This book comprehensively covers aortic dissection and acute aortic syndromes. Topics covered include the pathology, genetics, diagnosis, medical treatment and surgical management of uncomplicated and complicated aortic dissection, including endovascular stenting. In addition, imaging and follow-up procedures after initial surgical treatment are reviewed along with acute and chronic type A and type B dissection. Potential complications that can be encountered at various treatment stages and management strategies are also detailed. Aortic Dissection and Acute Aortic Syndromes comprehensively reviews aortic dissection in an easy to read, illustration-rich book. It is therefore an essential resource for both trainee and experienced cardiologist, cardiac surgeon and any other medical professionals involved in the management of these patients.

Mit neu entwickelten diagnostischen Moeglichkeiten und verbesserten Therapieverfahren ist eine zunehmend differenzierte Behandlung von Lungenmetastasen boesartiger Tumoren moeglich geworden. Je nach Ursprungstumor und klinischer Situation wird ein unterschiedliches Vorgehen empfohlen. Neben onkologischen Gesichtspunkten ruckt auch die verbleibende Lungenfunktion in den Mittelpunkt des Interesses. Die moderne Bildgebung, offene und minimal invasive Operationsverfahren und interdisziplinare Therapiekonzepte zu den einzelnen Tumorentitaten sind detailliert und praxisorientiert beschrieben.

This book discusses all thoracic diseases of surgical interest, from thorax malformations to airways disorders. It is divided into six main sections; the first two analyze general aspects, while the following three focus on malformations of the thorax, airways, esophagus and diaphragm. The final section describes the main pediatric tumors involving the chest and internal thoracic organs. Each chapter starts with a classification of the main pathologies related to the anatomical region considered. For each pathology, the various aspects of the diagnostic-therapeutic procedure are described in details - from the clinical presentation and diagnosis to the pre-operative preparation, the surgical aspects, and the post-operative course. Possible future developments are also evaluated. The volume will be a useful tool for specialists in pediatric and thoracic surgery, but will also represent an educational resource for medical and nursing students.

This book focuses on congenital heart disease (CHD) and emerging imaging technologies. It covers all clinically relevant aspects of the fascinating new cardiac imaging technologies, including a comprehensive explanation of their basic principles, practical aspects of novel clinical applications, and detailed descriptions of specific uses in the broad spectrum of clinically important adult CHD. Innovations and emerging technologies for diagnosis and therapeutics, evaluation and treatment are continually evolving, and due to these advances in non-invasive diagnosis, there has been a significant improvement in the survival rates for CHD patient. Novel approaches to trans-catheter interventions and advances in echocardiography, MRI and CT imaging are being developed and incorporated into routine clinical practice, while emerging three-dimensional printing technologies are fundamentally affecting patient care, research, trainee education, and interactions between multidisciplinary teams, patients, and caregivers. In addition, translational technologies on the horizon promise to take this nascent field even further. Exploring the applicability of these emerging technologies in improving our understanding of complex congenital cardiac defect anatomy and physiology will provide new treatment options for this unique population. Written by experts in the field who are also involved in patient care, this book discusses the practical application of innovations in advanced multimodality imaging in the daily clinical routine and offers tips and tricks for beginners.

The updated and expanded second edition of this book presents a contemporary review of the basic science, engineering technology, and clinical practice of cardiac bioelectric therapy. It covers the rapidly expanding technological development of pacemakers and defibrillators as well as ablative therapy, electrophysiological mapping, and other clinical diagnostic and therapeutic breakthroughs. The book highlights many different aspects of bioelectric therapy, including history, biophysical and computational concepts, basic electrophysiology studies, engineering technology advances, and clinical perspectives. In this revised edition, leading clinical and basic electrophysiologists share their perspectives on the science behind the mechanisms of cardiac arrhythmias; breakthrough technologies for scientific and clinical investigation of heart rhythm disorders; theoretical conceptualization of arrhythmias and treatment using state-of-the-art computational approaches; and novel approaches to treatment of cardiac arrhythmias using implantable devices, percutaneous ablation therapies, machine learning, and other approaches. The Second Edition of Cardiac Bioelectric Therapy is an essential resource for physicians, residents, fellows, and graduate students in clinical cardiac electrophysiology, cardiology, and cardiac surgery as well as researchers, professionals, and students in biomedical, mechanical, and electrical engineering.

Comprehensively addressing the topic of the compartment syndrome, this book covers all aspects of this painful and complex condition, ranging from the history to the pathophysiology and treatment in the various body compartments affected by the syndrome, as well as the short- and long-term outcomes. With an up-to-date literature review and the innovative content written by international opinion leaders, it offers all involved in the management of such complicated patients a much-needed source of reference. Discussing compartment syndrome in everyday practice, this book is of interest to surgeons, practicing physicians, anesthesiologists and nurses.

This volume is a "how-to guide" to treating thoracic trauma and emergencies for acute care surgeons. It highlights the diagnosis and management of thoracic disease and injuries, and each chapter includes algorithms that lead readers through the process of identifying and treating many common and some uncommon thoracic pathologies. The international team of authors provides readers with a unique and diverse approach to the operative and non-operative challenges encountered by ACS surgeons. The large number of figures offers readers insights into what they can expect to see when caring for these patients. The editors understand that the management of adults and children differ and have included a specific chapter on pediatrics. Given the broad audience and diverse settings in which the text can be used, the authors also provide details of care in limited-resource environments. The volume is a valuable tool for professionals interested in thoracic surgery and acute care surgery.

This book summarizes the branch tracing method for bronchoscopic diagnosis. Cytopathological and histopathological diagnoses are essential to making prognoses and selecting appropriate treatment for peripheral pulmonary lesions, notably lung cancer. In order to collect cell and tissue samples from peripheral pulmonary lesions for cytopathological and histopathological diagnoses, exfoliative cytodiagnosis and biopsy under bronchoscopy with endobronchial ultrasonography (EBUS) are currently used worldwide. Bronchial Branch Tracing highlights how to identify the bronchial branches that lead to peripheral pulmonary lesions and offers a valuable guide for all respiratory physicians, as well as surgeons, who frequently perform bronchoscopies, helping them understand the method and improve their technique.

Der Zusammenhang von Lernen und Krankheit ist Thema in einer Vielzahl von Fachdisziplinen: Eine lebensbedrohliche Erkrankung zwingt zum leidvollen Lernen, bietet aber auch die Chance der Persoenlichkeitsentwicklung. In diesem Buch wird der Zusammenhang zwischen Krankheit und Lernen von ausgewiesenen Expertinnen und Experten aus Psychologie, Medizin, Rechtswissenschaft, Theologie, Soziologie, Erziehungswissenschaft u. a. beleuchtet. Wissenschaftler haben empirisches Material aus dem DFG-Projekt "Lebenslanges Lernen im Kontext lebensbedrohlicher Erkrankungen" erhalten und aus der Sicht ihrer jeweiligen Disziplin die Krankheits- und Lernprozesse von Brustkrebs- und Herzinfarktpatienten analysiert. Damit tragen sie zur komparativen Erschliessung von zwei Volkskrankheiten bei. Datenmaterialien aus dem Buch (Krankengeschichten in pseudonymisierter Form) stehen fur universitare Lehr- und Forschungszwecke auf Anfrage unter dem Link www.Biographie-Krankheit-Lernen.de zur Verfugung. Geschrieben fur AErzte, Psychologen, Pflegewissenschaftler, Erziehungswissenschaftler sowie fur alle weiteren Berufsgruppen, die in der medizinischen Versorgung, Gesundheitsbildung und Forschung tatig sind.

Cardiac implantable device (CIED) infections are a key issue since they have serious consequences in terms of morbidity, mortality and associated costs for healthcare systems. Such infections are highly complex, which has implications for prevention (several factors underlie its development), diagnosis (requiring patient specific integration of several elements), acute treatment (choice of the antibiotic, lead extraction procedure), as well as long-term management (CIED re-implantation strategy and follow-up). Dealing with CIED infections requires appropriate organization of healthcare provision, with the creation of integrated hub-spoke referrals, and it has prompted many of the recent developments in CIED technologies: leadless pacemakers, subcutaneous defibrillators, antibacterial envelops and lead extraction devices. This book systematically examines all aspects of this multifaceted condition, discussing each clinical and organizational issue in a separate self-contained chapter. It starts by reviewing the epidemiology/pathophysiology of CIED infections, and then addresses acute and long-term management. Offering a comprehensive overview of the prevention of infections, considering both current and future perspectives, the book also provides practical suggestions along with recommendations from the literature in the field. This is the first book entirely focused on CIED infections. Written by an international team of leading experts it will appeal to broad audience, including cardiologists, electrophysiologists, infectious disease specialists, internists, healthcare professionals, health service managers and providers, researchers and those working in industries involved in the field.

This book provides a comprehensive introduction to artificial hearts, summarizing the latest advances in basic technologies, design, evaluation, and management. Featuring 11 chapters, it discusses the origins of the artificial heart, the mechanisms of heart failure, and the principles of artificial heart technologies. Further, it offers an overview of rotary pumps and volume-displacement pumps, and addresses total artificial hearts. Lastly, the book covers evaluation, selection, therapy management, challenges, and the latest innovations. Given its scope, it is a valuable resource for researchers and technicians in the area of biomedical engineering, as well as surgeons.

This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.

There are many excellent textbooks that exist in the area of implantable devices for arrhythmia control. Few textbooks, however, provide a case study approach. Collectively, these workbooks provide an approach to problem solving an electrocardiographic interpretation for patients with permanent pacemakers and defibrillators.

Volume 1 addresses patients with permanent pacemakers
Volume 2 examines interactions between pacemakers and implantable defibrillators
Volume 3 provides case studies of transtelephonic pacemakers electrocardiography
Volume 4 provides more pacemaker and implantable defibrillator troubleshooting cases

This volume takes a case-orientated approach, providing a diverse series of problems on a broad range of topics related to implantable defibrillators. The cases are divided into easy, moderate and complex according to their level of difficulty, allowing the reader to gauge their progress. This workbook is suitable for physicians, nurses, technicians, technologists and industry engineers, particularly those new to the field who are keen to learn in a practical way.

This book provides new perspectives on the pathogenesis of atherosclerosis. Chapters cover atherosclerosis risk factors, the effect of growth and aging on vascular architecture, and the crucial role the microvasculature plays in atherosclerosis development. Microvascular dysfunction would explain why the well-known risk factors actually put individuals at higher risk. This pathomechanism would also hold true not only for obstructive atheroma formation but also for aneurysmal dilatation as well as for aortic and peripheral artery dissection. When seen through this lens, novel preventive and therapeutic opportunities can be envisioned. Atherosclerosis Pathogenesis and Microvascular Dysfunction proposes a single unifying mechanism of atherosclerosis development and describes potential preventative and therapeutic avenues based on this concept. It therefore represents a timely and valuable resource for internal medicine, cardiology, angiology cardiovascular surgeons, pathology clinicians, researchers, trainees, and students.

State of the Art Surgical Coronary Revascularization is the most authoritative textbook ever dedicated to the art and science of surgical coronary revascularization, with 71 chapters, organized in 9 sections, and written by over 100 recognized world experts. It covers every aspect of the surgical management of coronary artery pathology and ischaemic heart disease. It provides extensive sections detailing pathophysiology, evaluation and medical and percutaneous management of ischaemic heart disease as well general outcomes and quality assessment for coronary artery bypass grafting (CABG). Pre-, intra- and postoperative management of CABG patients is emphasized in detail as are the core surgical principles in the conduct of CABG, with special focus on the selection of conduits and how to optimize the performance of both on- and off-pump surgery to reduce morbidity and mortality. There are detailed sections on how to improve outcomes with both arterial and venous bypass grafts. This comprehensive textbook also covers in detail less invasive approaches for CABG, CABG in special clinical situations and when CABG is combined with concomitant surgical procedures. In addition to underpinning all chapters with a strong and updated evidence basis, crucial practical surgical techniques are emphasised throughout, making this textbook the indispensable companion of all adult cardiac surgeons and allied health professionals interested in surgical coronary revascularization.

This book provides a comprehensive introduction to artificial hearts, summarizing the latest advances in basic technologies, design, evaluation, and management. Featuring 11 chapters, it discusses the origins of the artificial heart, the mechanisms of heart failure, and the principles of artificial heart technologies. Further, it offers an overview of rotary pumps and volume-displacement pumps, and addresses total artificial hearts. Lastly, the book covers evaluation, selection, therapy management, challenges, and the latest innovations. Given its scope, it is a valuable resource for researchers and technicians in the area of biomedical engineering, as well as surgeons.

In this concise but authoritative book, the authors take the reader through the epidemiology, risk factors and the basic mechanism of coronary artery disease. In addition, they explain how coronary microvascular dysfunction can lead to angina, even after successful angioplasty following a heart attack. The methods for diagnosis and the options for treatment are explained, ending with a discussion of the evolution of coronary angioplasty from balloon catheters to novel, fully resorbable polymeric drug eluting stents. Enclosed is a list of currently available commercial devices, as well as a listing of experimental products under research and development, so that readers can appreciate the serious nature of this disease and have an understanding of how the medical device sector is attempting to address this major healthcare problem. Globally in 2010, ischemic heart disease was the cause of 13.3% of all deaths. In the US alone, the direct medical costs from coronary artery disease and stroke are currently estimated to be $126 billion per year, and are expected to rise to $309 billion by 2035.

This text serves as a convenient one-stop resource on the pathogenesis, diagnosis and treatment of kidney diseases in context of advanced heart failure and presence of ventricular assist devices. Advances in managing heart failure, evidence-based practices and therapies are covered, along with the management of this unique and complex subset of patients. The book also provides insights into combined heart and kidney transplantation. Authored by leaders in nephrology, cardiology and transplantation, this book fills a critical knowledge gap in understanding and treating patients with acute or chronic dysfunction of the heart and kidneys and how one induces dysfunction in the other organ.

Cardiac Valve Replacement: Current Status is the proceedings of the Fourth Interna tional Symposium on the ST. JUDE MEDICAL@ valve. The first three symposia on this topic were held primarily for designated investigators involved in clinical trials of the ST. JUDE MEDICAL valve. The last meeting, chaired by Michael E. DeBakey, M.D., was held in November 1982 [1], immediately before the valve was released for general clinical use in the United States by the Food and Drug Administration. These proceedings then are the first comprehensive compilation of clinical data since that time; and they include, particularly in the discussions, the experience of physicians other than the original clinical investigators. Over the past 5 years the character of these symposia has changed. Whereas the first two dealt almost entirely with the ST. JUDE MEDICAL valve, the last two have evolved into a more generic cardiac valvular surgery meeting, focusing primarily on valve replacement rather than valve repair [2]. Thus, these proceed ings contain a wide spectrum of topics, including a keynote presentation on criteria for selection of cardiac valve substitutes in 1984, complications of cardiac valve replacement and their treatment, a review of the current status of cardiac valve substitutes other than the ST. JUDE MEDICAL valve and a consideration of cardiac valve replacement in special circumstances. Among these special circum stances are four presentations on pediatric use of the ST. JUDE MEDICAL valve.

This book explores the non-interventional aspects of interventional pulmonology, focusing on diseases of the central airways. As the field of bronchology and interventional pulmonology expands, newer conditions involving the central airways are being recognized with increasing frequency. Current literature has mainly focused on technical aspects of the subspecialty, but this book illuminates what else interventional pulmonology has to offer the pulmonologist, including diagnosis and alternate therapeutic options. Diseases of the Central Airways: A Clinical Guide presents techniques for the diagnoses, management and treatment of patients with intriguing central airway conditions such as: black bronchoscopy, tracheobronchomalacia, endobronchial tuberculosis, and tracheobronchopathia osteochondroplastica. In-depth chapters are written by international experts and are up-to-date and comprehensive reviews. This important new book will contribute significantly to the welfare of patients with lung ailments of the central airways.

This book describes the molecular mechanisms of lung cancer development and progression that determine therapeutic interventions in the era of genomics, when the rapid evolution in lung cancer diagnosis and treatment necessitates critical review of new results to integrate advances into practice. The text opens with background and emerging information regarding the molecular biology of lung cancer pathogenesis. Updated results regarding lung cancer prevention and screening are discussed, followed by chapters on diagnostic techniques and pathological evaluation. This leads on to a detailed presentation of treatment modalities, from surgery and radiation therapy to standard chemotherapy and targeted agents. The coverage includes resistance to therapy and the emergence of immunotherapy for lung cancer; in addition, the current evidence in respect of small cell lung cancer is summarized. The book presents insights from experts across disciplines to emphasize the importance of collaborative care. Advances in our understanding of issues in geriatric oncology and palliative care complete the comprehensive discussion of lung cancer.

This text provides a comprehensive, state-of-the-art review of catheter based approaches to valve and aortic diseases. The scope encompasses involve all the current and upcoming transcatheter aortic valve technologies as well as mitral, pulmonary and tricuspid valve technologies. Aortic diseases including transcatheter repair of descending aneurysms are included and the upcoming technologies designed to repair aortic dissections, traumatic injury, and ascending arch stent repair are highlighted. Catheter Based Valve and Aortic Surgery will be a useful tool for cardiac and vascular surgeons, interventional cardiologists, general cardiologists, and clinicians and researchers with an interest in these exciting new developments in structural heart and vascular diseases.

Over two centuries ago, oxygen was discovered as "air vital" the component of the earth's atmosphere necessary for life. Less than five years after this discovery, it was found that oxygen was both a life-sustaining and life threatening inhalant as it plays a role in the two extremes of the animal kingdom: life and death. In the subse quent years, we have made major strides in understanding the role of oxygen in maintaining life and volumes of information are now available on this topic. Our knowledge of the contribution of oxygen in cellular dysfunction and cell death which for the most part had lagged behind has begun to catch up. The deleterious ef fects of oxygen radicals and activated oxygen species on a variety of biological systems have now been described. Recently attention has also been focused on the toxic effects of oxygen on the cardiovascular system. The major aim of the present treatise is to offer an integrated view of the pathophysiological aspects of oxygen toxicity in the heart and blood vessels coupled with a review of therapeutic approaches (hopes?) with free radical scavengers and antioxidants. Internationally known expert investigators provide a concise and critical review on the topic of their expertise which also contains data from their own research."

For many years, there has been a great deal of work done on chronic congestive heart failure while acute heart failure has been considered a difficult to handle and hopeless syndrome. However, in recent years acute heart failure has become a growing area of study and this is the first book to cover extensively the diagnosis and management of this complex condition. The book reflects the considerable amounts of new data reported and many new concepts which have been proposed in the last 3-4 years looking at the epidemiology, diagnostic and treatment of acute heart failure.

There is no standard textbook at this time on endovascular management of thoracic aortic pathologies. Atlas of Thoracic Aortic Endografting contains clinical case scenarios as well as controversies to highlight the use of this new technology. The various aortic pathologies are discussed, combining etiology, diagnostic tools like intravascular ultrasound (IVUS) and 64 slice CT scans which are all state of the art technologies, endovascular treatment, management of endoleaks, reinterventions combined with techniques of trouble shooting. This book highlights the new changes in the management of thoracic aortic diseases.