This comprehensive work, aimed at both students and researchers
alike, systematically covers all aspects of prion diseases
(transmissible spongiform encephalopathies), from their history,
microbiology and pathology to their transmissibility and
prevention. The book describes diseases such as Creutzfeldt-Jakob
disease, kuru, mad cow disease (BSE), chronic wasting disease and
scrapie, highlighting their biochemical, molecular biological,
genetic, and clinical aspects. A detailed presentation of the
impact of prion diseases in fields such as pharmaceutics, blood
products, disinfection, surgical instruments and epidemiology
concludes with a discussion of preventive measures. A renowned
editorial team, representing the fields of medicine, veterinary
medicine and molecular biology, brought together 80 internationally
respected authors for this translation and new edition of the
successful German publication, not only from relevant research
fields, but also from industry and public health institutions. The
book includes chapters by, among many other notable scientists,
William J. Hadlow, who discovered the relationship between the
human and animal forms of prion diseases and Michael P. Alpers,
with 45 years of experience in Papua New Guinea investigating the
first known human epidemic form, kuru, transmitted by
endocannibalism. Further contributions from Gerald A. H. Wells, a
veterinary pathologist who described BSE and recognised its
similarity to scrapie, thus recording the first cases in 1986 of
the most important animal epidemic of modern times, and Robert G.
Will, a medical neurologist and epidemiologist who discovered the
emergence of the variant form of Creutzfeldt-Jakob disease in 1996,
underscore the strength of this author team. Carefully edited with
numerous illustrations, this work offers a systematic approach
committed to a clear presentation of the current knowledge of prion
diseases. It aims to inspire and stimulate interdisciplinary
cooperation, innovative research ideas and effective prevention.
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