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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Arterial Remodeling: A Critical Factor in Restenosis (Hardcover, 1997 ed.)
Loot Price: R5,929
Discovery Miles 59 290
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Arterial Remodeling: A Critical Factor in Restenosis (Hardcover, 1997 ed.)
Series: Developments in Cardiovascular Medicine, 198
Expected to ship within 10 - 15 working days
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Angioplasty has completely transformed the treatment of coronary
artery disease and is widely used, with more than 800,000
procedures performed worldwide per year. However, the enthusiasm
for angioplasty is shadowed by restenosis, which remains a critical
problem after the procedure, resulting in clinical recurrence in
over a third of patients. Recently, the mechanisms of restenosis
have been completely reappraised with an enriched understanding
that the original concept of neointimal hyperplasia may not be
accounting for the bulk of the problem. There is a desperate need
to heighten understanding of the remodeling process at the
molecular, cellular, and arterial level. Vascular remodeling is a
well established concept in the field of atherosclerosis and
hypertension, but only in recent years has its applicability to the
field of restenosis become pivotal. Accordingly, the editors
perceived the need to assemble the first book dedicated to the
concept of coronary artery remodeling in restenosis, in order to
clearly review the experiments leading to the remodeling hypothesis
and integrate this with the neointimal hyperplasia (tumor) model
for the development of the restenotic lesion. The authors of this
book present their experience to facilitate the understanding of
the mechanisms for coronary restenosis and remodeling. The various
experimental models, clinical issues, and basic mechanisms are
reviewed in detail, resulting in a fresh approach to a vexing
clinical problem. Arterial Remodeling: A Critical Factor in
Restenosis will be useful to the physician and trainee who have an
interest in restenosis, and specifically in the major
pathophysiologic process which determines the fate of arterial
healing in patients following percutaneous coronary
revascularization. It is hoped that this book will lay the
foundation for more effective therapies that will reduce the chance
of constrictive remodeling and improve the long-term efficacy of
non-surgical coronary revascularization in the future.
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