In this issue of Clinics in Laboratory Medicine, guest editor Dr. Fei Dong brings his considerable expertise to the topic of Molecular Oncology Diagnostics. Top experts in the field review current practices in molecular oncology diagnostics, highlighting the rapid clinical adoption of next generation sequencing techniques. The articles address key laboratory considerations in the molecular testing of cancer specimens and the impact of advanced testing strategies on patient care. Contains 15 practice-oriented topics including utility of single gene testing in cancer specimens; analytical principles of cancer next generation sequencing; principles and validation of bioinformatics pipelines for cancer next generation sequencing; panel sequencing for targeted therapy selection in solid tumors; and more. Provides in-depth clinical reviews on molecular oncology diagnostics, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Congenital and Acquired Bone Marrow Failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. Chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. Content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients. Contributors are world leading experts in the field of bone marrow failure. The book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine.

Pathophysiology of Bariatric Surgery: Metabolism, Nutrition, Procedures, Outcomes and Adverse Effects uses a metabolic and nutritional theme to explain the complex interrelationships between obesity and metabolic profiles before and after bariatric surgery. The book is sectioned into seven distinct areas, Features of Obesity, Surgical Procedures, Nutritional Aspects, Metabolic Aspects, Diabetes, Insulin Resistance and Glucose Control, Cardiovascular and Physiological Effects, and Psychological and Behavioral Effects. Included is coverage on the various types of bariatric surgery, including Roux-en-Y gastric bypass, gastric banding, sleeve gastrectomy, biliopancreatic diversion, and jejunoileal bypass, as well as the variations upon these procedures.

This volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of eye disease.

An Issue of Emergency Medicine Clinics of North A An Issue of Emergency Medicine Clinics of North A

MRI Atlas of Pituitary Imaging focuses on magnetic resonance imaging (MRI), the imaging modality of choice for the evaluation of pituitary disorders, since it provides a detailed anatomy of the pituitary gland and surrounding structures, particularly the soft tissues. A basic understanding and interpretation of MRI is important for many clinicians outside of the field of radiology, especially endocrinologists who may receive limited formal training in such areas. This concise Atlas includes a brief review of the principles of magnetic resonance imaging and then reinforces these principles by utilizing a case-based approach to review various pituitary pathologies. The Atlas serves as a strong clinical teaching aid for endocrinologists, radiologists, and neurosurgeons in training. It also serves as a great reference for physicians who are currently in practice.

"Integrative Anatomy and Pathophysiology in Traditional Chinese Medicine Cardiology" covers the structure, function, and pathology of the cardiovascular system from the TCM and western medical perspectives. It focuses specifically on western medicine anatomy and pathophysiology, along with TCM aspects of essence, qi, blood and body fluid concepts, production, and function to explain cardiovascular system dysfunction, its independent role and dependent interactions with the functions of other organ systems.

This book is designed for US-based licensed TCM practitioners as well as cardiology researchers.
Compares and contrasts the TCM basic theories and western medicine basic sciencesGives a specific connection between the heart dysfunction and the disease mechanisms of other organ systems using TCM and western medicine terms and diagnosesPrepares the practitioner to sit for the Niambi Wellness Integrative Anatomy and pathophysiology in cardiology final online exam

In this issue of Surgical Pathology Clinics, guest editor Michael T. Tetzlaff brings his considerable expertise to the topic of Dermatopathology. Top experts in the field cover key topics such as Mucosal Melanoma Molecular, Vasculitis, Nail Pathology, and more. Provides in-depth, clinical reviews on Dermatopathology, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 14 relevant, practice-oriented topics including PRAME immunohistochemical studies as an ancillary diagnostic test for difficult melanocytic lesions; Cutaneous Toxicities in the setting of immune checkpoint blockade: Oncodermatopathology; Update on Molecular genetic alterations of cutaneous adnexal neoplasms; and more.

Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies.
Identifies molecular targets and their accessibility for therapeutic interventionProvides information on biological features of tumor development and dissemination Background information provided for each topic

Epidemiology of Brain and Spinal Tumors provides a single volume resource on imaging methods and neuroepidemiology of both brain and spinal tumors. The book covers a variety of imaging techniques, including computed tomography (CT), MRI, positron emission tomography (PET), and other laboratory tests used in diagnosis and treatment. Detailed epidemiology, various imaging methods, and clinical considerations of tumors of the CNS make this an ideal reference for users who will also find diverse information about structures and functions, cytology, epidemiology (including molecular epidemiology), diagnosis and treatment. This book is appropriate for neuroscience researchers, medical professionals and anyone interested in a complete guide to visualizing and understanding CNS tumors.

Guest edited by Dr. Justin Bishop, this issue of Surgical Pathology Clinics will cover several key areas of interest related to Head and Neck Pathology. This issue is one of four selected each year by our series Consulting Editor, Dr. Jason Hornick. Articles in this issue include but are not limited to: Intraductal Carcinomas of the Salivary Gland, Sclerosing polycystic adenoma,Basal Cell Adenoma and Basal Cell Adenocarcinoma, Sialadenoma papilliferum, Papillary Neoplasms of the Salivary Duct System: A review, Myoepithelial carcinoma, Lymphoepithelial carcinoma of salivary glands, Epithelial-myoepithelial carcinoma, Salivary Duct Carcinoma: An aggressive salivary gland carcinoma with morphological variants, newly identified molecular characteristics, and emerging treatment modalities, Polymorphous adenocarcinoma, Emerging Entities in Salivary Pathology: A Practical Review of Sclerosing Microcystic Adenocarcinoma, Microsecretory Adenocarcinoma, and Secretory Myoepithelial Carcinoma,Genomic analysis of salivary gland cancer and treatment of salivary gland cancers, and more.

An autopsy is a surgical procedure that consists of a thorough examination of a corpse by dissection to determine the cause, mode, and manner of death or to evaluate any disease or injury that may be present for research or educational purposes. This book is a practical guide to autopsy for trainees in pathology and forensic medicine. The second edition has been fully revised to provide the latest advances and guidelines in the field. Beginning with an introduction to autopsy, its utility and techniques for both external and in situ examination, the following chapters explain autopsy procedures for different organ systems of the body, with an emphasis on dissection methods. The final sections explain autopsies in special situations such as in maternal death and in children, autopsy and the law, design of the autopsy room, biosafety, audit, and embalming. The text is further enhanced by photographs of dissection procedures, diagrams and tables. Key points Practical guide to autopsy techniques for trainees in pathology Fully revised, second edition providing latest advances and guidelines Highly illustrated with photographs, diagrams and tables Previous edition (9789386056160) published in 2017

This book offers a comprehensive overview of Alexander disease, a rare and devastating neurological disorder that often affects the white matter of the brain and spinal cord. Its distinctive neuropathology consists of abundant Rosenthal fibers within astrocytes (one of the four major cell types of the central nervous system). Nearly all cases are caused by variants in the gene encoding the intermediate filament protein GFAP, but how these changes in GFAP lead to the widespread manifestations of disease is poorly understood. Astrocytes, while discovered over a century ago, are themselves still much of a mystery. They exhibit considerable diversity, defy precise definition, and yet actively regulate many aspects of nervous system functioning. We also have incomplete understanding of Rosenthal fibers, odd structures that contain GFAP as just one of many components. Whether they are toxic or protective is unknown. Moreover, Rosenthal fibers are not absolutely unique to Alexander disease, and are seen sporadically in a wide variety of other conditions, including brain tumors and multiple sclerosis. GFAP is the third unknown. It is an ancient protein, arising early in the evolution of vertebrates, but its role in normal biology is still a matter of debate. Yet Alexander disease shows, without a doubt, that changing just a single of its 432 amino acids can lead to catastrophe, not just in the astrocytes where GFAP is produced but also in the other cells with which astrocytes interact. Despite all of the unknowns, much has been learned in the past 20 years, and it is time to share this knowledge. This book is intended for recently diagnosed patients and families, as well as non-specialist researchers interested in this neurological disease. It covers historical origins, the state of current knowledge, and prospects for what lies ahead, with citations to the primary literature given throughout.

This issue of Surgical Pathology Clinics, guest edited by Dr. Jessica Davis, is devoted to Challenges & Updates in Pediatric Pathology. Articles in this issue include: Advances and Pitfalls in the Diagnosis of Hirschsprungs Disease, Updates in Pediatric Enteropathies: Differential Diagnosis, Testing, and Genetics, Pediatric Liver Tumors: Updates in Classification, New Prognostic Indicators in Pediatric Adrenal Tumors: Neuroblastoma & Adrenal Cortical Tumors, Pediatric Cystic Lung Lesions, Strategies for the Neonatal Lung Biopsy: Histology to Genetics, Wilm's Tumor: Challenges and Newcomers in Prognosis, Pediatric Renal Tumors: Updates in the Molecular Era, Newcomers in Vascular Anomalies, Spindle Cell Rhabdomyosarcoma: Further Subcategorization, Pediatric & Infantile Fibroblastic/myofibroblastic Tumors in the Molecular Era, Round Cell Sarcomas: Newcomers and Diagnostic Approaches, CNS Embryonal Tumors: Testing Strategies for Integrated Diagnosis, Updates in Pediatric Gliomas, and more.

This book performs a distinct introduction to the pathology of the placenta and its membranes, abortion material included, with the aim to facilitate and protect the quality of the morphological placental diagnostics by the pathologists. Seven chapters with coloured figures illustrating gross anatomy, development and maturation of the placenta explain the functional morphology in its clinical correlation of single and multiple findings for the pathologists, obstetricians and neonatologists. Moreover, the book contributes to a better understanding of pre- and perinatal investigations, maternal diseases, fetal outcomes and follow up of the newborns, as well as to the prevention of worse outcome in further pregnancies. The atlas intends to stimulate the interest for perinatal pathology and to contribute to a better interdisciplinary understanding of pathologists and clinicians, midwives and nurses.

This issue of Clinics in Laboratory Medicine, guest edited by Dr. Vinay Subhash Mahajan, will focus on Immunology Laboratory Testing. Topics include, but are not limited to, Analysis of proteins and immunoglobulins in the clinical immunology laboratory; Antinuclear antibody tests; Serological diagnosis of rheumatoid arthritis; ANCA; Anti-phospholipid antibodies; Diagnostic pitfalls in autoantibody testing; Analysis of the complement pathway; Flow cytometric analysis of immune cell subsets; Testing of cellular immune function in immunodeficiencies; Food allergy testing; Evaluation of the immune response in transplantation; Laboratory testing in the context of biologics and cellular therapies; Testing immune-related adverse-events in cancer immunotherapy; Molecular diagnosis of inherited immune disorders; and Future of immunology lab testing.

This issue of Surgical Pathology Clinics, Guest Edited by Dr. Justine A. Barletta, will focus on Endocrine Pathology. Topics include, but are not limited to, Pitfalls in Thyroid Cytology, Prognostic Parameters in Differentiated Thyroid Carcinomas, Thyroid Tumors You Don't Want to Miss, Molecular Alterations in Thyroid Carcinomas, Treatment of Differentiated Thyroid Carcinomas, Treatment of Aggressive Thyroid Carcinomas, A Guide to Pheochromocytomas and Paragangliomas, A Diagnostic Approach to Adrenocortical Tumors, Treatment of Adrenocortical Carcinoma and Pheochromocytomas, Parathyroid Pathology, Neuroendocrine Tumors of the GI Tract and Pancreas, Treatment of GI Neuroendocrine Tumors, and Neuroendocrine Tumors of the Lung.

Saliva as a unique sample for health assessment is gaining attention among researchers of different fields in the last 20 years; being reflected in an impressive increase in the number of papers published studying saliva from different biological aspects in human and veterinary species. Once deemed merely a digestive juice is now considered a biological fluid capable of communicating information about physiopathological processes occurring in organisms, since saliva has been shown to contain molecular and bacterial compounds that can change in response to local and systemic pathologies. Furthermore, the interest of saliva as a diagnostic, prognostic and monitoring biofluid is forced by its non-invasive nature being of easy and inexpensive sampling, involving only minimal discomfort and allowing the collection of multiple/repeated specimens at anytime, anywhere and without need for specialized staff. In this contributed volume, the authors bring together, summarize and reflect the generated knowledge about saliva as a source of biomarkers for health and welfare evaluation in humans and animal models. This volume also highlights the importance of confounding factors, such as sampling methods, flow, total protein content, contamination, or storage. This book will serve as a manual for graduates, practitioners and researchers by providing general ideas about the possibilities and utilities of saliva in clinical practice or investigation, and indicating the main cautions each should have in mind before saliva usage.

This issue of Surgical Pathology Clinics, Guest Edited by Dr. Brooke Howitt, will focus on practical issues and updates around Gynecologic Pathology. This issue is one of four selected each year by the series Consulting Editor, Jason L. Hornick. Topics include, but are not limited to, Non-HPV associated squamous neoplasia of the vulva and vagina; HPV-associated squamous neoplasia of the lower female genital tract; Cervical glandular neoplasia: classification and staging; Preinvasive lesions of the endometrium; Endometrial carcinoma: Grossing, frozen section evaluation, staging, and senitnel lymph node evaluation; High grade endometrial carcinomas: Classification with molecular insights; Uterine mesenchymal tumors: Classification, staging, and updates in molecular testing; Smooth muscle neoplasia of the female genital tract; Germ cell tumors of the female genital tract; Fallopian tube neoplasia and mimics; Low grade serous neoplasia of the female genital tract; Ovarian high grade serous carcinoma: Staging, assessing site of origin and the post-neoadjuvant chemotherapy setting; Ovarian mucinous tumors; Endometrioid and clear cell tumors of the ovary; and Ovarian sex cord stromal tumors.