Over two centuries ago, oxygen was discovered as "air vital" the component of the earth's atmosphere necessary for life. Less than five years after this discovery, it was found that oxygen was both a life-sustaining and life threatening inhalant as it plays a role in the two extremes of the animal kingdom: life and death. In the subse quent years, we have made major strides in understanding the role of oxygen in maintaining life and volumes of information are now available on this topic. Our knowledge of the contribution of oxygen in cellular dysfunction and cell death which for the most part had lagged behind has begun to catch up. The deleterious ef fects of oxygen radicals and activated oxygen species on a variety of biological systems have now been described. Recently attention has also been focused on the toxic effects of oxygen on the cardiovascular system. The major aim of the present treatise is to offer an integrated view of the pathophysiological aspects of oxygen toxicity in the heart and blood vessels coupled with a review of therapeutic approaches (hopes?) with free radical scavengers and antioxidants. Internationally known expert investigators provide a concise and critical review on the topic of their expertise which also contains data from their own research."

Our understanding of the pathophysiology of acute myocardial infarction has grown enormously in recent years. This has led to an increasingly aggressive approach to management, designed to blunt the extent of infarction by salvaging acutely ischemic myocardium. Alternatives now include throm bolysis, PTCA with and without prior thrombolysis, and emergency bypass surgery, as well as the more aggressive use of a variety of drugs. This book consists of a series of chapters by experienced cardiologists and cardiovascular surgeons that present today's state of the art in managing acute myocardial infarction. It is written with the purpose of presenting practical approaches of value to the clinician related to the more complex problems faced in dealing with patients undergoing myocardial infarction. xi EARLY INTERVENTIONS IN ACUTE MYOCARDIAL INFARCTION 1. MANAGEMENT OF ARRHYTHMIAS IN THE CORONARY CARE UNIT NORA GOLDSCHLAGER, RODERICK WOODS, AND NEAL BENOWITZ With the advent of coronary care units, mortality from cardiac arrhythmias occurring during acute myocardial infarction has been unquestionably and dramatically reduced. In addition, continuous electrocardiographic monitoring has resulted in the recognition of specific arrhythmias related to acute ischemic heart disease and thus to the development of appropriate strategies for their management. This chapter will review certain specific aspects of those bradyarrhythmias and atrial and ventricular tachyarrhythmias that are seen most commonly in acute myocardial infarction. Pharmacologic therapy, including the use of some of the newer antiarrhythmic agents, will be discussed, as will pacemaker ther apy of both bradyarrhythmias and tachyarrhythmias."

The topic of heart failure although extensively researched and reported, has several gray areas. This is especially seen in determining strategies for combating advanced heart failure. The global burden of ischemic heart disease is increasing at an alarming rate to almost pandemic proportions. Even in the presence of state-of the art technology for prompt and successful coronary reperfusion, the population progressing to ischemic cardiomyopathy is substantial. The treatment strategies for ischemic cardiomyopathy do not always ensure optimal clinical results, the reasons for which are varied. The proper patient selection is vital as is the tailoring of suitable therapy. The approach is thus multi-pronged, of which surgical ventricular restoration (SVR) has a definite role. Despite various randomized studies like the STICH-hypothesis 2, where there was a huge selection bias, with patients subjected to an erroneous technique of SVR, with inadequate ventricular remodelling assessment. The present need is to understand the unique anatomy of the left ventricle, its function and perturbations with the onset of heart failure, in order to plan therapeutic strategies to restore near normal anatomy and function. A study of the hemodynamics in ischemic cardiomyopathy is essential, as it differs in certain aspects from other causes of heart failure like idiopathic dilated cardiomyopathy and valvular heart diseases. Since information on these aspects are scattered in various scholarly articles, a concise source in the form of a book would be appropriate and useful for both cardiologists and cardiac surgeons. This project represents a concise review of normal and abnormal cardiac anatomy and physiology, the evolution of SVR to EVLPP with validation of near normal ventricular restoration, plus act as a reference guide for cardiac surgeons with interest in SVR.

The two previous editions of "Applied Physiology in Intensive Care Medicine" proved extremely successful, and the book has now been revised and split into two volumes to enhance ease of use. In this second volume some of the most renowned experts in the field offer detailed reviews on measurement techniques and physiological processes of crucial importance in intensive care medicine. Throughout, a key aim is to help overcome the fundamental unevenness in clinicians understanding of applied physiology, which can lead to suboptimal treatment decisions. "Applied Physiology in Intensive Care" has been written by some of the most renowned experts in the field and provides an up-to-date compendium of practical bedside knowledge essential to the effective delivery of acute care medicine. It will serve the clinician as an invaluable reference source on key issues regularly confronted in everyday practice.

A definitive, comprehensive text on the technological developments and clinical applications of this critical subject matter. Written for the entire heart surgery team, this volume covers the physiology of cardiopulmonary bypass, mechanics and components of the heart-lung machine, the conduct of cardiopulmonary bypass in cardiac surgery, non-cardiac applications of cardiopulmonary bypass, and mechanical assistance of the failing heart and lung. The authors also give special consideration to such areas as blood conservation in cardiac surgery, religions objections to blood transfusions, medical-legal aspects and cardiopulmonary bypass, as well as warm blood cardioplegia and normothermic cardiopulmonary bypass.

A panel of recognized authorities comprehensively review the medical, surgical, and pathophysiologic issues relevant to lung volume reduction surgery for emphysema. Topics range from the open technique and video-assisted thoracoscopic approaches to LVRS, to anesthetic management, to perioperative and nursing care of the patient. The experts also detail the selection of candidates for LVRS, the clinical results and clinical trials in LVRS, and the effects of LVRS on survival rates.

With the introduction of cardiac surgery more than five decades ago and the use of the heart-lung machine for open heart surgical procedures granting the surgeon unlimited time in which to operate inside the heart, a complex task has been given to the Perfusionist. With a pairing of a perfusionist and a surgeon for each chapter, this book is an essential collection of techniques and protocols to aid in decision making in the operating room.

Core Topics in Thoracic Surgery provides accessible and concise coverage of the topics most often encountered in thoracic surgery practice. This handbook will guide the reader through revision of the topics covered in the FRCS(CTh) examination, and also covers more specialist topics in detail. In-depth technical sections offer guidance for difficult procedures, with useful commentaries from leading surgeons. A broad range of thoracic surgery issues are examined, with the latest evidence and information relevant to the speciality presented in a clear fashion. Combining an easy-to-use revision guide for trainees and a comprehensive reference text for cardiothoracic surgeons and recently appointed consultants, this is a one-stop guide to thoracic surgery. Authored by leading experts in the field, this resource will be invaluable to cardiothoracic surgeons, respiratory physicians and specialist nurses seeking to refresh or expand their knowledge of this field.

This book provides an unbiased and evidence-based guide to the potential role of interventional pulmonology as an alternative to thoracic surgery. Interventional pulmonology is a new and quickly growing sub-specialty in pulmonary medicine and increasingly more pulmonologists are turning to interventional therapies over the more costly and invasive surgical options. The text thoroughly presents detailed coverage of and diagnostic methods for many diseases and conditions that pulmonologists encounter daily, including: diffuse lung infiltrates, solitary lung nodule, undiagnosed exudative pleural effusion, pneumothorax, hemoptysis, and airway foreign body. Experts then detail treatment options, from both a surgical and interventional perspective, with guidance on: when each procedure is most appropriate, what can be performed by a pulmonologist (with guidelines on how those procedures are done) versus what needs to be referred to a thoracic surgeon or an intervention pulmonologist, and the benefits and disadvantages involved with each option. This is an ideal guide for pulmonologists, trainees, and students to better understand the full scope of possible treatment options for their patients and to make the best informed decision about patient care.

With the introduction of cardiac surgery more than five decades ago and the use of the heart-lung machine for open heart surgical procedures granting the surgeon unlimited time in which to operate inside the heart, a complex task has been given to the Perfusionist. With a pairing of a perfusionist and a surgeon for each chapter, this book is an essential collection of techniques and protocols to aid in decision making in the operating room.

This book provides a detailed account of the principles and practice of contemporary lung transplantation. An accomplished, international team of contributing authors have combined their expertise to provide scientific developments and clinical knowledge based on their extensive experience. The book covers pulmonary vascular and parenchymal lung disease, which necessitate transplantation, together with all aspects of the multidisciplinary management of lung transplant patients. It concludes by looking at future developments in the treatment of advanced respiratory failure. This multidisciplinary approach makes the publication suitable for several subspecialities in addition to pulmonary medicine and lung transplantation, including haematology, radiology and clinical psychology. It will serve as a valuable source of reference and practical information for medical specialists in transplantation and all those working in thoracic organ transplant units.

With an emphasis on the "how and why" of contemporary surgery, Operative Techniques in Surgery, Second Edition, features concise, bulleted text, full-color illustrations, and intraoperative photographs to clarify exactly what to look for and how to proceed. Meticulously edited by Drs. Mary T. Hawn, Aurora D. Pryor, Steven J. Hughes, Michael S. Sabel, Kellie R. Brown and Amy J. Goldberg, this comprehensive, two-volume surgical atlas focuses on the steps of each technique, rapidly directing you to the information you need to choose the right approach for each patient, perform it successfully, and achieve the best possible results. Coverage includes open as well as laparoscopic, robotic, endoscopic, and endovascular procedures in gastrointestinal, thoracic, esophageal, colorectal, hepatobiliary, breast, endocrine, dermatologic, vascular, and trauma surgery New, comprehensive section on trauma surgery, helmed by trauma expert Dr. Amy J. Goldberg New section editors for esophageal and foregut surgery and vascular surgery, Dr. Aurora D. Pryor minimally invasive surgery leader and Kellie R. Brown, expert in vascular surgery. New videos, personally selected by contributing authors and editors, accompany numerous chapters throughout the book Extensive updates throughout, including new coverage of the American Board of Surgery's SCORE Curricula for General Surgery and for Complex General Surgical Oncology Each procedure follows the same format: differential diagnosis, patient history and physical findings, imaging and other diagnostic studies, surgical management, techniques, pearls and pitfalls, postoperative care, outcomes, and complications Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This thesis addresses computation fluid dynamics modelling of aortic dissection (AD), in order to generate in silico diagnostic information and assess 'virtual surgery' outcomes. The thesis introduces several important advances in the modelling of aortic dissection and lays essential groundwork for further development of this technology. The work thesis represents a unique and major step forward in our understanding of AD using a patient-specific, systematic and coherent simulation approach, and is currently the most advanced work available on AD.

An interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis. The authors take advantage of new biological understanding, novel therapeutic targets, multiple available and well-studied therapeutic strategies, and the necessary imaging techniques to measure outcomes. Their in-depth discussions cover the identification of new therapeutic targets and pathways, the investigation of transcriptional factors, master switch molecules, cell-based approaches, chemokines, a better understanding of the effects of aging, endothelial dysfunction, and hypercholesterolemia in response to angiogenic stimuli. Highlights include examination of drug delivery problems, outcomes measure, stem therapy, high-risk interventions, development pathways, and future possibilities.

Take your surgical skills to the next level with Thoracic Surgery: Transplantation, Tracheal Resections, Mediastinal Tumors, Extended Thoracic Resections, a volume in the Master Techniques in Surgery Series! This thoracic surgery reference provides the richly illustrated, step-by-step guidance you need to perfect a full range of thoracic surgery techniques, avoid and manage complications, and achieve optimal outcomes. Key Features See exactly how to perform the full range of procedures , both open and minimally invasive, for lung transplantation, thoracic outlet syndrome, pectus repair, diaphragmatic plication, and removal of mediastinal tumors. Gain insights from international authorities , gleaning each expert's preferred techniques in rich detail. Efficiently review background, indications and contraindications, surgical techniques, avoidance of pitfalls, and management of complications and results for each procedure, as well as selected references for further reading. Don't miss Thoracic Surgery: Lung Resections, Bronchoplasty , the companion volume by Drs. Mathisen and Morse. Expand your repertoire with other volumes in the Master Techniques in Surgery Series! Overseen by Josef E. Fischer, MD , editor of the classic two-volume reference Mastery of Surgery , these titles cover a wide range of common and advanced procedures in the major subspecialties of general surgery, including breast surgery, colon and rectal surgery, esophageal surgery, gastric surgery, hepatobiliary and pancreatic surgery, and hernia. Now with the print edition, enjoy the bundled interactive eBook edition , offering tablet, smartphone, or online access to: Complete content with enhanced navigation A powerful search that pulls results from content in the book, your notes, and even the web Cross-linked pages , references, and more for easy navigation Highlighting tool for easier reference of key content throughout the text Ability to take and share notes with friends and colleagues Quick reference tabbing to save your favorite content for future use

Key Clinical Topics in Cardiology presents a brand new addition to the Key Clinical Topics series. The book provides a comprehensive overview of the subject, comprising over 60 carefully selected topics in alpha order that together provide an extensive understanding of the management of cardiovascular disorders. This collection of highly practical guides systematically addresses management techniques for a large number of clinical settings. Edited by experienced specialists, with contributions from consultants who have recognised expertise in their field, this book provides an authoritative and up-to-date guide on cardiovascular medicine. Designed to enable rapid access to core information, KCT Cardiology offers effective exam revision and the ideal quick reference for day-to-day practice. Key points Over 60 topics presented in alpha order, from acute advanced life support to tumours Effective exam revision for postgraduate trainees in cardiology preparing for certification Succinct coverage of cardiac treatment modalities and complications Includes clinical photos and diagrams to improve understanding of concepts Contributions from experienced specialists to ensure authoritative, accurate content

As societies have aged and aortic diseases have become more prevalent, advances in diagnostic imaging and surgical techniques have brought significantly improved results for patients. In cardiovascular surgery, important questions remain to be addressed, however. "Strategy for Cardio-aortic and Aortic Surgery" was the theme of the 7th Keio University International Symposium for Life Sciences and Medicine. Meeting in Tokyo, researchers and specialists in cardiac surgery from around the world discussed crucial issues in their field. Papers from the symposium, collected in this volume, cover a broad range of topics, including recent advances in diagnostic imaging, brain protection during aortic surgery, spinal protection during thoracoabdominal aneurysm repair, treatment of type A acute aortic dissection, and stent-grafts and less-invasive aortic surgery. This unique book provides valuable information especially for aortic, cardiovascular, and thoracic surgeons.

Despite all efforts and success in medical treatment, the incidence of (end-stage) chronic heart failure is increasing. Cardiac transplantation remains the only definite option; however, due to the shortage of donor organs, very few people benefit. Therefore, surgery of end-stage heart failure using conventional techniques has gained new interest after the introduction of the Batista operation. However, a clear surgical identification of the patients to be included in this group is lacking. Left ventricular reduction surgery as well as reduction of the base of the heart using mitral annuloplasty or mitral valve replacement, sparing both papillary muscles, is used in selected patients with satisfying results and good survival. Long-term mechanical support with subsequent surgical remodeling or supporting myoplasty may result in a beneficial alternative to heart transplantation.

This text is a fully updated and revised third edition of a highly successful text. The format of this text is unique and has been very successful. A total of 286 short chapters organized into 24 Sections provide operative dictation templates for all of the common and the vast majority of the uncommon and even rare operations performed by general and vascular surgeons. Each chapter also provides a succinct synopsis of the operation through bullet-ed lists which include Indications, Essential Steps, Note these Variations, and Complications. The book thus serves two purposes: these operative dictation templates can be used verbatim when dictating the operative note for a procedure; and the book provides ready reference to the trainee going into the operating room to do the procedure for the first time, or to someone preparing for their Board examinations. Space for notes allows surgeons to personalize the book and turn it into a resource unique to their situation. Fully updated and expanded, Operative Dictations in General and Vascular Surgery, Third Edition includes significant additions that include flexible endoscopic procedures (now recognized as a core part of general surgery training and practice), single incision laparoscopic cholecystectomy, and robotic approaches to the rectum. The endovascular procedures have been significantly expanded, as have the approaches to venous disease and to A-V fistula creation. Operative Dictations in General and Vascular Surgery, Third Edition is intended for practicing surgeons, who may modify each template to reflect their own individual practice. It also serves as a concise reminder of essential steps in those operations that may be only rarely performed.

This text provides a comprehensive, state-of-the-art review of catheter based approaches to valve and aortic diseases. The scope encompasses involve all the current and upcoming transcatheter aortic valve technologies as well as mitral, pulmonary and tricuspid valve technologies. Aortic diseases including transcatheter repair of descending aneurysms are included and the upcoming technologies designed to repair aortic dissections, traumatic injury, and ascending arch stent repair are highlighted. Catheter Based Valve and Aortic Surgery will be a useful tool for cardiac and vascular surgeons, interventional cardiologists, general cardiologists, and clinicians and researchers with an interest in these exciting new developments in structural heart and vascular diseases.

The pioneering surgeon Dr. Denton Cooley performed his first human heart transplant in 1968 and astounded the world in 1969 by conducting the first successful implantation of a totally artificial heart in a human being. Over the course of his career, Cooley and his associates performed thousands of open-heart operations and pioneered the use of new surgical procedures. Of all his achievements, however, Cooley was most proud of the Texas Heart Institute, which he founded in 1962 with a mission to use education, research, and improved patient care to decrease the devastating effects of cardiovascular disease. In 100,000 Hearts, Cooley tells about his childhood in Houston, his education at the University of Texas, his medical-school training at the University of Texas Medical Branch in Galveston and Johns Hopkins, and his service in the Army Medical Corps. While at Johns Hopkins, Cooley assisted in a groundbreaking operation to correct an infant's congenital heart defect, which inspired him to specialize in heart surgery. Cooley's detailed descriptions of working in the operating room at crucial points in medical history offer a fascinating perspective on the distance medical science traveled in just a few decades.

Cardiopulmonary Transplantation and Mechanical Circulatory Support provides a comprehensive review of the field. Written for all tiers of healthcare professionals managing such complex patients. The handbook tackles all topics within this field, including heart failure, heart transplantation, lung transplantation, and all tiers of mechanical circulatory support in adults and paediatric patients. The chapters are written by prominent and globally respected experts in Europe and North America, providing their evidence base as well as personal, practical hints and tips for all practitioners.

Extracorporeal membrane oxygenation (ECMO) has been in clinical use for some 40 years, but it is only in the past decade that its application in the treatment of life-threatening circulatory and respiratory failure has truly flourished. This book presents a comprehensive overview of both pathophysiological and practical aspects of circulatory and respiratory extracorporeal support. The basics of ECMO, including its history, the "ECMO team," cannulation, materials, and blood- surface interactions, are first discussed. The various indications for and particular characteristics of circulatory and respiratory extracorporeal life support are then described in detail in the main part of the book. Patient care during ECMO and monitoring of the ECMO patient are also carefully covered, with explanation of the management of technical and clinical complications and transport-related problems. Further topics include long-term therapy options beyond ECMO, such as ventricular assist devices and transplants, outcome, the new frontiers of ECMO for organ procurement and future challenges. The authors are well-known experts in the field whose authoritative contributions and attention to practical aspects will be invaluable for novices and experienced practitioners alike.

Use of the transcervical approach in thoracic surgery has advanced significantly during the past 60 years, owing primarily to advances in technology. Nevertheless, the possibilities of this approach have never been compiled in a systematic way. This book aims to rectify the situation by describing, in a structured way, all the thoracic procedures that can be performed using the transcervical approach. Indications and contraindications, surgical techniques, complications, and results are all covered, based on the authors experience and published reports. The contents encompass diverse surgical endoscopic procedures for diagnosis and staging, use of the transcervical approach for surgery to the thymus and mediastinum, lungs and bronchi, trachea and esophagus and miscellaneous items including the role of robotic surgery."

Over a decade after the last edition, Operative Thoracic Surgery, Sixth Edition has been thoroughly revised and updated by a team of prestigious international contributors. Particular emphasis is given to new and emerging techniques, particularly minimally invasive procedures, ensuring that the book remains an essential resource for surgeons in training, residents and fellows in thoracic and esophageal surgery, and fully qualified practitioners needing a definitive reference. Additional text describes the principles and justification of choosing each procedure, pre-operative assessment and preparation, post-operative care and outcomes. Print Versions of this book also include access to the ebook version.