, the book relates normal body functioning to the physiologic changes that occur as a result of disease and provides concise yet complete coverage of how the body works. The Fifth Edition, which is based on the comprehensive Porth's Pathophysiology , 10th edition, includes a dynamic art program, unit-opening case studies, and lifespan content threaded throughout. 3D animations online and a brilliant art program enhance the learning experience. Key benefits of Essentials of Pathophysiology include: Unit Opening Case Studies prepare students for clinical practice and put a real face on pathophysiology and help relate the clinical presentation to the underlying pathophysiology. "Chunked" content, including learning outcomes and summary statements, encourages students to pause to review salient points. Full-color Art increases understanding of key concepts showing the clinical manifestations of diseases and disease processes. Lab References are easily accessible with lists of common suffixes and prefixes, normal laboratory values in both conventional and SI units, and a comprehensive glossary. Narrated Animations , available on thePoint, bring to life the most clinically relevant and difficult to understand disorders. The leading content is also incorporated into Lippincott CoursePoint, a dynamic learning solution that integrates this book's curriculum, adaptive learning tools, and real-time data reporting into one powerful student learning experience. Learn more at www.NursingEducationSuccess.com/CoursePoint.

This book 1. explores current methods and techniques employed by paleopathologists as means to highlight the range of data that can be generated. 2. introduces a range of diseases and conditions that have been noted in the fossil, archaeological, and historical record, offering readers a foundational understanding of pathological conditions, along with their potential etiologies. 3. will be indispensable for archaeologists, bioarchaeologists and historians, and those in medical fields, as it reflects current scholarship within paleopathology and the field's impact on our understanding of health and disease in the past, the present, and implications for our future.

Biochemical parameters represent better, precise, and objective tools toward the assessment of the nutritional status of children in comparison to anthropometric, clinical, and dietary methods. They constitute laboratory tests to estimate the concentration of circulating nutrients in body fluids. Biochemical parameters are suggestive of acute or subclinical conditions when other methods of nutritional assessment fail to interpret the condition. These parameters exhibit substantial variability in their reproducibility. Moreover, these parameters are novel tools in the hands of clinicians for screening of the nutritional status of children. Key Features Covers the latest biochemical parameters for nutritional assessment Updated content is useful for clinicians, nutritionists, and general practitioners A unique and concise treatise covering descriptive and research-based work on a crucial health issue of worldwide prevalence About the Author Anil Gupta, PhD, is the Dean of Research at Desh Bhagat University and Professor and Head, Department of Physiology and Biochemistry at Desh Bhagat Dental College and Hospital, Mandi Gobindgarh, Punjab, India.

With the interest in biomarkers available for diagnostic, therapeutic, prognostic and research applications growing rapidly, it is now expected that every pathologist should be aware of the correct application of immunohistochemistry in daily practice. This fully updated fourth edition provides practical guidance about preparation, key uses and pitfalls of antibodies for immunohistology in a unique A-Z format. Seventeen full colour infographics present detail about specific biomarkers, including FOXL2, GATA3 and SOX10, pulling out information about expression in tissues and prognosis. Expanded with new biomarkers and the removal of biomarkers that are no longer in common use, each entry in this concise new edition follows a standard structure for quick and easy access by busy readers.

Post-mortems may have become a staple of our TV viewing, but the long history of this practice is still little known. This book provides a fresh account of the dissections that took place across early modern Europe on those who had died of a disease or in unclear circumstances. Drawing on different approaches and on sources as varied as notes taken at the dissection table, legal records and learned publications, the chapters explore how autopsies informed the understanding of pathology of all those involved. With a broad geography, including Rome, Amsterdam and Geneva, the book recaptures the lost worlds of physicians, surgeons, patients, families and civic authorities as they used corpses to understand diseases and make sense of suffering. The evidence from post-mortems was not straightforward, but between 1500 and 1750 medical practitioners rose to the challenge, proposing various solutions to the difficulties they encountered and creating a remarkable body of knowledge. The book shows the scope and diversity of this tradition and how laypeople contributed their knowledge and expectations to the wide-ranging exchanges stimulated by the opening of bodies.

Maintaining the first edition's unique parallel to the strategy used by pathologists and pulmonologists to arrive at a patient's diagnosis in daily practice, Diagnostic Pulmonary Pathology starts with the patient and their biopsy findings, directing the pathologist or clinician to the proper diagnosis. With many advances in pulmonary pathology, radiology, and pulmonary medicine, this new edition provides thorough updates in: progress in classification and diagnosis of interstitial lung diseases evolution of our understanding of pre-neoplastic lesions technology in histopathology molecular pathology thoracic radiology Written by contributing doctors who are at the forefront of recent advancements, Diagnostic Pulmonary Pathology: is organized based on how the patient should be approached, and the patient's own projections, signs, symptoms, and disease provides new imaging techniques and molecular diagnostic tests investigates the new classification schemes, i.e. classification and terminology for lung neoplasms, pulmonary hypertension, and lung transplant rejection gives coverage of the merging of radiology and pathology, including molecular imaging

This book covers several aspects of inhalation toxicology ranging from inhalation drug abuse to battlefield chemical inhalation lung injury, and emphasizes pathophysiology and therapy.

Containing all the new as well as classical methodologies used in the investigation of amino acid and protein metabolism in human and animal models, this book is needed because of the dramatic increase in research in this field. There is no other book currently on the market that covers these methods of investigation. Methods for Investigation of Amino Acid and Protein Metabolism explores areas such as amino acid transfer across tissue membranes, past and new applications using stable isotopes, protein synthesis in organs and tissues, and more. Because of the importance of research methods in the field of amino acid and protein nutrition and metabolism, this book facilitates the reader's integration of the concepts involved in these investigative research methods and their corollaries. In addition to helping any nutrition investigator design and conduct appropriate research protocols in this area of nutrition, this book assists students who are planning to investigate amino acid and protein metabolism in humans or laboratory animals.

Filling a gap in the literature, this atlas stands as a unique authoritative source to thoroughly review the many immunofluorescence patterns seen in immunodermatology for conditions such as immunobullous diseases, connective tissue diseases, vasculitis, and other miscellaneous dermatologic disorders.

This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research. Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques. A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNS assesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters examines the multidrug resistance protein P-glycoprotein as a natural transporter analyzes current drug designs to known requirements for transport looks at drug delivery systems for the brain and much more! Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.

Remarkable advances have occurred since the Series 3 Fascicle published in 1995 with paradigm shifts in every dimension of our understanding of lung tumors including clinical, radiologic, histopathologic, cytopathologic, immunohistochemical, molecular and therapeutic aspects. The molecular revolution leading to effective targeted therapies and breakthroughs in immunotherapy for lung cancer have led to novel approaches incorporating the concept of personalized medicine for patients who historically had little hope. These advances have strengthened the place of pathologists to play a central role in the multidisciplinary team that is now needed to properly diagnose and manage lung cancer patients.

This atlas presents not only the differential diagnosis but also the detailed morphologic, immunophenotypic, and especially genetic characteristics of the majority of hematolymphoid malignancies. An expert hematopathologist here provides a valuable resource to understand, use, or interpret one or more of these diagnostic modalities with confidence. This new edition has a compact format with up-to-date information - especially on genetic aspects - and will be an indispensable reference for all professionals in the specialty. *Provides an unrivalled visual resource for differential diagnosis in neoplastic hematopathology *Enables specialist and trainee oncologists and pathologists alike to understand, use, and interpret diagnostic modalities with confidence *Supplies quick access to information via tables, algorithms, and composite figures

Quality refers to the amount of the unpriced attributes contained in each unit of the priced attribute. Leffler, 1982 Quality is neither mind nor matter, but a third entity independent of the two, even though Quality cannot be defined, you know what it is. Pirsig, 2000 The continuous formulation of good practices and procedures across fields reflects the importance of the recognition and maintenance of "quality" for nearly every profession. The widespread introduction of point-of-care testing, centralization of activities in large core laboratories, and the increase in number and complexity of diagnostic testing worldwide has driven changes in the organization of laboratory diagnostics over the past decades. As such, laboratory diagnostics, continuously catching up to updated techniques and complex procedures, need to stay vigilant about safety and good practices adjustments. Although widely defined and quantified, the concept of quality is an intrinsic feature of the human psyche and decision making. Written to improve laboratory work, Quality Assurance in the Pathology Laboratory examines: Quality assurance of quantifiable methods applied in laboratory medicine and toxicology Quality aspects of emerging disciplines including personalized therapy and virtopsy Regulatory and logistic instrumentation that ensure quality in laboratory methods Professional education at the graduate and postgraduate levels Laboratory diagnostics substantially contributes to clinical decision making by providing valuable information for the screening, diagnosis, therapeutic monitoring, and follow-up of most-if not all-human disorders. Providing general insights into the quality assurance aspects of pathology and laboratory medicine, this book aids in improving laboratory work and, at the same time, shows the possibilities and limits of all logistic and legal tools related to quality issues.

This book is a comprehensive treatise on infective and inflammatory pathologies of the cornea with corresponding clinical images and diagrammatic illustrations. Corneal infections and inflammations are a major cause of ocular morbidity and visual impairment. Early diagnosis and treatment can lead to improved visual outcome and quality of life. Both infectious (bacterial, fungal, viral and protozoan) and non-infectious keratitis that cause corneal vascularisation, scarring and vision loss are covered extensively. The illustrated clinical findings presented in the form of diagrams, photographs, cases and videos aim to serve as a practical teaching tool for fellows, trainees and practising ophthalmologists. KEY FEATURES Focuses on clinically relevant parts of corneal diseases, using illustrations with arrows indicating different pathologies and signs Serves as a ready clinical compendium for trainees, fellows and ophthalmologists Explores various corneal pathologies through a wealth of accompanying illustrations and teaching videos

The scope of Neuromuscular Pathology continuous to expand, as evidenced by the numerous multivolume and speciality texts published in recent years. This short textbook provides a complete overview of both clinical and histological aspects of common and rare neuromuscular diseases. The objective is twofold: to provide information about neuromuscular diseases in a simplified, integrated, and rapidly accessible format suited to those initially encountering the discipline, and also to provide a clear approach using simple pictures, tables and algorithms to illustrate histological features in muscle and nerve biopsy. This volume is conveniently divided into three sections with a total of 30 chapters. The first section deals with basic principles of neuromuscular histology and physiology, processing technique, histochemistry, and laboratory management. The second and third sections deal with neuromuscular diseases that are summarized in a stepwise approach, complemented by algorithms and organized tables. A simplified, integrated, and rapidly accessible format covering both common and rare neuromuscular diseases Clear simple illustrations, organized tables and algorithms to aid the reader in finding an easy approach to accurate diagnosis Practical tips to facilitate histopathological diagnosis. Clinical scenarios discussing common neuromuscular conditions Neurologists, neuropathologists, trainees and medical students involved in clinical neuroscience and pathology will find this guide of practical benefit in both education and practice.

This book serves as a quick study guide during the stages of examination preparation for the pediatric pathology boards. The material covers most of the major topics in pediatric pathology including the fetal, perinatal, infant, child, and organ system pathology. It includes a short quiz containing 115 questions with photomicrographs for each, and an answer key inserted at the end of the book.

Rapid evolution of technical advances in infrared sensor technology, image processing, "smart" algorithms, databases, and system integration paves the way for new methods of research and use in medical infrared imaging. These breakthroughs permit easy-to-use, high-sensitivity imaging that can address key issues of diagnostic specificity and engender a new level of diagnostic standardization, thus enabling the even wider use of infrared imaging as a viable, non-invasive, lower-cost, safe and accessible first-line detection modality. Edited by the inventor of the MedATR concept that leads to the first IR-CAD for the early detection of breast cancer, Medical Infrared Imaging presents many of the new ideas, concepts, and technologies that are key to the wider acceptance of infrared imaging as a revolutionary new standard. Beginning with the worldwide advances and their medical applications from a historical perspective, the book provides detailed and comprehensive information on the technology and hardware resulting from these innovative breakthroughs that will make currently contributory infrared information even more pertinent. The book covers the physics and physiological basis of thermal imaging, and such cutting-edge concepts as: dynamic thermal imaging, thermal tomography, the important role of infrared in a multi-modality imaging setting, and novel processing techniques for the early detection of breast cancer. A significant portion of the book introduces new applications such as biometric facial recognition and the clinical use and quantification of the TAU technique which uses functional imaging to determine the relevance, the stage, and the progression of diseases. Effective and reproducible results are crucial and the book emphasizes the importance of standardization, calibration, and protocols. Finally, the editor includes chapters on the use of databases for storage and retrieval of images and the ethical obligations of infrared research and clinical practice. As a comprehensive state-of-the-science and indication of future directions, Medical Infrared Imaging provides the medical and biomedical engineering communities with the tools to fully utilize and further advance the applications of infrared imaging.

The Postmaster looked over my shoulder. As I turned to look I saw a flicker of movement from across the street. I felt unseen eyes peer at me. He walked away without another word. I watched as he climbed onto his bicycle and sped away down the street. I turned back and looked over my shoulder. Someone had been watching us. 1904. Thomas Bexley, one of the first forensic photographers, is called to the sleepy and remote Welsh village of Dinas Powys, several miles down the coast from the thriving port of Cardiff. A young girl by the name of Betsan Tilny has been found murdered in the woodland - her body bound and horribly burnt. But the crime scene appears to have been staged, and worse still: the locals are reluctant to help. As the strange case unfolds, Thomas senses a growing presence watching him, and try as he may, the villagers seem intent on keeping their secret. Then one night, in the grip of a fever, he develops the photographic plates from the crime scene in a makeshift darkroom in the cellar of his lodgings. There, he finds a face dimly visible in the photographs; a face hovering around the body of the dead girl - the face of Betsan Tilny.