Cardiopulmonary Bypass: Advancements in Extracorporeal Life Support provides comprehensive coverage on the technological developments and clinical applications of extracorporeal technologies, including the underlying basic science and the latest clinical advances in the field. Written by experts around the world, this book comprises all characteristics of cardiopulmonary bypass as well as chapters regarding equipment, physiology and pathology, pediatric aspects and clinical applications. Important highlights include the latest updates regarding minimal invasive cardiopulmonary bypass (MICPB), extracorporeal circulatory and respiratory support (ECCRS) in cardiac and non-cardiac patients, ECMO support in COVID-19, and updated guidelines of extracorporeal technologies. This book is an invaluable resource to clinicians, researchers and medical students in the fields of cardiothoracic surgery, cardiac anesthesiology, intensive care, and perfusion technology.

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition.

Heart failure occurs in almost epidemic proportions, placing a huge burden on both the healthcare system, and sufferers and their families. This can only rise over coming years as the ageing population, particularly in industrialized countries, increasingly suffers from heart failure and its related comorbidities. The care of this group of patients has evolved significantly over recent years as our knowledge and understanding of the pathophysiology of heart failure has developed. It has become evident that supportive care is integral to comprehensive heart failure care, and this book provides an evidence-based overview of heart failure aetiology, its management, and the supportive care required by patients throughout the course of their disease. Supportive Care in Heart Failure integrates the complexities of heart failure care, bridging knowledge bases from cardiology and cardiothoracic surgery, general medicine and palliative care. The book reviews essential information about epidemiology and pathophysiology of heart failure, and evidence-based medical, device, surgical and interdisciplinary management. It addresses the evaluation and management of quality of life, common symptoms and problems associated with heart failure, and the holistic approach to supportive care throughout the course of the illness through the end of life. Prognostication, communication, and ethical decision making are reviewed in detail. Heart failure has traditionally presented a challenge to physicians, as a generally progressive condition with significant symptoms, a poor quality of life, and high mortality. But by applying the principles of palliative medicine, it is possible to offer a supportive care approach that synthesizes the experience of both the heart failure specialist and the palliative care physician, and offers the best possible quality of care to this group of patients.

Principles of Heart Valve Engineering is the first comprehensive resource for heart valve engineering that covers a wide range of topics, including biology, epidemiology, imaging and cardiovascular medicine. It focuses on valves, therapies, and how to develop safer and more durable artificial valves. The book is suitable for an interdisciplinary audience, with contributions from bioengineers and cardiologists that includes coverage of valvular and potential future developments. This book provides an opportunity for bioengineers to study all topics relating to heart valve engineering in a single book as written by subject matter experts.

In this issue of Surgical Clinics, guest editor Dr. Daniel G. Cuadrado brings his considerable expertise to the topic of Cardiothoracic Surgery. In this issue, top experts in the field provide updates on the most common procedures in cardiothoracic surgery, including articles on the lung, heart and chest, as well as two articles on epidemiology that give an accurate scope of heart disease. Contains 15 relevant, practice-oriented topics including lung cancer: epidemiology and screening; open surgical and extended resections for lung cancer; surgical management of pneumothorax and pleural space disease; management of coronary artery disease; minimally invasive and sub-lobar resections for lung cancer; and more. Provides in-depth clinical reviews on cardiothoracic surgery, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Thoracic Surgery Clinics, guest editor Farid Shamji brings considerable expertise to the topic of Lung Cancer. Provides in-depth, clinical reviews on Lung Cancer, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Make optimal use of the latest coronary stenting techniques and adjunctive devices with well-rounded guidance from Coronary Stenting, a companion volume to Dr. Topol s Textbook of Interventional Cardiology. This comprehensive, up-to-date interventional cardiology book keeps you abreast of the latest trial data on efficacy and safety as well as cutting-edge clinical applications in coronary stenting. "This book guides you through everything in percutaneous intervention that you need to know." Reviewed by Perfusion, Apr 2015 Achieve optimal outcomes and minimize complications with expert guidance from the foremost teachers and writers in the field of interventional cardiology. Implement the latest knowledge on cutting-edge topics such as drug-eluting stent design; appropriate interpretation of randomized clinical trials and comparative effectiveness studies of coronary stents; the use of fractional flow reserve, intravascular ultrasound and optical coherence tomography to optimize lesion selection and stent implantation; anterograde and retrograde approaches to chronic total occlusions; and percutaneous revascularization of diabetics and patients with left main or multivessel disease. Quickly and easily find the coronary stenting information you need thanks to highly templated chapters and high-quality full-color illustrations that incorporate the latest clinical trial data into recommendations for proper patient and device selection. Access the fully searchable text online, download images, and more at Expert Consult.

The heart is our most important - and perhaps most mysterious - organ.

Every day it pumps 9000 litres of blood and beats around 100,000 times. But the heart is more than just a pump. In all major human cultures, it is seen as the source of love, sympathy, joy, courage, strength and wisdom. Why is this so?

Having witnessed the extraordinary complexity and unpredictability of human hearts in the operating theatre - each one individual in its make-up, like a fingerprint - heart surgeon Reinhard Friedl went on a search for answers. He examined closely the latest findings in neurocardiology and psychocardiology, and in The Beat of Life he shares his discoveries, using riveting personal stories to illustrate the complex relationship between the heart, the brain and the psyche.

Mechanical cardiovascular assist devices must be properly designed to avoid damage to the blood they contact. The factors that affect the hemocompatibility of a cardiovascular assist device include three major non-physiological components - the material, fluid flow paths, and flow related stresses, - as well as the device interaction with the native vasculature. Furthermore, the interaction of the device with the blood is not static. Foreign surfaces activate blood components including platelets, leukocytes and the coagulation cascade. Thrombus formation on the surface of the device can alter the fluid dynamics in a manner that causes erythrocyte damage ranging from significant hemolysis to sub-lethal trauma that can take many days to weeks to develop into a significant clinical problem. This sub-lethal blood trauma is not easily detectable without special equipment, which is typically unavailable in routine clinical practice. Surveillance for blood damage is often sub-optimal in the clinical setting, but once clinically relevant hemolysis occurs, crucial decisions - device removal, replacement, or additional medical therapies including surgery or plasmapheresis - that take into account the risk/benefit of intervention must be quickly evaluated. The various preclinical designs and testing, surgical considerations, available surveillance techniques, and clinical consequences will be discussed using recent and historical case reports to highlight key points.

This issue of Interventional Cardiology Clinics will explore Updates in Percutaneous Coronary Intervention. Curated by the series Editor-in-Chief, Dr. Matthew J. Price, this issue will cover topics and advances in the field that are relevant for practicing clinicians. This issue is one of four selected each year by Dr. Price. The volume will include articles on: Current Concepts in Intraprocedural Pharmacology During PCI; Periprocedural Myocardial Infarction in Contemporary Practice; Newer Generation Metallic Stents: Design, Performance Characteristics, and Outcomes; Distal Transradial Access for Coronary Angiography and Intervention; Clinical Outcomes Data for iFR-guided PCI; Culprit-only or Complete Revascularization During STEMI in Patients with and Without Shock; Technical Approaches to Left Main Coronary Intervention: Contemporary Best Practices; Robotic Assisted Percutaneous Coronary Intervention; Orbital Atherectomy: A Comprehensive Review; and Percutaneous revascularization of spontaneous coronary artery dissection, among others.

This issue of Interventional Cardiology Clinics, edited by the series Editor-in-Chief, Dr. Matthew Price, will cover Transcatheter Closure of Patent Foramen Ovale. Some of the topics discussed in this issue include, but are not limited to, PFO and the Interatrial Septum: Clinical-Anatomic Correlations; Current Dataset for PFO Closure in Cryptogenic; Stroke: Randomized Clinical Trials and Observational Studies; PFO closure: Devices and Technique; Identification and quantification of PFO-mediated shunts: echocardiography and transcranial Doppler; PFO closure for Hypoxemia; and Imaging Assessment of the interatrial Septum for ASD and PFO closure, among others.

This issue of Surgical Clinics of North America focuses on Cardiothoracic Surgery, and is edited by Dr. John H. Braxton. Articles will include: Review of ICU Management of the Cardiac and Thoracic Surgery Patient and the Team Approach; Minimally Invasive and Robotically Assisted Cardiac Surgery; Surgical Treatment of Heart Failure; The Changing Face of the Cardiothoracic Surgical Team; Thoracic Trauma and Management; Minimally Invasive and Robotically Assisted Thoracic Surgery; The Impact on Less Invasive Surgery on Esophageal Diseases; Lung Cancer Screening and its Impact of Surgical Volume; The Surgical Treatment of Coronary Artery Occlusive Disease: Modern Treatment Strategies for an Age Old Problem; Transcutaneous Valve Repair and Update; Robotic Lobectomy and Segmentectomy: Technical Details and Results; Diagnostic Imaging and Newer Modalities for Thoracic Diseases: PET Imaging and EBUS for Staging and its Implication for Lung Cancer; Mitral Valve Repair: French Correction vs. American Correction; Cardiac Screening in the Noncardiac Surgery Patient; and more!

This issue of Surgical Oncology Clinics of North America, guest edited by Dr. Mark Krasna, is devoted to Lung Cancer. Dr. Krasna has assembled expert authors to review the following topics: Epidemiology for Lung Cancer; Screening for Lung Cancer; Pathology for Lung Cancer; Treatment of Patients with Oligometastatic Disease for NSCLC; SBRT/Ablative Therapies for NSCLC; Mediastinal Staging for Lung Cancer; VATS Lobectomy for NSCLC; Robotic Lung Resection for NSCLC; Pneumonectomy for NSCLC; Bronchoscopy-Diagnostic and Therapeutic for NSCLC; Neoadjuvant Therapy for Lung Cancer; Molecular/Targeted Therapy for Lung Cancer; Adjuvant Therapy for Stage 1and 2 NSCLC, and more!

This book describes the molecular mechanisms of lung cancer development and progression that determine therapeutic interventions in the era of genomics, when the rapid evolution in lung cancer diagnosis and treatment necessitates critical review of new results to integrate advances into practice. The text opens with background and emerging information regarding the molecular biology of lung cancer pathogenesis. Updated results regarding lung cancer prevention and screening are discussed, followed by chapters on diagnostic techniques and pathological evaluation. This leads on to a detailed presentation of treatment modalities, from surgery and radiation therapy to standard chemotherapy and targeted agents. The coverage includes resistance to therapy and the emergence of immunotherapy for lung cancer; in addition, the current evidence in respect of small cell lung cancer is summarized. The book presents insights from experts across disciplines to emphasize the importance of collaborative care. Advances in our understanding of issues in geriatric oncology and palliative care complete the comprehensive discussion of lung cancer.

Prevention and Management of Post-Operative Complications is reviewed extensively in this important Thoracic Surgery Clinics of North America issue. Articles include: Cardiovascular complications following thoracic surgery; Pain management following thoracic surgery; Persistent air leak and pleural space management following pulmonary resection; Bronchopleural fistula and empyema after anatomic lung resection; Postoperative respiratory failure; Complications following carinal surgery and bronchial sleeve resection; Anastomotic leak following esophagectomy; Management of conduit necrosis following esophagectomy; Functional conduit disorders complicating esophagectomy; Complications following surgery for achalasia and anti-reflux disease; Complications following tracheal and laryngotracheal resection; Management of thoracic nerve injury; Chest wall resection and reconstruction: management of complications; Management of chylothorax; and more!

Management of Intra-operative Crises is reviewed extensively in this important Thoracic Surgery Clinics of North America issue. Articles include: Massive Airway Hemorrhage; Great Vessel Injury; Endotracheal Tube Management and Obstructed Airway; Perioperative or Operative Pulmonary Embolus; Acute Intraoperative Aspiration; Patent Mammary Disruption During Thoracic Surgery; Immediate Post-lobectomy Crisis Management; Cardiopulmonary Bypass, Rapid Pacing, and ECMO for Emergent Intraoperative Thoracic Situations; Unexplained Intraoperative Hypotension; Coagulopathy & Anticoagulation during Thoracic Surgery; Perioperative Pneumonectomy Management; Pulmonary Artery Bleeding during VATS; Tracheal Repair and Airway Management; and more!

Lung Cancer Screening is reviewed extensively in this important Thoracic Surgery Clinics of North America issue. Articles include: CT screening: The Early Lung Cancer Action Program Experience; Lung Cancer Screening: The Mayo Experience; National Lung Screening Trial; Health Risks from CT Lung Cancer Screening; The European Perspective of Lung Cancer Screening; Surgeons and Lung Cancer Screening: Rules of Engagement; The National Comprehensive Cancer Network Recommendations for Lung Cancer Screening; The United States Preventive Services Task Force Recommendations for Lung Cancer Screening; Current Estimate of Costs of Lung Cancer Screening in the US; Refining Strategies to Identify Population to be Screened for Lung Cancer; Long-term Oncologic and Financial Implications of Lung Cancer Screening; and more!

This issue of Thoracic Surgery Clinics is devoted to "Robotic Surgery." Editor Bernard Park, MD of Hackensack University Medical Center brings together the top experts to review this important topic in thoracic surgery. Articles in this issue include: Robotic Thoracic Surgery: Technical Considerations and Learning Curve; VATS-based Approach for Robotic Lobectomy; Total Port Approach for Robotic Lobectomy; Long-term Results for Robotic Lobectomy for Lung Cancer; Robotic Segmentectomy and Pneumonectomy; Robotic Benign Esophageal Procedures; Robotic Esophagectomy (Ivor Lewis and McKeown Approaches); Robotic Thymectomy for Myasthenia Gravis; Robotic Thymectomy for Thymic Neoplasms; and Robotic versus Video-Assisted Thoracic Surgery: Advantages and Disadvantages.