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Books > Medicine > Surgery > Plastic & reconstructive surgery
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Progress in Fibrin Sealing (Paperback)
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Progress in Fibrin Sealing (Paperback)
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Fibrin plays a central role in wound healing. It has a hemostatic
effect by forming a temporary wound closure and assists in
neovascularization and fibroblast prolifera- tion. It therefore
makes the repair of injured or severed parts of the human body by
simple glueing possible, a notion that men have dreamed of since
ancient times. The first modern attempts in this direction, using
clotting substances derived from human blood to achieve hemostasis,
were reported by Bergel (in 1909), Grey (in 1915), and Harvey (in
1916), who used fibrin powder or fibrin patches to control bleeding
from parenchymatous organs. Two decades later Young and Medawar
(1940) and Cronkite (1944) used blood plasma or fibrin solutions,
adding thrombin to seal nerve anastomoses and to fix skin grafts in
humans. Due to the poor adhesive strength of the fibrinogen the
results were unsatisfactory. In 1972 a new era in fibrin sealing
was initiated by Matras. By using highly concentrated fibrinogen in
combination with factor XIII (fibrin-stabilizing factor) and by
delaying fibrinolysis with a fibrinolysis inhibitor (aprotinin), a
method was developed which after satisfactory results in animals,
soon began to be applied in humans.
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