Cardiopulmonary Bypass: Advancements in Extracorporeal Life Support provides comprehensive coverage on the technological developments and clinical applications of extracorporeal technologies, including the underlying basic science and the latest clinical advances in the field. Written by experts around the world, this book comprises all characteristics of cardiopulmonary bypass as well as chapters regarding equipment, physiology and pathology, pediatric aspects and clinical applications. Important highlights include the latest updates regarding minimal invasive cardiopulmonary bypass (MICPB), extracorporeal circulatory and respiratory support (ECCRS) in cardiac and non-cardiac patients, ECMO support in COVID-19, and updated guidelines of extracorporeal technologies. This book is an invaluable resource to clinicians, researchers and medical students in the fields of cardiothoracic surgery, cardiac anesthesiology, intensive care, and perfusion technology.

Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition.

This issue of the Interventional Cardiology Clinics edited by Jason Rogers covers various approaches, techniques, and therapies for Transcatheter Mitral Value Intervention. Topics include, but are not limited to: Echocardiographic Imaging of the Mitral Valve for Transcatheter Interventions, Use of Computed Tomography to Guide Mitral Interventions, Transseptal Puncture for Mitral Interventions, MitraClip Therapy for Mitral Regurgitation: Primary MR, Coronary Sinus-Based Approach to Mitral Regurgitation, and Transcatheter Mitral Valve Replacement.

This issue of Thoracic Surgery Clinics of North America focuses on Pulmonary Metastasectomy. Articles will include: Biology of Pulmonary Metastases; Preoperative Evaluations and Indications for Metastasectomy; Open Approaches to Pulmonary Metastases: Thoracotomy and Sternotomy; Ablative Approaches for Pulmonary Metastases: RFA, microwave, SBRT; Role of Lymphadenectomy with Pulmonary Metastasectomy; Results of Pulmonary Resection: Colorectal Carcinoma; Results of Pulmonary Resection: Sarcoma and Germ Cell Tumors; Isolated Lung Perfusion; Immunotherapy; Medical Management of Pulmonary Metastases: Is There a Role for Surgery?; Thoracoscopic Management of Pulmonary Metastases; Results of Pulmonary Resection: Other Epithelial Malignancies; Thoracoscopic Lung Suffusion; and more!

Heart failure occurs in almost epidemic proportions, placing a huge burden on both the healthcare system, and sufferers and their families. This can only rise over coming years as the ageing population, particularly in industrialized countries, increasingly suffers from heart failure and its related comorbidities. The care of this group of patients has evolved significantly over recent years as our knowledge and understanding of the pathophysiology of heart failure has developed. It has become evident that supportive care is integral to comprehensive heart failure care, and this book provides an evidence-based overview of heart failure aetiology, its management, and the supportive care required by patients throughout the course of their disease. Supportive Care in Heart Failure integrates the complexities of heart failure care, bridging knowledge bases from cardiology and cardiothoracic surgery, general medicine and palliative care. The book reviews essential information about epidemiology and pathophysiology of heart failure, and evidence-based medical, device, surgical and interdisciplinary management. It addresses the evaluation and management of quality of life, common symptoms and problems associated with heart failure, and the holistic approach to supportive care throughout the course of the illness through the end of life. Prognostication, communication, and ethical decision making are reviewed in detail. Heart failure has traditionally presented a challenge to physicians, as a generally progressive condition with significant symptoms, a poor quality of life, and high mortality. But by applying the principles of palliative medicine, it is possible to offer a supportive care approach that synthesizes the experience of both the heart failure specialist and the palliative care physician, and offers the best possible quality of care to this group of patients.

Principles of Heart Valve Engineering is the first comprehensive resource for heart valve engineering that covers a wide range of topics, including biology, epidemiology, imaging and cardiovascular medicine. It focuses on valves, therapies, and how to develop safer and more durable artificial valves. The book is suitable for an interdisciplinary audience, with contributions from bioengineers and cardiologists that includes coverage of valvular and potential future developments. This book provides an opportunity for bioengineers to study all topics relating to heart valve engineering in a single book as written by subject matter experts.

In this issue of Surgical Clinics, guest editor Dr. Daniel G. Cuadrado brings his considerable expertise to the topic of Cardiothoracic Surgery. In this issue, top experts in the field provide updates on the most common procedures in cardiothoracic surgery, including articles on the lung, heart and chest, as well as two articles on epidemiology that give an accurate scope of heart disease. Contains 15 relevant, practice-oriented topics including lung cancer: epidemiology and screening; open surgical and extended resections for lung cancer; surgical management of pneumothorax and pleural space disease; management of coronary artery disease; minimally invasive and sub-lobar resections for lung cancer; and more. Provides in-depth clinical reviews on cardiothoracic surgery, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of Thoracic Surgery Clinics, Guest Editor Farid Shamji brings considerable expertise to the topic of Lung Cancer in this second issue covering this topic. Top experts in the field cover key topics such as biological treatments, improving anesthesia safety in pulmonary resection for lung cancer, history of surgical instruments in thoracic surgery, The Hemithorax - the empty chest syndrome, and more. Provides in-depth, clinical reviews on lung cancer, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 16 relevant, practice-oriented topics including Assessment of Operability and Resectability in Lung Cancer; Complications of chest wall resection in conjunction with pulmonary resection; Sepsis in the postpneumonectomy space: pathogenesis, recognition and management; Neuroendocrine cancers of the lung: natural history, pathological classification, biological behaviour and treatment; and more.

The heart is our most important - and perhaps most mysterious - organ.

Every day it pumps 9000 litres of blood and beats around 100,000 times. But the heart is more than just a pump. In all major human cultures, it is seen as the source of love, sympathy, joy, courage, strength and wisdom. Why is this so?

Having witnessed the extraordinary complexity and unpredictability of human hearts in the operating theatre - each one individual in its make-up, like a fingerprint - heart surgeon Reinhard Friedl went on a search for answers. He examined closely the latest findings in neurocardiology and psychocardiology, and in The Beat of Life he shares his discoveries, using riveting personal stories to illustrate the complex relationship between the heart, the brain and the psyche.

In this issue of Thoracic Surgery Clinics, guest editor Farid Shamji brings considerable expertise to the topic of Lung Cancer. Provides in-depth, clinical reviews on Lung Cancer, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Mechanical cardiovascular assist devices must be properly designed to avoid damage to the blood they contact. The factors that affect the hemocompatibility of a cardiovascular assist device include three major non-physiological components - the material, fluid flow paths, and flow related stresses, - as well as the device interaction with the native vasculature. Furthermore, the interaction of the device with the blood is not static. Foreign surfaces activate blood components including platelets, leukocytes and the coagulation cascade. Thrombus formation on the surface of the device can alter the fluid dynamics in a manner that causes erythrocyte damage ranging from significant hemolysis to sub-lethal trauma that can take many days to weeks to develop into a significant clinical problem. This sub-lethal blood trauma is not easily detectable without special equipment, which is typically unavailable in routine clinical practice. Surveillance for blood damage is often sub-optimal in the clinical setting, but once clinically relevant hemolysis occurs, crucial decisions - device removal, replacement, or additional medical therapies including surgery or plasmapheresis - that take into account the risk/benefit of intervention must be quickly evaluated. The various preclinical designs and testing, surgical considerations, available surveillance techniques, and clinical consequences will be discussed using recent and historical case reports to highlight key points.

This issue of Thoracic Surgery Clinics, guest edited by Drs. Dean Donahue and Hugh G. Auchincloss, is devoted to Thoracic Outlet Syndrome. Drs. Donahue and Auchincloss have assembled expert authors to review the following topics: Embryology and Anatomy of the Thoracic Outlet; Evaluation of Patients with Neurogenic Thoracic Outlet Syndrome; Reoperation for Persistent or Recurrent Neurogenic Thoracic Outlet Syndrome; Surgical Technique: Supraclavicular First Rib Resection; Evaluation and Management of Venous Thoracic Outlet Syndrome; How Common is Thoracic Outlet Syndrome?; Surgical Technique: Minimally Invasive First Rib Resection; Radiographic Evaluation of Thoracic Outlet Syndrome; Evaluation and Management of Arterial Thoracic Outlet Syndrome; and more!

This issue of Thoracic Surgery Clinics, guest edited by Drs. Virginia R. Litle and Robert J. Canelli, is devoted to Peri-operative Management of the Thoracic Patient. Drs. Litle and Canelli have assembled expert authors to review the following topics: Preoperative Evaluation of Patients Undergoing Thoracic Surgery; Prehab of the Thoracic Patient; Enhanced Recovery after Thoracic Surgery; Surgical Approaches for Esophagectomy: Open, Minimally Invasive, Robotic. What is the Approach Algorithm?; Intraoperative Anesthetic Management of the Thoracic Surgery Patient; Intraoperative Surgical and Anesthetic Concerns for Robotic Approach to the Thoracic Surgery Patient; Prevention of Postoperative Prolonged Air-leak after Pulmonary Resection; Intraoperative Pre-emptive Prevention of Esophagectomy Complications: Role of Feeding Tubes, Pyloric Drainage Procedures, Anastomotic Buttressing; Interventional Pulmonology: A Brave New World; Pain Management in Thoracic Surgery; Management of Complications after Lung Resections; Management of complications after esophagectomy; and more!

This issue of Thoracic Surgery Clinics, guest edited by Drs. Jyoti Patel and Jessica Donington, is devoted to Advances in Systemic Therapy for Non-Small Cell Lung Cancer. Drs. Patel and Donington have assembled expert authors to review the following topics: Adjuvant and Neoadjuvant Immunotherapy; Combining Immunotherapy with Radiation in Lung Cancer; Adjuvant Chemotherapy; ALK Mutations; Molecular Targets Beyond the Big 3; Advances in Systemic Therapy; Liquid Biopsies in NSCLC; Combining Immunotherapy and Chemotherapy for NSCLC; ROS-1 Mutations; EGFR Mutations; and more!

This issue of Thoracic Surgery Clinics, guest edited by Drs. Vincenzo Ambrogi and Tommaso Mineo, is devoted to Nonintubated Thoracic Surgery. Drs. Ambrogi and Mineo have assembled expert authors to review the following topics: Technical issues and patient safety in nonintubated thoracic anesthesia; Management of primary and secondary pneumothorax in nonintubated VATS; Treatment of pleural effusions with nonintubated VATS; Nonintubated VATS for chest infections; Nonintubated VATS lung biopsy for interstitial lung disease; Nonintubated VATS wedge resection of peripheral early lung cancer; Anatomical segmentectomy in nonintubated VATS; VATS lobectomy for lung cancer in nonintubated anesthesia; Nonintubated VATS tracheal and bronchial sleeve resection for lung cancer; Nonintubated tracheal surgery; Management of intraoperative crisis during nonintubated thoracic surgery; Team training for nonintubated thoracic surgery; and more!

This issue of Thoracic Surgery Clinics of North America, guest edited by Dr. Joshua Sonett, is devoted to Thymectomy for Myasthenia Gravis. Dr. Sonett has assembled expert authors to review the following topics: Role of Thymus in the Immune System; A Neurologist's Perspective to Understanding Myasthenia Gravis: Clinical Perspectives of Etiology, Diagnosis and Preoperative Treatment; A Neurologist's Perspective on Thymectomy for Myasthenia Gravis: Current Perspective and Future Trials and Medications; Surgical Approaches to Myasthenia Gravis: Perspective of Anatomy and Radicality in Surgery; Surgical Techniques for Myasthenia Gravis: VATS; Surgical Techniques for Myasthenia Gravis: RATS; Surgical Decision Making: Thymoma and Myasthenia Gravis; Immune Syndromes and the Thymus: Is There a Role of Thymectomy?; Surgical Techniques for Myasthenia Gravis: Transcervical; Surgical Technique for Myasthenia Gravis: Subxyphoid Approach; History of Thymectomy for Myasthenia Gravis; and more!

This issue of Interventional Cardiology Clinics will explore Updates in Percutaneous Coronary Intervention. Curated by the series Editor-in-Chief, Dr. Matthew J. Price, this issue will cover topics and advances in the field that are relevant for practicing clinicians. This issue is one of four selected each year by Dr. Price. The volume will include articles on: Current Concepts in Intraprocedural Pharmacology During PCI; Periprocedural Myocardial Infarction in Contemporary Practice; Newer Generation Metallic Stents: Design, Performance Characteristics, and Outcomes; Distal Transradial Access for Coronary Angiography and Intervention; Clinical Outcomes Data for iFR-guided PCI; Culprit-only or Complete Revascularization During STEMI in Patients with and Without Shock; Technical Approaches to Left Main Coronary Intervention: Contemporary Best Practices; Robotic Assisted Percutaneous Coronary Intervention; Orbital Atherectomy: A Comprehensive Review; and Percutaneous revascularization of spontaneous coronary artery dissection, among others.

This issue of Thoracic Surgery Clinics of North America, guest edited by Drs. Jean Deslauriers, Farid Shamji, and Bill Nelems, is the first of two devoted to Fundamentals of Airway Surgery. The editors have assembled expert authors to review the following topics: Birth of Airway Surgery and Evolution over the Past Half-Century; Regional and Applied Anatomy of the Tracheo-Bronchial Tree from Larynx to Segmental Bronchus; Advanced Technologies for Imaging and Visualization of the Tracheobronchial Tree; Anesthesia and Gas Exchange during Airway Surgery; The Importance of Good Communications Between Anesthesiologists and Thoracic Surgeons; Tracheal Injuries Complicating Prolonged Intubation and Tracheostomy; Biology of Adenoid Cystic Carcinoma of the Tracheo-Bronchial Tree and Principles of Management; Pathology of Primary Tracheobronchial Malignancies other than Adenoid Cystic Carcinomas; Tuberculosis and Other Granulomatous Diseases of the Airway; Tracheobronchomalacia and Expiratory Collapse of Central Airways; Management of Idiopathic Laryngo-Tracheal Stenosis; Subglottic Tracheal Resection and Synchronous Laryngeal Reconstruction with Preservation of the Recurrent Laryngeal Nerves: The Pearson Operation; Laryngeal Split and Rib Cartilage Interpositional Grafting: Treatment Option for Glottic/Subglottic Stenosis in Adults; Distal Tracheal Resection and Reconstruction; Factors Favoring and Impairing Healing of Tracheal Anastomosis; Prophylaxis and Treatment of Complications After Tracheal Resection; Non-Operative Endoscopic Management of Benign Tracheo-Bronchial Disorders; From Open to Bedside Percutaneous Tracheostomy; Anterior Mediastinal Tracheostomy; and more!

This issue of Thoracic Surgery Clinics of North America, guest edited by Dr. Sharon Ben-Or, is devoted to Thoracic Surgery in the Special Care Patient. Dr. Ben-Or has assembled expert authors to review the following topics: Thoracic surgery in the pregnant patient; Thoracic surgery in early stage small cell lung cancer; Lung cancer in the post transplant / immunosuppressed patient; The postpneumonectomy patient; Thoracic surgery considerations in the obese patient; Thoracic surgery considerations in the pediatric patient; Esophagectomy after weight reduction surgery; Thoracic surgery considerations in the mentally ill or handicapped patient; Lung cancer with concomitant cardiac disease; Malignant pleural effusion and the trapped lung; Empyema from an obstructing lung cancer; Synchronous esophageal and lung cancer; Thoracic surgery considerations in the AIDS patient; and more!