This two-part issue of Endocrinology and Metabolism Clinics of North America provides the endocrinologist with comprehensive essential updates about tumors of the gastroenteropancreatic system. Topics covered include the history and development of the gastroenteropancreatic endocrine axis; the changing face and epidemiology of neuroendocrine tumors (NETs); chromogranins current state of the art, pathology of gastroenteropancreatic (GEP) disorders; new and emerging syndromes related to gastrointestinal (GI) hormones; an update on incretins; prospects for ghrelin in the clinic, obesity/appetite and hedonism; GI motility disorders; gastric bypass and GI hormones; pancreatic exocrine function and GI hormones; harnessing the pancreatic stem cell; how to diagnose NETs before there are METs; NETs in kids: combining the SEER data for children and adults with site differences; novel biomarkers for NETs; standard imaging techniques for NETs; novel peptide imaging: glucagon receptor; signaling mechanism in NETs as targets for therapy; update on clinical trials; nutrition and the GEP; peptide radiotherapy; in vitro analysis of NETs: the role of angiogenesis; modern lab evaluation of peptide and amines: a continuing role for radioimmunoassay?; surgery/surgical management of NETs; and evaluation and quality of life in NETs patients.

Irritable bowel syndrome is a type of functional bowel disorder causing symptoms of abdominal pain and altered bowel habits such as diarrhoea (IBS-D) and constipation (IBS-C). This book uses the 'whole evidence' approach to give an overview of the available evidence for Chinese medicine treatment for irritable bowel syndrome, particularly subtypes IBS-D and IBS-C.The book starts by summarising the conventional understanding of irritable bowel syndrome, including its subtypes, aetiology, diagnosis and current available treatments. Data from Chinese medicine classical literature and clinical studies are then discussed. Evidence from clinical studies are evaluated using high-quality and rigorous scientific methodology. For IBS-D and IBS-C, evidence from treatment modalities including Chinese herbal medicine, acupuncture and combination Chinese medicine therapies are presented. The findings are analysed and potential implications for clinical practice and research are explored. Experimental studies that describe the potential mechanisms of action of key herbs are summarised. In the final chapter, current evidence of Chinese medicine for IBS-D and IBS-C are synthesised, recommendations for contemporary clinical practice and future research are also offered.The book is a helpful guide for clinicians and students of Chinese and integrative medicine, offering a comprehensive synthesis of both classical and contemporary knowledge that can integrated into their clinical practice for people with irritable bowel syndrome.

Dysphagia: Diagnosis and Treatment of Esophageal Motility Disorders provides a interdisciplinary overview of the diagnosis and management of dysphagia and other esophageal symptoms. All aspects of dysphagia are covered, with detailed consideration of both physiology and evaluation methods. Hot topics include coverage on the pharmacological causes of dysphagia, the physiology of normal swallowing, ambulatory pH monitoring as well as recurrent dysphagia after treatments. The content is grounded in evidence-based medicine that is the result of clinical outcome research, both prospective and randomized, making this the perfect reference for clinical researchers and a go-to for general surgeons, foreguts surgeons, thoracic surgeons and gastroenterologists.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies.

The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics and Dysbiosis is a one-stop reference on the state-of-the-art research on gut microbial ecology in relation to human disease. This important resource starts with an overview of the normal microbiota of the gastrointestinal tract, including the esophagus, stomach, Ileum, and colon. The book then identifies what a healthy vs. unhealthy microbial community looks like, including methods of identification. Also included is insight into which features and contributions the microbiota make that are essential and useful to host physiology, as is information on how to promote appropriate mutualisms and prevent undesirable dysbioses. Through the power of synthesizing what is known by experienced researchers in the field, current gaps are closed, raising understanding of the role of the microbiome and allowing for further research.

The Digestive System in Systemic Autoimmune Diseases, Second Edition, represents the state-of-the-art in the field of digestive disorders in the most common systemic autoimmune diseases. This volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations. International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico, and South Africa share their knowledge in this detailed volume. The book provides an overview of our current understanding of digestive disorders in the most common systemic autoimmune diseases.

In this issue of Clinics in Liver Disease, guest editor Dr. John V. Binu brings his considerable expertise to the topic of Primary Biliary Cholangitis. PBC leads to inflammation and scarring of the small bile ducts, and, if untreated, can lead to cirrhosis and liver failure. In this issue, top experts provide a state-of-the-art review of diagnosis and treatment for this chronic, progressive liver disorder. Contains 13 practice-oriented topics including genetics of primary biliary cholangitis; prognostic scoring systems in PBC; overlap syndromes and PBC; non-invasive evaluation of fibrosis and portal hypertension in PBC; treatment of PBC: first- and second-line therapies; novel therapies for PBC; and more. Provides in-depth clinical reviews on primary biliary cholangitis, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Barrett's Esophagus: Emerging Evidence for Improved Clinical Practice is a comprehensive reference on the treatment and new imaging modalities of Barrett's Esophagus for researchers, clinicians, and scholars. Each chapter is composed from the perspective of investigators who summarize the data as well as the reasoning behind why those studies were conceived. In addition, the future directions of research are discussed within each chapter, providing insights from the investigators. Research questions are described, and cutting-edge applications are explained. Each chapter contains clinical scenarios to highlight the directions in which the research is, and should be, heading.

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