In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Pierre Gholam has put together topics that provide a current clinical update on the treatment and management of patients with drug-induced liver injury (DILI). Expert authors have contributed clinical review articles on the following topics: Epidemiology, Predisposing Factors and Outcomes; Genetic Predisposition to DILI; Causality Assessment Frequent Offenders and Patterns of Injury; Quantitative Systems Toxicology Approaches to Understand and Predict DILI; Liver Histology: Diagnostic and Prognostic Features; Acute Liver Failure Secondary to DILI; DILI in Persons with Pre-existing Chronic Liver Disease; DILI in the Setting of Statin Use; DILI in the Setting of Analgesic Use; DILI Secondary to Herbals and Dietary Supplements; and DILI Reporting and Resources for the Clinician. Readers will come away with the information they need to improve outcomes in patients with DILI.

Together with Consulting Editor Dr. Charles Lightdale, Dr. Qiang Cai has put together a comprehensive issue devoted to gastroparesis. Expert authors have contributed clinical review articles on the following topics: Epidemiology and Pathophysiology of Gastroparesis; Non-Diabetic Gastroparesis; Clinical Manifestations and Natural History of Patients with Gastroparesis; Evaluation of Patients with Suspected Gastroparesis; Symptomatic Management of Gastroparesis; Gastric Electrical Stimulator for treatment of Gastroparesis; Surgical Treatment for Gastroparesis; Botulinum Toxin Injection for Treatment of Gastroparesis; Stent Placement for Treatment for Gastroparesis; Technical Aspects of Per Oral Endoscopic Pyloromyotomy; Gastric Emptying Scintigraphy for Evaluation of Patients with Gastroparesis before Per Oral Endoscopic Myotomy; Outcomes of Per Oral Endoscopic Pyrolomyotomy in France; Outcomes of Per Oral Endoscopic Pyloromyotomy in China; Outcomes of Per Oral Endoscopic Pyloromyotomy in the United States.. Readers will come away with the information they need to improve endoscopic techniques and improve patient outcomes.

In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Tarek Hassanein has assembled top experts in hepatology to bring current information on the topic of Hepatitis B Virus. The issue provides the most current information on the prevention and care of infected patients. Specific articles are devoted to the following topics: Global perspective on HBV infections in the era of effective vaccines; Understanding the natural history of HBV infection and the new definitions of cure and the endpoints of clinical trials; HBV/HCV coinfection in the era of HCV-DAAs; Antiretroviral effects on HBV/HIV coinfection and the natural history of liver disease; Impact of HBV infection on HCC and liver transplantation; HBV in pregnant women and their infants; WHO guidelines for prevention, care and treatment of individuals infected with HBV: A US perspective; Reconciling the difference between the major HBV treatment guidelines: AASLD, EASL, APASL; HBV/HDV coinfection: A challenge for therapeutics; and The effects of hepatic steatosis on the natural history of HBV infection. Readers will come away with the current information they need to manage patient outcomes.

Based on the 20th edition of Harrison’s Principles of Internal Medicine, this book is dedicated to the field of gastroenterology in all its scope. It caters to medical professionals at all levels. Not only can this be used by aspiring doctors to prepare for medical entrance examinations, but also by seasoned physicians to update knowledge long after it has been acquired. It is sign-posted with references and contains over 2,500 questions. A comprehensive and authentic question bank on gastroenterology. Designed for postgraduate and superspecialty medical entrance examinations. Based on the 20th edition of Harrison’s Principles of Internal Medicine. Contains 2,500+ multiple choice questions. Caters to medical professionals at all levels.

In consultation with Consulting Editor, Dr. Alan Buchman, Dr. Stanley J. Naides has put together a state-of the-art issue of the Gastroenterology Clinics of North America devoted to Laboratory Monitoring of Gastrointestinal and Hepatobiliary Disease. Clinical review articles from expert authors are specifically devoted to the following: Inborn Errors of Metabolism and the GI track; Primary Immunodeficiency and the gut; Liver fibrosis determination; IBD; Autoimmune liver disease diagnosis and classification; Laboratory Diagnosis of Viral hepatitis; IgG4-RD with Emphasis on its GI Manifestation; Bowel Microbiome in Health and Disease; AAV System; and Celiac Disease. Readers will come away with the latest information they need to diagnose and monitor patients with gastrointestinal and hepatobiliary disease.

Dr. Charles Lightdale selected top expert Dr. Charles Lichtiger to serve as Guest Editor for this issue of Gastrointestinal Endoscopy Clinics devoted to Inflammatory Bowel Disease. The issue uniquely addresses the questions that arise when trying to treat and diagnose IBD. Further, it provides information on what the future might look like for endoscopists. Articles are devoted to the following topics: The Era of Anti-TNF's is Over: What do we know, don't know, and yearn to know; Prognostigating the Course of IBD- Is it an art or Science; Treat to Target: What is Target and How do we Treat; The Microbiota and the Immune Response: What is the Chicken and What is the Egg; The Role of the Radiologist in Determining Disease Severity; Capsule Endoscopy and Small Bowel Enteroscopy: Have they Rendered the Radiologist Obsolete; Dysplasia Surveillance; Endoscopic Submucosal Dissection: Are We Transitioning to it; Strictures in Crohn's Diagnosis and UC: Is there a role for the gastroenterologist, endoscopist, or is it always the surgeon; Endoscopy in the Postoperative Patient with CD or UC: Does it Translate to better Outcomes; The Role of Histology in Determining Disease Activity, Treatment, and Prognosis: Are we there yet; Perianal Disease: The role of Endoscopy, EUS, EUA, Laser Therapy, Sealing Agents, and Stem Cells; Imaging of Mucosal Inflammation: Current Developments and Future Perspectives for IBD; Surgery in IBD: Is there any need for Open Procedures. Readers will come away with a state-of-the-art understanding about the current and future clinical picture for endoscopy in IBD.

In consultation with Dr. Charles Lightdale, Dr. DiMaio has assembled a list of articles devoted to endoscopy in hepatology with the most current and clinically relevant content. Dr. DiMaio invited top experts from well-known institutions to contribute reviews on the following topics: EUS in the evaluation of unexplained biliary dilation and liver function test abnormalities; EUS-guided liver biopsy; Advances in endoscopic imaging of the biliary tree; Expert evaluation of indeterminate biliary strictures; Stenting for benign and malignant biliary strictures; Endoscopic management of biliary issues in the liver transplant patient; Endoscopic management of complex biliary stone disease; EUS-guided biliary drainage; ERCP and EUS-guided drainage of the gallbladder; EUS-guided interventions for the measurement and treatment of portal hypertension; Endoscopic management of portal hypertension-related bleeding; EUS for diagnosis and staging of liver tumors; ERCP-guided ablation for cholangiocarcinoma; and EUS-guided ablation of liver tumors. Readers will come away with the most current clinical information they need to improve outcomes in patients with liver disease.

Not just another diet or exercise book, but a unique reference tool that discusses a difficult subject with wisdom and wit and provides concise, expert information on how to optimize bowel function, prevent disease, and achieve great health.

Many bacteria, viruses, protozoa, and fungi play key roles in the development of gastrointestinal diseases, and this practical reference brings you up to speed with this increasingly important area. Covering a broad range of GI diseases and cancers, this resource provides an expert overview of the field, ideal for all gastroenterologists and infectious disease physicians. Covers infections associated with gastroesophageal reflux disease and Barrett's esophagus, gallbladder disease, acute pancreatitis, small intestinal bacterial overgrowth, irritable bowel syndrome, inflammatory bowel disease, appendicitis, Whipple Disease, Crohn's Disease, and more. Discusses esophageal cancer, gastric cancer, cholangiocarcinoma, hepatocellular carcinoma, and colorectal cancer. Includes chapters on gut microbiome, fecal transplants, and the molecular pathgenesis of gastrointestinal infections. Consolidates today's available information on this timely topic into a single convenient resource.

In consultation with Dr. Charles Lightdale, Dr. Cai has assembled a list of articles devoted to gastroparesis with the most current and clinically relevant content. Dr. Cai invited top experts from well-known institutions to contribute reviews on the following topics: Epidemiology and Pathophysiology of Gastroparesis; Diabetic Gastroparesis and Non-Diabetic Gastroparesis; Clinical Manifestations and Natural History of Patients with Gastroparesis; Evaluation of Patients with Suspected Gastroparesis; Symptomatic Management of Gastroparesis; Gastric Electrical Stimulator for Treatment of Gastroparesis; Surgical Treatment for Gastroparesis; Botulinum Toxin Injection for Treatment of Gastroparesis; Stent Placement for Treatment for Gastroparesis; Technical Aspects of Per Oral Endoscopic Pyloromyotomy; Gastric Emptying Scintigraphy for Evaluation of Patients with Gastroparesis before Per Oral Endoscopic Myotomy; Outcomes of Per Oral Endoscopic Pyrolomyotomy in France; Outcomes of Per Oral Endoscopic Pyloromyotomy in China; and Outcomes of Per Oral Endoscopic Pyloromyotomy in the United States. Readers will come away with the most current clinical information they need to inform clinical decisions to improve patient outcomes.

The Guest Editor, Dr. Robert J. Shulman, and Consulting Editor, Dr. Alan Buchman, have created a thorough review of the current clinical updates on treating children with gastrointestinal disorders and diseases. Expert authors have submitted review articles on the following topics: Update on Diet Management of Functional GI Disorders; Brain-Gut Axis: Clinical Implications; Pancreatitis: Molecular Mechanisms and Management; Inflammatory Bowel Disease: What Very Early Onset Disease Teaches Us; GI Development: Implications for Management of the Preterm and Term Infant; Infectious Diarrhea: New and Emerging Issues; New Insights into the Pathogenesis and Treatment of Malnutrition; Infantile Colic: New Insights into an Old Problem; Constipation: Beyond the Old Paradigms; Integration of Biomedical and Psychosocial Treatments in Functional GI Disorders; GI Neuropathies: New Insights and Emerging Therapies; Food Sensitivities: Fact versus Fiction; IBD in Children: A Focus on Quality Improvement and Pediatric Focused Care; Molecular Advances in the Understanding of Pediatric Cholestasis; Assessment and Treatment of Nonadherence in Transplant Recipients; and Update on Fatty Liver Disease in Children. Readers will come away with the current updates they need to diagnose and treat pediatric patients and improve outcomes.

Digestive Diseases in Sub-Saharan Africa: Changes and Challenges provides an in-depth examination into the rise of western digestive diseases in Sub-Saharan Africa (SSA). For those interested in the causes of the major diseases of the 'West', the patterns in Africa have always reflected on the emergence of western diseases and elucidated the pattern of these conditions and their clinical course. Coverage includes the present epidemiology of GI diseases in SSA, the trends that are occurring, and the context of other emerging diseases. Appropriate for researchers, gastroenterologists and internists, this book brings together the latest research in a single, complete volume.

With consultation of Dr. Charles J. Lightdale, Consulting Editor, Dr. Poneros has created created a state-of-the-art look at endoscopy for pancreatic disease. Top authors have contributed clinical reviews in the following areas: Acute Pancreatitis: Evidence Based Management Decisions ; Endoscopic Cyst Gastrostomy; ERCP for Recurrent Acute Pancreatitis ; Autoimmune Pancreatitis; Total Pancreatectomy with Autologous Islet Cell Transplantation; Pancreatic Insufficiency: What is the Gold Standard?; Current Guideline Controversies in the Management of Pancreatic Cystic Neoplasms; How to Manage Incidentally Found Pancreatic Neuroendocrine Tumors; Update in Celiac Block; The Use of Biomarkers in Risk Stratification of Cystic Neoplasms; Interventional EUS in the Pancreas; How to Avoid Post-ERCP Pancreatitis; and The Role of Genetic in Pancreatitis. Readers will come away with the clinical information they need to utilize endoscopic procedures in the treatment and management of pancreatic disease.

Dr. Gralnek is considered an authority on GI bleeding, and he has invited experts in their respective fields to contribute to this issue. The content is divided up between Acute Non-Variceal Upper GI Hemorrhage and Acute Lower Gastrointestinal Hemorrhage. Articles are devoted to the follow topics: Initial assessment, risk stratification and early management; Endotherapy of peptic ulcer bleeding; Endoscopic hemostasis of non-variceal, non-ulcer UGIH; Emerging endoscopic treatments for NVUGIH; The cutting edge: doppler ultrasound in guiding endoscopic hemostasis; The role of interventional radiology in NVUGIH; Managing antithrombotic agents in the setting of acute GI bleeding; Patient presentation, risk stratification and initial management; Colonoscopy: Diagnosis, timing and bowel preparation; The role of endoscopic hemostasis therapy; and Prevention of recurrent lower GI hemorrhage. Readers will come away with the most current clinical infomration on how to manage and prevent GI bleeding.

New Concepts in the Management of Septic Perianal Conditions provides a comprehensive review of the medically important basic and clinical aspects of perianal diseases in adults. This book presents current, medically important information in the rapidly changing field of anorectal diseases, including significant topics like perianal abscess and fistula. It provides an accurate source of clinically relevant information that is presented clearly and succinctly, making it perfect for the diagnosis, treatment and management of septic perianal conditions.

The Guest Editors have put together a concise monograph on the latest advances in transplantation of the liver, intestine, and pancreas. Expert authors have written comprehensive reviews on the following topics: Living donor liver transplantation: Technical innovations; Liver transplantation for cholangiocarcinoma; Immunological monitoring to personalize immunosuppression after liver transplantation; Status of adult LDLT in US based on A2ALL; Pediatric liver transplantation; Modern treatment of fulminant liver failure; Intestinal failure and rehabilitation; Adult intestinal transplantation; Pediatric intestinal transplantation; Living donor intestinal transplantation; Endoscopic follow-up of intestinal transplant recipients; Multivisceral transplantation; Pancreas transplantation for DM1 and DM2; and Robotic pancreas transplantation. Readers will come away with the clinical information they need to stay current on issues surrounding gastrointestinal transplantations.

Interventional Inflammatory Bowel Diseases: Endoscopic Management and Treatment of Complications covers the preparation, principle, techniques, and damage control of complications in endoscopic therapy, providing the ultimate guidance in endoscopic management of IBD. With contributions from a panel of international leading experts in the field, perspectives are included from GI pathologists, GI radiologists, gastroenterologists, advanced endoscopists, IBD specialists and colorectal surgeons. Recommendations from experts are also included within each chapter. By bridging medical and surgical treatment modalities for IBD, this is the perfect reference for GI researchers, medical students, therapeutic GI endoscopists, IBD specialists, surgeons and advanced health care providers.

Top expert Dr. Jacques Van Dam has compiled the most current clinical reviews on lumen-apposing stents, an important emerging field in interventional endoscopy that can substitute for more invasive surgeries. Authors have addressed the following topics in this issue: Fluid collections and pseudocysts as a complication of acute pancreatitis; Surgical management of pancreatic pseudocysts; Evolution of EUS-guided cyst gastrostomy; EUS-guided drainage of pancreatic fluid collections; EUS-guided biliary drainage as an alternative to ERCP; EUS-guided gallbladder drainage; Novel uses of LAMS; Lumen-apposing stents: Which one and why; Safety of LAMS; Endoscopic closure of fistuli; and How the experts do it: Step-by-step guide. Readers will come away with the knowledge they need to incorporate the use of LAMs in their clinical repertoire.

Brain Tryptophan Perturbation in Hepatic Encephalopathy: Implications for Effects by Neuropsychoactive Drugs in Clinical Practice; F. Bengtsson, et al. Hepatic Encephalopathy in Acute Liver Failure: Role of the Glutamate System; A. Michalak, et al. Glutamate and Muscarinic Receptors in the Molecular Mechanisms of Acute Ammonia Toxicity and of Its Prevention; M.D. Minana, et al. Studies on the Pharmacological Properties of Oxindole (2-Hydroxyindole) and 5-Hydroxyindole: Are They Involved in Hepatic Encephalopathy?; F. Moroni, et al. The Involvement of Ammonia with the Mechanisms That Enhance GABA-ergic Neurotransmission in Hepatic Failure; E.A. Jones, A.S. Basile. Direct Enhancement of GABA-ergic Neurotransmission by Ammonia; J.-H. Ha, et al. The Peripheral Benzodiazepine Receptor and Neurosteroids in Hepatic Encephalopathy; M.D. Norenberg, et al. Ornithine Aminotransferase as a Therapeutic Target in Hyperammonemias; N. Seiler. Sparse-Fur (spf) Mouse as a Model of Hyperammonemia: Alterations in the Neurotransmitter Systems; I.A. Qureshi, K.V.R. Rao. Abnormal Gene Expression Causing Hyperammonemia in Carnitine-Deficient Juvenile Visceral Steatosis (JVS) Mice; T. Saheki, et al. 7 Additional Articles. Index.

Several new scientific developments in the area of nutrition and an increasing interest in the nutritional interventions in gastrointestinal diseases justify a timely issue on on Nutritional Management of Gastrointestinal Disease. The articles in this issue are very relevant to our readers because diet and nutritional therapy positively affect various bodily functions, reduce the risk of disease progression, and optimize outcomes in patients with gastrointestinal disorders. Expert authors have written reviews devoted to the following topics: Malnutrition in GI disorders; Detection and nutritional assessment; Enteral feeding: Access and its complications; Parenteral nutrition: Indications, access and complications; Nutritional aspects of acute pancreatitis; Nutritional therapy in chronic pancreatic; Nutritional interventions in chronic intestinal pseudoobstruction and scleroderma; The role of diet in the treatment of irritable bowel syndrome; and Nutritional considerations in celiac disease and non-celiac gluten sensitivity. Readers will have a complete clinical understanding of best practices and outcomes for the gastroenterologist managing GI diseases.

Krankheiten der Leber.- Akute und chronische Virushepatitiden.- Bakterielle und parasitare Leberkrankheiten.- Leberkrankheiten bei Aids.- Autoimmunhepatitiden und Overlap syndrome.- Primar-biliare Zirrhose, primar-sklerosierende Cholangitis und "Vanishing-bile-duct"-Syndrom.- Hamochromatose (hereditare Hamochromatose; sekundare Eisenuberladungssyndrome).- Morbus Wilson.- ?1-Antitrypsinmangel.- Zystische Fibroese.- Primare Stoffwechsel- und Speicherkrankheiten.- Porphyrien.- Hyperbilirubinsyndrome.- Medikamentoese/toxische Leberschaden und alkoholische Leberkrankheiten.- Nichtalkoholische Steatohepatitis (NASH).- A Vaskulare Lebererkrankungen.- B Graft-versus-Host-Krankheit der Leber.- Pulmonale Komplikationen bei Leberkrankheiten.- Leber- und Systemerkrankungen.- Leber: Wechselwirkungen mit dem hamatopoetischen System.- Hep atop athien in der Schwangerschaft.- Krankheiten der Gallenblase und Gallengange.- Cholezystolithiasis und Choledocholithiasis.- Cholezystitis.- Cholangitis.- Anomalien der Gallenwege und Strikturen.- Sphinkter-Oddi-Dysfunktion.- Aids-assoziierte Cholangitis.- Leberzirrhose und Komplikationen.- Leberzirrhose.- Leberzirrhose und portale Hypertension.- Leberzirrhose und Aszites.- Hepatische Enzephalopathie.- Leberzirrhose und spontan-bakterielle Peritonitis.- Leberzirrhose und Nierenfunktionsstoerungen.- Leberzirrhose und Gerinnungsstoerungen.- Tumoren der Leber, Gallenblase und Gallenwege.- Benigne Tumoren der Leber, Gallenblase und Gallenwege.- Maligne Tumoren der Leber und Gallenwege.- Lebermetastasen.- Leberveranderungen bei hamatologischen Neoplasien.- Akutes Leberversagen und Transplantation.- Akutes fulminantes Leberversagen.- Indikationen zur Lebertransplantation.- Vorbereitung zur Lebertransplantation.- Intra- und postoperatives Management bei Lebertransplantation.- Nachsorge bei Lebertransplantation.- Pharmakotherapie und Ernahrung.- Pharmakotherapie bei vorgeschadigter Leber.- Leber und Ernahrung.- Sozialmedizinische Beurteilung bei Leber und Gallekrankheiten.- Sozialmedizinische Aspekte.