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This new edition provides the latest information and insights into the molecular basis for lung cancer. Since the publication of the previous edition of this volume, dramatic changes have occurred with the classification of lung cancer, biomarker testing, and molecular therapy. The book covers these changes, providing updates and new insights on the background of lung cancer, testing methods, and the molecular pathology of specific cell types, including adenocarcinoma, squamous cell carcinoma, small cell carcinoma, and precursor and preinvasive lesions. Authored by experts in the field, Precision Molecular Pathology of Lung Cancer, Second Edition remains one of the few books that comprehensively covers the new molecular pathology of lung cancer and is a valuable resource for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, and thoracic radiologists.
This book concerns the treatment of cardiac disease in chronic renal failure patients who represent a specific group of patients that almost universally will develop coronary artery disease and frequently valvular problems all secondary to their renal failure. Unfortunately, this same group is at increased risk for surgical/percutaneous intervention. Many physicians will struggle with patient management issues due to the inherent difficulties and increased risk of many treatment options. The book will summarize the current technology and treatment plans for these patients that will optimize their long-term outcomes. It will become the bible on current treatment that many physicians and other health care professionals will want to reference every time they are consulted on a ppatient with renal failure and significant heart disease.. This book concerns the treatment of cardiac disease in chronic renal failure patients who represent a specific group of patients that almost universally will develop coronary artery disease and frequently valvular problems all secondary to their renal failure. Unfortunately, this same group is at increased risk for surgical/percutaneous intervention. Many physicians will struggle with patient management issues due to the inherent difficulties and increased risk of many treatment options. The book will summarize the current technology and treatment plans for these patients that will optimize their long-term outcomes. It will become the bible on current treatment that many physicians and other health care professionals will want to reference every time they are consulted on a patient with renal failure and significant heart disease. This text outlines treatment plans for chronic renal failure patients with cardiac disease and has a strong clinical focus. This is an invaluable reference source for physicians and other health care professionals managing patients with renal failure and significant heart disease
This thesis addresses computation fluid dynamics modelling of aortic dissection (AD), in order to generate in silico diagnostic information and assess `virtual surgery' outcomes. The thesis introduces several important advances in the modelling of aortic dissection and lays essential groundwork for further development of this technology. The work thesis represents a unique and major step forward in our understanding of AD using a patient-specific, systematic and coherent simulation approach, and is currently the most advanced work available on AD.
Get expert, step-by-step guidance on a wide variety of both open and interventional cardiac surgical techniques. Atlas of Cardiac Surgical Techniques, 2nd Edition, helps you expand your surgical repertoire and hone your skills with a vividly illustrated, easy-to-navigate text, procedural videos online, and pearls and pitfalls throughout. This revised atlas covers the surgical procedures you need to master, including minimally invasive techniques, robotic surgery, aortic dissection, and much more. Seven brand-new chapters cover Hybrid Coronary Revascularization, Aortic Valve Repair Techniques, Transcatheter Aortic Valve Replacement, Robotic Mitral Valve Surgery, Surgery for Hypertrophic Cardiomyopathy, Approaches and Techniques to Extra-Corporeal Membrane Oxygenation, and Pulmonary Endarterectomy. Multiple new contributing authors offer a fresh perspective in their areas of expertise. A consistent chapter format guides you quickly from surgical anatomy and preoperative considerations through operative steps and postoperative care. Online videos highlight key stages of surgical procedures. More than 400 full-color images, line drawings, and intraoperative photographs clearly depict the step-by-step progression of procedures. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
This book describes the molecular mechanisms of lung cancer development and progression that determine therapeutic interventions in the era of genomics, when the rapid evolution in lung cancer diagnosis and treatment necessitates critical review of new results to integrate advances into practice. The text opens with background and emerging information regarding the molecular biology of lung cancer pathogenesis. Updated results regarding lung cancer prevention and screening are discussed, followed by chapters on diagnostic techniques and pathological evaluation. This leads on to a detailed presentation of treatment modalities, from surgery and radiation therapy to standard chemotherapy and targeted agents. The coverage includes resistance to therapy and the emergence of immunotherapy for lung cancer; in addition, the current evidence in respect of small cell lung cancer is summarized. The book presents insights from experts across disciplines to emphasize the importance of collaborative care. Advances in our understanding of issues in geriatric oncology and palliative care complete the comprehensive discussion of lung cancer.
This book is the first available practical manual on the open abdomen. Practicing physicians, surgeons, anesthesiologists, nurses, and physiotherapists will find in it a ready source of information on all aspects of open abdomen management in a wide variety of settings. The coverage includes, for example, the open abdomen in trauma, intra-abdominal sepsis, and acute pancreatitis, step-by-step descriptions of different techniques with the aid of high-quality color figures, guidance on potential complications and their management, and features of management in different age groups. The book contents illustrate the most recent innovations and drawing upon a thorough and up-to-date literature review. Useful tips and tricks are highlighted, and the book is designed to support in daily decision making. The authors include worldwide opinion leaders in the field, guaranteeing the high scientific value of the content.
As the first revision text aimed specifically at the Knowledge-Based Assessment, Essential Revision Notes for Cardiology KBA is the cornerstone of your revision for this new and compulsory examination. Each chapter exactly maps the core cardiology training curriculum, giving measurable assurance that you are getting the information you need to pass. Each chapter is written by a senior cardiology trainee in collaboration with a senior consultant who has expertise in that specific field, ensuring that the content is both authoritative and accessible. Drawing on the latest guidelines and documents, the concise, bullet-pointed layout allows easy access to and digestion of the key points you'll need during revision. Numerous tables, boxes and figures make this the ideal accompaniment to retaining the large and varied amount of information needed to pass the examination.
Nearly all of us will, at some point, know someone who was born with a heart defect. But, as the surgical scars so often remain hidden, we just might not realise it.; Powerfully telling of the patients and their experiences, Open Hearts is a remarkable medical story: we are often so focused on 'extraordinary' people and their achievements, we forget just how incredible the 'ordinary' achievements of living can be.; Until the 1960s 'blue babies' were a striking sight in our streets. Suffering from congenital heart disease offered a bleak outlook to young patients and a heartbreaking experience for parents. Very few would make it to adulthood; now, in the West at least, most have a much higher chance of survival.; In Open Hearts Kate Bull, formerly a cardiologist at Great Ormond Street Hospital, tells not just of the development of heart surgery in children, but of the patients, past and present, whose lives have been transformed. Besides the technology, the sociology of medicine has changed substantially since the 1950s - think of the atmosphere of children's wards.Other things have barely changed - consider the dread of kissing your child goodbye at the door of an operating theatre in any era. ; Children's heart surgery is often seen as a medical triumph; but, for all the successful operations completed, thousands of pioneering patients have gone before, perhaps facing their own uncertain futures. Today, we place great hope in the power of science. Many lives have been saved; but, sometimes, we ask medicine to do more than it can.; By turns frightening, heart-wrenching and inspiring, Open Hearts is a powerful story of medical progress, hope and survival.
It is now 20 years since thoracoscopic surgery first entered everyday hospital practice, revolutionizing surgery and offering major benefits to patients. The intervening years have witnessed rapid progress, with the development of a variety of specialized techniques and equipment. This superbly illustrated book provides authoritative and comprehensive descriptions of the various minimally invasive techniques that are currently employed in thoracic and cardiac surgery. A wide range of thoracoscopic procedures are explained and discussed, and detailed attention is also paid to robotic and robot-assisted surgical techniques. Throughout, the emphasis is on clear description of procedures and identification of practical aspects of relevance in surgical practice. The authors are some of the world's most experienced thoracic and cardiac surgeons, and many of them have contributed greatly to the exploration and development of the field.
This book spans topics in both congenital and acquired right heart disease providing readers with detailed information on the physiology, anatomy and myocardial mechanics of the right ventricle (RV), while describing the use of echo and MRI imaging to diagnose, and new developments in surgery and cardiac catheterization to treat. Right Ventricular Physiology, Adaptation and Failure in Congenital and Acquired Heart Disease includes extensive discussion of RV-pulmonary interactions, pulmonary hypertension and ventricular-ventricular interactions, including specific topics in embryology, fetal RV function, RV mechanics, pathophysiology of RV adaptation/ failure, molecular aspects of RV dysfunction, congenital heart disease, pulmonary arterial hypertension, pulmonary valve replacement, stem cell and future therapies. It is thus important reading for all cardiovascular medicine professionals, but especially pediatric cardiologists and surgeons, those who manage t hese patients in the cardiac care unit and investigators studying the RV.
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