Insulin: Deficiency, Excess and Resistance in Human Disease
provides an overview of the role of insulin in the pathogenesis of
prevalent non-communicable diseases such as obesity, type 2
diabetes, cardiovascular disease, and cancer, along with a
comprehensive review of insulin replacement therapies and novel
cardioprotective and insulin-sensitizing drugs. Notable advances in
precision diagnosis and therapy for single gene subtypes of
diabetes in recent years are also discussed. The discovery of
insulin and its lifesaving introduction into clinical practice is
one of the most celebrated accomplishments of medical science.
However, despite decades of progress and major technical advances,
the goal of providing insulin replacement therapy that truly mimics
normal physiology remains elusive.
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