In August of 1991, a second Dartmouth International Workshop on the
corpus callosum was convened to share and discuss the progress that
had been made over the decade that had passed following the first
workshop. A nucleus of basic and clinical scientists came together
to discuss their work and the work of others in a field that has
been broadened clinically by the addition of many new centers
throughout the world that are now performing corpus callosotomy for
intractable epilepsy. This text was stimulated by the participants'
presentations and associated fertile discussions. It is compiled
from the conference and subsequent studies. It reflects, both at
the basic and clinical level, an important and expanding field of
neural science endeavor. In keeping with the present and rapidly
expanding field of outcomes assessment, callosotomy is again
evaluated in light of a further decade of surgery and follow-up.
Callosotomy continues to be a useful, palliative procedure and the
indications for its use have been better established. The basic
science section is a supplement to the first edition and elaborates
progress in both new data and ideas. The section on experimental
epilepsy models adds further support to the clinical rationale for
callosotomy. Perhaps of greater importance is the contribution of
experimental models to our understanding of the propagation of
seizure activity. The section on the neuropsychology of the split
brain patient demonstrates the continuing major contributions to
the understanding of brain and behavior that pour forth from this
cornucopia.
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