Once considered an experimental therapy, lung transplantation is now regarded as a viable treatment option for selected patients with end-stage lung diseases. As more and more of these cases arise, it becomes imperative for those involved in the care of lung transplant patients to have a vast understanding of the multidiscipline process of lung transplantation. This text provides a comprehensive overview of this process covering everything from the history of the lung transplant program to the long term effects of the procedure.

Heart transplantation remains one of the major scientific achievements of twentieth century medicine. During the past four decades, it has evolved from an unproven experimental surgical technique to the most effective form of therapy for refractory end-stage heart disease. It has captured the public's imagination and expanded our understanding of fundamental immunologic mechanisms that are responsible for cellular and humorally-mediated immunity. Despite its successes, many clinical and scientific problems remain. One or more bouts of acute cellular or humoral (vascular) rejection will occur in over 75% of transplant recipients despite current immunosuppressive strategies. Further, rejection directly results in approximately 20% of post-transplant deaths and is believed to play a major role in the development of late allograft dysfunction and coronary vasculopathy. This book by international experts in the fields of transplantation medicine, immunobiology and cardiac imaging provides the reader with an up-to-date, consise summary of the latest developments in the diagnosis and treatment of acute cardiac rejection. It is axiomatic that a more complete understanding of the pathogenic processes involved in rejection will ultimately lead to its prevention. This volume will be useful to transplant cardiologists, cardiovascular surgeons, cardiac pathologists and transplant scientists who seek to prolong the lifespan and improve the quality of life of their transplant recipients.

A TIMES BEST BOOK OF 2019 An intimate and compelling exploration into the unique psyche of the heart surgeon, by one of the profession's most eminent figures. Although Professor Stephen Westaby was born with the necessary coordination and manual dexterity, it was a head trauma sustained during university that gifted him the qualities of an exceptional heart surgeon: qualities that are frequently associated with psychopathy. His thirty-five-year career has been characterised by fearlessness and ruthless ambition; leaving empathy at the hospital door as thousands of patients put their lives in his hands. For heart surgeons, the inevitable cost of failure is death and in The Knife's Edge, Westaby reflects on the unique mindset of those who are drawn to this exhilarating and often tragic profession. We discover the pioneers who grasped opportunities and took chances to drive innovation and save lives. Often difficult, uninhibited and fearless, theirs is a field constantly threatened by the risk of public failure. Like those before him, Westaby refuses to draw the line in his search of a lifetime solution to problems of the heart. His determination is unerring - a steadfastness underpinned by his unusual mind. But as we glimpse into the future of cardiac surgery, for all its remarkable scientific advancement, one question remains: within the confines of socialised medical healthcare systems, how can heart surgeons - individuals often hardwired with avoidance of self-doubt, a penchant for glory and a flagrant disregard for authority - truly flourish?

This text provides a comprehensive, state-of-the-art review of catheter based approaches to valve and aortic diseases. The scope encompasses involve all the current and upcoming transcatheter aortic valve technologies as well as mitral, pulmonary and tricuspid valve technologies. Aortic diseases including transcatheter repair of descending aneurysms are included and the upcoming technologies designed to repair aortic dissections, traumatic injury, and ascending arch stent repair are highlighted. Catheter Based Valve and Aortic Surgery will be a useful tool for cardiac and vascular surgeons, interventional cardiologists, general cardiologists, and clinicians and researchers with an interest in these exciting new developments in structural heart and vascular diseases.

The landscape of cardiac surgery is changing, as is the field of interventional cardiology. The idea of accessing and replacing a failing valve through the patients vasculature has become the most rapidly expanding therapy of choice in cardiovascular disease. Transcatheter Valve Therapies chronicles the astonishing advances that have taken place in the field and prepares readers for the challenging future of cardiac valve therapies. Designed to meet the growing needs of cardiologists, cardiac surgeons, anesthetists, and general practitioners, the book covers all aspects from logistic needs to clinical outcomes. It provides a comprehensive overview of transcatheter valve therapies and the necessary understanding for a successful clinical introduction at individual institutions. Topics include: Epidemiologic considerations Aspects of balloon aortic valvuloplasty as a stand-alone procedure or as part of the transcatheter valve replacement The history of how transcatheter valve therapies were implemented into surgical practice New imaging modalities The particularities of transcatheter access Aortic root anatomy Emerging technologies and future design improvements Development steps of aortic devices and potential solutions for transcatheter tricuspid, mitral, and pulmonary valve replacement The rigorous testing requirements for endovascular medical devices Clinical results of aortic transcatheter valve therapies in easy accessible text and table formats The future of transcatheter valve therapies All topics are discussed based on the author's own clinical and experimental experience in the field. This volume is essential for anyone involved in transcatheter valve implantation, clinicians wishing to become more involved in improving transcatheter valve therapies, and researchers engaged in building and creating new medical technologies to shape the cardiovascular landscape of the future.

Since publication of the First Edition, advances in the diagnosis and prevention and treatment strategies of the vulnerable plaque have necessitated this greatly expanded second edition. With several new chapters covering mainly diagnostic and treatment options, The Handbook of the Vulnerable Plaque will remain the benchmark text for all interventional cardiologists treating vulnerable patients by providing the physician with comprehensive insight into the world of the vulnerable plaque.

Following the recent publication of new guidelines by the European Society of Cardiology, this fully up-to-date work provides cardiologists and cardiac surgeons with the first comprehensive guide to post-operative management of patients who have undergone heart valve surgery. An international team of contributors, all recognized authorities in their field, and themselves contributors to the new guidelines, present evidence-based recommendations for managing a range of clinical problems in both adults and children, extending from immediate care in the hospital setting, through to long-term considerations for the primary care physician. Topics covered include:* rehabilitation * management of thrombosis* hemolysis* rheumatic fever* endocarditis* special considerations such as care of the patient undergoing non-cardiac surgery. Illustrated with numerous graphics, checklists and flow charts to enable readers to locate information rapidly and easily, Heart Valve Disease provides practical guidance on a range of common clinical scenarios, encompassing immediate post-operative care in the hospital as well as long-term management in the primary care settings.

The first in the Problems in Anesthesia seris, Cardiothoracic Surgery examine and provide guidance for a number of problematic clinical scenarios in cardiothoracic surgery anesthesia. This is a field which is growing in complexity due to the increasingly diverse set of conditions that are now treated surgically, and also due to developments in technology which are leading to different approaches to even common problems. This book will be of interest to the qualified specialist and the general trainee in anesthesiology.

Cases are presented followed by an approach to the case, utilizing the various experiences of anesthesiologists from both sides of the Atlantic. The case-based teaching relates the material to the clinic, and the discussion then explains the options in approach. Each chapter concludes with a series of essential tips in dealing with the various problems. Cases covered range from the common (e.g. off-pump coronary bypass) to the rare (e.g. anesthetic management of the patient with carcinoid heart disease).

The aim of the book is to allow readers to learn from both the successes and the complications within the cases covered, and in this way disseminate knowledge amongst those working in the field as well as pave the way for further investigation and continued advancement.

This book provides a comprehensive introduction to artificial hearts, summarizing the latest advances in basic technologies, design, evaluation, and management. Featuring 11 chapters, it discusses the origins of the artificial heart, the mechanisms of heart failure, and the principles of artificial heart technologies. Further, it offers an overview of rotary pumps and volume-displacement pumps, and addresses total artificial hearts. Lastly, the book covers evaluation, selection, therapy management, challenges, and the latest innovations. Given its scope, it is a valuable resource for researchers and technicians in the area of biomedical engineering, as well as surgeons.

50 Studies every Vascular Surgeon Should Know presents key studies that have shaped the practice of Vascular Surgery. Selected using a rigorous methodology, the studies cover topics including carotid artery disease, aortic aneurysm, peripheral artery disease, trauma, venous disease and vascular access. For each study, a concise summary is presented with an emphasis on the results and limitations of the study, and its implication for practice. An illustrative clinical case concludes each review to highlight the impact of the study on clinical practice. This book is a must read for vascular surgeons, especially those in training and preparing for board exams, as well as anyone who wants to learn more about the data behind clinical practice.

This text, published in the profession's centenary year, traces the history of cardiac surgery from ancient times to the present, detailing clinical developments with facsimilies of the original articles, consent forms from the first heart transplant, newspaper articles, and correspondence. The text follows a set pattern, describing the historical background to each new procedure, facsimilies of the original articles, bibliography of the main clinicians, and a commentary putting each development into its historical context.

This new edition of the bestselling step-by-step introduction to cardiac pacemakers now includes additional material on CRT and an accompanying website. It retains the effective use of full-page illustrations and short explanations that gained the book such enormous popularity and now provides information on recent advances in cardiac pacing, including biventricular pacing for the treatment of heart failure.

The recent widespread application of minimally invasive techniques has had a profound impact on the diagnosis and therapy of thoracic disorders, including in the pediatric age group. This book is intended as a practical guide to the current approaches in pediatric thoracic surgery. Up-to-date information is provided on the surgical techniques employed for diagnosis and therapy in a wide range of congenital and acquired thoracic pathologies from the prenatal age to adolescence. Among the disorders considered in detail are cystic malformations of the lung, chest wall deformities, diaphragmatic hernias, esophageal anomalies, mediastinal tumors, laryngeal anomalies, and thoracic infections. The authors are distinguished experts in the field from across the world. "Pediatric Thoracic Surgery" will be of value not only for pediatric thoracic surgeons but also for adult thoracic surgeons, pediatric anesthetists, and pediatric respiratory physicians.

This book provides an overview of the etiology of coronary artery disease and focuses on the main therapies and drug interventions currently available. It highlights drug pharmacology and therapeutic challenges, with a special emphasis on the underlying principles of available therapeutics and the on-going development of drugs for coronary artery disease. The book is divided into eight chapters, the first of which describes the classical mechanism of coronary artery disease and its clinical presentations. Chapter 2 lists the principles of and related evidence on the prevention and treatment of coronary artery disease. This includes diet and lifestyle management, and guidelines for the treatment of acute coronary syndrome and stable coronary artery disease. In turn, Chapter 3 describes revascularization treatments, covering percutaneous coronary interventions, coronary artery bypass grafts and thrombolysis. This chapter also addresses the main therapeutic challenges. The following chapters provide an overview of three major categories of coronary artery disease drugs, which target thrombosis (Chapter 4), lipid metabolism (Chapter 5), and hypertension (Chapter 6). Heart failure constitutes the major health burden in the late stage of coronary artery disease; accordingly, current heart failure therapeutics and related drug pharmacology are described in Chapter 7. In closing, Chapter 8 provides a summary of on-going clinical trials for coronary artery disease drug development and discusses a number of promising areas in which intensive research into new therapeutics is being pursued. Given its scope, the book will be of interest to clinicians, medical students and research scientists, as well as to pharmaceutical professionals who are seeking new therapies and drugs for coronary artery disease and related disorders.

Although cardiac surgery has made an enormous progress during the last decades, the discipline has to cope with essential changes: Patients are increasingly cared for by cardiologists and therefore referred to the surgeon in a later stage of disease. Consequently, they are more often in an increasingly serious state or in advanced age with significant comorbidities.

In order to meet the requirements of these different patient groups, cardiosurgical treatments require special protectional strategies for the heart in order to perform the planned operations safely. This book presents the latest knowledge of modern techniques of myocardial protection taking into consideration the different patient groups and current scientific strategies. Furthermore, it discusses present and future scientific approaches in myocardial protection and preservation.

With an emphasis on the "how and why" of contemporary surgery, Operative Techniques in Surgery, Second Edition, features concise, bulleted text, full-color illustrations, and intraoperative photographs to clarify exactly what to look for and how to proceed. Meticulously edited by Drs. Mary T. Hawn, Aurora D. Pryor, Steven J. Hughes, Michael S. Sabel, Kellie R. Brown and Amy J. Goldberg, this comprehensive, two-volume surgical atlas focuses on the steps of each technique, rapidly directing you to the information you need to choose the right approach for each patient, perform it successfully, and achieve the best possible results. Coverage includes open as well as laparoscopic, robotic, endoscopic, and endovascular procedures in gastrointestinal, thoracic, esophageal, colorectal, hepatobiliary, breast, endocrine, dermatologic, vascular, and trauma surgery New, comprehensive section on trauma surgery, helmed by trauma expert Dr. Amy J. Goldberg New section editors for esophageal and foregut surgery and vascular surgery, Dr. Aurora D. Pryor minimally invasive surgery leader and Kellie R. Brown, expert in vascular surgery. New videos, personally selected by contributing authors and editors, accompany numerous chapters throughout the book Extensive updates throughout, including new coverage of the American Board of Surgery's SCORE Curricula for General Surgery and for Complex General Surgical Oncology Each procedure follows the same format: differential diagnosis, patient history and physical findings, imaging and other diagnostic studies, surgical management, techniques, pearls and pitfalls, postoperative care, outcomes, and complications Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Key Clinical Topics in Cardiology presents a brand new addition to the Key Clinical Topics series. The book provides a comprehensive overview of the subject, comprising over 60 carefully selected topics in alpha order that together provide an extensive understanding of the management of cardiovascular disorders. This collection of highly practical guides systematically addresses management techniques for a large number of clinical settings. Edited by experienced specialists, with contributions from consultants who have recognised expertise in their field, this book provides an authoritative and up-to-date guide on cardiovascular medicine. Designed to enable rapid access to core information, KCT Cardiology offers effective exam revision and the ideal quick reference for day-to-day practice. Key points Over 60 topics presented in alpha order, from acute advanced life support to tumours Effective exam revision for postgraduate trainees in cardiology preparing for certification Succinct coverage of cardiac treatment modalities and complications Includes clinical photos and diagrams to improve understanding of concepts Contributions from experienced specialists to ensure authoritative, accurate content

This comprehensive resource brings together the most current theories, evidence and best practice parameters for the use of nocturnal non-invasive ventilation (nNIV). Chapters focus on the application of acute and chronic nNIV in patients with cardio-respiratory disorders over a range of major medical settings. Updates on past and recent research in this field are highlighted. Authored by leading clinicians and investigators, Nocturnal Non-Invasive Ventilation provides practical and cutting-edge knowledge to physicians, researchers and allied health professionals on the front lines of treating cardio-respiratory and sleep disorders.

Principles of Heart Valve Engineering is the first comprehensive resource for heart valve engineering that covers a wide range of topics, including biology, epidemiology, imaging and cardiovascular medicine. It focuses on valves, therapies, and how to develop safer and more durable artificial valves. The book is suitable for an interdisciplinary audience, with contributions from bioengineers and cardiologists that includes coverage of valvular and potential future developments. This book provides an opportunity for bioengineers to study all topics relating to heart valve engineering in a single book as written by subject matter experts.

This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM's role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.