Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 10 offer a valuable guide to both cellular processes, while encouraging researchers to explore their potentially important connections. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. This is the tenth volume of the multivolume series that discusses, in detail, almost all aspects of the autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. Volume 10 of the Autophagy series discusses the role of a novel binuclear palladacycle complex that inhibits melanoma growth through apoptosis and autophagy.

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations.

Nutritional Pathophysiology of Obesity and Its Comorbidities: A Case-Study Approach challenges students and practitioners to understand the role of nutrients within the pathophysiology and development of disease, specifically those diseases which develop as a result of obesity. Through a case-based approach, the author presents complex clinical scenarios that require multiple treatment strategies, including targeted diet modification as an adjuvant to medical therapy. The book is divided into 9 modules and 5 appendices each of which covers aspects of obesity and its comorbidities. Within each module, a case is detailed with relevant history, laboratory and physical data, and follow-up information. Each case is followed by a resource section which delineates current understanding of the pathophysiology of the condition, as well as the actions of nutrients and food components shown to modify these processes. A "further readings" section cites current supporting clinical and basic literature as well as published guidelines.

Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals. While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42.

This is the first comprehensive book about surgery on and around the vertebral artery all along its cervical and intracranial course. This vessel has been considered for long as out of surgical reach leaving many different pathologies not or incompletely treated. The surgical exposure and control of the vertebral artery not only permit to treat lesions of the vertebral artery wall or developed in contact to it but also to improve the access to the intervertebral foramen (tumors, osteophytes), to the anterior aspect of the spinal cord (tumors, spondylotic spurs), to the foramen magnum and to the jugular foramen. This book written by leading experts includes all aspects of vertebral artery surgery from anatomy to imaging, surgical techniques and pathologies; it is illustrated by many figures especially operative views and schematic drawings so that the beginner as well as the experienced surgeon find useful information. One of the editors of this book (B. GEORGE) was recently awarded the Olivecrona award for his work on the surgery of the vertebral artery.

With other texts written at either too high or too low a level, this book meets the needs of PTA students for usable, understandable pathology related to clinical application. Extensively illustrated, this book allows students to more easily comprehend and maintain interest in otherwise complicated pathological processes. The fourteen chapter format effectively fits within a chapter per week course structure, or each chapter may be used as a stand alone module within any course. And as your students prepare to graduate, encourage them to keep this book to use as a clinically relevant reference as practicing PTAs!

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of cardiovascular pathology, including new cardiac devices, molecular panels and genetics, the latest tumor classifications, up-to-date COVID-19 information, and imaging, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Cardiovascular is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. Covers all areas of cardiovascular pathology, organizing chapters by how specimens are most often encountered in practice-biopsy, surgical specimens, transplant, and autopsy-as well as by anatomic site Contains significantly updated information throughout (text, images, illustrations, and references) including the latest World Health Organization and International Collaboration on Cancer Reporting tumor classifications, as well as new details related to staging and grading of tumors of the heart, and COVID-19 information Evaluates a new generation of cardiac devices in surgical and autopsy specimens in both images and text Includes new material on genetics and sudden cardiac death and cardiomyopathy, recent recommended amyloid treatment therapies, and new information on the reclassification of pulmonary arterial hypertension Features more than 1,400 images, including carefully annotated histology and gross pathology photos, vivid medical illustrations, photomicrographs, and electron micrographs to help practicing and in-training pathologists reach a confident diagnosis Employs consistently templated chapters, bulleted content, key facts, a variety of tables, annotated images, pertinent references, and an extensive index for quick, expert reference at the point of care Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

Avoid unnecessary diagnostic markers, and pathology pitfalls with this practical approach to head and neck surgical pathology. Written by experts in the field, this book features practical algorithms and ninety illustrative cases, guiding the reader through neoplastic and non-neoplastic head and neck pathology, with ease. With additional access to the full online version, including expandable images on Cambridge Core, achieve accuracy every time. Master practical challenges of efficiently diagnosing diseases in lesions of the nasopharynx, sinonasal tract, salivary glands, oral cavity lesions and soft tissues of the neck. Confidently provide all aspects of care, in tackling new entities in the field, through to reviewing appropriate ancillary studies. Discover a clinical history, histopathology, differential diagnosis and teaching points with each case, alongside working with state-of-the-art immunohistochemistry and molecular technologies. Equipping the reader to make successful diagnoses, maximise surgery time, and avoid common errors, this invaluable guide supports busy practitioners worldwide.

The interpretation of melanocytic tumors represents probably the most difficult task in the field of dermatopathology. The second edition of this text and atlas depicts a broad range of the most important and most challenging melanocytic lesions. Each individual case is illustrated with at least three high-quality color photographs and is commented on at length, highlighting the diagnostic clues. The goal of the authors is to assist the ordinary pathologist in making a precise workable diagnosis in their daily practice. They achieve this by providing simple criteria that will serve as a sound basis for an unequivocal diagnosis of either a benign or a malignant melanocytic neoplasm. The reader will find Histological Diagnosis of Nevi and Melanoma to be an invaluable guide to correct diagnosis even in difficult or rare cases.

Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies.
Identifies molecular targets and their accessibility for therapeutic interventionProvides information on biological features of tumor development and dissemination Background information provided for each topic

Part of the highly regarded Biopsy Interpretation Series, Biopsy Interpretation of the Liver, 4th Edition, provides practical, highly illustrated information on the diagnosis and prognosis of the full range of biopsies of the liver. Practical, well-organized, and highly readable, this fully revised volume by Dr. Michael S. Torbenson addresses both common and unusual issues that arise in the day-to-day interpretation of liver biopsies, teaching the best diagnostic practices as well as how to avoid the most common pitfalls. Frames each diagnosis in its most common clinical context, explaining how the pathology can be used to make key clinical management decisions. Presents key differential features of tumors, organized according to diagnostic category Features high-quality photomicrographs and illustrations throughout, including updated images both in print (over 700) and online-more than 900 images in all. Includes two new chapters on Radiology Report Interpretation and Cytogenetics and Genomics. Provides access to more than 100 questions and answers online for self-assessment and review. , Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. ,

Artificial Intelligence Applications in Human Pathology deals with the latest topics in biomedical research and clinical cancer diagnostics. With chapters provided by true international experts in the field, this book gives real examples of the implementation of AI and machine learning in human pathology.Advances in machine learning and AI in general have propelled computational and general pathology research. Today, computer systems approach the diagnostic levels achieved by humans for certain well-defined tasks in pathology. At the same time, pathologists are faced with an increased workload both quantitatively (numbers of cases) and qualitatively (the amount of work per case, with increasing treatment options and the type of data delivered by pathologists also expected to become more fine-grained). AI will support and leverage mathematical tools and implement data-driven methods as a center for data interpretation in modern tissue diagnosis and pathology. Digital or computational pathology will also foster the training of future computational pathologists, those with both pathology and non-pathology backgrounds, who will eventually decide that AI-based pathology will serve as an indispensable hub for data-related research in a global health care system.Some of the specific topics explored within include an introduction to DL as applied to Pathology, Standardized Tissue Sampling for Automated Analysis, integrating Computational Pathology into Histopathology workflows. Readers will also find examples of specific techniques applied to specific diseases that will aid their research and treatments including but not limited to; Tissue Cartography for Colorectal Cancer, Ki-67 Measurements in Breast Cancer, and Light-Sheet Microscopy as applied to Virtual Histology.The key role for pathologists in tissue diagnostics will prevail and even expand through interdisciplinary work and the intuitive use of an advanced and interoperating (AI-supported) pathology workflow delivering novel and complex features that will serve the understanding of individual diseases and of course the patient.

This book provides state of the art information on the pathogenesis, diagnosis, and treatment of a range of inflammatory, autoimmune, and idiopathic neuromuscular disorders. The opening section discusses the differential diagnosis of acquired myopathies based on clinical, electrophysiological, muscle biopsy, and serological criteria, with special focus on the role of electromyography and antibody testing. Each of the relevant clinical entities is then discussed in detail, the coverage including, for example, myasthenia gravis, polymyositis, immune-mediated neuropathies, multifocal motor neuropathies, amyotrophic lateral sclerosis, paraneoplastic neuropathies, and diabetic polyneuropathy. Clear guidance is provided on currently available treatments, with descriptions of the latest advances in physiotherapy, drug therapy, and respiratory care. Other features of this clinically oriented book are the inclusion of many illustrative case presentations and contributions by international authors from leading centers.

Cardiovascular Pathology, Fifth Edition provides a comprehensive treatise on the pathology of cardiovascular diseases, combining presentations of detailed pathology of cardiovascular diseases coupled with contemporary insights into etiology and pathogenesis. Twenty-two chapters cover general topics, including cardiovascular genetics, heart failure, and transplantation, and specific congenital and acquired cardiovascular diseases, therapeutic interventions, and forensic aspects. New chapters address the scope of practice and training in cardiovascular pathology, with a focus on major diagnostic approaches used in contemporary practice and research in cardiovascular pathology, and a perspective on the field of cardiovascular regenerative medicine linked to the basic pathobiology of cell-based therapy. The book provides a unique combination of details of pathological anatomy essential for pathologists involved in the evaluation of cardiovascular specimens and cardiovascular diseases, and is an excellent reference for anyone interested in the natural history and therapeutic advances in the cardiovascular field.

Using a unique outline format, Anatomic and Clinical Pathology Review is both a concise guide for board preparation and a practical quick reference for both residents and practitioners. It covers the major organ systems and subspecialty areas you'll encounter on the certification and recertification exam, including well-established correlations with contemporary molecular and genomic medicine. This comprehensive, easy-to-use review by Dr. Meghan M. Hupp provides the information you need to confidently recognize and accurately diagnose diseases and interpret what you see under the microscope and in the laboratory. Distills the essential information needed to prepare for both the Anatomic and Clinical Pathology board exams in an easy-to-read outline format. Provides high-yield, at-a-glance summaries in quick reference format for all topics that are encountered by pathology residents and practitioners in the boards. Uses brief, to-the-point explanatory text to make key facts easier to memorize. Incorporates current molecular and serologic tumor markers, techniques, and findings as appropriate. Features numerous high-quality illustrations that provide a visual guide to histologic appearance of key entities. Ideal for junior residents as a framework for rotations through the subspecialties, for senior residents and fellows to prepare for boards and their future practice, and for newly practicing pathologists. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Pre-order the heart-wrenchingly honest new book about life and death from forensic pathologist and bestselling author of Unnatural Causes, Dr Richard Shepherd. 'This book is about death, but in it I will take readers on a journey through life . . .' Dr Richard Shepherd, Britain's top forensic pathologist, has spent a lifetime close to the dead. As a medical detective, each autopsy he carries out is its own unique investigation, uncovering the secrets not only of how a person died, but also of how, through every stage of life, the risks to each of us ebb and flow. Through twenty-four of his most intriguing, enlightening and never-before-told cases, Dr Shepherd shares autopsies that span the seven ages of human existence, and have taught him as much about the marvels of life as the inevitability of death. From old to young, from murder to misadventure, and from illness to accidental death, each of these bodies has something to reveal: about human development, about mortality, about its owner's life story, about justice and even about Shepherd himself. From the bestselling author of Unnatural Causes comes a powerful, moving and above all reassuring book about death as it touches our own lives - how to understand it, how best to postpone it, and, when our time comes (as it must), how to embrace it as the last great adventure. __________ Praise for Dr Richard Shepherd 'Gripping, grimly fascinating, and I suspect I'll read it at least twice' Evening Standard 'A deeply mesmerising memoir of forensic pathology. Human and fascinating' Nigella Lawson 'An absolutely brilliant book. I really recommend it, I don't often say that but it's fascinating' Jeremy Vine, BBC Radio 2 'Puts the reader at his elbow as he wields the scalpel' Guardian 'Fascinating, gruesome yet engrossing' Richard and Judy, Daily Express 'Fascinating, insightful, candid, compassionate' Observer

Selected as a Doody's Core Title for 2022! Fully revised and up- to- date, Ioachim's Lymph Node Pathology, 5th Edition, offers valuable guidance in the diagnostic interpretation of lymph node biopsies. Continuing the tradition of excellence established by Dr. Harry L. Ioachim, Dr. L. Jeffrey Medeiros of The University of Texas MD Anderson Cancer Center offers a comprehensive, clinically useful approach to all the various nonmalignant lesions, lymphomas, other neoplasms, and metastatic tumors in lymph nodes. Discussion of each pathologic entity includes definition, clinical syndrome, histopathology, immunopathology, molecular genetic findings, and differential diagnosis. In addition, chapters have a useful checklist for each entity. "Brings together the background information, the morphologic descriptions, the recommended procedures, the supportive illustrations, and the interpretation of results necessary to make the correct diagnosis." (from the Preface to the fourth edition) Features expanded information on the methods of flow cytometry, immunohistochemistry, and molecular diagnosis. Contains more than 700 high-quality illustrations, including over 600 in full color. Includes sections on normal lymph node; diagnostic methods; lymphadenitides; lymphadenopathies; lymphomas; lymphoproliferative disorders associated with immune deficiencies; dendritic cell, histiocytic and granulocytic/monocytic neoplasms; spindle cell neoplasms of lymph nodes; vascular neoplasms of lymph nodes; and metastatic tumors in lymph nodes. Incorporates guidelines of the revised fourth edition of the World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. , Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. ,

This is the first textbook worldwide on the speech pathology management of chronic refractory cough. It offers a comprehensive overview of the condition, outlines therapy in great detail and consolidates recent advances in this area. It provides all materials needed for speech pathologists to assess and treat individuals with chronic refractory cough. All practical resources and tools needed to treat the condition are provided in one practical and accessible publication. Speech pathologists can access all the information from one single source thus saving time during busy caseloads. The included extensive background material will be helpful for both novice and experienced clinicians. These materials are not available in any other format. Resources include a CD with patient handouts and exercise sheets in printable pdf format, and excel spreadsheet files to help calculate symptom scores. The book is written by people who currently specialize in the clinical assessment and management of patients with chronic refractory cough and who have an active research program.By outlining laryngeal hypersensitivity, the book sets up the reader/practitioner to take advantage of upcoming developments in the field of chronic refractory cough. Cough is such a common experience that it in fact accounts for the largest number of ambulatory health care visits internationally. Most cases of acute cough resolve spontaneously however Chronic Refractory Cough is another matter. This is defined as a cough that lasts for longer than eight weeks, and persists despite medical treatment; and it is a significant health problem for many people. Often lasting for months or even years, chronic refractory cough has debilitating side effects including stress urinary incontinence, depression, poor sleep, headaches and reduced quality of life. Some patients resign from work and many avoid social situations. Even simple activities such as conversing or using the telephone can become distressing because talking can trigger coughing episodes. Although medical treatment is ineffective for Chronic Refractory Cough, speech pathology intervention can be effective in treating the condition.Understanding laryngeal function in chronic refractory cough has changed, and there are now effective treatment programs that can be used to help people with these problems.However while speech pathology intervention is effective in treating refractory chronic refractory cough, patients have difficulty accessing this intervention outside of specialist voice clinics. Management of chronic refractory cough is an expanding area for speech pathologists, yet many have limited clinical exposure to the treatment of this condition and comprehensive details of the theory and treatment are not readily available in published form. This book, the result of a therapy program which is defined by the authors, who are both practicing clinicians as well as researchers, and based on evidence and background research, can be used by speech pathologists in all clinics. Laryngeal hypersensitivity is emerging as the key concept in chronic refractory cough. It is the target of mechanisms studies, novel therapies and also novel pharmacological developments. This book will explain the importance of laryngeal hypersensitivity, how it can be recognized, and how it can be treated.Speech pathologists, referring medical specialists and patients have expressed a need for more specialized speech pathology services for the management of chronic refractory cough.In particular, speech pathologists are requesting more comprehensive and cohesive information to guide their patient management.Presently, there are no widespread education programs and material is generally disseminated through journal articles published in a wide array of literature and by word of mouth. This book fills the gap. It is the first manual available to speech pathologists to support their treatment of chronic refractory cough and to eliminate their reliance on conference presentations, infrequent journal articles and short textbook descriptions. Presented here are a comprehensive overview of the conditions, detailed outlines of therapy options, and qualified guidance on recent advances in this area that speech pathologists need and are looking for when treating these patients.

Part of the in-depth and practical Pattern Recognition series, Practical Pulmonary Pathology, 4th Edition, helps you arrive at an accurate diagnosis by using a pattern-based approach. Leading diagnosticians in pulmonary pathology offer practical assistance in identifying all major neoplastic and non-neoplastic diseases of the lungs, guiding you from a pathological pattern through the appropriate work-up, around the pitfalls, and to the best diagnosis. More than 1,000 high-quality illustrations capture key morphologic patterns for a full range of common and rare conditions and assist in the interpretation of complex diagnostic puzzles. A unique "visual index" at the beginning of the book directs you to the exact chapter and specific page you need for in-depth diagnostic guidance. Helps you quickly recognize the vast variety of appearances of the lung that result from infections, tumors, and tumor-like lesions, both malignant and benign. Discusses advances in molecular diagnostic testing, its capabilities and its limitations, including targeted/personalized medicine. Incorporates clinicopathologic background and relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the tools you need to master the latest breakthroughs in diagnostic technology. Covers the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities. Color-codes patterns to specific entities, and summarizes key points in tables, charts, and graphs so you can quickly and easily find what you are looking for. Shares the knowledge and expertise of new co-editor, Dr. Maxwell L. Smith. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Now fully revised to include recent advances in the field, the second edition of Bone and Soft Tissue Pathology, a volume in the Foundations in Diagnostic Pathology series, is an essential foundation text for residents and pathologists. The popular template format makes it easy to use, and new information throughout brings you up to date with what's new in the field, including advances in molecular diagnostic testing and new diagnostic biomarkers. Practical and affordable, this resource is ideal for study and review as well as everyday clinical practice.Key features of this practical text include: A consistent, user-friendly format that explores each entity's clinical features, pathologic features (gross and microscopic), ancillary studies, differential diagnoses, and prognostic and therapeutic considerations. A focus on specific features of selected neoplastic and non-neoplastic entities, including broad and in-depth differential diagnoses. Review of normal histology before examining abnormal findings, enabling you to conveniently compare their characteristics in one place at one time. Clinical information on treatment and prognosis, enabling you to better understand the clinical implications of the diagnosis. Nearly 1,000 full-color, high-quality illustrations with extensive figure legends, as well as abundant boxes and tables throughout. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. What's NEW in this edition: Advances in molecular diagnostic testing and its capabilities and limitations, including targeted/personalized medicine. New diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities. The latest TNM staging and WHO classification systems. New co-editor Dr. Gunnlaugur Petur Nielsen of Harvard Medical School joins Dr. Andrew L. Folpe and expert, internationally recognized pathologists who keep you up to date with the latest information in the field.

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of head and neck pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Head and Neck is a one-stop reference for accurate, complete pathology reports-ideal as a day-to-day reference or as a reliable teaching resource. Provides a clear framework for a better understanding of the clinical and histopathologic appearances of more than 325 new or evolving entities of the head and neck and endocrine organs Features updates on recent changes in the field and current information from the AJCC Cancer Staging Manual, 8th Edition, and the World Health Organization Classification of Head and Neck Tumours, 5th Edition Covers numerous new diagnostic entities, including intraductal carcinoma, sclerosing polycystic adenoma, microsecretory adenocarcinoma, adamantinoma-like Ewing sarcoma, SMARCB1- and SMARCA4-deficient carcinomas, and HPV-related multiphenotypic sinonasal carcinoma Contains major updates on sinonasal tract, salivary gland, and odontogenic tumors; oropharyngeal squamous cell carcinoma and its correct classification and staging; the recent significant reclassification of neuroendocrine tumors; and changes in terminology and identification for head and neck soft tissue tumors Suggests supporting studies in a realistic clinical context, with tables and immunohistochemical charts that assist with management decisions and prognostic outcome predictions Features more than 3,200 images, including full-color drawings of head and neck anatomy, development pathway drawings, staging protocol illustrations, and genetic pathway graphics; radiologic images, clinical photographs, and gross images; and histology, histochemistry, immunohistochemistry, in situ hybridization, and molecular images; as well as more than 2,600 additional online-only images Employs consistently templated chapters, bulleted content, key facts, and annotated images for quick, expert reference at the point of care Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices