This handbook on vacuolar and plasma membrane H+-ATPases is the first to focus on an essential link between vacuolar H+-ATPase and the glycolysis metabolic pathway to understand the mechanism of diabetes and the metabolism of cancer cells. It presents recent findings on the structure and function of vacuolar H+-ATPase in glucose promoting assembly and signaling, in addition to describing the regulatory mechanisms of vacuolar H+-ATPase in yeast cells, neural stem cells, kidney cells, cancer cells, as well as under diabetic conditions.

This invaluable guide, endorsed by the UKMi and reflecting the extensive experience of the UK Renal Pharmacy Group, features drug monographs guiding physicians in how to prescribe, prepare, and administer drugs to patients with different levels of kidney function and when undergoing renal replacement therapy. It has been fully updated for this fifth edition to include up to 100 additional drugs, while maintaining the clear structure and format that is easy to use and simple to follow in the busy clinical setting. It continues to offer support and guidance to health care professionals enabling them to prescribe medications to their renal patients appropriately and safely.

Das Grundlagenwerk fur Dialyse-Teams

Fur die professionelle Versorgung von Dialysepatienten und Nierenkranken finden Pflegende und medizinische Fachangestellte hier alles Wissenswerte rund um das Gebiet der Nephrologie und Dialyse, u. a.: pflegerische Aufgabenbereiche akuter und chronischer Nierenerkrankungen Ernahrungsempfehlungen bei Dialysepflicht Planung und Organisation der Arbeitsablaufe in Dialyseeinrichtungen Nierentransplantation.

Verstandlich geschrieben, mit zahlreichen Abbildungen, Tabellen und Merksatzen erganzt, eignet sich das Werk hervorragend zum Lernen und Nachschlagen.

• Alle Inhalte der Fachweiterbildung Nephrologie und Dialyse
• Stellenbeschreibungen fur Fachpersonal in der Nephrologie und Dialyse
• Glossar wichtiger Fachbegriffe

Empfohlen von der Deutschen Gesellschaft fur Fachkrankenpflege und Funktionsdienste."

This book has been complied by a group of doctors and nurses from all the over the world. The editors of this book aim to ensure that the reader gets the different perspective of how haematuria is managed all over the world. Chapter contributions have been received from the UK, USA, Spain, India, Japan, Albania, Singapore and Sri Lanka. From a patient's perspective, finding blood in the urine can be a very frightening experience and must be investigated. This book helps provides an update on the common Aetiologies and Management of both adult and paediatric patients. In the book there are contributions from both Nephrologists and Urologists discussing the details of both visible and non-visible haematuria which will help guide the reader with the best management strategies for these groups of patients. Also presented in this book are chapters which purely focus on the patient's perspective of haematuria.

Creatinine, a muscle waste product, is widely interpreted as a measure of renal function. However, the serum level reflects not only renal excretion, but also the generation, intake, and metabolism of creatinine. In this book, the authors present current research in the study of the production, diagnostic uses and role in renal disease of creatinine. Topics include the diagnostic use of creatinine in pre-eclampsia; serum creatinine and its effect and management in renal and hepatic disease; evaluation of renal function in patients with cirrhosis; the role of creatinine in kidney disease in neonates, infants and children; and retinol X creatinine in kidney disease.

The past three decades witnessed a plethora of scientific investigations into the pathogenesis of diabetic nephropathy, which attempt to seek the role of several potential cytokines, growth factors, second messengers, vasoactive factors, and candidate genes in leading to structural and functional demise of the kidneys in diabetes. Establishing more extensive knowledge of pathogenesis is crucial to expand the therapeutic options for diabetic nephropathy. While there are a few monographs dealing with the subject of diabetic nephropathy, this book is an exclusive treatise on the current knowledge about the pathogenesis of this condition. This book offers the most current data on the pathogenic factors incriminated in the nephropathy of diabetes.

Much of the progress in the understanding of the physiology of vitamin D and its role in calcium and phosphorus homeostasis has been made in recent years. Active vitamin D plays a central role in the regulation of calcium by increasing calcium and phosphorus absorption in the gastrointestinal tract, by stimulating osteoclast activity and stimulating calcium absorption in the distal tubule. Progressive kidney disease is associated with a decline in production and impairment of the action of vitamin D, which leads to an inadequate serum calcium control. This book clarifies the components in Vitamin D therapy and other health factors in regard to kidney disease.

Hepatitis C virus (HCV) infection affects more than 170 million people worldwide and is recognised as both a cause and consequence of end-stage kidney failure. The incidence rates of HCV infection are considerably higher in dialysis patients than in the general population and are 3-fold higher in haemodialysis patients than peritoneal dialysis patients. Risk factors for HCV infection in dialysis patients include blood transfusion number, haemodialysis duration, dialysis unit HCV prevalence, prior kidney transplantation, intravenous drug use, male gender and older age. This book reviews the epidemiology of HCV in dialysis and discusses strategies for screening, transmission prevention, treatment and evaluation/management prior to kidney transplantation.

Advances in long-term improvement and outcomes of patients with kidney disease will require the use of novel biomarkers to identify patients at high risk for kidney disease and to diagnose kidney disease early for effective treatment. A biomarker is a substance found in the blood, body fluids or tissues that provides a measure of normal biological or pathological processes or response to pharmacological compounds or drugs. There are a wide variety of biomarkers including but not limited to mRNA, proteins and peptides, and lipid molecules. In AKI, important pathophysiological processes such as inflammation, apoptotic and necrotic cell death and, tubule regeneration may be reflected in blood or urine. An array of candidate markers along with clinical information in long-term clinical studies with appropriate analytical methodologies will likely provide prognostic information. Despite well-known limitations, currently the most widely used biomarkers for the early diagnosis of CKD and AKI are proteinuria, serum creatinine and blood urea nitrogen. Most clinicians are aware that serum creatinine and blood urea nitrogen are poor biomarkers due to inherent characteristics of these molecules and handling by the kidney. Creatinine is secreted and urea nitrogen is reabsorbed by the renal tubules. Many endogenous substances interfere in the assay for creatinine. Serum creatinine and urea appear late after acute kidney injury and the serum levels in part depend on the generation (large or small body mass). Acute kidney injury is a non steady state condition thus serum creatinine and urea nitrogen will lag behind kidney injury. For these reasons new biomarkers are imperative. With knowledge of these limitations in use of current biomarkers and the lack of progress in reducing the mortality and morbidity from kidney disease, there has been a great surge of interest in identifying novel biomarkers with a particular emphasis on the early diagnosis of kidney disease. A variety of methods have been employed including transcriptomics, proteomics, gene arrays and lipidomics. Currently, candidate biomarkers have been found in different disorders and have been tested in humans and many candidate biomarkers have yet to be identified. Most studies to date are preliminary and require validation in large multicentre studies followed by commercial assay development validation and testing. This new book outlines the rapid advances made in the field of biomarker development for kidney disease in which a variety of novel molecules have been identified and studied in humans.

Kidney cancer usually occurs in older adults and constitutes about 2 per cent of all adult cancers (more frequent in men than women). It is also known as nephrocarcinoma, renal cell carcinoma, hypernephroma, and Grawitz's tumour. This book includes within its scope the prevention, risk factors, symptoms, diagnosis, treatment, and rehabilitation of kidney cancer. Leading-edge scientific research from throughout the world is presented.

This new edition provides readers with a practice-based approach to all aspects of clinical nephrology. Extensively updated, it offers invaluable practical advice on how to manage specific illnesses and, uniquely, the importance of establishing systems and processes to improve patient safety, enhance the patient pathway and guidance on how to systematically improve clinical governance.

A unique feature of this book are the tips and tricks and, suggestions for avoiding common errors based on the vast experience of the authors. In addition, the Editor has collated a list of links to international registries and guidelines as well as selected disease specific organisations, providing both clinicians and patients with access to helpful and recommended resources.

Designed and written in a user-friendly fashion, Primer in Nephrology continues to be the definitive reference for practising nephrologists, trainees and non-nephrologist who encounter renal patients in their daily practice.

This book is a comprehensive guide to extracorporeal stone wave lithotripsy (ESWL) that includes a step-by-step approach for treating every possible kidney stone position. The book has an easy to read structure that will help readers understand ESWL quickly. Written by leading experts who have used ESWL to treat over 23000 patients, this book brings together years of practical knowledge and expertise in one concise volume. The book aims to utilise this knowledge and allow people to independently carry out kidney stone treatment on patients. Diagrams and illustrations show the methods and techniques needed in ESWL, as well as the potential complications.

Kidney Disease: From advanced disease to bereavement provides guidance to renal and palliative care professionals dealing with patients with advanced kidney disease, who are approaching end of life. The book describes the tools used to achieve a good death including advance care planning, symptom control law and ethics, recognizing dying, withdrawal of treatment, and a holistic approach to patient care. By using case histories, the book highlights how to facilitate good communication between patients, families and their renal and palliative teams. There are also chapters on support for carers and bereavement. Revised and updated, this new edition is written in a bullet point style to provide an indispensable guide to the day-to-day management of patient care. This pocketbook will be an essential guide for nephrologists, renal nurses, nephrologist trainees, and doctors and nurses working in palliative care.

The kidneys are responsible for many key bodily functions, but their primary role as a filter of toxins makes them extremely susceptible to disease. Often these diseases can only be diagnosed through a renal biopsy, a complicated procedure requiring ancillary immunologic and molecular diagnostic techniques. Many academic centers set aside dedicated laboratories specifically for renal pathology due to the amount of expertise required. This book covers all methods used by renal pathologists to diagnose a wide range of kidney diseases. Unlike most literature on renal pathology, this book is situated on the midpoint between encyclopedic and superficial coverage, written for the signing-out pathologist. While focusing on tumors and transplantation rejection, a full spectrum of infectious, inflammatory, and congenital disorders is covered in both pediatric and adult populations and is analyzed not only by light microscopy but by each applicable diagnostic modality available. The text is illustrated with more than 1,000 photomicrographs and diagrams, including a CD-ROM of all images.

Issues in Kidney Disease - Chronic Kidney Disease (CKD) is a collection of 17 detailed chapters written by world leaders and experts in nephrology in order to provide a comprehensive review of kidney disease using evidence-based recommendations and guidelines. This book starts with an excellent introduction and classification of CKD and progresses into various important aspects of CKD care including prevention, diabetes, hypertension, acid-base disturbances, genetic and age considerations, glomerulonephritis, interstitial nephritis, aging, as well as considerations for patients in pregnancy and with malignancy. This book will appeal to trainees and practicing clinicians in internal and family medicine, as well as nephrology, who would like current and practical clinical knowledge of chronic kidney disease to help improve the lives of patients with this condition.

Issues in Kidney Disease-Acute Kidney Injury is a collection of nineteen independent chapters written by internationally renowned authors, covering a wide range of topics, including the basic concepts and management of acute kidney injury (AKI), contrast induced nephropathy, acute tubular necrosis, interstitial nephritis, glomerulonephritis, obstructive uropathy, COVID-19, cardiorenal and hepatorenal syndrome. This book also addresses kidney injury in specialized populations like pregnant patients and patients with kidney transplant. A whole chapter is also dedicated to imaging in patients with kidney injury. This book will appeal to renal fellows, nephrologists, and practicing physicians involved in the care of AKI patients in critical care units and medical floors, including all those interested in the advances and innovations undergoing in this field. It brings timely and updated reviews and addresses trends, challenges, and controversies of kidney injury.

Volume 13 begins by examining how lipid abnormalities in chronic kidney disease attract continuous attention due to their unclear involvement in chronic kidney disease patient outcomes. If kidney function declines, inflammation and oxidative stress progress and lipid disturbances develop, and malnutrition may ameliorate dyslipidemia in advanced chronic kidney disease. Although rare, pancreatic trauma can significantly impact the life of a patient, with some requiring a total pancreatectomy which will result in pancreatogenic diabetes. Diagnosis can be difficult, especially in children, with clinical symptoms being absent in many. As such, the authors discuss the current scientific literature on the diagnosis and management of pancreatic trauma and the promising use of autologous islet cell transplant in these patients. The authors go on to present the state-of-art knowledge on the effects of adenotonsillectomy and rapid maxillary expansion on the dentofacial development of children, clarifying what might be expected regarding facial growth after normalizing the mode of breathing and increasing the width of the maxilla. Following this, this compilation summarizes the growth and development processes of the face to describe the theories and mechanisms of facial growth and development. Next, the management of multi-drug resistant tuberculosis and extreme drug resistance tuberculosis is discussed, along with the latest World Health Organization guidelines and policy recommendations for treatment. The literature regarding the clinicopathological features of mucosa-associated lymphoid tissue of the dura is reviewed, focusing on how to differentiate mucosa-associated lymphoid tissue of the dura from clinical and pathologic mimics. In the closing study, changes in the molecular mechanism inside an ensemble up to 3 mio Daltons in human muscle in members of one family from eight to 67 years old are investigated using non-invasive gravitational mass spectroscopy.

This comprehensive guide covers the causes, characteristics, and presentations of acute kidney injury (AKI), as well as prevention and treatment. The first part of the book features chapters on the epidemiology and diagnosis of AKI. This is followed by sections on pathophysiology, clinical syndromes and patient management. Authored by leading clinicians, epidemiologists, basic scientists, and clinical trialists, this book captures the latest evidence and best practices for treating patients with AKI.

Cancer and the Kidney covers the challenging overlap area of nephrology and oncology. Kidney problems in cancer patients, and cancer that affects kidney patients, are both very real clinical issues in medicine. For example, cancer is a common complication of kidney transplantation, and up to half of all survivors of bone marrow transplant may develop chronic kidney disease.
Since publication of the first edition in 2005, there have been many changes in this area. These include the recognition of chronic kidney disease after uninephrectomy for cancer, the occurrence of medication toxicities of the EGFR antagonists and of the VEGF antagonists, and changes in the approach to multiple myeloma. In this new edition, the primary authors cover diverse subjects in this area, ranging from assessment of kidney function, to paraneoplastic disorders, acquired cysts and native kidney cancers, and all points inbetween. Each chapter starts with a case study to ensure a practical focus, and there are numerous illustrations throughout. Specialists and trainees in nephrology and in oncology will find it a useful starting point and reference, as will physician assistants and nurse practitioners who work in these fields.

This book provides a comprehensive and up-to-date overview of all key issues related to kidney and urinary tract disease in full-term and premature newborns. Among the many topics addressed are fluid and electrolyte abnormalities, hydronephrosis, urinary tract infection, obstructive uropathy and renal replacement therapy. The approach throughout is clinically oriented, the aim being to provide the reader with hands-on guidance. Each chapter commences with a clinical case vignette and concludes with a take-home message highlighting key aspects of practical importance. In addition, however, informative reviews of the literature and the basic sciences are included. No other book currently on the market focuses solely on the newborn, and Kidney and Urinary Tract Diseases in the Newborn will be especially valuable to those undergoing fellowship training in neonatology or pediatric nephrology/urology.

This new edition is a comprehensive guide to recent advances in the diagnosis and treatment of renal disorders in children. Beginning with an introduction to anatomy and physiology, the following chapters describe various diagnostic tools. The following sections cover numerous renal disorders and their management. The sixth edition has been fully revised and updated with expanded chapters on fluids and electrolytes, cystic kidneys, tubular disorders, acute kidney injury, chronic kidney disease, and renal transplantation. A new chapter on chronic peritoneal dialysis has also been included. The book is highly illustrated with algorithms, tables and diagrams to enhance learning. Key points Comprehensive guide to recent advances in diagnosis and treatment of paediatric renal disorders Fully revised, new edition with expanded chapters and new topics Covers numerous renal disorders, diagnostic tools and processes, and treatment Previous edition (9789350252437) published in 2011

The field of interventional nephrology needs to be viewed as a new road towards improving the diagnostic methods and the dialysis access care provided to chronic kidney disease patients across the world. The above issues remain a weak link in the training of young nephrologists and a major hurdle both in the planning and maintenance phase of renal replacement therapy, as well as in the accuracy and safety of diagnosing renal impairment causation. Traditionally, the procedural aspect of care has been left in many cases to surgeons and/or radiologists. The above facts lead in many cases to patient inconvenience and high health care cost. The aim of this book is not only learning the necessary skills to perform renal medical procedures, but for nephrologists to assume leadership roles in coordinating a team to provide the best possible care. Mostly, this book is focused on details and "secrets" that can make the results better than we expect. Introducing renal physicians to the insertion of tunneled lines, medical insertion of peritoneal catheters and kidney biopsies (native and transplant) from the nephrologist's view is a great need in renal society. The primary focus of this book is to generate interest and awareness of the scope of interventional nephrology. The nephrology community across the world needs to evaluate the available resources to discuss the role of various team members and strive to improve patient care. Editors' and authors experiences are exposed in the book, which tends to help the growth and progress of this subspecialty. The trend is also seen as a recruiting tool to train the nephrology workforce in the future.