Not too long ago, it was thought that inflammation of blood vessels was the sole manifestation of systemic autoimmune diseases. Today, however, we know that disorders of coagulation, injuries to both neutrophils and endothelial cells, and certain lipids and amino acids are all intricately involved in the development of vascular disease. How are all these processes linked? What strategies can we employ or develop to halt the progression of vascular damage? What are the best ways to control acute vasculitis and vasospasm therapeutically? What are the risks and benefits of various strategies for the prevention of clotting? How soon should we initiate preventive strategies that protect blood vessels from arteriosclerosis in people with acute rheumatic diseases? What should be the nature of those strategies?

Vascular Manifestations of Systemic Autoimmune Diseases provides answers to all these questions. Ronald Asherson, Richard Cervera,Steven B. Abramson, Jean-Charles Piette, and Douglas Triplett- all international experts in the field-have assembled a collection of works that provide a comprehensive analysis of vascular irregularities. Now that most individuals survive the onset of acute systemic autoimmune diseases and live for decades more, halting the long-term attack on vasculature is increasingly important.
Vascular Manifestations of Systemic Autoimmune Diseases not only describes the clinical symptoms of vascular diseases; it also covers in one volume the many mechanisms involved in the pathogenesis of these disorders and addresses the newest treatments available for them.

Trusted by generations of cardiologists for the latest, most reliable guidance in the field, Braunwald's Heart Disease, 11th Edition, remains your #1 source of information on rapidly changing clinical science, clinical and translational research, and evidence-based medicine. This award-winning text has been completely updated, providing a superior multimedia reference for every aspect of this fast-changing field, including new material about almost every topic in cardiology. A unique update program by Dr. Braunwald creates a "living textbook" by featuring weekly Hot off the Press, periodic Late-Breaking Clinical Trials (including links to authors' presentation slides), and monthly Focused Reviews. More than a dozen new chapters cover Chronic Lung Disorders and Cardiovascular Disease; Transcatheter Treatment of Congenital Heart Disease; Approach to the Patient with Valvular Heart Disease; Obesity and Cardiometabolic Disease; Environmental Exposures and CVD; Approach to the Patient with Cardiac Arrhythmias; Cardio-oncology, Precision Medicine, and more. New information on clinical cardiovascular genetics; MR PET; MR device compatibility; fibrosis; fusion imaging; OCT; IVUS; left atrial appendage exclusion approaches and other topics. Many new videos that elucidate coronary, peripheral, valvular, congenital heart diseases and other cardiovascular diseases. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Clinical management and signs are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic. The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner. The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately. Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be included. This book will be written for the general cardiologist and the clinical geneticist who is involved in cardiac patients and will provide answers to question such as: Which genes are involved and which mutations? What is the effect of the mutation at cellular level? Which genes should be tested and why? What is the value of a molecular diagnosis? Does it influence therapy? When should the first degree relatives be tested and in which way?

* Tom Kenny, one of the best-known and well-respected educators in EP brings his signature style to this new primer * Practical, accessible, highly illustrated approach makes learning easy * Provides an overview of the algorithms and devices offered by the world s five pacemaker manufacturers * Offers clinicians learning objectives, test questions and essential points in bulleted lists * Perfect introductory guide to the topic, assumes little baseline knowledge and appropriate for residents, fellows, EP nurses, general clinical cardiologists, EP fellows and industry professionals

Of all the complications which arise from diabetes, cardiovascular complications are by far the most prevalent and the most deadly. Authored by some of the world's leading names in this area, this outstanding book provides all those managing diabetic patients with clinical, practical and succinct guidance to the diagnosis and management of cardiovascular complications in diabetes. With a joint endocrinology and cardiology focus, and with the very latest in clinical guidelines from the ADA, EASD, AHA, ASC and ESC, selected highlights include: - The role of new biomarkers of cardiovascular disease in diabetes - The latest on diagnosis of cardiovascular problems via vascular imaging - Hypertension and cardiovascular disease in the diabetic patient - Dyslipidaemia and its management in type 2 diabetes - Management of thrombosis, acute coronary syndrome and peripheral arterial disease in diabetes Key points, case studies and self-assessment questions allow for rapid-reference, quick understanding of all topics, thus ensuring that this is perfect reading for endocrinologists, diabetes specialists and cardiologists of all levels managing patients with diabetes and associated cardiovascular problems.

This book describes a wide range of interventional procedures currently employed in the treatment of cardiac diseases in women with the aim of enabling not only interventional cardiologists but also cardiologists and cardiac surgeons to refine their approach to female patients and thus improve outcomes. The book reflects the increasing awareness of gender differences with regard to coronary artery disease and structural valve heart disease. Examples include myocardial infarction, which carries a worse prognosis in women in part because they suffer from this disease mostly in the 7th decade of life, present more frequently with hemodynamic instability and later from symptom onset, and have fragile, small and tortuous coronary arteries that are more technically demanding in the context of primary percutaneous coronary intervention. Another example is symptomatic aortic stenosis, which carries a better prognosis in women who undergo trans-catheter aortic valve implantation partially due to a better annulus-prosthesis match, which leads to less residual paravalvular regurgitation, better left ventricular function and lower aggregation of comorbidities. Further, in women left ventricular response to aortic stenosis is typified by muscle hypertrophy with a small ventricular cavity. These differences are reflected in the clinical manifestations and their impact on diagnosis, treatment, and choice of tools and devices for use in interventional procedures. By explaining the at times subtle variances in disease and treatment techniques for female and male patients, this book will help practitioners select the most appropriate procedures and materials in a range of settings.

Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald's Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. Covers the pathophysiological basis for the development and progression of heart failure. Serves as a definitive resource to prepare for the ABIM's Heart Failure board exam. 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition). Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Dr Kusumoto s unique new book takes a step-wise, patient-centered approach to guide readers through the thought process required during an electrophysiology study and the development of new findings. * Follows a case based step-wise approach focused on the EP lab that allows readers to follow along with the thought process behind how experienced electrophysiologists first diagnose, then prepare, treat and manage patients with common rhythmic abnormalities, including atrial fibrillation * Written by award-winning Mayo Clinic Physician-educator Dr. Fred Kusumoto * Ideal for fellows, new EPs, nursing and technical staff in the EP lab * Includes clinical questions to help readers test their understanding of the steps and concepts covered in the book and prepare for certification exams

This book is a comprehensive guide to vascular imaging and endovascular interventions. Divided into fifteen sections, the first chapters provide an overview of vascular imaging, radiation safety, contrast agents and pharmacologics. The following sections cover vascular anatomy, pathology and non-invasive vascular imaging, with each topic further divided by anatomical region. The text continues with detail on angiographic techniques, then each of the following sections provides in depth information on the diagnosis and treatment of different vascular diseases. The book concludes with discussion on male and female genitoreproductive diagnosis and interventions. Written by internationally recognised authorities in the field, this book is highly illustrated with clinical images and diagrams. Key Points Comprehensive guide to vascular imaging and endovascular interventions Provides overview of vascular imaging, radiation safety, contrast agents and pharmacologics Covers diagnosis and treatment of numerous vascular disorders Internationally recognised author team

Cardiovascular MR imaging has become a robust, clinically useful mod- ity, and the rapid pace of innovation and important information it conveys have attracted many students whose goal is to become adept practitioners. In turn, many excellent textbooks have been written to aid this process. These books are necessary and useful in helping the student learn the underlying pulse sequences used in CMR, as well as the imaging findings in a variety of disorders. However, one of the difficulties inherent in learning CMR from a book is that the printed format is not the ideal medium to d- play the dynamic imaging that comprises a typical CMR case. For instance, it may be difficult to perceive focal areas of wall motion abnormality on serial static pictures, but these abnormalities are often easily seen on cine loops. One might say that trying to learn CMR solely from a standard textbook with illustrations is like trying to learn to drive by looking at snapshots obtained through the windshield of a moving car. The learner needs to see the cardiac motion and decide if it is normal or abnormal; he or she needs to be in the driver's seat. An additional limitation of the ava- able textbooks on CMR is that while they often have superb illustrations of abnormal findings, these images have been preselected.

Coronary artery disease (CAD) is the leading cause of death and illness in the United States, and though much progress has been made in reducing cardiac risk factors, obesity and diabetes mellitus are on the rise. Preventing Illness Among People With Coronary Heart Disease explores recent advances in drug treatments for CAD risk factors and how these interventions can play an important role in improving the length and quality of patients'lives by addressing health behaviors and the need for behavioral change. This advanced text shows readers how mental health problems such as anxiety, depression, and alcoholism interplay with patients'physical health and how certain interventions can improve patients'outlook and health status.Preventing Illness Among People With Coronary Heart Disease brings together researchers from a variety of disciplines to address subjects critical to secondary and tertiary preventive care for patients with coronary heart disease (CHD). This outstanding volume concentrates on studies from three major areas to help primary care practitioners and family practice physicians intervene successfully with risky behaviors among their patients prone to or afflicted with coronary artery disease. These include the effects of heart disease on patients'mental health and quality of life and the role of formal behavioral interventions in promoting health among patients with heart disease.Readers of Preventing Illness Among People With Coronary Heart Disease acquire a solid understanding of the factors influencing CAD patients'behavioral patterns and mental states and how the prevalence of CAD can be reduced. Among the vital topics readers learn about are: the effects of alcohol upon CHD and blood pressure CHD risk factors in the elderly exercise interventions coping strategies and cardiac illness strategies for assessment and prevention smoking and cardiovascular diseasePreventing Illness Among People With Coronary Heart Disease seeks to provoke greater discussion and scientific activity among professionals in the field to improve understanding of the interplay of mental health, physical health, and behavioral medicine for patients with heart disease. Primary care practitioners, family practice physicians, medical students, and others interested in preventive cardiology, preventive care, or chronic disease management will learn about recent advances in research and treatment approaches that can be applied immediately to daily practice.

Diagnostic Pathology: Vascular offers a specific focus on vascular pathology, making it ideal for the practicing pathologist, dermatologist, pediatrician, or trainee. This easy-to-use, comprehensive reference book takes a multidisciplinary approach to diagnosis and boasts superior medical images - including radiology, gross pathology, and clinical photographs - on a wide variety of rare entities. This is your essential guide to understanding vascular pathology and diagnosis! Organ system-based approach to the diagnosis of vascular tumors includes diagnostic criteria and decision-making paradigms to rule out mimics in specific anatomic locations. Essential information is distilled into a bulleted format with numerous high-quality images to facilitate learning. "Key Facts" highlight the quick criteria needed for diagnosis or adequacy evaluation at the time of a procedure. Extensive clinical, radiographic, and histologic library of images of vascular lesions set in specific anatomic locations. Updated classification schema for vascular tumors, proliferations, and malformations modified from the current International Society for the Study of Vascular Anomalies and the 2013 WHO Bone and Soft Tissue Tumor book. Molecular genetic characteristics section for each tumor highlights additional possible ancillary techniques that can be employed for diagnostic purposes. Includes the most current immunohistochemical techniques useful for characterizing specific vascular tumors and utilizing in malignancy. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.

Comparative Cardiovascular Dynamics of Mammals offers never-before-published data on the structure and function of the circulatory systems of the different mammalian species. This text explores classic allometry, dimensional analysis, and modern hemodynamics to establish similarity principles that provide a necessary and important step in understanding the natural common design and functional features of the cardiovascular systems of different mammals. Fluid and blood vessel mechanics, pulse transmission characteristics, cardiac energetics and mechanics, as well as heart-arterial system interaction are included in this essential reference. The sensitivity of parameters and similarity of principles in the diagnosis of cardiovascular diseases are also addressed. This book also describes the natural processes involved in the functional development of the mammalian cardiovascular system. By using modern methods to present recent findings on the similarities and differences of the mammalian cardiovascular system, the author provides an easily understood approach to this dynamic field of study.

Cardiovascular disease (CVD) is the number one killer of men and women in industrialized countries. In older age groups, CVD is also the most important cause for hospitalization, and, in many countries, it is the basis of early retirement from work. Thus, CVD is associated with enormous costs for care and loss of productivity, as well as for disabilities, pensions, etc. All this has motivated clinicians and scientists to develop and implement new methodologies and technologies to better care for patients who are hospitalized for heart disease.
Efforts to improve care in the acute phases of coronary heart disease (CHD) have been successful. During the last decade, the immediate mortality risk of a patient admitted to coronary care for a suspected myocardial infarction or other acute coronary syndrome has decreased to less than 10%. Despite these achievements, CVD continues to represent a major threat to the health of middle-aged and elderly men and women.
This volume addresses myriad aspects of CHD prevention, including biobehavioral and psychosocial factors, behavioral epidemiology, behavioral intervention models, and policy. The first section of the text provides an introduction to CVD prevention and behavioral medicine. The second section introduces two theoretically different approaches to preventive action, high-risk and population-based strategies. The third section describes and discusses the important questions of how behavioral sciences can be conceptually integrated into traditional, medically based, preventive efforts. The fourth section presents both population and high-risk behavioral intervention approaches.
In summary, this volume examines the social environment and its potentials for preventive actions, reviews the psychosocial and biobehavioral mechanisms involved in these effects, and describes concrete and practical implementations of behavioral medicine knowledge as they have been applied to CHD prevention.

Part of the highly regarded Diagnostic Pathology series, this updated volume by Drs. Dylan V. Miller and Monica P. Revelo is an ideal point-of-care reference for the accurate diagnosis of complex cardiovascular specimens. Concise, focused chapters, supported by tables, diagrams, radiographs, and photographs, provide essential information to keep you up to date with new cardiac devices, the increased use of molecular panels, WHO updates, and much more. Hundreds of images, including photomicrographs, spectacular gross images, electron micrographs, and vivid medical illustrations Separate sections on specimens encountered in the settings of biopsy, surgical resection, and autopsy Time-saving reference features include bulleted text, tables of diagnostic criteria, annotated images, and an extensive index Thoroughly updated content includes new cardiac devices that require pathologic evaluation; increasing volumes of established devices in surgical and autopsy specimens; the increasing use of molecular panels in the evaluation of cardiomyopathy, aortic diseases, sudden cardiac death, and myocarditis; and updates from an international consensus on cardiac tumor reporting (ICCR) A new chapter on TAVR (transcatheter) valves, plus updates to the chapters on prosthetic valves, LVADs, stents (including a description of 2 new methods of preparing sections that can be done in any histology lab), and more A new section, Autopsy Evaluation of Cardiovascular Disease, includes 9 chapters from the Diagnostic Pathology: Hospital Autopsy volume Updates from the new edition of the WHO blue book for cardiac tumors Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Disease conditions that affect the human heart and the methods used to diagnose and treat them are all covered in one concise volume. * Illustrations include diagrams of the heart, examples of test results, and images of devices used to treat heart disease * A glossary defines medical terms used in the book

This third volume in the "Progress in Hypertension" series is dedicated to the memory of Professor Kozo Okamoto the creator of spontaneously hypertensive rats (SHR), stroke-prone spontaneously hypertensive rats (SHRSP) and malignant stroke-prone spontaneously hypertensive rats (M-SHRSP). The papers in this volume deal with pathophysiology and pharmacology of SHR. The contributions describe new trends in SHR research from haemodynamic characteristics to immunological views. The emphasis is placed on the development of transgenic rats and the use of tissue culture studies to elaborate SHR characteristics. The possible use of SHRSP as a model of cerebrovascular dementia can also serve as a novel concept to facilitate the study of vascular dementia. The role of excitatory amino SHR are also covered in this book.

The increase of emotional stress has disturbing effects on the neurohumoral regulation of metabolic processes, especially in relation to the cardiovascular system, and increases the changes of organisms developing atherosclerosis. This book studies the effects on the cardiovascular system (in IHD patients) caused by emotions of diverse biological qualities (both positive and negative). At the same time, the relationship between these effects on the functional activity of various hormonal systems and the blood coagulation system are studied in order to determine the mechanisms and development of atherosclerotic processes.

Netter's Cardiology, 2nd Edition, by Marschall S. Runge, Cam Patterson, and George Stouffer, uses visually rich Netter artwork to efficiently provide you with a concise overview of cardiovascular anatomy, pathophysiology, diagnosis, and management. In print and online, you'll rapidly access complete introductions to common issues in cardiology, including annotated references of the most important articles, guidelines, and available evidence. Downloadable images and over 20 printable patient handouts facilitate patient education and enhance your personal presentations. Netter - it's how you know. Efficiently review key details of anatomy, pathophysiology, and clinical presentation with detailed, crystal-clear artwork by Frank H. Netter, MD and other illustrators working in the Netter tradition. Apply dependable clinical advice from Marschall S. Runge, MD, PhD, Cam Patterson, MD and George Stouffer, MD and utilize diagnostic and therapeutic algorithms and clinical pathways developed by the many world-renowned chapter contributors. Utilize annotated references to the most important resources and evidence-based studies. Benefit from expanded coverage of cardiovascular imaging including echocardiography, stress testing and nuclear imaging, and CT and MRI. Access the complete searchable contents online, download Netter artwork for your personal use, and print patient education handouts to share the visual didactic power of Netter with your patients. Gain a concise and visual overview of the common conditions in cardiology

Written by world-renowned leaders in the fields of clinical electrophysiology and arrhythmology, the volume has represented since many years a biannual update on the most recent advances in the diagnosis, prognosis and treatment of cardiac arrhythmias. The main chapters deal with atrial fibrillation and other supraventricular tachyarrhythmias, diagnosis and management of ventricular arrhythmias, risk stratification and prevention of sudden death in post-MI patients. The systematic and didactic approach to each topic makes the book a very useful tool for physicians working in the field.

Now in its second edition, this practical guide offers clear-headed guidance to the successful application of catheter ablation for atrial fibrillation. This book concentrates on clinically-relevant information that providers can put to immediate use caring for patients. * Takes a clear-headed practical approach to ablation of atrial fibrillation long on actionable, clinically-relevant guidance, succinct and to-the-point on the theory behind the procedure * Edited by three leading, internationally-known electrophysiologists with extensive experience in ablation for atrial fibrillation * Written by international team of experts reflecting global best practices from centers with considerable experience in the use of catheter ablation * Format designed to serve the needs of electrophysiologists regardless of experience, electrophysiology fellows, electrophysiology nurses and lab technical staff * Covers hot topics such as new noninvasive imaging techniques, the treatment of challenging left atrial flutters, options for persistent atrial fibrillation and when a redo ablation is needed; and novel application of ablation targeting the autonomic nervous system

This book describes the most recent insights into heart failure and the role played by autonomic nervous system pathophysiology in it, discussing the therapeutic implications. While current therapeutic approaches are able to control the effects of excessive adrenergic activation in heart failure syndrome, the underlying abnormalities of adrenergic control remain unaltered and can still cause progression to unmanageable end-stage heart failure. New therapeutic pathways are therefore being explored with a view to developing interventions that can directly modulate adrenergic over-activity and restore a more appropriate balance in neural control of the cardiovascular system. The book opens by examining current heart failure therapies. Advances in our understanding of autonomic regulation/dysregulation in heart failure are then discussed in detail, in the context of the search for more effective therapies. A concluding section addresses the role of autonomic nervous system denervation in heart failure. The authors are top scientists from leading research centers.

This book is a practical guide to the differential diagnosis and treatment of patients presenting in the Emergency Department with syncope or arrhythmias, including bradyarrhythmias, atrial fibrillation, narrow and wide QRS tachycardias. In addition, clear advice is provided on the management of patients with cardiac devices and possible dysfunction, electrical storm, or a requirement for urgent surgery. For each topic, a literature review of epidemiology, physiopathology, differential diagnosis, and treatment is conducted. Furthermore, practical suggestions are offered for short-term management, e.g., regarding the decision on when and where to hospitalize the patient; these proposals do not replace but rather summarize or integrate the current guidelines. The book is designed both for emergency physicians and cardiologists, who will be the first to evaluate and treat patients with arrhythmias or potentially arrhythmic problems in the emergency setting. It will also be a useful textbook for students and residents in Cardiology and Emergency Medicine.

This new edition is an integral source of information on Atherosclerosis. It covers topics such as newer coronary risk factors, high-density lipoprotein metabolism, lipid-lowering drugs, endothelium and thrombosis in atherogenesis, and contributing risk factors. With over 500 exceptional photographs, diagrams, and charts, each chapter illustrates an important facet of diagnosing and treating this common and often fatal disease.