This book "Neuroplasticity and its Dark Sides" stresses some less
well-known aspects of neuroplasticity, namely that are two kinds of
neuroplasticity, one that is beneficial to the individual and one
that is harmful. Activation of neuroplasticity is important for
learning new skills and adapting to changing demands but
neuroplasticity can also create symptoms and signs of common and
widespread diseases such as chronic neuropathic pain and severe
tinnitus. Spasticity and some forms of spasm are also caused by
such maladaptive neuroplasticity, plasticity disorders. Plastic
changes also play important roles in many other disorders. This is
the dark side of neuroplasticity. Understanding the dark sides of
neuroplasticity is important for treatment of many common
disorders. For example, reversing such bad plastic changes would be
an ideal treatment if it could be done effectively and with little
adverse side effects. The book also describes the pathophysiology
of some common neurological disorders where expression of
neuroplasticity is evident or where it may play a role in producing
the symptoms. Three appendices provides the anatomical and
physiological bases for The book discusses how activation of
neuroplasticity can cause symptoms of diseases and it provides a
comprehensive description of the basis for neuroplasticity in
general. The roles of the ability to change the efficacy of
synapses and change in protein synthesis are discussed in detail.
The book discusses another less well-understood property of
neuroplasticity, namely that not all brain systems are plastic. The
fact that attempts to change sexual preferences have been generally
unsuccessful indicates that the function of some neural circuits in
the brain cannot be changed or are difficult to change, which means
that some circuits are "hard-wired." Personalities have shown
difficult to change thus indicating that some very complex
circuitry in the brain may be less plastic than normally assumed.
Long-term memory is another example of brain circuits that are
difficult to change. Failed success in treatment of posttraumatic
stress syndrome (PTSD) shows that some memory functions are
difficult to change. Understanding of neuroplasticity can benefit
diagnosis and treatment of many disorders of the nervous system.
The results of basic neuroscience studies of neuroplasticity are
fundamental for the understanding the normal as well as many forms
of abnormal function of the central nervous system. Up-to-date
information about the pathophysiology of disorders where
neuroplasticity is a factor can provide better treatment of many
diseases. This book promotes the use of knowledge about
neuroplasticity in diagnosis and treatment of disorders of the
nervous system.
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