Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standardization and regulations. The book first explores specific drug delivery systems such as gastrointestinal, ocular, pulmonary, transdermal, and vaginal and rectal. It then discusses novel applications for nano, cosmetics, nutraceuticals, wound healing and cancer treatment. Finally, there is a section focusing on standardization and regulation which includes an enhancement of properties. This book is an essential resource for pharmacologists, pharmaceutical scientists, material scientists, botanists, and all those interested in natural products and drug delivery systems developments.

Membranes in Pulmonary Vascular Disease, Volume 82, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters from recognized experts on topics such as Sphingolipids in Vascular Lung Disease, Endothelial Glycocalyx, Cholesterol Regulation of Endothelial Cell Calcium Homeostasis in Pulmonary Hypertension, Mechanosensitive Channels and Gap Junction Channels in EC, Endothelial Protrusions in Junctional Integrity and Barrier Function, Cortical Actin Dynamics in Endothelial Permeability, Endothelial Microparticles and Exosomes, Store Operated TRP Channels and Endothelial Responses, and Caveolin and Endothelial NO signaling.

Encyclopedia of Cardiovascular Research and Medicine, Four Volume Set offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine.

This issue of the Interventional Cardiology Clinics edited by Jason Rogers covers various approaches, techniques, and therapies for Transcatheter Mitral Value Intervention. Topics include, but are not limited to: Echocardiographic Imaging of the Mitral Valve for Transcatheter Interventions, Use of Computed Tomography to Guide Mitral Interventions, Transseptal Puncture for Mitral Interventions, MitraClip Therapy for Mitral Regurgitation: Primary MR, Coronary Sinus-Based Approach to Mitral Regurgitation, and Transcatheter Mitral Valve Replacement.

This issue of Neuroimaging Clinics of North America focuses on Plaque Imaging. Articles will include: 3D carotid plaque MR imaging, Analysis of multi-contrast carotid plaque MR imaging, Incorporating carotid plaque imaging into routine clinical carotid MRA, PET-CT imaging to assess future cardiovascular risk, Utility of combining PET and MR imaging of carotid plaque, 3D carotid plaque ultrasound, Contrast-enhanced carotid plaque ultrasound, Detection of vulnerable plaque in patients with "cryptogenic stroke," Measuring plaque burden in secondary prevention of asymptomatic patients with known carotid stenosis, Plaque imaging in primary prevention of cardiovascular disease, Plaque imaging to decide on optimal treatment: medical versus CEA versus CAS, Clinical perspective of carotid plaque imaging, and more!

Heart failure is the only cardiovascular disease that is increasing. The impact on the critical care environment and the health care system, as a whole, is significant from both a cost and burden to the system perspective. There are 6.5 million hospital days a year and nearly $40 billion dollars in yearly health care costs attributed to heart failure in the United States. There are more Medicare monies spent for diagnosing and treating heart failure than any other Diagnosis Related Group. There is a 24% hospital re-admission rate for this diagnosis which leads to financial implications for health care systems. The human cost is also significant. Less than half of Americans diagnosed with heart failure survive greater than 5 years. The ongoing health care needs and cost of this chronic disease takes a significant toll on patients' finances, time and quality of life. Over $2.9 billion dollars is spent annually on the pharmaceutical management of heart failure in the United States. This diagnosis is the leading cause of hospitalization for patients who are 65 years of age and older. Few health care providers in the critical care environment are not affected by heart failure on a routine basis. Caring for these patients and their families is both a challenging and yet a rewarding experience. This edition will provide critical care nurses with a comprehensive heart failure review which is essential in caring for this challenging population given the dynamic health and critical care environments.

Coronary artery disease continues to be a major cause of morbidity and mortality in the United States and throughout the world. This issue of the Heart Failure Clinics provides a contemporary and concise, yet extensive, review on all aspects of the management of patients with coronary artery disease. Topics include but are not limited to: Epidemiology, Traditional and Novel Risk Factors in Coronary Artery Disease; Acute Coronary Syndromes: Unstable Angina and Non-ST Elevation Myocardial Infarction; Calcium Scoring and Cardiac Computed Tomography; Coronary Artery Disease and Diabetes Mellitus; Cardiac Syndrome X; and Revascularization Options: Coronary Artery Bypass Surgery and Percutaneous Coronary Intervention.

This issue of Physical Medicine & Rehabilitation Clinics will focus on stroke rehabilitation and will include articles such as: Mechanisms of stroke recovery, Insights from basic sciences, Stroke recovery and predictors of rehabilitation outcomes, Upper limb motor impairments, Post-stroke spasticity, Communication disorders and dysphagia, Neuropharmacology of Recovery, Robotic therapy, and many more.

This issue of Heart Failure Clinics examines the critical role of team-based care in the management of patients with heart failure. Articles address Team-Based Care for Prevention, Patients Hospitalized with Heart Failure, Transitions of Care, Outpatients, Managing Cardiac Comorbidities, Managing Non-cardiac Conditions, Cardiac Rehabilitation and Exercise Training, External Telemonitoring, Ambulatory Hemodynamic Cardiac Device Monitoring, Advanced Heart Failure, and Palliative and End-of-Life Care.

This issue of Cardiology Clinics examines the timely topic of Lipidology. In addition to the New Recommendations - ACC/AHA Lipid Guidelines, the issue also includes Familial Hypercholesterolemia; LDL Apheresis; Lipids in Pregnancy and Women; Diabetes and Lipidology; Diabetic Dyslipidemia; Fatty Liver Disease; Lipids and HIV Disease; Residual Risk; and Statins' effects on diabetes, cognition, and liver safety.

Atrial fibrillation is the most common cardiac arrhythmia. This issue of Cardiology Clinics examines following facets of atrial fibrillation: epidemiology and societal impact, risk factors and genetics, mechanisms, diagnosis and follow-up, rate versus rhythm control, antiarrhythmic drug therapy, catheter ablation, surgery, antithrombotic and anticoagulant therapy, left atrial appendage exclusion, management of patients with heart failure and structural heart disease, and novel treatment paradigms.

Cardiac MR is explored in this important issue in MRI Clinics of North America. Articles will include: MR physics in practice; Ventricular mechanics: Techniques and applications; MR safety issues particular to women; Novel MR applications for evaluation of pericardial diseases; 4D flow applications for aortic diseases; T1 mapping: technique and applications; ARVD: An updated imaging approach; Imaging the metabolic syndrome; Coronary MRA: how to optimize image quality; Prognostic role of MRI in nonischemic myocardial disease; MRI for valvular imaging; MRI for adult congenital heart disease assessment; Cardiac MRI applications for cancer patients; Applications of PET-MRI for cardiovascular disease; Rings and slings, and more.

Vasculitis is a term for a group of rare diseases that have in common inflammation of blood vessels and there are many types of vasculitis, and they may vary greatly in symptoms, severity and duration. Vasculitis can range from mild to life-threatening and early detection and treatment of severe vasculitis can prevent permanent damage.

Drs. Stephen Bohan and Josh Kosowsky have assembled a panel of expert authors for this edition on Cardivascular Emergencies. Topics include: Ischemia, Heart Failure, Congenital Heart Disease, Supreventricular Dysrhythmias, Atrial Fibrillation, Uncommon Dysrhythmias, Electrophysiology, Pericardial Disease, and Cardiac Arrest.

This issue of Critical Care Nursing Clinics will focus on Responses to Catastrophic Disasters. Article topics include cultural and spiritual competencies of the healthcare provider in a disaster, Psychological responses, disaster planning and aftermath, considerations for elderly and vulnerable populations, and forensic nursing.

Coronary heart disease is the major cause of death in all industrialized countries. It may present to many hospital departments so a sound knowledge of managing acute cardiology is needed. This is a new edition of a widely used, key reference for health professionals who care for cardiac patients. It is practical, easy to understand, up to date and with a large resource of references for further reading. It not only encompasses modern cardiology practice, but also considers how the patient came to arrive on coronary care, and what will happen them after they leave. The combined authorship of doctor and nurse reflects the close teamwork vital to the management of both patients and their families. Management of the cardiac patent is a complex process and this book has a clear approach conveying the necessary information in an easily understood way. It also has an excellent evidence base to ensure best practice and should appeal to staff in every cardiac unit. "a classic text" British Journal of Cardiology "a standard textbook..highly recommended" Intensive and critical care nursing journal Up to date coverage of a rapidly developing field Offers a multi-disciplinary approach to coronary care Easy to read and therefore easily understood Research/evidence based content ensures best practice Adds material that reflects the growing literature on nurse-lead approaches to chest pain assessment, defibrillation, thrombolysis and specialist clinics (heart failure and dysrhythmias). Updates content in line with the latest guidelines from various medical bodies.

The Encyclopedia of Heart Diseases is an accurate and reliable source of in-depth information on the diseases that kill more than 12 million individuals worldwide each year. In fact, cardiovascular diseases are more prevalent than the combined incidence of all forms of cancer, diabetes, asthma and leukemia. In one volume, this Encylopedia thoroughly covers these ailments and also includes in-depth analysis of less common and rare heart conditions to round out the volume's scope. Researchers, clinicians, and students alike will all find this resource an invaluable tool for quick reference before approaching the primary literature.
* Coverage of more than 200 topics, including: applied pharmacology of current and experimental cardiac drugs, gene therapy, MRI, electron-beam CT, PET scan put in perspective, cardiac tests costs and justification, and new frontiers in cardiovascular research
* More than 150 helpful figures and illustrations
* Dr. Khan is a well-published and respected expert in heart and heart diseases

With a wealth of sound practical advice, from the authors' years of extensive experience, this book will be invaluable for all those prescribing aerobic exercise programmes for cardiovascular health including: general practitioners, physiotherapists, nurses, exercise instructors and advisors.Covers traditional and contemporary approaches Many easy-to-use charts for the calculation of exercise intensities and aerobic exercise programmes Well referenced and thoroughly tested

Heart failure occurs in almost epidemic proportions, placing a huge burden on both the healthcare system, and sufferers and their families. This can only rise over coming years as the ageing population, particularly in industrialized countries, increasingly suffers from heart failure and its related comorbidities. The care of this group of patients has evolved significantly over recent years as our knowledge and understanding of the pathophysiology of heart failure has developed. It has become evident that supportive care is integral to comprehensive heart failure care, and this book provides an evidence-based overview of heart failure aetiology, its management, and the supportive care required by patients throughout the course of their disease. Supportive Care in Heart Failure integrates the complexities of heart failure care, bridging knowledge bases from cardiology and cardiothoracic surgery, general medicine and palliative care. The book reviews essential information about epidemiology and pathophysiology of heart failure, and evidence-based medical, device, surgical and interdisciplinary management. It addresses the evaluation and management of quality of life, common symptoms and problems associated with heart failure, and the holistic approach to supportive care throughout the course of the illness through the end of life. Prognostication, communication, and ethical decision making are reviewed in detail. Heart failure has traditionally presented a challenge to physicians, as a generally progressive condition with significant symptoms, a poor quality of life, and high mortality. But by applying the principles of palliative medicine, it is possible to offer a supportive care approach that synthesizes the experience of both the heart failure specialist and the palliative care physician, and offers the best possible quality of care to this group of patients.

Eureka: Cardiovascular Medicine is an innovative book for medical students that fully integrates core science, clinical medicine and surgery. The book benefits from an engaging and authoritative text, written by specialists in the field, and has several key features to help you really understand the subject: Chapter starter questions - to get you thinking about the topic before you start reading Break out boxes which contain essential key knowledge Clinical cases to help you understand the material in a clinical context Unique graphic narratives which are especially useful for visual learners End of chapter answers to the starter questions A final self-assessment chapter of Single Best Answers to really help test and reinforce your knowledge The book starts with the First Principles chapter which clearly explains the key concepts, processes and structures of the cardiovascular system. This is followed by a Clinical Essentials chapter which provides an overview of the symptoms and signs of cardiovascular disease, relevant history and examination techniques, investigations and management options. The Disease-based chapters give concise descriptions of all major disorders, e.g. ischaemic heart disease, hypertension and heart failure, each chapter introduced by engaging clinical cases that feature unique graphic narratives. The Emergencies chapter covers the principles of immediate care in situations such as cardiac arrest and acute MI. An Integrated care chapter discusses strategies for the management of chronic conditions across primary and other care settings Finally, the Self-Assessment chapter comprises 80 multiple choice questions in clinical Single Best Answer format, to thoroughly test your understanding of the subject. The Eureka series of books are designed to be a 'one stop shop': they contain all the key information you need to know to succeed in your studies and pass your exams.

Atkinson's Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology.

Part of the renowned Braunwald family of references, Clinical Lipidology: A Companion to Braunwald's Heart Disease provides today's clinicians with clear, authoritative guidance on the therapeutic management of patients with high cholesterol levels and other atherogenic lipid disorders. An invaluable resource for cardiologists, lipidologists, endocrinologists, and internal medicine physicians, this one-stop reference covers everything from basic science and the pathogenesis of atherothrombotic disease to risk assessment and the latest therapy options. Now fully updated from cover to cover, the 3rd Edition offers unparalleled coverage of lipidology in an accessible and user-friendly manner. Thoroughly covers the assessment, diagnosis, and treatment of patients with elevated levels of lipids and lipoproteins, including all the latest research-based recommendations, therapeutic breakthroughs, and related clinical advances.  Presents the latest data on clinical guidelines, risk assessments, and established and emerging pharmacologic and nonpharmacologic therapies-all from internationally recognized experts in the field.  Features condensed, streamlined content that focuses on clinical applications and applying concepts to the practice setting. Chapters have now been completely reorganized into sections on risk assessment; therapy; new and evolving therapeutic targets and platforms; and special populations.  Includes new chapters on Polygenic Risk Scores; Inclisiran; Bempedoic Acid; Selective Peroxisome Proliferator-Activated Receptor-a Modulator: Pemafibrate; Evolving Therapeutic Targets: Lp(a), ANGPTL3, and ApoC-III; New Therapeutic Platforms: Gene Therapy and Genome Editing; and more.  Contains new or expanded content on inflammation; genetic testing; troponins for risk assessment; statins and role of bile acid sequestrants, niacin, and fibrates; mAbs; CANTOS and CIRT; colchicine; IL-6; and cellular, molecular, and genetic therapy.  Provides treatment algorithms throughout, as well as case vignettes that highlight the most common clinical questions in each chapter.  Incorporates the latest guidelines from the AHA, ACC, ESC, and EAS, as well as future directions for ongoing research and emerging applications.  Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.