Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standardization and regulations. The book first explores specific drug delivery systems such as gastrointestinal, ocular, pulmonary, transdermal, and vaginal and rectal. It then discusses novel applications for nano, cosmetics, nutraceuticals, wound healing and cancer treatment. Finally, there is a section focusing on standardization and regulation which includes an enhancement of properties. This book is an essential resource for pharmacologists, pharmaceutical scientists, material scientists, botanists, and all those interested in natural products and drug delivery systems developments.

Membranes in Pulmonary Vascular Disease, Volume 82, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this new volume presenting interesting chapters from recognized experts on topics such as Sphingolipids in Vascular Lung Disease, Endothelial Glycocalyx, Cholesterol Regulation of Endothelial Cell Calcium Homeostasis in Pulmonary Hypertension, Mechanosensitive Channels and Gap Junction Channels in EC, Endothelial Protrusions in Junctional Integrity and Barrier Function, Cortical Actin Dynamics in Endothelial Permeability, Endothelial Microparticles and Exosomes, Store Operated TRP Channels and Endothelial Responses, and Caveolin and Endothelial NO signaling.

Encyclopedia of Cardiovascular Research and Medicine, Four Volume Set offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine.

Heart failure is the only cardiovascular disease that is increasing. The impact on the critical care environment and the health care system, as a whole, is significant from both a cost and burden to the system perspective. There are 6.5 million hospital days a year and nearly $40 billion dollars in yearly health care costs attributed to heart failure in the United States. There are more Medicare monies spent for diagnosing and treating heart failure than any other Diagnosis Related Group. There is a 24% hospital re-admission rate for this diagnosis which leads to financial implications for health care systems. The human cost is also significant. Less than half of Americans diagnosed with heart failure survive greater than 5 years. The ongoing health care needs and cost of this chronic disease takes a significant toll on patients' finances, time and quality of life. Over $2.9 billion dollars is spent annually on the pharmaceutical management of heart failure in the United States. This diagnosis is the leading cause of hospitalization for patients who are 65 years of age and older. Few health care providers in the critical care environment are not affected by heart failure on a routine basis. Caring for these patients and their families is both a challenging and yet a rewarding experience. This edition will provide critical care nurses with a comprehensive heart failure review which is essential in caring for this challenging population given the dynamic health and critical care environments.

This issue of Physical Medicine & Rehabilitation Clinics will focus on stroke rehabilitation and will include articles such as: Mechanisms of stroke recovery, Insights from basic sciences, Stroke recovery and predictors of rehabilitation outcomes, Upper limb motor impairments, Post-stroke spasticity, Communication disorders and dysphagia, Neuropharmacology of Recovery, Robotic therapy, and many more.

This issue of Neuroimaging Clinics of North America focuses on Plaque Imaging. Articles will include: 3D carotid plaque MR imaging, Analysis of multi-contrast carotid plaque MR imaging, Incorporating carotid plaque imaging into routine clinical carotid MRA, PET-CT imaging to assess future cardiovascular risk, Utility of combining PET and MR imaging of carotid plaque, 3D carotid plaque ultrasound, Contrast-enhanced carotid plaque ultrasound, Detection of vulnerable plaque in patients with "cryptogenic stroke," Measuring plaque burden in secondary prevention of asymptomatic patients with known carotid stenosis, Plaque imaging in primary prevention of cardiovascular disease, Plaque imaging to decide on optimal treatment: medical versus CEA versus CAS, Clinical perspective of carotid plaque imaging, and more!

Coronary artery disease continues to be a major cause of morbidity and mortality in the United States and throughout the world. This issue of the Heart Failure Clinics provides a contemporary and concise, yet extensive, review on all aspects of the management of patients with coronary artery disease. Topics include but are not limited to: Epidemiology, Traditional and Novel Risk Factors in Coronary Artery Disease; Acute Coronary Syndromes: Unstable Angina and Non-ST Elevation Myocardial Infarction; Calcium Scoring and Cardiac Computed Tomography; Coronary Artery Disease and Diabetes Mellitus; Cardiac Syndrome X; and Revascularization Options: Coronary Artery Bypass Surgery and Percutaneous Coronary Intervention.

This issue of Cardiology Clinics examines the timely topic of Lipidology. In addition to the New Recommendations - ACC/AHA Lipid Guidelines, the issue also includes Familial Hypercholesterolemia; LDL Apheresis; Lipids in Pregnancy and Women; Diabetes and Lipidology; Diabetic Dyslipidemia; Fatty Liver Disease; Lipids and HIV Disease; Residual Risk; and Statins' effects on diabetes, cognition, and liver safety.

This issue of Heart Failure Clinics examines the critical role of team-based care in the management of patients with heart failure. Articles address Team-Based Care for Prevention, Patients Hospitalized with Heart Failure, Transitions of Care, Outpatients, Managing Cardiac Comorbidities, Managing Non-cardiac Conditions, Cardiac Rehabilitation and Exercise Training, External Telemonitoring, Ambulatory Hemodynamic Cardiac Device Monitoring, Advanced Heart Failure, and Palliative and End-of-Life Care.

Atrial fibrillation is the most common cardiac arrhythmia. This issue of Cardiology Clinics examines following facets of atrial fibrillation: epidemiology and societal impact, risk factors and genetics, mechanisms, diagnosis and follow-up, rate versus rhythm control, antiarrhythmic drug therapy, catheter ablation, surgery, antithrombotic and anticoagulant therapy, left atrial appendage exclusion, management of patients with heart failure and structural heart disease, and novel treatment paradigms.

Cardiac MR is explored in this important issue in MRI Clinics of North America. Articles will include: MR physics in practice; Ventricular mechanics: Techniques and applications; MR safety issues particular to women; Novel MR applications for evaluation of pericardial diseases; 4D flow applications for aortic diseases; T1 mapping: technique and applications; ARVD: An updated imaging approach; Imaging the metabolic syndrome; Coronary MRA: how to optimize image quality; Prognostic role of MRI in nonischemic myocardial disease; MRI for valvular imaging; MRI for adult congenital heart disease assessment; Cardiac MRI applications for cancer patients; Applications of PET-MRI for cardiovascular disease; Rings and slings, and more.

Vasculitis is a term for a group of rare diseases that have in common inflammation of blood vessels and there are many types of vasculitis, and they may vary greatly in symptoms, severity and duration. Vasculitis can range from mild to life-threatening and early detection and treatment of severe vasculitis can prevent permanent damage.

Drs. Stephen Bohan and Josh Kosowsky have assembled a panel of expert authors for this edition on Cardivascular Emergencies. Topics include: Ischemia, Heart Failure, Congenital Heart Disease, Supreventricular Dysrhythmias, Atrial Fibrillation, Uncommon Dysrhythmias, Electrophysiology, Pericardial Disease, and Cardiac Arrest.

This issue of Critical Care Nursing Clinics will focus on Responses to Catastrophic Disasters. Article topics include cultural and spiritual competencies of the healthcare provider in a disaster, Psychological responses, disaster planning and aftermath, considerations for elderly and vulnerable populations, and forensic nursing.

Coronary heart disease is the major cause of death in all industrialized countries. It may present to many hospital departments so a sound knowledge of managing acute cardiology is needed. This is a new edition of a widely used, key reference for health professionals who care for cardiac patients. It is practical, easy to understand, up to date and with a large resource of references for further reading. It not only encompasses modern cardiology practice, but also considers how the patient came to arrive on coronary care, and what will happen them after they leave. The combined authorship of doctor and nurse reflects the close teamwork vital to the management of both patients and their families. Management of the cardiac patent is a complex process and this book has a clear approach conveying the necessary information in an easily understood way. It also has an excellent evidence base to ensure best practice and should appeal to staff in every cardiac unit. "a classic text" British Journal of Cardiology "a standard textbook..highly recommended" Intensive and critical care nursing journal Up to date coverage of a rapidly developing field Offers a multi-disciplinary approach to coronary care Easy to read and therefore easily understood Research/evidence based content ensures best practice Adds material that reflects the growing literature on nurse-lead approaches to chest pain assessment, defibrillation, thrombolysis and specialist clinics (heart failure and dysrhythmias). Updates content in line with the latest guidelines from various medical bodies.

The Encyclopedia of Heart Diseases is an accurate and reliable source of in-depth information on the diseases that kill more than 12 million individuals worldwide each year. In fact, cardiovascular diseases are more prevalent than the combined incidence of all forms of cancer, diabetes, asthma and leukemia. In one volume, this Encylopedia thoroughly covers these ailments and also includes in-depth analysis of less common and rare heart conditions to round out the volume's scope. Researchers, clinicians, and students alike will all find this resource an invaluable tool for quick reference before approaching the primary literature.
* Coverage of more than 200 topics, including: applied pharmacology of current and experimental cardiac drugs, gene therapy, MRI, electron-beam CT, PET scan put in perspective, cardiac tests costs and justification, and new frontiers in cardiovascular research
* More than 150 helpful figures and illustrations
* Dr. Khan is a well-published and respected expert in heart and heart diseases

A highly clinical, practical book on carotid diseases, which focuses on management options. For each management question an expert from Europe and from the US offer their views, and for particularly controversial topics more than one author has been invited to comment. Conclusions or management options are summarised in a box at the conclusion of each topic, which allows easy referral. The book is divided up into three main parts, covering pre-operative work-up, operative aspects and post-operative care. Chapters include evidence-based recommendations and experts personal opinions and reflect on-going clinical debate.Practical, focussed and clinically relevant. Highlights the most controversial issues with expert opinions on each.Management options summarised for easy referral. An up-to-date summary on the challenging area of carotid disease.Reflects on-going clinical practice. Includes evidence-based information.Covers many practical and controversial issues that are not mentioned in the mainstream textbooks. Includes expert input from 60 experienced clinicians from the US and Europe.Reflects queries and problems faced by surgeons in their day-to-day work.

With a wealth of sound practical advice, from the authors' years of extensive experience, this book will be invaluable for all those prescribing aerobic exercise programmes for cardiovascular health including: general practitioners, physiotherapists, nurses, exercise instructors and advisors.Covers traditional and contemporary approaches Many easy-to-use charts for the calculation of exercise intensities and aerobic exercise programmes Well referenced and thoroughly tested

In an easy-to-use format, this pocket-sized reference provides clear and precise access to basic EKG information and EKG recognition guidelines that nurses use daily. The guide helps readers to accurately identify EKG rhythms and provides clear explanations of cardiac anatomy and electrical conduction pathways along with a step-by-step approach for evaluating EKG rhythm strips. The book also addresses various clinical causes of each rhythm. Real-life cardiac case scenarios and the generous use of practice rhythm strips will help students to master the challenging task of identifying EKG rhythms clearly and accurately. The book provides bullet-point lists that highlight core concepts. Written for nursing students and new nurses, this resource will also be a helpful tutorial for seasoned nurses needing a quick refresher. This book was originally published under the Fast Facts series by Springer Publishing Company.

This volume sets out to consider a range of cardiac diseases for which drugs may play a therapeutic role by virtue of their effects on aspects of the immune system. The book reviews diseases of the heart which may involve an immunopharmacological component, and methods and techniques for the study of physiological and biochemical functions in the heart. An important focus is the immunopharmacology of the coronary vascular endothelium and the role of cellular and biochemical components of the immune system in the pathogenesis of atherosclerosis. The content also includes a review of the use of immunologically relevant agents in the setting of cardiac transplantation from aclinical perspective. Immunotherapy has a definite role to play in cardiology to a greater or lesser extent than other forms of intervention, depending on the type of cardiac disease. Immunopharmacology of the Heart aims to identify and clarify this role and points to potential developments of the future. Immunopharmacology of the Heart is a volume for the SYSTEMS theme of The Handbook of Pharmacology. In common with all other volumes it contains standardized illustrations and terms/abbreviations (glossaries of illustrations and terms published at the back of the volume). Other topics covered include: Leukocytes and their role in ischaemic heart disease. Complement activation. Sudden cardiac death. The stunned myocardium and reperfusion injury.

Heart failure occurs in almost epidemic proportions, placing a huge burden on both the healthcare system, and sufferers and their families. This can only rise over coming years as the ageing population, particularly in industrialized countries, increasingly suffers from heart failure and its related comorbidities. The care of this group of patients has evolved significantly over recent years as our knowledge and understanding of the pathophysiology of heart failure has developed. It has become evident that supportive care is integral to comprehensive heart failure care, and this book provides an evidence-based overview of heart failure aetiology, its management, and the supportive care required by patients throughout the course of their disease. Supportive Care in Heart Failure integrates the complexities of heart failure care, bridging knowledge bases from cardiology and cardiothoracic surgery, general medicine and palliative care. The book reviews essential information about epidemiology and pathophysiology of heart failure, and evidence-based medical, device, surgical and interdisciplinary management. It addresses the evaluation and management of quality of life, common symptoms and problems associated with heart failure, and the holistic approach to supportive care throughout the course of the illness through the end of life. Prognostication, communication, and ethical decision making are reviewed in detail. Heart failure has traditionally presented a challenge to physicians, as a generally progressive condition with significant symptoms, a poor quality of life, and high mortality. But by applying the principles of palliative medicine, it is possible to offer a supportive care approach that synthesizes the experience of both the heart failure specialist and the palliative care physician, and offers the best possible quality of care to this group of patients.

The prevention of coronary heart disease (CHD) has never been more important. Throughout the world death rates from cardiovascular causes are rising and are soon estimated to overtake infectious diseases as the leading global cause of death for the first time in history. All healthcare professionals need to understand what causes this disease and how to prevent it. This new edition of this highly successful book brings together the latest information and research on CHD; in particular, the health professional's role in prevention of the disease. It gives practical advice on correcting these factors through lifestyle and medical management. Updates for the second edition include:coverage of the new large lipid-lowering drug trials therapeutic advances in the use of thrombolytic, antiplatelet and anti-hypertensive drugs advances in treatments including diabetic control, anti-smoking therapy, prescription of exercise and the use of dietary advice. This book is aimed at the broad range of professionals who come into contact with CHD patients and with those at risk of CHD, including nurses, physiotherapists, dieticiansdietitians, occupational therapists, clinical psychologists, general practitioners, doctors who are involved in prevention and rehabilitation and all staff working in coronary care units, lipid and hypertension clinics and general cardiology clinics. evidence-based content ensures a firm scientific basis for practice the practical nature of the content can be immediately applied in the working environment e.g. smoking cessation strategies, dietary counseling and risk assessment the multidisciplinary group of contributors ensures that the content reflects the multidisciplinary nature of CHD prevention work case studies and practice exercises enable the application of theory to practice summaries of key points facilitate understanding and retention the implications from clinical governance legislation, the National Service Frameworks and Joint British Recommendations on prevention of CHD in clinical practice recent research outcomes e.g. the HOT trial diabetes and its links with CHD material relating to ethnic minorities more 'global' statistics where possible to make the text more appealing to international markets the inequalities arising from socio-economic exclusion