Currently, intensive effort is being directed toward the
identification of molecular targets that can provide approaches to
the development of novel therapeutic strategies in cancer
management. This book focuses on metastasis-associated genes,
metastasis promoter and suppressor genes, which relate specifically
to behavioral alterations of cancer cells in epithelial mesenchymal
transition, cancer stem cell maintenance and propagation, and to
the acquisition of invasive and metastasis faculty. The function of
these genes has implications for cell cycle regulation and cell
proliferation and so constitute an essential element in cancer
growth and dissemination. The emphasis in this book is on how
appropriate these genes are as molecular targets and how
practicable are the constituents of their signal transduction
systems as potential candidates and how accessible they are to
targeted therapy. Written in a straightforward and clear style with
background information supporting the new research, this book will
be useful for students and researchers in cancer therapies.
Identifies molecular targets and their accessibility for
therapeutic interventionProvides information on biological features
of tumor development and dissemination Background information
provided for each topic
General
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