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Books > Medicine > Clinical & internal medicine > Endocrinology > Diabetes
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The Renin-Angiotensin System: Current Research Progress in The Pancreas - The RAS in the Pancreas (Hardcover, 2010 ed.)
Loot Price: R4,704
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The Renin-Angiotensin System: Current Research Progress in The Pancreas - The RAS in the Pancreas (Hardcover, 2010 ed.)
Series: Advances in Experimental Medicine and Biology, 690
Expected to ship within 10 - 15 working days
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The human pancreas consists of two organs in one: the exocrine
gland made up of pancreatic acinar cells and duct cells that
produce digestive enzymes and sodium bicarbonate, respectively; the
endocrine gland made up of four islet cells, namely alpha-, beta-,
delta- and PP-cells that produce glucagon, insulin, somatostatin
and pancreatic polypeptide, respectively. While the physiological
role of exocrine p- creas is to secrete digestive enzyme
responsible for our normal digestion, absorption and assimilation
of nutrients, the endocrine pancreas is to secrete islet peptide h-
mones maintaining our glucose homeostasis. The pancreatic functions
are nely regulated by neurocrine, endocrine, paracrine and/or
intracrine mechanisms. Thus, dysregulation of these pathways should
have signi cant impacts on our health and disease. Nevertheless,
the underlying mechanisms by which pancreatic functions are
regulated remain poorly understood. Recent basic science and
clinical studies con rm myriad physiological and pathophysiological
roles of the tissue renin-angiotensin systems (RAS). Of parti- lar
interest is the recent identi cation of a local and functional RAS
in the pancreas, which in uences both its exocrine and endocrine
function. Its role in the pat- genesis of pancreatic diseases
including diabetes and pancreatitis is increasingly recognized, as
is the therapeutic potential of RAS antagonism: RAS blockade l- its
disease progression of type 2 diabetes mellitus and impaired
glucose tolerance, and may also protect against pancreatic in
ammation.
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