The gastrointestinal tract is the most important of the three major routes of entry (and clearance) of xenobiotics and biologic entities into the bodies of mammals. As such, it is also the major route for administration of pharmaceuticals to humans. Gastrointestinal Toxicology, Second Edition describes the mechanism for entry and clearance of xenobiotics, as well as the barriers, immunologic and metabolic issues, and functions present in the GI tract. Appearing in this volume are also considerations of the microbiome and its actions and influence on the function of the GI tract and on the toxicity and pharmacodynamics of ingested substances (including nutrients, toxins, and therapeutics). These fifteen chapters written by experienced experts in the field address methods to evaluate GI function; specifics of GI function and toxicity assessment in canines and minipigs; classes of compounds with their toxicity; species differences; and the toxicity (and promise) of nanoparticles. Those needing to understand the structure, function, and methods of studying the GI tract will find this volume a singular source of reference.

This reference supplies a comprehensive and current overview of every aspect of gastrointestinal microbiota. Expertly written chapters cover conventional and molecular techniques for the study of differing microbial populations, as well as the analysis of microbial activity and interaction with host bodies. Illustrative and up-to-date, this source showcases how fluctuations in our diet, environment, and pharmaceutical intake affect microbial composition and behavior.

With 2300 radiological images dispersed throughout the text, this source provides an expansive armamentarium of case studies and examples showcasing both common and uncommon liver pathologies. Serving as an unparalleled how-to source for the investigation of liver disease by MRI, this guide demonstrates key MRI techniques currently utilized in clinical practice, as well as explains the choice of acquisition sequences, specific parameters, and the use of contrast media for each application.

YAMADA'S Handbook of Gastroenterology The GI doctor's classic portable, clinically-focused and authoritative reference, revised and updated The revised and updated fourth edition of Yamada's Handbook of Gastroenterology focuses on the clinical aspects of patients presenting with gastrointestinal and liver disease. The book is a portable, quick reference tool designed to assist trainees and practicing gastroenterologists in the practical assessment and clinical management of patients. The Handbook is divided into two parts; the first is symptom focused and the second highlights diseases. Each chapter features key practice points, essentials of diagnosis, potential pitfalls and case studies. In addition, the book includes multiple choice questions and answers to enhance understanding. The fourth edition includes updated clinical practice guidelines from National Societies (American Gastroenterological Association, American Society for Gastrointestinal Endoscopy, American Association for the Study of Liver Disease and American College of Gastroenterology). The new edition also offers many new photographs of endoscopic, radiographic and histopathologic images. This important resource: Contains both symptom- and disease-focused chapters, and covers all clinical conditions and symptoms likely to be encountered Presents case studies, practice points, essentials of diagnosis boxes, society guideline comparisons, and MCQs for self-assessment tailored to ABIM Board level Offers an abundance of management algorithms and flowcharts to help plot the best route for clinical care Includes a full-colour plate section Written for gastroenterology, hepatology and internal medicine specialists, Yamada's Handbook of Gastroenterology, Fourth Edition continues to offer a succinct guide for daily use on the wards and also as a resource for preparation for GI Boards and re-certification.

The most up-to-the-minute reference on CT, MR, PET, and ultrasound imaging methods As continuing advances in computed tomography, ultrasound, magnetic resonance imaging, and nuclear imaging spur the development of more accurate, safer, and less invasive modalities for gastrointestinal imaging quickly rendering traditional procedures obsolete medical professionals need only look to this definitive step-by-step guide for introduction, clear illustration, and comprehensive coverage of cutting-edge techniques ranging from virtual colonoscopy to dynamic imaging of the pelvic floor.

The brain-gut connection has been increasingly implicated in biopsychosocial well-being. While there are numerous factors that directly and indirectly impact on how the gut and the brain interact, there is a growing awareness that gastrointestinal conditions need to be viewed and treated as part of a multidisciplinary approach. Psychogastroenterology for Adults: A Handbook for Mental Health Professionals is the first book to provide mental health professionals with an evidence-based, practical guide for working with patients living with gastrointestinal conditions. Timely and accessibly written, this book provides a unique, comprehensive introduction to psychogastroenterology, offering a step-by-step guide to evidence-based psychological treatment protocols. Broad in scope and expertise, the book is divided into four parts. It opens with an overview of the field, moving on to outline psychological concerns and conditions in gastroenterological (GI) cohorts. Further, it covers various approaches to psychogastroenterology, including psychopharmacological and eHealth practices. In closing, the book looks to the future, providing guidance on supervision in psychogastroenterology, and exploring challenges in the field. Written by experts in the field, this book will be an indispensable resource for those who wish to enhance their knowledge and practice of psychogastroenterology in the mental health profession, including psychologists, psychiatrists, psychosomatic medicine specialists, nurses and social workers.

The novice to the advanced practitioner will find value in having this handy reference on parenteral nutrition. It contains sections on order review, compounding, and drug shortage management. This latest edition is expanded to 13 chapters and is updated with ASPEN safety consensus recommendations and clinical guidelines. It features comprehensive information to help practitioners safely, effectively, and confidently care for patients receiving parenteral nutrition. The third edition includes new chapters on: Competency Multichamber-bags Electronic health records >br> A quick-reference handbook with interdisciplinary guidance on: Access devices, formulations, and prescriptions Treatment for common mechanical, metabolic, and infectious complications Order review, compounding, and drug shortage management Management of patients outside the hospital Considerations for pediatric patients

Disorders of the gastrointestinal tract make up some of the most common illnesses experienced across the lifespan affecting individuals in infancy, childhood and adulthood. This essential guide to the gastrointestinal system will enable nurses and allied health professionals to apply principles of anatomy and physiology to clinical practice. Taking a practical and evidence-based approach, each chapter explores associated anatomy, function and abnormalities. Chapters use selected pathology and associated pathophysiology, from across the lifespan, to support understanding of how disorders can disrupt the development and function of the gastrointestinal tract. The accessible writing style and full colour illustrations make this an ideal introduction for students and professionals new to gastrointestinal care.

Hepatocyte and Kupffer Cell Interactions presents a comprehensive discussion of historical and recent information regarding this diverse field of research. The role of Kupffer cells and hepatoctyes in normal physiology, nonseptic pathological states, and in sepsis is examined. Microanatomy and methods of experimental study are covered as well. In each of the book's chapters, the role of the Kupffer cell and hepatocyte interaction is placed in context with information on particular liver functions or disease states. Hepatocyte and Kupffer Cell Interactions is an essential reference for leukocyte specialists, gastroenterologists, immunologists, and other researchers working in this fascinating field.

Acute pancreatitis is a common cause of acute abdomen. Diagnoses is difficult as the symptoms mimic that of many other medical and surgical conditions. Patients with severe acute pancreatitis can develop multiple organ failure and need intensive care. As its management is multi-disciplinary involving gastroenterologists, radiologists and surgeons, this book shall appeal to every doctor, irrespective of the specialty. This focused book conveys the knowledge of the basic concepts of acute pancreatitis in an innovative way. Original photographs and figures are used for the better understanding of the readers. In this pocketbook, various aspects related to acute pancreatitis are covered in a unique, simple and easy-to-read A-to-Z format and will be useful to medical students, post-graduate trainees and practicing doctors as a ready reckoner for pancreatitis. Key Features: * Innovative and unique A - Z format. * focuses on signal knowledge and fast clinical management of various facets of different types of acute pancreatitis. * Comprehensive approach with interesting facts. * Lucid and self-explanatory text. * Can be used as a ready reckoner pocketbook .

A Sunday Times bestseller - now with revised and expanded content on the exciting new science about the gut-brain link. Our gut is as important as our brain or heart, yet we know very little about how it works and many of us are too embarrassed to ask questions. In Gut, Giulia Enders breaks this taboo, revealing the latest science on how much our digestive system has to offer. From our miraculous gut bacteria - which can play a part in obesity, allergies, depression and even Alzheimer's - to the best position to poo, this entertaining and informative health handbook shows that we can all benefit from getting to know the wondrous world of our inner workings.

Well-illustrated throughout and with in-depth analyses, Nutrition, Diet Therapy, and the Liver provides a holistic understanding of the causative elements that precipitate liver disease and the nutritional factors and regimens that reverse deteriorating hepatic function. This up-to-date resource also incorporates emerging fields of science and significant discoveries. With contributions from leading experts of international repute in their respective fields, the book first emphasizes the important role nutrition plays not only in the prevention of liver disease but also in the reversal of liver dysfunction. The second section covers various aspects of alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) as well as the consequent steatohepatitis that encompasses the whole spectrum of triglyceride accumulation, inflammation, fibrosis, and end-stage cirrhosis of the liver. The book then focuses on the mounting evidence in support of alcohol abuse, hepatitis viruses, and immune diseases as key predisposing factors in the incidence of hepatocellular carcinomas. The final section evaluates the importance of nutrition in the treatment of liver diseases in infants versus adults, including recovery after liver transplantation.

The organs of the gastro-intestinal tract play an essential role in sustained physical activity, but their consideration in exercise-related literature has, to this point, been limited. Physical Activity and the Gastro-Intestinal Tract is the first book to explain the function and response to exercise of the gastro-intestinal system, in cases of both health and disease, and helps to shed light on the role they play in acute and chronic exercise. Professor Roy Shephard synthesises previously disparate research to explain the physiology, function, pathology of disease and role of exercise in both health and chronic disease, covering topics including: physical activity and the oesophagus gastro-duodenal function and physical activity physical activity and peptic ulcers physical activity and gastro-oesophageal cancers physical activity and the function of the large bowel physical activity and chronic intestinal inflammation. With each chapter including a thorough bibliography and signposts to further reading, Physical Activity and the Gastro-Intestinal Tract provides a complete reference for understanding how exercise affects the function of the digestive organs. It is an important text for academics and upper-level students in sports medicine and exercise physiology, and for health professionals in preventative medicine.

Serotonin and Gastrointestinal Function provides a comprehensive review of current research into the mechanisms by which serotonin acts on gastrointestinal tissues. This book covers neurochemistry, physiology, pharmacology, and clinical issues relevant to serotonin in the gastrointestinal tract. The editors have brought together the most relevant information from the molecular to the clinical level. Each chapter is written by investigators experienced in research on serotonin's actions in the gut. This book will be useful to basic scientists, clinical investigators, graduate and postgraduate students.

Ulcerative colitis is a chronic condition that has a number of long-term complications and creates certain short-term problems for the sufferer. Michael Kelly, himself a sufferer, describes the experience of ulcerative colitis from the perspective of men and women who have had the disease and examines the social and psychological issues surrounding the condition. This book should be of interest to professionals in training and practice in the fields of medicine, nursing, medical sociology and social medicine.

An overview of the etiology, pathogenesis, diagnosis, and treatment of inflammatory bowel disease is contained in this valuable two-volume publication. Chapters include discussions of experimental animal models for enteritis, colitis and colon cancer.
The clinical aspects of inflammatory bowel disease are presented, with sections describing symptoms and signs, fertility and pregnancy, special features of childhood disease, and disease in the elderly, and complications.
In addition, pathologic aspects are included, with chapters on the pathology of idiopathic ulcerative colitis, Crohn's disease, and ultrastructure features. In summary, the therapy of idiopathic inflammatory bowel disease is discussed especially for gatroenterologists, graduate students and clinicians from various disciplines involved in the management of its complications.

The medical specialty of paediatric gastroenterology is focused on problems and disorders within the gastrointestinal tract, liver and pancreas of children from infancy until age eighteen. This inspirational compilation provides information on current research and clinical practice regarding the psychosocial aspects of paediatric gastrointestinal conditions, with contributions from international specialists and experts in the field. The chapters in Part I act as an introduction to understanding gastrointestinal disorders and consider key theoretical aspects and central issues. Part II investigates management and intervention concerns and includes patient narrative, offering unique insights for professional reflection. Part III looks at the unique characteristics of the anatomy and physiology of normal development and the maturation of the digestive system in infants. It also includes a compendium of assessment measures and a highly practical toolkit containing flow charts, clinical interview schedules, handouts and leaflets designed specifically for parents. It offers health professionals, students and trainees a muchneeded multidisciplinary perspective on the psychosocial considerations of children and young people with gastrointestinal disorders and their families. 'The series has a deliberately international focus, which reflects the paediatric psychology community and brings together material that is otherwise unavailable in this form. An inspiring and reliable resource for day-to-day paediatric practice'. From the series introduction by Angela Southall and Clarissa Martin

Highly Commended, BMA Medical Book Awards 2015 During the past 20 years, there has been an explosion of clinical, basic science, and translational research leading to a better understanding of the physiology and disease processes in the gastrointestinal system of children. Endoscopic techniques have improved, correlation of radiographic and biopsy findings with disease have become better defined, and advances in transplant care have led to markedly improved survival, even in the smallest of infants. Pediatric Gastroenterology: A Color Handbook explores the entirety of pediatric gastroenterology, including the gastrointestinal tract, liver, pancreas, and associated nutrition, radiographic, and endoscopic considerations. It covers a large number of diverse topics and provides a basic overview of pediatric gastrointestinal disease. The book presents multitude of endoscopic, histologic, and radiographic images as well as illustrations and metabolic pathways to convey a better understanding of disease processes. It also includes a list of recommended readings provided by the chapter authors, giving you a solid introduction to pediatric gastroenterology.

From a Harvard Medical School dream team-the most important insights on managing digestive and hepatic diseases in the palm of your hand Presented in a streamlined, templated style that makes learning and retaining key information effortless, CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, and Endoscopy, Fourth Edition offers authoritative insights for accurately diagnosing and effectively treating digestive tract and liver disorders. This peerless guide delivers authoritative coverage of the entire spectrum of gastroenterology and hepatology conditions, from stomach and esophageal to pancreatic and liver disorders, with very chapter outlining the essentials of diagnosis for each condition. Logically organized, the book begins with a section on general concerns, such as acute abdominal pain, and progresses to specific disease categories. High-yield overview of an effective treatment approach for chronic hepatitis C provides key perspectives on improving patient outcomes. Features 90+ full-color endoscopic and radiographic images enhance clinical decision-making and clarify imaging techniques Essentials of Diagnosis provide at-a-glance review of both common and rare digestive disorder Updated references to recently-published clinically relevant articles Includes continued coverage of the revised national guidelines

Practical Fluoroscopy of the GI and GU Tracts highlights the critical role of fluoroscopy in the diagnosis of luminal GI and GU diseases, presenting both the fundamentals and nuances for performing and interpreting all types of these examinations. The text presents detailed descriptions of the techniques for performing GI and GU fluoroscopic procedures in a logical, stepwise format. Practical tips, advice and solutions address the problems and pitfalls commonly encountered during these examinations. Clear, concise, yet comprehensive descriptions of the relevant clinical and radiographic findings and differential diagnoses also provide a focused approach for interpreting GI and GU studies. A plethora of carefully annotated figures illustrate the pertinent findings. Practical Fluoroscopy of the GI and GU Tracts is a must-have text for both radiology trainees and experienced radiologists and is an essential addition to the library of every radiology training program and the fluoroscopy suite of every radiology practice.

Get relief from your inflammatory bowel disease symptoms Crohn's disease and ulcerative colitis are diseases that disrupt your body's ability to digest food, absorb nutrition, and eliminate waste in a healthy manner. Crohn's And Colitis For Dummies is the ultimate reference to these common forms of inflammatory bowel disease (IBD), including tips on how to recognize and control the symptoms, so you can get your life back. Get ideas for keeping disease in check through diet and lifestyle changes, learn about the various medical and surgical treatment options, and discover healthier living with this friendly Dummies guide. This updated edition covers the latest research on IBD and new therapies that are helping today's Crohn's and colitis patients. You'll also find resources that will help and offer hope as you navigate your diagnosis. Learn about the different forms of inflammatory bowel disease Ask the right questions at the doctor's office Make simple changes that will improve your symptoms Know that there's hope and that you are not alone This book is perfect for anyone who has been recently diagnosed with Crohn's or colitis, and for those who suspect they may have an IBD. If you're a caregiver or family member of an IBD sufferer, you'll also love the easy-to-understand information inside.

Hepato-Pancreato-Biliary (HPB) surgery is now firmly established within the repertoire of modern general surgery. This new edition has been completely rewritten by world-leading surgeons to reflect the considerable advances made in the surgical management of HPB disorders since the highly successful first edition. This new edition includes: An in depth coverage of benign and malignant disorders of the liver, pancreas, and bile ducts and gallbladder A comprehensive section on anatomy, imaging, and surgical technique Over 20 new chapters, including a complete account of pediatric HPB disorders Illustrated with almost 300 high-resolution images, many in full-color Surgical Management of Hepatobiliary and Pancreatic Disorders, Second Edition, comprehensively covers the full spectrum of common HPB diseases and associated surgical techniques to assist not only the general surgeon in regular practice, but also surgical trainees and those in related specialties of oncology, radiology, gastroenterology, and anesthesia.

Inflammation is the body's ancestral response to its greatest threats: injury and foreign microbes. But as the threats we face have evolved, new science reveals simmering inflammation underneath the surface of everything from heart disease and cancer to mysterious autoimmune conditions. In A Silent Fire, gastroenterologist Shilpa Ravella takes us on a lyrical quest across time, around the world and into the body to reveal hidden inflammation at the root of modern disease-and how we can control it. We meet an eccentric Russian zoologist, the passionate yet flawed inventor of Kellogg's Cornflakes, and dedicated researchers working on the frontiers of medical and nutritional science today. With fascinating case studies, Ravella debunks common myths about "anti-inflammatory" lifestyles-adding or eliminating any one food, for example, is not a cure-all-and unmasks the links between food, the microbiome and inflammation. A paradigm-shifting understanding of human health, A Silent Fire shows us how to live not only long, but well.

It is estimated that 80 percent of women have some degree of cellulite. Although there are no permanent solutions for cellulite, dermatologists recognize that this is an issue of importance for many women. This guide reviews current research on the pathophysiology and treatment of cellulite, as well as the many recent developments in medical therapy, liposculpture, and pharmacy to combat the appearance of cellulite in the female figure.

The field of gastrointestinal motility disorders has been expanding in recent times largely due to advances in diagnostic modalities. This coupled with new evidence to support best practices has increased the interest among clinical gastroenterologists, researchers, teachers and trainees.New advancesin the field of evaluation of functional bowel diseases and motility disorders, such as high-resolution manometry, 24-h pH impedance monitoring, Bravo capsule pH-metry, barostat, balloon expulsion test, barium and MR defecography, biofeedback, hydrogen breath tests, motility capsule (smartpill) etc. have significantly expanded the scope and outcome of treating such these disorders. However, presently there is nocomprehensiveguidethat coversall aspects of evaluation of GI motility.This contributed volumewill havechapters written by a panel of experts from the global academia, including from India, Singapore, Japan, Taiwan, Thailand, Europe and USA, integrating the body of knowledge on evaluation methods with evidence of best practices for the management of motility disorders. A chapter on how to set-up a manometry laboratory provides key information for clinicians and researchers who are planning to start working in this area. With 20 chapters in the book supported with numerous tables, flow charts, schematic diagrams and images, professionals will find it an essential reading.