This special issue of the Handbook of Experimental Pharmacology on Heart Failure covers the entire spectrum of the field, from the current understanding and definitions of heart failure, to epidemiology and the importance of co-morbidities, clinical trial design and biomarkers, as well as imaging technologies. The main focus of this book is to review current and emerging heart failure therapies and potential targets for treatment.

Hypertension is another name for high blood pressure. It can lead to severe complications and increases the risk of heart disease, stroke, and death. Blood pressure is the force exerted by the blood against the walls of the blood vessels. Comprising more than 1000 pages, this book is a complete guide to the diagnosis and management of hypertension. Divided into 19 sections, the text begins with an introduction to hypertension, its causes, risk factors, and how it presents in different sectors of the population. The next chapters discuss diagnostic methods and echocardiography. The following sections cover hypertension associated with other disorders including heart failure, stroke, renovascular diseases, metabolic syndrome, and many more. Numerous clinical management strategies are discussed in depth, as well as cardio-oncology, nutrition, and ECMO (Extracorporeal Membrane Oxygenation - a procedure that uses a machine to take over the work of the lungs and sometimes, the heart). A complete section is dedicated to paediatric cardiology and hypertension. With an internationally recognised editor and author team, the comprehensive text is highly illustrated with clinical photographs, diagrams and tables. The book also includes full online access. Key points Comprehensive guide to diagnosis and management of hypertension comprising over 1000 pages Internationally recognised editor and author team Highly illustrated with clinical photographs, diagrams and tables Includes full online access to the book

The use of proteomics to study complex diseases such as cardiovascular disease, the leading cause of death in developed countries, has grown exponentially in recent years. Proteomics is a rapidly expanding investigation platform in cardiovascular medicine and is becoming integrated and incorporated into cardiovascular research. The proteomics field continues to develop with major improvements in mass spectrometry instrumentation, methodology and data analysis. Heart Proteomics: Methods and Protocols complies a selection of techniques and methods that target the numerous processes implicated in the pathophysiology of heart. Chapters cover protocols and updated methods in the heart proteomic area with a particular focus on MS-based methods of protein and peptide quantification and the analysis of posttranslational modifications as well as descriptions of system biology approaches, which provide a better understanding of normal and pathological processes. Written in the successful Methods in Molecular Biology (TM) series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Heart Proteomics: Methods and Protocols is a representative selection of methods that will prove to be a useful resource for experienced proteomics practitioners and newcomers alike.

The book comprises contributions by some of the most respected scientists in the field of mathematical modeling and numerical simulation of the human cardiocirculatory system. It covers a wide range of topics, from the assimilation of clinical data to the development of mathematical and computational models, including with parameters, as well as their efficient numerical solution, and both in-vivo and in-vitro validation. It also considers applications of relevant clinical interest. This book is intended for graduate students and researchers in the field of bioengineering, applied mathematics, computer, computational and data science, and medicine wishing to become involved in the highly fascinating task of modeling the cardiovascular system.

Cardiovascular disease is the leading cause of morbidity and premature death of modern era medicine. It is estimated that approximately 81 million people in the United States (US) currently have one or more of the many forms of cardiovascular disease, resulting in 1 in every 2.8 deaths, or 900,000 deaths per year. 40% of all deaths in Europe are a result of cardiovascular disease in people under the age of 75. Aneurysms form a significant portion of these cardiovascular related deaths and are defined as a permanent and irreversible localised dilation of a blood vessel greater than 50% of its normal diameter. Although aneurysms can form in any blood vessel, the more lethal aneurysms develop in the cranial arteries, and in the thoracic aorta and abdominal aorta. Frequently aneurysms are undetected and if left untreated may eventually expand until rupture with very high levels of morbidity and mortality. The biomechanics and mechanobiology of aneursymal diseases are not fully understood and this monograph aims to provide new insights into aneurysm aetiology and behavior based on the most recent biomechanics research related to this important topic. The contributors to this volume bring together a unique blend of expertise in experimental, computational and tissue biomechanics relating to aneurysm behavior and enable the reader to gain a fresh understanding of key factors influencing aneurysm behavior and treatment. Biological risk factors such as tobacco smoking, sex, age, hypertension, family history and mechanobiological risk factors such as aneurysm geometry and shape as well as mechanical properties of the diseased tissues are considered in detail as are many of the diagnostic and treatment options.

Transplantation of the Heart and HeartLungs (N.E. Shumway). Physiologic Principles and Clinical Use of Hypothermia (L.K. Davis, R.F. Davis). Anesthetic Evaluation and Management in Bloodless Surgery (N.S. Faithfull). Normothermic Mycocardial Preservation, an Optimal Approach for Myocardial Protection During All Forms of OpenHeart Surgery (R.E. Engelman et al.). Pharmacologic Manipulations to Minimize Bloodloss in Cardiac Surgery (A.C. Cernaianu, A.J. DelRossi). Sutureless Intraluminal Ring Grafts for Aortic Replacement (G.M. Lemole). Immunologic Consequences of Transfusion (P.I. Tartter). Traumatic Rupture of the Thoracic Aorta (R.C. Camishion, J.B. Alexander). Cardiomyoplasty (R.C.J. Chiu). Current Status of Autotransfusion (R.A. Vertrees, A.C. Cernaianu). Transesophageal Echocardiology (W.H. O'Connor). The Use of Circulatory Support in Cardiac Surgery (R.L. Kormos). 9 additional articles. Index.

This volume of "Advances in Cell Aging and Gerontology" provides a timely review on the molecular and cellular basis of cardiovascular diseases (CVD). Age itself is the leading risk factor for cardiovascular diseases, which include loss of vasomotor function, athero- and arterio-sclerosis, hypertension, congestive heart failure and stroke. Together these pathologies comprise the leading causes of permanent disability, hospitalization and death for individuals over the age of 65. Thus, there is a critical need to assess both the age-associated causes leading to CVD as well as the current state of knowledge on preventive regimens designed to slow or modulate disease progression.

This book concisely summarizes the current knowledge related to the major aspects contributing to cardiovascular disfunction in the elderly as well as potential ways of maintaining or improving human cardiovascular healthspan.

An ECG, or electrocardiogram, is a simple test that records the rhythm and electrical activity of the heart. It is commonly used to detect abnormal heart rhythms and investigate the cause of chest pains. It is important for clinicians to recognise and interpret ECG patterns accurately to ensure correct diagnosis and effective treatment. This book is step by step guide to performing and interpreting ECGs. Divided into 11 sections, the text begins with an overview of the history of ECGs and the physiology of the heart and its conduction system. The next chapters discuss the basics of ECG, the leads and their placement, and normal ECG morphology. The following sections cover systematic interpretation of ECGs, arrhythmias, paediatric ECG interpretation and congenital anomalies, and finally, differential diagnosis. The second edition of this practical guide has been fully revised to include the latest advances in the field. Line diagrams and clinical images further enhance learning. Key points Step by step guide to performing and interpreting ECGs Fully revised, second edition covering latest advances in the field Highly illustrated with line diagrams and clinical images Previous edition (9789350900864) published in 2012

This book is a practical guide to the diagnosis and management of cardiovascular diseases and disorders. Presented in a step by step approach covering patient history, signs and symptoms, examination and investigation, diagnosis, and treatment methods, each chapter covers a different cardiac condition. The second edition has been fully revised and new topics added to provide clinicians with the latest advances in the field. The comprehensive text is further enhanced by more than 200 clinical photographs, diagrams and tables to assist learning. Key points Comprehensive guide to diagnosis and management of cardiovascular diseases and disorders Fully revised, second edition with new topics added Highly illustrated with clinical photographs, diagrams and tables Previous edition (9789350259856) published in 2012

Clinical Diagnosis of Congenital Heart Disease is the latest edition of this comprehensive, highly illustrated guide to the diagnosis of congenital heart disease. Divided into 31 sections, each chapter discusses a different aspect of congenital heart disease, clearly explaining history, assessment, imaging, clinical diagnosis and management techniques. This third edition has been fully revised to provide the latest advances in the field, with in depth discussion on new diagnostic modalities. Each topic concludes with a summary of key points, and includes schematic diagrams depicting abnormal anatomy and its pathophysiological consequences. Key Points Highly illustrated guide to diagnosis of congenital heart disease Fully revised, third edition with in depth discussion on new diagnostic modalities Each topic features a summary of key points and schematic diagrams of abnormal anatomy Previous edition (9789351529125) published in 2015

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning.
Volume 3 is devoted to the set of mediators of the cell surface, especially ion and molecular carriers and catalytic receptors that, once liganded and activated, initiate signal transduction pathways. Intracellular cascades of chemical reactions trigger the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Primary mediators are included in models of regulated cellular processes, but multiple secondary signaling components are discarded to allow simple, representative modeling and to manage their inverse problems.

The textbook will describe the relationship between human cardiopulmonary system and exercise in a format that is related to the mode of exercise, health status and aging. It will include data regarding exercise training principles and the adaptations of the cardiopulmonary following: anaerobic, resistance and aerobic training. A more in-depth presentation of the cardiopulmonary system adaptations in pressing environments such as: warm, cold and altitude. Therefore, students will experience a depth and extent of content balanced with unique and effective learning features: It will help students find the way by both the text and subject matter. Knowing cardiopulmonary exercise function in health and disease will allow understand new research and findings relevant to cardiovascular status as assessed by cardiopulmonary exercise indices. It will bring together investigational exercise physiologists, cardiologists and scientists who share a wealth of experience needed to judge the cardiovascular status and function, and the impairments of patients with a variety of cardiac dysfunction. This book will provide a comprehensive, updated presentation of the information of the cardiovascular system as a whole, and its individual components.

Enthusiastically acclaimed by medical students and faculty worldwide, this text is specifically designed to prepare students for their first encounters with patients with cardiovascular disease. Thoroughly revised by internationally recognized Harvard Medical School faculty and a team of select cardiology fellows and internal medicine residents, this seventh edition equips students with a clear, complete, and clinically relevant understanding of cardiovascular pathophysiology, setting a strong foundation for patient diagnosis and management. New seventh edition highlights: Review questions and answers in each chapter prepare students for course and board exams. New contributors include cardiology fellows and internal medicine residents, who worked closely with faculty to extend coverage of clinically pertinent issues for medical students. Updated content reflects the latest understanding of mechanisms of cardiac disease and technological advances. Classic student-friendly features: Full-color illustrations help readers visualize and quickly grasp key concepts. Medical imaging and color clinical photographs show real-world examples of many clinically relevant cardiovascular conditions. Introductory chapter outlines and end-of-chapter summaries provide organized, quick review of core information. Bonus online study tools: Animations help support understanding of complex, dynamic disease processes. Interactive question bank reinforces learning and improves retention.

This collection of reviews will be of considerable interests to biologists and MDs working on any aspect of cardiovascular function. With state-of-the-art reviews written by competent experts in the field, the content is also of interest for MSc and PhD students in most fields of cardiovascular physiology.

This book offers readers a comprehensive biomaterials-based approach to achieving clinically successful, functionally integrated vasculogenesis and myogenesis in the heart. Coverage is multidisciplinary, including the role of extracellular matrices in cardiac development, whole-heart tissue engineering, imaging the mechanisms and effects of biomaterial-based cardiac regeneration, and autologous bioengineered heart valves. Bringing current knowledge together into a single volume, this book provides a compendium to students and new researchers in the field and constitutes a platform to allow for future developments and collaborative approaches in biomaterials-based regenerative medicine, even beyond cardiac applications.

Many athletes suffer health and sports consequences related to inadequate nutrition to meet their sports demands. It often goes unrecognized and untreated if they do not have the stereotypical diagnosis of an “eating disorder.” Highly marketable for those looking to gain an extra edge above the competition by maximizing their health through appropriate nutrition and mental work. The book has background information on the problem and serves as an instruction manual for coaches and parents. Female athletes’ personal narratives are dispersed within the information.

This book collects several contributions, written both by statisticians and medical doctors, which focus on the identification of new diagnostic, therapeutic and organizational strategies in order to improve the occurrence of clinical outcomes for Acute Coronary Syndromes (ACS) patients. The work is structured in two different parts: the first one is focused on cooperative project mainly on statistical analysis of large clinical and administrative databases; the second one faces the development of innovative diagnostic techniques, with specific reference to genetic and proteomic, and the evolution of new imaging techniques for the early identification of patients at major risk of thrombotic, arrhythmic complications and at risk of poor revascularization.

CARDIAC VALVE ALLOGRAFTS (HOMOGRAFTS) highlights the current controversy about freehand subcoronary aortic valve and root replacement with regard to postoperative morbidity and long term durability. It discusses particular implantation techniques of preference in young patients and in different root pathology. Other chapters address intermediate- and long-term results on cardiac valve and vascular homografts for treating complicating cardiac valve and aortic infections. The chapter on basic science additionally makes this book a highly authoritative reference source for cardiac surgeons, physicians and scientists. This work provides a current survey of the state-of-the-art.

Subjects in the monograph "Biophysics of the Failing Heart" include state of the art chapters considering major biophysical mechanisms for why hearts responding to acquired or inherited stressors enter into maladaptive processes eventually leading to an inability of the heart to respond efficiently to hemodynamic loads especially during exercise. The chapters describe biophysical techniques that have been applied to determine the triggers for the heart failure process as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. By its emphasis on biophysical aspects of a prevalent clinical condition, the monograph is unique in its perspective and focus. The breadth of information in the chapters all in one place will be of value to clinicians and researchers at all levels. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. In most cases, combinations of clinician scientists and researchers author the chapters. A main benefit of the book is couched in its didactic approach together with its emphasis on how biophysical concepts and techniques aid in diagnosis and development of new therapies.

This book introduces the latest research in molecular, cellular, and tissue engineering of the vascular system. Topics covered include the roles of endothelial surface glycocalyx as a mechano-sensor and transducer for blood flow, a barrier to water and solute transport across the vascular wall and to the interaction between circulating cells and the vessel wall, the roles of nuclear envelope proteins and nuclear lamina in regulating vascular functions under blood flow-induced forces, and the roles of smooth muscle cells and extracellular components in arterial vasoconstriction. Other topics covered include non-surgical vascular interventions for coronary artery diseases, genesis and mechanisms of atherosclerotic plaque microcalcifications and human abdominal aortic aneurysms, experiments and modelling for red blood cell and tumor cell movement in microcirculation, transport across the blood-brain barrier and its role in Alzheimer's disease, mathematical models for cell survival after hyperthermia, application of hypothermia in enhancing treatment for brain and spinal cord injuries, and damage of eardrums due to blast waves. This is an ideal book for biomedical engineers and researchers, medical researchers, and students in biomedical engineering and medical sciences.

"Electrical Disease of the Heart, 2nd Edition, volume 2, " covers the diagnostic and treatment options available in the management of electrical diseases and with its companion volume provides the latest developments in the field of experimental and clinical cardiac electrophysiology, genetics, pharmacology and interventional therapies of various clinical arrhythmogenic entities. This bookis highly relevant to a broad audience, ranging from medical and graduate students, to clinicians and scientists."