IBS is an invisible disease - sufferers battle on pretending nothing is wrong and hiding their embarrassing symptoms. And it isn't life-threatening - so why would anyone take it seriously? Yet it can seriously restrict how we live, work and play. Based on their experience as both sufferers and health specialists, Dr Arroll and Professor Dancey provide the latest guidance on causes, diagnosis and treatment, including the hugely significant part played by stress.

Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future documents the monumental advances that have been made in our understanding of chronic HCV during the past decade. The first section reviews the natural history of chronic HCV, how this virus can affect other organs in addition to the liver, and whether treating chronic HCV alters the natural history of this disease. Section 2 reviews the advances that have been made in the treatment of chronic HCV during the past decade with interferon based therapy. Separate chapters on response guided therapy and how to manage the adverse events associated with these medications provide the physician with the concepts required to more effectively treat chronic HCV now and in the future. As the genetics of virologic response have recently been elucidated, a chapter is devoted to helping the clinician understand how genes that modulate disease processes and their treatment are identified and utilized in clinical care. Section 3 deals with the future of HCV treatment and specific inhibitors of HCV. Specific chapters explain how targets for drugs are identified and how drugs are then developed and tested; how mutations of HCV develop and how anti-viral agents will affect this process; the most up to date data regarding the treatment of chronic HCV with peginterferon, ribavirin and anti-viral agents; and the potential to treat chronic HCV with just oral anti-viral agents and without peginterferon and ribavirin in the future. The final section of this book covers issues related to liver transplantation in patients with chronic HCV. Separate chapters review the natural history of chronic HCV in liver transplant recipients and the impact of utilizing HCV positive donors. The volume concludes with chapters that cover the treatment of chronic HCV both prior to and after liver transplantation with potent anti-viral agents. Chronic Hepatitis C Virus: Lessons from the Past, Promise for the Future is a valuable resource for all physicians caring for patients with chronic HCV.

Contemporary Coloproctology covers colorectal surgery, as practiced today, in an easily accessible format with emphasis on bringing key facts rapidly into focus. It is ideal reading both for the medical trainee and the practicing colorectal surgeon. As well as a succinct presentation of the current colorectal knowledge base, each chapter contains practical advice and pearls of wisdom from established practicing clinicians. A unique feature of the format is the identification of key references and questions and scenarios that present real life decisions in colorectal surgery. Edited and authored by outstanding surgeons in their fields, this book brings the reader expertise in surgery and management across the various conditions encountered in coloproctology.

This book is a compilation of endoscopic images of the upper gastrointestinal tract. The 3rd edition is enriched with high-resolution digital images highlighting the classification and staging of endoscopically relevant diseases. Serial documentation of diseases and procedures like corrosive injury, variceal obliteration, peptic ulcer etc. provides a complete, informative and interesting perspective. Rare conditions like Dieulafoy's disease and Gastric antral vascular ectasia (GAVE) have been extensively discussed along with common diseases of the GI tract. This book outlines the technique and interpretation of endoscopic images proving to be a helpful guide to endoscopy practitioners. Key Features Explores various GI tract diseases through coloured, high resolution clinical photographs. Serves as a useful reckoner for trainee endoscopists and practitioners pursuing gastroenterology or gastrointestinal endoscopy. The text is updated with tables, flowcharts, classifications and international treatment guidelines.

Leading experts in the fields of gastroenterology, surgery, and radiology comprehensively review the pathophysiology, diagnosis, management, and treatment of acute bleeding disorders of the GI tract. The authors break down acute bleeding into upper and lower GI tract sources and provide a differential diagnosis for each disease, evidence-based algorithms for clinical practice, treatment modalities for its management, and standards of care. The authors outline the many dilemmas faced by physicians in their approach to their patients, such as localization of the bleeding source (upper vs lower), the need and timing for emergency endoscopy, and the timing for radiologic intervention and/or surgery.

As the population ages, clinicians are facing an increasing number of elderly patients with colorectal cancer. These patients pose unique challenges as they have more comorbidities and lower functional reserves. In addition, the treatment goals may differ from those in younger patients. This book discusses in depth the different aspects of management of colorectal cancer in the elderly. After the provision of pertinent background information on the normal physiology of aging, screening and diagnosis are discussed. Subsequent chapters focus on a range of issues associated with the surgical and perioperative care of these patients and with adjuvant treatment and palliative care. Each chapter provides helpful take-home messages in bullet point form, and numerous informative figures and tables are also included. The authors are surgeons, physicians, anesthetists, geriatricians, oncologists, and allied health professionals with extensive experience in the field.

Inflammatory bowel disease - i.e. ulcerative colitis and Crohn's disease - not only creates significant patient morbidity but also imposes a diagnostic and therapeutic challenge to the physician in charge of these patients. Since the development of sulphasalazine by Dr Nanna Svartz in Sweden half a century ago, important improvements in the prognosis of ulcerative colitis and Crohn's disease have been achieved. This book makes an attempt to present and discuss some of the most recent advances in diagnostic procedures and therapeutic approaches to inflammatory bowel disease with special respect to Crohn's disease. Although the fmal diagnosis of ulcerative colitis and Crohn's disease is generally based on endoscopic, histological or X-ray examinations, nuclear medicine and its imaging procedures have established their place in certain aspects of inflammatory bowel disease. One chapter of this book is dedicated accordingly to the indications of nuclear diagnostic procedures in the clinical setting. Sulphasalazine has been the mainstay of medical therapy in ulcerative colitis and Crohn's disease of the colon. Recently 5-aminosalicylic acid has been discovered to be its active compound and sulphapyridine was found to be the component responsible for most of the adverse effects of sulpha salazine. It is not surprising that many studies have investigated 5-amino salicylic acid as a single therapeutic agent in inflammatory bowel disease."

This guide focuses on the answers to patient questions that are frequently posed to providers who care for patients with GI motility disorders. Additionally, the text guides clinicians through the complicated diagnostic and therapeutic/management approaches to motility disorders, including common and specialized tests, drug initiation, medications side effects, and disease complications. Written by experts in the field, Gastrointestinal Motility Disorders: A Point of Care Clinical Guide is a valuable reference for busy clinicians who need the best evidence-based answers to patient questions at their fingertips.

The organs of the gastro-intestinal tract play an essential role in sustained physical activity, but their consideration in exercise-related literature has, to this point, been limited. Physical Activity and the Gastro-Intestinal Tract is the first book to explain the function and response to exercise of the gastro-intestinal system, in cases of both health and disease, and helps to shed light on the role they play in acute and chronic exercise. Professor Roy Shephard synthesises previously disparate research to explain the physiology, function, pathology of disease and role of exercise in both health and chronic disease, covering topics including: physical activity and the oesophagus gastro-duodenal function and physical activity physical activity and peptic ulcers physical activity and gastro-oesophageal cancers physical activity and the function of the large bowel physical activity and chronic intestinal inflammation. With each chapter including a thorough bibliography and signposts to further reading, Physical Activity and the Gastro-Intestinal Tract provides a complete reference for understanding how exercise affects the function of the digestive organs. It is an important text for academics and upper-level students in sports medicine and exercise physiology, and for health professionals in preventative medicine.

This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world's population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection. This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.

Endoscopic ultrasound has revolutionized the approach to lesions inside and outside the gastrointestinal tract. It has opened the door for gastroenterologists to explore organs outside of the GI lumen, such as the lymph nodes, lung, pancreas, and liver. Endoscopic Ultrasound covers all aspects of endoscopic ultrasound, from the basics to the interventional indications. Richly detailed chapters describe the utility of EUS in different parts of the body and are organized based on body site Pioneers in the field summarize new studies, and the direction of EUS in practice. Endoscopic Ultrasound provides a ready reference that will help physicians and support staff that are beginning EUS, as well as trained ultrasonographers who wish to arm themselves with a comprehensive reference and explore the future of the field.

Cytochromes are proteins that catalyze electron transfer reactions of well-known metabolic pathways and are classified in various superfamilies. The CYP, or P450, superfamily accounts for 90% of the oxidative metabolism of clinical drugs. One member of this superfamily, P450 2D6 (or CYP2D6), singlehandedly metabolizes about 25% of all medications in the human liver. Cytochrome P450 2D6: Structure, Function, Regulation, and Polymorphism reviews the current knowledge of CYP2D6 as well as the maturing body of evidence indicating its significance to clinical and pharmacological researchers and practitioners. This book focuses on the critical role CYP2D6 plays in the human liver. It examines the genetic, epigenetic, physiological, pathological, and structural factors of the gene that govern the highly variable metabolism of a number of drugs in clinical use. It highlights the impact of the functional roles of CYP2D6 on clinical practice and drug development and also discusses implications for precise medicine, strategies to avoid adverse drug reactions, and paths for future research. Cytochrome P450 2D6 is a unique, valuable book focusing on a single but immensely powerful human gene. It provides the first single source of comprehensive information on CYP2D6 that serves as an important reference for medical, biomedical, pharmaceutical, and nursing researchers, practitioners, and students.

Written by world authorities on the subject, this reference comprehensively covers every aspect of colorectal cancer. Addressing the molecular mechanisms, genetics, identification, and therapy of disease, this guide covers new pharmaceutical developments, current screening protocols, and modern methods of disease management by specialists at renowned institutions such as the Royal Marsden Hospital, the Memorial Sloan Kettering Cancer Center, and the Vanderbilt-Ingram Cancer Center.

Advanced Imaging of the Abdomen is invaluable to the practising radiologist, and the more senior radiology resident and fellow, who is looking for a background reference source when discussing a suggested imaging approach with the referring physician.

The book includes extensive lists, tables, line drawings and illustrations - ultrasonography, computed tomography, magnetic resonance images, scintigraphy. It bridges the interface between the referring clinician and radiologist when faced with a patient suspected of having a complex or more unusual abdominal condition.

Significant scientific progress has been made in recent years in the aetiopathogenesis of chronic inflammatory bowel diseases (IBD), that has changed or will change in the future the diagnostic and therapeutic approach in these diseases. The relevance of classical conventional IBD therapies has been critically re-evaluated under criteria of evidence-based medicine approaches. On the other hand, new therapeutic options have emerged. These include modern immunomodulators, biologics, probiotics, worm eggs and extracorporeal therapies. The clinical relevance of these new modalities is often difficult to assess for physicians who do not work frequently with IBD patients.

Celiac Disease is an authoritative text intended to educate healthcare practitioners, gastroenterologists, physicians and nutritionists about the diverse manifestations, complications and management of gluten-sensitive enteropathy. The seventeen-chapter text provides the latest research on pathophysiology, including animal models, immunopathogenesis, genetics and the intestinal microflora. The book also features chapters on diagnosis, monitoring, complications and nutritional management, including therapies on the horizon. The text concludes with appendices that provide educational tools for symptom monitoring and dietary guidance. Written by specialists in their respective fields, Celiac Disease is a comprehensive resource that provides the healthcare practitioner an evidence-based practical guide to pathogenesis and therapy of celiac disease.

Gout: Basic Science and Clinical Practice is a thoroughly researched comprehensive text which covers all important aspects of gout, including its genetics, pathophysiology, diagnosis, and management. Gout is probably the most common rheumatic disease after osteoarthritis and is becoming more common with the prevalence of the metabolic syndrome in the US, and in many other countries. Only about 10% of patients with gout are treated by rheumatologists and this often leads to inadequate diagnosis and treatment in general medical practice. Written by an expert in the field this book is valuable reference for rheumatologists and others in the medical profession who are interested in understanding and managing this important disease.

A must-have reference for both beginning and experienced endosonographers, Endosonography, 5th Edition, coves the full spectrum of endoscopic ultrasound (EUS) in a single, convenient resource. Concise, easy-to-navigate chapters keep you abreast of changes in this dynamic field, and nearly 150 procedural videos reinforce techniques of common, clinically relevant procedures. Covering both standard and newer techniques, this authoritative reference covers everything you need to know-from basic applications to advanced interventions. Guides you step by step through both introductory and advanced techniques, covering everything from interpretation and accurate diagnosis to treatment recommendations. Employs a user-friendly, templated format to cover all topics from basic applications to advanced interventions, with procedures organized by body system. Includes a new chapter on Endo-Hepatology, and an increased focus on using EUS for interventions. Features 20 new procedural videos covering topics such as esophageal and gastric cancer; mediastinal lesions and lung cancer; pancreatic tumors; and bile duct, gallbladder, and ampullary lesions. Covers recent improvements and new applications in guided fine-needle EUS for diagnosis and cancer staging. Features high-quality images with correlative illustrations, diagnostic algorithms, examination checklists, and key points boxes throughout. Provides nearly 150 how-to-videos of both diagnostic and therapeutic procedures performed by expert endosonographers that demonstrate effective techniques and the proper use of equipment. Provides practical information on establishing an endoscopic practice, from what equipment to buy to effective cytopathology services. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.

This book describes the surgical bariatric procedures most frequently performed worldwide and examines their evolution in recent years both within Italy and internationally. For each operation, indications, the surgical technique, potential complications, and the outcomes with respect to weight and obesity-associated comorbidities are presented. In view of the significant failure rate revealed by studies on the long-term results of bariatric surgery, the problem of weight regain and revision surgery are also discussed in detail, covering the different types of revision, conversion to other procedures, and the main outcomes. In addition, individual chapters focus on selected topics of importance. The role of bariatric surgery in the cure of type 2 diabetes ("diabetes surgery") is discussed and the debate over the significance of gastroesophageal reflux disease and hiatal hernia for choice of procedure is summarized. Finally, the most common endoluminal procedures, which have been gaining in importance, are described and other bariatric operations, outlined.

This book is the proceedings of Falk Symposium 151 on 'Emerging Issues in Inflammatory Bowel Diseases', held in Sydney, Australia, on 24-25 March 2006, the first symposium of its kind both in the southern hemisphere and in the Asia--Pacific region. All contributors are leaders in their field of IBD across a wide spectrum of geographical regions and ethnicity. The book presents the first major text where East meets West in IBD. The major issues of concern in the regions where IBD is a relatively common disease include the role of genetic and environmental factors in pathogenesis and disease expression, the application of sophisticated diagnostic tools, and the best use of biological agents in therapy.

First suggested in 1863 by Marey, abdominal compartment syndrome, (ACS), is a constellation of the physiologic sequelae of increased intra-abdominal pressure, (IAP), termed intra-abdominal hypertension, (IAH). Recent observations suggest an increasing frequency of this complication in all types of patients, neonates to the elderly and in diverse clinical conditions, surgical to non-surgical. Even chronic elevations of IAP seem to effect the various organ systems in the body. Despite its obvious clinical implications, not enough attention is paid to IAP and IAH. ACS is still not uniformly appreciated or diagnosed. Only a few medical and surgical intensivists believe in the concept of IAH and actively attempt its prevention and treatment. The result, as is strongly substantiated by retrospective and prospective data, is a successful reduction in organ failures and mortality. Abdominal compartment syndrome is a condition that, until recently, has been poorly appreciated, despite important potential implications for all organ systems. Recent interest has helped clarify the local and systemic effects of increased intra-abdominal pressure and heightened awareness of the importance of early recognition and treatment. This book, written by international experts in the field, follows the first World Congress on Abdominal Compartment Syndrome held in Noosa, Australia in December 2004, and provides an excellent update on this topical subject. Comprehensively constructed, this book covers all key aspects of the syndrome, from definitions and diagnosis to monitoring and management, and is supported throughout by appropriate and ample illustrations. Many of the detrimental consequences of abdominal compartment syndrome are reversible with appropriate and timely intervention, and, although many questions remain unanswered regarding this condition, this book provides a welcome and detailed source of current information and opinion on abdominal compartment syndrome, which will be he