Glycerophospholipid and sphingolipid-derived lipid mediators
facilitate the transfer of messages not only from one cell to
another but also from one subcellular organelle to another. These
molecules are not only components of neural membranes but also
storage depots for lipid mediators. Information on the generation
and involvement of lipid mediators in neurological disorders is
scattered throughout the literature in the form of original papers
and reviews. This book will provide readers with a comprehensive
description of glycerophospholipid, sphingolipid and
cholesterol-derived lipid mediators and their involvement in
neurological disorders.
The purpose of this book is to present readers with cutting edge
and comprehensive information on lipid mediators in a manner that
is useful not only to students and teachers but also to researchers
and physicians. This monograph has 11 chapters. Chapters 1 and 2
describe the generation of various lipid mediators from neural
membrane glycerophospholipids, sphingolipids, and cholesterol, and
their involvement and roles in signal transduction processes.
Chapters 3 and 4 describe cutting edge information on roles of
various isoforms and paralogs of phospholipases A2 in the
generation of glycerophospholipid-derived lipid mediators and
interactions among phospholipases A2, C, and D in the nucleus.
Chapter 5 describes metabolism and roles of bioactive ether lipids
in brain. Chapters 6 and 7 are devoted to excitotoxicity-mediated
modulation of lipid mediators in neurological disorders and recent
developments in kainic acid-induced neurotoxicity. Chapters 8 and 9
describe the health benefits of n-3 fatty acids (docosahexaenoic
and eicosapentaenoic acids) in diet, the mechanisms of their action
in cardiovascular and cerebrovascular systems, and comparison of
n-3 fatty acid s effect with cholesterol lowering drugs (statins).
Chapter 10 describes the contribution of neural membrane lipids in
apoptosis and necrosis. Finally, Chapter 11 provides readers and
researchers with a perspective that will be important for future
research work on bioactive lipid mediators.
This book will be particularly accessible to neuroscience
graduate students and teachers, as well as researchers. It can be
used as a supplemental text for a range of neuroscience courses.
Clinicians and pharmacologists will find this book useful for
understanding molecular aspects of lipid mediators in
neurodegeneration in acute neural trauma (stroke, spinal cord
trauma and head injury) and neurodegenerative diseases (Alzheimer
disease, Parkinson disease, and Huntington disease). This monograph
will be the first to provide a comprehensive description of
glycerophospholipid, sphingolipid, and cholesterol-derived
mediators, their interactions with each other in normal brain and
in brain tissue from neurological disorders.
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